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Scientists in bid to pinpoint undiscovered MS treatments

Posted: Published on July 18th, 2013

Researchers from Edinburgh University and University College London (UCL) will test whether medicines for the conditions could benefit certain people with MS. Scotland has the highest prevalence of MS in the world, with around 10,500 people affected. It causes loss of mobility, muscle spasms, slurred speech and fatigue. It is hoped the drugs will work on those who have secondary progressive multiple sclerosis, which is characterised by increasing disability, by protecting the nerves from damage. The scientists believe the trial could revolutionise the way patients with MS are treated and, because the drugs are already licensed and known to be safe, it could shave years off the time usually needed before new treatments can be rolled out. Dr Jeremy Chataway, consultant neurologist and lead researcher on the trial based at UCL, said: "While there are an increasing number of treatments for MS that can reduce the frequency or severity of MS relapses, there's nothing that can stop the rapid accumulation of disability in people with secondary progressive MS. "It's a huge unmet need in the treatment of the condition and, despite many clinical trials, scientists have so far failed to find anything that works." Dr Susan Kohlhaas, head of biomedical … Continue reading →

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MS hope from 'off-the-shelf' drugs

Posted: Published on July 18th, 2013

17 July 2013 Last updated at 02:44 ET By Helen Briggs BBC News Existing drugs for motor neurone disease, asthma and heart disease are being tested as possible treatments for advanced multiple sclerosis (MS). About 500 people with late-stage MS are to enrol in clinical trials in England and Scotland to see if three common drugs can slow disease progression. Research suggests the medicines may protect the brain from further damage. There is currently no treatment for secondary progressive MS, a form of the disease marked by increased disability. About 100,000 people are living with MS in the UK. Symptoms include problems with walking, balance, speech, vision and extreme fatigue. Treatments are available to help with relapses and symptoms of MS during the early stages of the disease. However, despite clinical trials, scientists have so far failed to find a medicine that works in the late stages of MS. Now, after reviewing published data on drug treatments that might help protect nerves in the brain, UK researchers are focusing on three drugs that are licensed for other conditions. The three drugs are amiloride - currently licensed to treat heart disease and high blood pressure; ibudilast - an asthma drug used … Continue reading →

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Gut bacteria linked to immune system cancer, lymphoma

Posted: Published on July 18th, 2013

Featured Article Academic Journal Main Category: Lymphoma / Leukemia / Myeloma Article Date: 17 Jul 2013 - 8:00 PDT Current ratings for: Gut bacteria linked to immune system cancer, lymphoma 4.6 (5 votes) Scientists say they have discovered that specific bacteria found in the intestines are major contributors to lymphoma, a cancer of the white blood cells in the immune system. The researchers, from the Jonsson Comprehensive Cancer Center (JCCC) at the University of California in LA (UCLA), studied mice with ataxia-telangiectasia (A-T), a genetic disease that is associated with a high rate of B-cell lymphoma in humans and mice. Their study is published in The Journal of Cancer Research. The human gut has around 100 trillion bacterial cells from up to 1,000 different species, the researchers say. They add that every person's microbiome (the body's bacterial make-up) is different as a result of the effects of diet and lifestyle, and the childhood source of bacteria. From this, the scientists wanted to see whether the differences in people's microbiomes would affect their risk of developing lymphoma, and whether changing the bacteria could reduce this risk. The results were that mice who had a certain type of intestinal bacteria lived much … Continue reading →

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SHC Video 17 Natural Hormone Replacement Therapy – Video

Posted: Published on July 18th, 2013

SHC Video 17 Natural Hormone Replacement Therapy By: SuperiorhealthWoodst … Continue reading →

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Digging through the lasting confusion about the safety of hormone replacement therapy

Posted: Published on July 18th, 2013

After a decade of rancorous debate over the risks and benefits of menopausal hormone therapy, experts from more than a dozen top medical organizations worldwide have finally come to something resembling a consensus. What did they decide, and why are women still baffled? What is menopausal hormone therapy? Also called hormone replacement therapy, its a treatment for women in the throes of menopause, the inevitable period of life when estrogen naturally declines. Taking estrogen or a combination of estrogen and another hormone, progestin, the synthetic form of progesterone, can alleviate some of the symptoms of menopause, including hot flashes, night sweats, insomnia and vaginal dryness, said Atlanta endocrinologist Scott Isaacs. Women typically hit menopause around age 51. Why is hormone therapy controversial? Hormone therapy has been under intense scrutiny since 2002, when a large study called the Womens Health Initiative reported that taking additional hormones specifically the combination of estrogen and progestin increased the risk of blood clots, stroke, breast cancer, heart attacks and gall bladder disease for some women. For a woman with a uterus, estrogen treatment alone raises her chance of getting endometrial cancer. The researchers abruptly halted the study, concluding that risks outweighed benefits. Almost overnight, millions … Continue reading →

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Stem Cell Research Presentation Lupo – Video

Posted: Published on July 18th, 2013

Stem Cell Research Presentation Lupo By: Marty Lupo … Continue reading →

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France lifted ban on embryonic stem cell research – Video

Posted: Published on July 18th, 2013

France lifted ban on embryonic stem cell research The national assembly of France has voted to a lift a ban on embryonic stem cell research, which could pave the way for crucial scientific developments. It i... By: AlJazeeraEnglish … Continue reading →

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Keeping the Reserve Force Home

Posted: Published on July 18th, 2013

Newswise KANSAS CITY, MO - Hematopoietic stem cellsbone marrow-derived adult stem cells that give rise to the wide variety of specialized blood cellscome in two flavors: the reserve force sits quietly waiting to be called upon while the active arm continually proliferates spawning billions of blood cells every day. In their latest study, researchers at the Stowers Institute for Medical Research reveal a new mechanism that is critical in maintaining the delicate balance between the two. Publishing in the July 17 advance online issue of Nature, the team led by Stowers Investigator Linheng Li, Ph.D., reports that genomic imprinting, a process that specifically shuts down one of the two gene copies found in each mammalian cell, prevents the reservists from being called up prematurely. Active HSCs (hematopoietic stem cells) form the daily supply line that continually replenishes worn-out blood and immune cells while the reserve pool serves as a backup system that replaces damaged active HSCs and steps in during times of increased need, explains Li. In order to maintain a long-term strategic reserve of hematopoietic stem cells that lasts a lifetime it is very important to ensure that the back-up crew isnt mobilized all at once. Genomic imprinting provides … Continue reading →

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Genomic imprinting maintains a reserve pool of blood-forming stem cells in mouse bone marrow

Posted: Published on July 18th, 2013

July 17, 2013 Hematopoietic stem cells -- bone marrow-derived adult stem cells that give rise to the wide variety of specialized blood cells -- come in two flavors: the reserve force sits quietly waiting to be called upon while the active arm continually proliferates spawning billions of blood cells every day. In their latest study, researchers at the Stowers Institute for Medical Research reveal a new mechanism that is critical in maintaining the delicate balance between the two. Publishing in the July 17 advance online issue of Nature, the team led by Stowers Investigator Linheng Li, Ph.D., reports that genomic imprinting, a process that specifically shuts down one of the two gene copies found in each mammalian cell, prevents the reservists from being called up prematurely. "Active HSCs (hematopoietic stem cells) form the daily supply line that continually replenishes worn-out blood and immune cells while the reserve pool serves as a backup system that replaces damaged active HSCs and steps in during times of increased need," explains Li. "In order to maintain a long-term strategic reserve of hematopoietic stem cells that lasts a lifetime it is very important to ensure that the back-up crew isn't mobilized all at once. Genomic … Continue reading →

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Inside Story: Medicine and Drugs in China – Video

Posted: Published on July 18th, 2013

Inside Story: Medicine and Drugs in China Follow us on TWITTER: http://twitter.com/cnforbiddennews Like us on FACEBOOK: http://www.facebook.com/chinaforbiddennews A leading global pharmaceutical comp... By: ChinaForbiddenNews … Continue reading →

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