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Early brain stimulation may help stroke survivors recover language function

Posted: Published on June 28th, 2013

June 27, 2013 Non-invasive brain stimulation may help stroke survivors recover speech and language function, according to new research in the American Heart Association journal Stroke. Between 20 percent to 30 percent of stroke survivors have aphasia, a disorder that affects the ability to grasp language, read, write or speak. It's most often caused by strokes that occur in areas of the brain that control speech and language. "For decades, skilled speech and language therapy has been the only therapeutic option for stroke survivors with aphasia," said Alexander Thiel, M.D., study lead author and associate professor of neurology and neurosurgery at McGill University in Montreal, Quebec, Canada. "We are entering exciting times where we might be able in the near future to combine speech and language therapy with non-invasive brain stimulation earlier in the recovery. This could result in earlier and more efficient aphasia recovery and also have an economic impact." In the small study, researchers treated 24 stroke survivors with several types of aphasia at the rehabilitation hospital Rehanova and the Max-Planck-Institute for neurological research in Cologne, Germany. Thirteen received transcranial magnetic stimulation (TMS) and 11 got sham stimulation. The TMS device is a handheld magnetic coil that delivers … Continue reading →

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Drug Combo May Reduce Risk of Second Stroke: Study

Posted: Published on June 28th, 2013

By Steven Reinberg HealthDay Reporter WEDNESDAY, June 26 (HealthDay News) -- After suffering a stroke or a mini-stroke, patients are usually given aspirin to prevent clots that can cause another stroke. Now a new study suggests that adding the drug Plavix (clopidogrel) to the mix can reduce the risk of a second stroke by nearly a third over aspirin alone. Both drugs target clotting agents in the blood, called platelets, preventing them from grouping together and forming clots. The drug combination is commonly used after a heart attack, but until now there hasn't been enough data to suggest it would work in stroke or mini-stroke, officially known as a transient ischemic attack (TIA). "Giving two drugs that block platelets works a lot better than aspirin alone in people who have had a minor stroke or TIA," said researcher Dr. S. Claiborne Johnston, a professor of neurology at the University of California, San Francisco. The trial was done in China, so whether the results would be the same in the United States isn't known. "They probably are, but we would like to see them confirmed," Johnston said. To do so, a similar trial is under way in the United States with … Continue reading →

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InVivo Therapeutics CEO’s Appearance on Fox News Channel’s “Tech Take” to be Available on FoxNews.com

Posted: Published on June 28th, 2013

CAMBRIDGE, Mass.--(BUSINESS WIRE)-- InVivo Therapeutics Holdings Corp. (NVIV), a developer of groundbreaking technologies for the treatment of spinal cord injuries (SCI) and other neurotrauma conditions, today announced that due to the unpredictability of live television, CEO Frank Reynolds appearance on Fox News Channels Tech Take scheduled for today, Thursday, June 27th will no longer be aired on television at 1:00pm ET. The segment will instead be available on Fox News Channels website at http://www.FoxNews.com later today. About InVivo Therapeutics InVivo Therapeutics Holdings Corp. is utilizing polymers as a platform technology to develop treatments to improve function in individuals paralyzed from traumatic spinal cord injuries. The company was founded in 2005 based on proprietary technology co-invented by Robert S. Langer, ScD. Professor at Massachusetts Institute of Technology, and Joseph P. Vacanti, MD, who is affiliated with Massachusetts General Hospital. In 2011, the company earned the prestigious David F. Apple Award from the American Spinal Injury Association for its outstanding contribution to spinal cord injury medicine. The publicly traded company is headquartered in Cambridge, MA. For more details, visit http://www.invivotherapeutics.com. Safe Harbor Statement Certain statements contained in this press release that are not historical facts may constitute forward-looking statements within the meaning … Continue reading →

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Health Headlines: Spinal cord injury breakthrough

Posted: Published on June 28th, 2013

Researchers at the Cleveland Clinic have taken a step forward in the treatment of severe spinal cord injuries. They regrew nerve cells across the site of the injury in paralyzed adult rats and restored the animals' bladder function. The study appears in the June 26 issue of The Journal of Neuroscience. This step means scientists might be able to restore other bodily functions after an injury. When the spinal cord is injured, nerves in the brain are disconnected from cells in the cord that control the bladder and the urethra. When the body scars after the injury, it slows the growth of severed nerve fibers and results in the permanent loss of bladder control. Scientists paired a chemical to promote cell growth with a scar-busting enzyme to create a more hospitable environment for the nerves at the injury site. The enzyme chondroitinase and the chemical called fibroblast growth were used in this study. Months after the procedure was performed on rats, they resumed bladder function. Scientists do caution that several challenges must be met before this type of therapy could be tested in people. Original post: Health Headlines: Spinal cord injury breakthrough … Continue reading →

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SCI patients treated with own olfactory ensheathing cells realize neurologic improvement

Posted: Published on June 28th, 2013

Public release date: 28-Jun-2013 [ | E-mail | Share ] Contact: Robert Miranda cogcomm@aol.com Cell Transplantation Center of Excellence for Aging and Brain Repair Putnam Valley, NY. (June 28 2013) A team of researchers in Poland who treated three of six paraplegics with spinal cord injury using transplanted olfactory ensheathing cells found that the three treated patients showed neurological improvement and no adverse effects while the three control patients who did not receive transplants saw no improvement. The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/ct0799tabakow. "Most accepted treatments for spinal cord injury focus on techniques of early neuro-protection aimed at maximum prevention of secondary spinal cord injury and methods to stimulate plasticity in the central nervous system," said study corresponding author Dr. Pawel Tabakow of the Department of Neurosurgery, Wroclaw Medical University in Wroclaw, Poland. "These measures have helped patients with incomplete spinal injury, but results in patients with complete spinal injury remained limited." According to the researchers, among the various kinds of neurotrophic cells being tested for transplantation to treat spinal cord injury, OECs deserve "special attention" because they are unique in their natural ability to stimulate … Continue reading →

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Bangalore hospital claims Parkinson’s breakthrough

Posted: Published on June 28th, 2013

Bangalore, June 27 : Columbia Asia Referral Hospital in Yeshwanthpur, has claimed that it has achieved success in curing neuro-degenerative disorder Parkinson's disease after conducting Deep Brain Stimulation (DBS) surgery. New developments like DBS technology helped one of it's patient Nagraj (name changed) and many others like him to return to a normal life. Nagraj underwent Deep Brain stimulation surgery at Columbia Asia Referral Hospital, Yeshwanthpur, Bangalore. Post-surgery he has shown significant improvements and is back to performing all his routine activities, the hospital authority claimed. The doses of his medicines have come down and the side effects of medicines have reduced. Nagaraj, a scholar by profession, was suffering from Parkinson's disease for the past 10 years. He suffered from slowness of movements, difficulty maintaining balance, muscle rigidity and tremors. He was on medication for several years which resulted in severe side effects in the form of dizziness and hallucinations. He thought that he would now be reduced to a bedridden person and had almost given up on life. The main feature of Parkinson's disease involves disruption of motor functions (muscle and movement). However, lack of energy, mood changes, memory loss and pain can also occur as part of the … Continue reading →

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UA Tech Park’s ‘incubator’ developing diagnostics for early treatment of Parkinson’s

Posted: Published on June 28th, 2013

TUCSON - The Michael J. Fox Foundation recently granted Tucson-based MSDx $75,000 dollars with the task of detecting Parkinson's Disease long before the major symptoms hit. "The problem with Parkinson's disease is by the time you diagnose it, with shaking hands or something like that, all the nerves involved in controlling that have been damaged or destroyed. So coming in with a treatment is no use at that point," said Dr. Ramesh Nayak, director of research for MSDx. MSDx is a company developing monitoring and diagnostic products for brain diseases. Working out of the business incubator labs at the UA Tech Park, they've already been successful with monitoring the progression of multiple sclerosis. The Michael J. Fox Foundation has given them the chance to move into Parkinson's. "So when these nerves degenerate, this damaged nerve tissue is just sitting there, and the immune system is activated. Cells from the immune system come from the blood, gobble up this damaged material, and we found that some of these cells come back into the blood stream," said Nayak. Those damaged nerves in that blood have a dark pigment, a sign of Parkinson's. That is what the folks at MSDx are looking for … Continue reading →

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How Head Injuries Seem To Affect The Risk For Stroke

Posted: Published on June 28th, 2013

The cause of strokes in younger people remains largely a mystery. The cause of strokes in younger people remains largely a mystery. Twenty percent of strokes hit people under age 65, and the cause of many of those strokes remains a mystery. Having had a concussion or other traumatic brain injury might make the risk of a stroke more likely, a study says. Back in 2011, researchers in Taiwan had unearthed an association between traumatic brain injury and stroke by combing through hospital records. It's one of those "Oh, really?" findings that gets scientists itching to check it out themselves. Researchers at the University of Michigan and the VA Center for Clinical Management and Research took on the challenge. They dug through billing records from emergency rooms in California from 2005 to 2009. They found more than 436,000 people who had come to the ER with a traumatic brain injury. Those people were 30 percent more likely to have a stroke afterwards than people who hadn't had a traumatic brain injury. A little over one percent of them ended up having a stroke later on. The results were published online in the journal Neurology. The researchers found that people under … Continue reading →

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Edge Therapeutics Reports Positive Early Clinical Experience with EG-1962 to Prevent Serious Complications after Brain …

Posted: Published on June 28th, 2013

NEW PROVIDENCE, N.J. & DSSELDORF, Germany--(BUSINESS WIRE)-- Edge Therapeutics announced today positive preliminary results from the first human use of EG-1962, the Companys novel bioabsorbable nimodipine microparticle formulation for the prevention of delayed cerebral ischemia (DCI), a life-threatening complication of subarachnoid hemorrhage (SAH), typically resulting from a ruptured brain aneurysm or traumatic brain injury. There are approximately 90,000 patients in North America and Europe who are at risk for DCI, most of whom would be candidates for EG-1962. Researchers at Heinrich-Heine-University Hospital in Dsseldorf, Germany conducted an open-label study to assess the safety and tolerability of EG-1962, which delivers therapeutic and sustained concentrations of nimodipine directly to the site of brain injury. Eleven patients were treated and 10 met pre-defined enrollment criteria, which included a low level of consciousness on admission to the emergency room and high hemorrhage volumes. Investigators found that there were no adverse events or other safety concerns related to EG-1962. Additionally, good clinical outcome, as measured by the Glasgow Outcome Scale (GOS) 30 days after SAH, was observed in all 10 patients who met the enrollment criteria. Based on similar patients treated in past clinical studies, researchers would have expected approximately half of these patients to … Continue reading →

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Traumatic Brain Injury May Also Elevate Stroke Risk, Says New Study

Posted: Published on June 28th, 2013

June 27, 2013 Brett Smith for redOrbit.com Your Universe Online People who suffer a traumatic brain injury (TBI) often have to learn to cope with physical or mental difficulties after the event. Now, a new study in the journal Neurology shows that they may also face double jeopardy from increased risk of stroke. Both stroke and traumatic brain injury are common, costly and leading causes of severe disability in adults, and approximately 20 percent of strokes occur in adults under age 65, said study author Dr. James F. Burke, a neurologist at the University of Michigan. A large proportion of stroke risk is unexplained, especially in the young, so if we can identify new risk factors, we have the potential to prevent more strokes and improve outcomes. In the study, researchers culled through five years of California hospital records for adults who either went to the emergency room or were admitted to a hospital for TBI or other trauma without brain injury. Almost 440,000 people with TBI were included in the study along with about 740,000 trauma victims who showed no signs of brain trauma. After an average of around 28 months, one percent of all those included in the … Continue reading →

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