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Stem cells in urine have potential for numerous therapies

Posted: Published on August 1st, 2013

Stem cells in urine directed to become several different cell types, indicating many therapeutic uses. Could harvesting stem cells for therapy one day be as simple as asking patients for a urine sample? Researchers at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine and colleagues have identified stem cells in urine that can be directed to become multiple cell types. "These cells can be obtained through a simple, non-invasive low-cost approach that avoids surgical procedures," said Yuanyuan Zhang, M.D., Ph.D., assistant professor of regenerative medicine and senior researcher on the project. Reporting online in the journal Stem Cells, the team successfully directed stem cells from urine to become bladder-type cells, such as smooth muscle and urothelial, the cells that line the bladder. But the urine-derived cells could also form bone, cartilage, fat, skeletal muscle, nerve, and endothelial cells, which line blood vessels. The multipotency of the cells suggests their use in a variety of therapies. "These stem cells represent virtually a limitless supply of autologous cells for treating not only urology-related conditions such as kidney disease, urinary incontinence and erectile dysfunction, but could be used in other fields as well," said Zhang. "They could also potentially be used to … Continue reading

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Stem cells in urine easy to isolate and have potential for numerous therapies

Posted: Published on August 1st, 2013

July 31, 2013 Could harvesting stem cells for therapy one day be as simple as asking patients for a urine sample? Researchers at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine and colleagues have identified stem cells in urine that can be directed to become multiple cell types. "These cells can be obtained through a simple, non-invasive low-cost approach that avoids surgical procedures," said Yuanyuan Zhang, M.D., Ph.D., assistant professor of regenerative medicine and senior researcher on the project. Reporting online in the journal Stem Cells, the team successfully directed stem cells from urine to become bladder-type cells, such as smooth muscle and urothelial, the cells that line the bladder. But the urine-derived cells could also form bone, cartilage, fat, skeletal muscle, nerve, and endothelial cells, which line blood vessels. The multipotency of the cells suggests their use in a variety of therapies. "These stem cells represent virtually a limitless supply of autologous cells for treating not only urology-related conditions such as kidney disease, urinary incontinence and erectile dysfunction, but could be used in other fields as well," said Zhang. "They could also potentially be used to engineer replacement bladders, urine tubes and other urologic organs." Being able to … Continue reading

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New Research Uses Ethical Stem Cells to Create Liver Buds and Artificial Bones

Posted: Published on August 1st, 2013

NEW YORK, July 31, 2013 /PRNewswire/ --This month, scientific journals have reported on two more studies that highlight how stem cells found in babies' umbilical cord blood and cord tissue represent the future of medical treatments for serious diseases and injuries. Nature, The International Weekly Journal of Science, reported that Japanese scientists have successfully engineered rudimentary human livers, or "liver buds", using three types of stem cells. And, ScienceDaily reported that Spanish scientists have patented a biomaterial that helps create artificial bones using umbilical cord blood stem cells. These developments are among many in an industry that is pioneering stem cell-based therapies for many life threatening and debilitating diseases and injuries, including some that children may be more susceptible to as a result of family medical history. In Japan, the researchers used human induced pluripotent stem cells (iPSCs), endothelial cells, and mesenchymal stem cells (MSCs) to create liver buds. When they implanted the liver buds in mice, the liver buds performed some functions of a liver, including protein production and drug metabolism. iPSCs are a type of pluripotent stem cell artificially derived from a non-pluripotent cell. MSCs can be found in babies' umbilical cord tissue and placenta tissue and can … Continue reading

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Part 2 Stem Cell Therapy – Video

Posted: Published on July 31st, 2013

Part 2 Stem Cell Therapy By: Tiffany Vinson … Continue reading

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DOCTORS DIVIDED | Performing 'unproven' stem-cell procedures vs following DOH guidelines

Posted: Published on July 31st, 2013

By: Jet Villa, InterAksyon.com July 31, 2013 8:46 AM InterAksyon.com The online news portal of TV5 MANILA, Philippines - Filipino physicians are now divided over the controversial stem cell therapy. Doctors from the Philippine College of Physicians, Philippine Society of General Internal Medicine (PSGIM), Philippine Society of Hematology and Blood Transfusion (PSHBT), and Philippine College of Chest Physicians (PCCP) have lambasted their colleagues from the Philippine Society for Stem Cell Medicine (PSSCM) for performing unproven procedures. The groups also lamented that PSSCM even charges exorbitant fees when it is the patients who should be paid as these procedures are still under experimental stage. We are here to inform the public that they may be being deceived now. There are doctors who are making it appear that stem cell therapy is a panacea, the cure for all diseases when, in fact, there are limited indication where it can be used for, said PCP Vice President Dr. Anthony Leachon in a health forum. In a separate interview, PSSCM spokesman Dr. Leo Olarte admitted that there is still limited use for the therapy but PSSCM members just go by the guidelines of the DOH. We follow the DOH guidelines and what is allowed … Continue reading

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Medistem Presents Its ERC-124 Stem Cell Product at CRYO 2013

Posted: Published on July 31st, 2013

SAN DIEGO, CA--(Marketwired - Jul 31, 2013) - Medistem, Inc. (PINKSHEETS: MEDS), announced today it's President and Chief Scientific Officer, Thomas E. Ichim, Ph.D., presented at the CRYO 2013 Conference held in Bethesda, Maryland on Monday July 29th. The CRYO 2013 Conference was sponsored by the Society for Cryobiology, which, this year, is celebrating 50 years of member accomplishments.The Society for Cryobiology, founded in1964, attracts experts from biological, medical and physical sciences and its mission is to promote scientific research in low temperature biology, to improve scientific understanding in this field, and to disseminate and apply this knowledge to the benefit of mankind. Dr. Ichim presented the Company's cryopreservation process in the manufacturing and shipment of its ERC-124 product, an allogeneic universal donor stem cell derived from the endometrium (lining of the uterus). "Through the use of cryopreservation we have been able to ship our ERC-124 product internationally with no loss of therapeutic potency.This has allowed us to centralize our ERC-124 manufacturing process and ship to point of care sites worldwide," said Dr. Ichim."We are honored to have been selected by the Society for Cryobiology to present details of our processes at its 50th Annual Meeting." Medistem is the only … Continue reading

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New State-Sponsored Stem Cell Study Launches for Alzheimer’s Disease

Posted: Published on July 31st, 2013

The war against Alzheimer's disease is getting another round of stem cell research thrown at it. While this involves a public company, the reality is that Alzheimer's is truly a holy grail for any company that can make progress against the degenerative brain disease. StemCells, Inc. (STEM) has formally launched its Alzheimer's disease program under support of the California Institute for Regenerative Medicine. Alzheimer's disease has no cure and all drug efforts to date have only delayed or slowed the progression of the disease. Most drug studies have ended before even making it to the formal U.S. Food and Drug Administration (FDA) application process because the efficacy has been so limited. The Alzheimer's Association indicates that roughly 5.4 million Americans have the disease, and the situation will worsen as our population continues to age. The annual cost is projected to be from $150 billion to $200 billion per year in the United States alone to treat the patients with Alzheimer's disease. The Most Corrupt Countries in the World Why today's study launch matters is that its stated goal is to file an Investigational New Drug (IND) application with the FDA within four years. It will evaluate StemCells' proprietary HuCNS-SC product … Continue reading

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Cancer Immunotherapy Platform Targets Broad Range of Metastatic Cancers

Posted: Published on July 31st, 2013

IRVINE, Calif.--(BUSINESS WIRE)-- California Stem Cell, Inc. (CSC) has announced the completion of an internal study demonstrating that the companys proprietary immunotherapy manufacturing process can be applied to multiple cancer types. Originally developed for late stage metastatic melanoma, the platform tissue culture technology has also been shown to work with tumor tissues from hepatocellular carcinoma, ovarian cancer, glioblastoma multiforme, and other solid tumor cancers. The unique principle supporting CSCs cancer immunotherapeutic approach is purification of tumor stem cells isolated from a patients own tumor tissue, to use as an antigenic source. While prior companies processes typically took months and often yielded unreliable or unusable materials, CSC has standardized its platform technology for reproducibility, resulting in optimized high cell yields, and efficient and scalable manufacturing. The companys proprietary stem cell culturing technologies, performed under cGMP conditions, have resulted in a consistent production time of less than 8 weeks, with a 100% success rate in generating lines with potential applicability to a broad range of cancer types. Such significant improvements in the manufacturing time and success rate are critical when working with late stage cancers that typically have a short window for treatment, said Gabriel Nistor, M.D., CSC Vice President of Research … Continue reading

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Stem cell treatment no panacea, docs say

Posted: Published on July 31st, 2013

By Jeannette I. Andrade Philippine Daily Inquirer Researcher Shruti Dave (right) and assistant Chetan Patel work on stem cell cultures at the Transplantation Biology Research Centre at The Institute of Kidney Disease and Research Centre (IKDRC), Civil Hospital campus in Ahmedabad on February 6, 2013. The Philippine College of Physicians wants the Food and Drug Administration to more strictly regulate the use of stem cell therapy, which was being wrongfully projected as a cure-all. AFP FILE PHOTO MANILA, PhilippinesThe Philippine College of Physicians (PCP) wants the Food and Drug Administration (FDA) to more strictly regulate the use of stem cell therapy, which was being wrongfully projected as a cure-all. At a press conference in Quezon City on Tuesday, PCP vice president Dr. Anthony Leachon said the use of stem cell therapy to treat almost all medical conditions was becoming rampant even though the treatment has been tested and approved only for some blood and bone marrow cancers and primary immune deficiencies. This poses serious safety issues, he warned. Leachon said the use of the treatment to cure other diseases or even slow down aging has not been scientifically proven in clinical studies. He said current government regulations were centered on … Continue reading

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Silk brain implants could stop epilepsy from progressing

Posted: Published on July 31st, 2013

The group of neurological disorders known as epilepsy not only cause disruptive, alarming seizures, but those seizures also tend to increase in frequency and severity over time. While the majority of patients can gain some control of their condition via medication or surgery, approximately 30 percent cannot. Now, however, help may be on the way ... in the form of tiny pieces of silk implanted in the brain. The silk is designed to store and subsequently release adenosine, a nucleoside that has been shown to decrease neuronal excitability and thus decrease seizures studies have suggested that epileptics may have abnormally low adenosine levels. The substance is continuously released from the implant over the course of 10 days, after which the biodegradable silk harmlessly dissolves into the body. A team of scientists from Portand, Oregons Legacy Research Institute, Oregon Health and Sciences University (OHSU) and Tufts University in Boston experimented with placing the implants in the brains of rats that were already in the early stages of epilepsy. Although the animals werent completely cured of their disorder, they did proceed to experience a four-fold reduction in seizures. One specific type of epilepsy involves the formation of new excitatory circuits in an … Continue reading

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