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Featured Article Academic Journal Main Category: Epilepsy Also Included In: Pediatrics / Children's Health Article Date: 12 Aug 2013 - 9:00 PDT Current ratings for: Genetic clues to epilepsy discovered by scientists 3.25 (4 votes) Scientists have discovered two new genes linked to severe forms of childhood epilepsy, a breakthrough reached with new genetic technology, according to a study published in the journal Nature. Researchers say that the genetic research technique may be a highly effective way of making discoveries about other complex neurological disorders like epilepsy. According to the Centers for Disease Control and Prevention (CDC), epilepsy affects more than 2 million people in the US. More than 300,000 of these are children under the age of 15. This most recent research is part of a worldwide study called Epilepsy 4000 (Epi4k), analyzing DNA from 4,000 epilepsy patients and their relatives. Researchers from Duke University Medical Center and staff from the National Institutes of Health (NIH) created a series of international research institutions named Epilepsy Centers Without Walls. The centers enabled the researchers to conduct an analysis of DNA sequences and patient information of participants. The researchers say that DNA and clinical data was originally collected through the NIH-funded … Continue reading →

Public release date: 11-Aug-2013 [ | E-mail | Share ] Contact: Rebecca Scott rebeccas@unimelb.edu.au 61-383-440-181 University of Melbourne Results from a landmark international study using state of the art technology has revealed new genetic mutations that cause epilepsy. The findings could help to advance treatments for the most severe forms of epilepsy. The global study, led by the University of Melbourne and Austin Hospital (Aus), Duke University and the University of California, San Francisco (US), used advanced gene technology known as exome sequencing to identify new genes that cause severe childhood epilepsies. Epilepsy is a brain condition that affects an estimated 50 million people worldwide. As part of a larger project analysing 4,000 genomes from epilepsy patients around the world, researchers have discovered in one group of patients, two new genes and 25 epilepsy-causing mutations. The research suggests there will be common pathways to target epilepsies with drugs and other therapies. It was published today in Nature. Co study leader Professor Sam Berkovic, Director of the Epilepsy Research Centre, University of Melbourne and Austin Hospital said the study was a major conceptual advance in how we analyse epilepsies, helping researchers to better identify their genetic causes and improve treatment options. … Continue reading →

Public release date: 12-Aug-2013 [ | E-mail | Share ] Contact: Susan Griffith susan.griffith@case.edu 216-368-1004 Case Western Reserve University Parents of children with epilepsy and mental health problems have a new go-to resource. Researchers from Case Western Reserve University and Cleveland Clinic have created "What you should know about mental health in youth with epilepsy," an information booklet and CD that answers questions about children's medical and psychological issues. About 2 million Americans, or roughly one percent of the population, have epilepsy, according to The Epilepsy Foundation. It also reports that mental health issues, including depression, affect about 30 percent of children with epilepsy. Depression contributes to suicide, which is higher among adolescents with epilepsy than the general teen populations. So many parents naturally wonder what can be done to help their children. Drawing from their experiences with families and children with epilepsy, Jane Timmons-Mitchell, PhD, from the Begun Center for Violence Prevention Research and Education at the Jack, Joseph and Morton Mandel School of Applied Social Sciences, and Tatiana Falcone, MD, an assistant professor of medicine in the Child and Adolescent Psychiatrist Epilepsy Center at Cleveland Clinic, created the guide. The information includes sections on child development, epilepsy and … Continue reading →

Researchers: Autism/induced labor link no reason to change current use. Olivia Kelly (6) takes a kiss from Buck the therapy dog at the Life Skills/Touch Point Autism Services "Milk and Cookies with Santa" event in Maryland Heights, Missouri. UPI/Bill Greenblatt License photo Published: Aug. 12, 2013 at 7:49 PM ANN ARBOR, Mich., Aug. 12 (UPI) -- U.S. researchers say they found a correlation between pregnant women whose labors are induced or augmented and an increased risk of autism. Senior author Marie Lynn Miranda of the University of Michigan said the findings did not prove cause and effect, but suggested the need for more research, particularly as labor induction and augmentation have been used more frequently in recent years. "Additional studies are needed to differentiate among potential explanations of the association, such as: underlying pregnancy conditions requiring the eventual need to induce/augment, the events of labor and delivery associated with induction/augmentation, and the specific treatments and dosing used to induce/augment labor such as exogenous oxytocin and prostaglandins," Miranda said in a statement. Lead author Simon G. Gregory of Duke University analyzed records of all births in North Carolina over an eight-year period and matched 625,042 births with corresponding public school records, … Continue reading →

Girls with anorexia may tend to have traits that are usually found in people with autism, a new study suggests. Researchers compared 66 teen girls who had anorexia with about 1,600 girls who did not have the eating disorder, using questionnaires they had previously developed to assess thinking and personality types in children with autism. The girls with anorexia were found to have more interest in systems and order, and lower scores in empathy a profile more similar to people with autism than to typical adolescents, the researchers said. The finding suggests the two conditions may share certain features, such as rigid attitudes and behaviors, a tendency to be very self-focused and a fascination with detail, the researchers said. Traditionally, anorexia has been viewed purely as an eating disorder. This is quite reasonable, since the girls dangerously low weight and their risk of malnutrition or even death has to be the highest priority for treatment, said Simon Baron-Cohen, a professor of developmental psychopathology at the University of Cambridge in England. But his study suggests that underlying the surface behavior, the mind of a person with anorexia may share a lot with the mind of a person with autism, Baron-Cohen said. … Continue reading →