What are mesenchymal stem cells and how can they be used for osteoarthritis treatment? http://www.stemcellsarthritistreatment.com Stem cells in the adult can come from blood sources or from non-blood sources. Mesenchymal stem cells or mesenchym... By: Nathan Wei … Continue reading →

Washington, July 16 (ANI): Researchers at Massachusetts General Hospital (MGH) have used vascular precursor cells derived from human induced pluripotent stem cells (iPSCs) to generate, in mice, functional blood vessels that lasted as long as nine months. In their report, the investigators describe using iPSCs - reprogrammed adult cells that have many of the characteristics of embryonic stem cells - from both healthy adults and from individuals with type 1 diabetes to generate blood vessels on the outer surface of the brain or under the skin of mice. "The discovery of ways to bring mature cells back to a 'stem-like' state that can differentiate into many different types of tissue has brought enormous potential to the field of cell-based regenerative medicine, but the challenge of deriving functional cells from these iPSCs still remains," Rakesh Jain, PhD, director of the Steele Laboratory for Tumor Biology at MGH and co-senior author of the study, said. "Our team has developed an efficient method to generate vascular precursor cells from human iPSCs and used them to create networks of engineered blood vessels in living mice," he said. The ability to regenerate or repair blood vessels could make a crucial difference in the treatment of … Continue reading →

A team of scientists has been able to engineer stable and functional blood vessels in mice using induced pluripotent stem (iPS) cells taken from humans. The blood vessels lasted for 280 days in the brain of the mice. The scientists are from Massachusetts General Hospital, Boston, and Harvard Stem Institute, Harvard University. The skin cells of healthy people and those with Type I diabetes were used to produce iPS cell lines, and, in turn, the blood vessels. The results of the study are published online on July 16 in the Proceedings of the National Academy of Sciences (PNAS) journal. This work is proof of concept demonstration that vascular precursor cells endothelial precursor cells and mesenchymal precursor cells from iPS cells can be used to engineer blood vessels. While endothelial cells form the inner lining of blood vessels, mesenchymal cells provide structural stability. 3 specific markers The method of deriving these two cells from iPS cells was by using three specific markers. The way we did it enabled us to engineer blood vessels in vivo [inside the mice] using sophisticated microscopy and mouse models, said Dr. Rekha Samuel, Professor of Pathology at the Centre for Stem Cell Research, CMC, Vellore, Tamil … Continue reading →

July 15, 2013 Massachusetts General Hospital (MGH) researchers have used vascular precursor cells derived from human induced pluripotent stem cells (iPSCs) to generate, in an animal model, functional blood vessels that lasted as long as nine months. In their report being published in PNAS Early Edition, the investigators describe using iPSCs -- reprogrammed adult cells that have many of the characteristics of embryonic stem cells -- from both healthy adults and from individuals with type 1 diabetes to generate blood vessels on the outer surface of the brain or under the skin of mice. "The discovery of ways to bring mature cells back to a 'stem-like' state that can differentiate into many different types of tissue has brought enormous potential to the field of cell-based regenerative medicine, but the challenge of deriving functional cells from these iPSCs still remains," says Rakesh Jain, PhD, director of the Steele Laboratory for Tumor Biology at MGH and co-senior author of the study. "Our team has developed an efficient method to generate vascular precursor cells from human iPSCs and used them to create networks of engineered blood vessels in living mice." The ability to regenerate or repair blood vessels could make a crucial difference … Continue reading →

Javascript is currently disabled in your web browser. For full site functionality, it is necessary to enable Javascript. In order to enable it, please see these instructions. 50 minutes ago Magnetic iron oxide particles could be used to help doctors direct stem cells to particular parts of the body. Here, a bar magnet was applied to the tail during injection. Otherwise most of the cells (labeled with a fluorescent dye) end up in the liver and lungs. Magnets could be a tool for directing stem cells' healing powers to treat conditions such as heart disease or vascular disease. By feeding stem cells tiny particles made of iron oxide, scientists at Emory and Georgia Tech can use magnets to attract the cells to a particular location in the body after intravenous injection. The results are published online in the journal Small and will appear in an upcoming issue. The paper was a result of collaboration between the laboratories of W. Robert Taylor, MD, PhD, and Gang Bao, PhD. Taylor is professor of medicine and biomedical engineering and director of the Division of Cardiology at Emory University School of Medicine. Bao is professor in the Wallace H. Coulter Department of Biomedical Engineering … Continue reading →

redOrbit Staff & Wire Reports Your Universe Online Massachusetts General Hospital (MGH) researchers have managed to create long-lasting blood vessels from reprogrammed human induced pluripotent stem cells (iPSCs), This groundbreaking research is published in the latest issue of the Proceedings of the National Academy of Sciences (PNAS) Early Edition. Using vascular precursor cells derived from iPSCs, reprogrammed adult cells that have several of the same characteristics of embryonic stem cells, the scientists were able to create functional blood vessels in an animal model that lasted up to nine months. In their study, the authors describe how they used cells from both healthy adults and those with type 1 diabetes to generate blood vessels under the skin or on the brains outer surface in mice. The discovery of ways to bring mature cells back to a stem-like state that can differentiate into many different types of tissue has brought enormous potential to the field of cell-based regenerative medicine, but the challenge of deriving functional cells from these iPSCs still remains, said co-author Rakesh Jain, director of the MGH Steele Laboratory for Tumor Biology. Our team has developed an efficient method to generate vascular precursor cells from human iPSCs and used them … Continue reading →

Public release date: 16-Jul-2013 [ | E-mail | Share ] Contact: Quinn Eastman qeastma@emory.edu 404-727-7829 Emory Health Sciences Magnets could be a tool for directing stem cells' healing powers to treat conditions such as heart disease or vascular disease. By feeding stem cells tiny particles made of iron oxide, scientists at Emory and Georgia Tech can use magnets to attract the cells to a particular location in the body after intravenous injection. The results are published online in the journal Small and will appear in an upcoming issue. The paper was a result of collaboration between the laboratories of W. Robert Taylor, MD, PhD, and Gang Bao, PhD. Taylor is professor of medicine and biomedical engineering and director of the Division of Cardiology at Emory University School of Medicine. Bao is professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. Co-first authors of the paper are postdoctoral fellows Natalia Landazuri, PhD, and Sheng Tong, PhD. Landazuri is now at the Karolinska Institute in Sweden. The type of cells used in the study, mesenchymal stem cells, are not embryonic stem cells. Mesenchymal stem cells can be readily obtained from adult tissues such as bone … Continue reading →