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FDA-Approved Clinical Trial to Test Effectiveness of Fat-Derived Regenerative Cells on Heart Failure Patients

Posted: Published on May 30th, 2013

HOUSTON--(BUSINESS WIRE)-- Doctors at the Texas Heart Institute (THI) at St. Lukes Episcopal Hospital (SLEH) announced that they have performed an investigational procedure on six patients in a new FDA-approved clinical trial to evaluate therapy that uses regenerative cells derived from a patients own adipose (body fat) tissue to treat a severe form of heart failure. The trial, known as ATHENA, marks the first such study in the United States using adipose-derived regenerative cells, known as ADRCs, which are harvested using a technology developed by Cytori Therapeutics, a biotechnology company that specializes in cell therapies. Previous studies in Europe have shown the safety and feasibility of the therapy. We have found that body fat tissue is a valuable source of regenerative stem cells that are relatively easy to access, said Dr. James T. Willerson, THIs president and medical director and a principal investigator in the trial. We have high hopes for the therapeutic promise of this research and believe that it will lead quickly to larger trials. The trial involves patients suffering from chronic heart failure due to coronary heart disease, which blocks blood flow to the heart, reduces the hearts oxygen supply and limits its pumping function. According to … Continue reading →

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Pioneering blood trials 'agreed'

Posted: Published on May 30th, 2013

Pioneering blood trials 'agreed' The world's first human trials of synthetic blood will take place in Scotland, it has been reported. Researchers from the Scottish Centre for Regenerative Medicine (SCRM) in Edinburgh have been granted a licence to make blood from stem cells which can be tested on humans, the Scotsman has reported. The licence from the UK's Medicines and Healthcare products Regulatory Agency (MHRA) will allow scientists at SCRM to attempt to manufacture blood on an industrial scale which will help to tackle shortages and stop the transfer of infections from blood donors, according to the paper. These trials on humans will be the first stage in establishing more large-scale clinical trials and could result in regular use of synthetic blood. Researchers will use stem cells from adult donors - known as induced pluripotent stem cells - as part of this project instead of the more controversial embryotic ones. Project leader Marc Turner said: "In the first part of the project we used human embryonic stem cell lines and one of the problems with using those lines is you can't choose what the blood group is going to be. Over the last few years there has been a lot … Continue reading →

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Scottish News: Stem cells blood trial licensed

Posted: Published on May 30th, 2013

May 30 2013 The world's first human trials of synthetic blood could take place in Scotland, it has been reported. Researchers from the Scottish Centre for Regenerative Medicine (SCRM) in Edinburgh have been granted a licence to make blood from stem cells which could be tested on humans, The Scotsman has reported. The licence from the UK's Medicines and Healthcare products Regulatory Agency will allow scientists at SCRM to attempt to manufacture blood on an industrial scale which will help to tackle shortages and stop the transfer of infections from blood donors, according to the paper. Trials on humans, if approved, would be the first stage in establishing more large-scale clinical trials and could result in regular use of synthetic blood. Researchers will use stem cells from adult donors - known as induced pluripotent stem cells - as part of this project instead of the more controversial embryotic ones. Project leader Marc Turner said: "In the first part of the project we used human embryonic stem cell lines and one of the problems with using those lines is you can't choose what the blood group is going to be. "Over the last few years there has been a lot of … Continue reading →

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World's first human trials of synthetic blood 'agreed'

Posted: Published on May 30th, 2013

The world's first human trials of synthetic blood will take place in Scotland, it has been reported. Researchers from the Scottish Centre for Regenerative Medicine (SCRM) in Edinburgh have been granted a licence to make blood from stem cells which can be tested on humans, The Scotsman has reported. The licence from the UK's Medicines and Healthcare products Regulatory Agency (MHRA) will allow scientists at SCRM to attempt to manufacture blood on an industrial scale which will help to tackle shortages and stop the transfer of infections from blood donors, according to the paper. These trials on humans will be the first stage in establishing more large-scale clinical trials and could result in regular use of synthetic blood. Researchers will use stem cells from adult donors - known as induced pluripotent stem cells - as part of this project instead of the more controversial embryotic ones. Project leader Marc Turner said: "In the first part of the project we used human embryonic stem cell lines and one of the problems with using those lines is you can't choose what the blood group is going to be. "Over the last few years there has been a lot of work on induced … Continue reading →

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Stem cells blood trial licensed

Posted: Published on May 30th, 2013

The world's first human trials of synthetic blood could take place in Scotland, it has been reported. Researchers from the Scottish Centre for Regenerative Medicine (SCRM) in Edinburgh have been granted a licence to make blood from stem cells which could be tested on humans, The Scotsman has reported. The licence from the UK's Medicines and Healthcare products Regulatory Agency will allow scientists at SCRM to attempt to manufacture blood on an industrial scale which will help to tackle shortages and stop the transfer of infections from blood donors, according to the paper. Trials on humans, if approved, would be the first stage in establishing more large-scale clinical trials and could result in regular use of synthetic blood. Researchers will use stem cells from adult donors - known as induced pluripotent stem cells - as part of this project instead of the more controversial embryotic ones. Project leader Marc Turner said: "In the first part of the project we used human embryonic stem cell lines and one of the problems with using those lines is you can't choose what the blood group is going to be. "Over the last few years there has been a lot of work on induced … Continue reading →

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Science news from Harvard Stem Cell Institute

Posted: Published on May 30th, 2013

Public release date: 29-May-2013 [ | E-mail | Share ] Contact: Joseph N. Caputo joseph_caputo@harvard.edu 617-476-1492 Harvard University May brought a major advancement in the science of aging when two Harvard Stem Cell Institute (HSCI) researchers announced their discovery of a protein circulating in the blood of mice and humans that shows potential to be a treatment for age-related heart failure. The protein, called GDF-11, reduced the size and thickness of the heart walls when injected into old mice. There are hundreds of investigators in the HSCI network solving different problems related to cell biology and illness. This month, we feature recently published work by three laboratories on: a therapy for graft-versus-host disease, intestinal stem cell circadian rhythms, and new hope for people suffering from a rare blood disorder. Human Clinical Trials Move Forward With Promising Therapy for Graft-Verses-Host Disease HSCI investigators have developed a better picture of why a recently discovered therapy for graft-versus-host disease (GVHD) is more effective than anything currently available to patients. In 2011, human clinical trials showed that immune system signaling molecule interleukin 2 (IL-2) both improved GVHD symptoms in patients and completely stopped the progression of the condition. Surprisingly, HSCI Executive Committee member Jerome … Continue reading →

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International Stem Cell Corporation Initiates IND-Enabling Study in Parkinson's Disease Program

Posted: Published on May 30th, 2013

CARLSBAD, CA--(Marketwired - May 30, 2013) - International Stem Cell Corporation (OTCQB: ISCO) (www.internationalstemcell.com) a California-based biotechnology company developing novel stem cell based therapies, announced today the initiation of its IND-enabling pharmacology and toxicology non-human primate studies, under the direction of Yale School of Medicine Professor D. Eugene Redmond Jr. MD, the internationally recognized neurosurgeon and a leader in the use of stem cells for the treatment of Parkinson's disease. The studies will use non-human primates with moderate to severe Parkinson's disease symptoms to assess the safety and functional efficacy of ISCO's proprietary stem cell-derived neuronal cells. The endpoints of these multi-dose studies include determining cell fate, biodistribution and primate behavioral evaluations using a standardized rating scale to assess potential extrapyramidal side effects associated with the cell engraftment. The first, interim results are expected in Q4 of 2013 with the final results available in Q2 of 2014. Leading the studies will be Prof. Redmond, a recognized expert in the use of transplanted neural cells to treat parkinsonism in primates and the development of effective replacement strategies using stem cell derived neurons. In his career of over 25 years, Prof. Redmond has made many significant contributions in the field of cellular … Continue reading →

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Adventist Hospital offers stem cell therapy

Posted: Published on May 30th, 2013

THE Davao Adventist Hospital is now offering services for autologous stem cell therapy. Marketing officer Kim Endrei Go said the therapy is the first in Davao City and an alternative treatment for degenerative diseases of joints and bones caused by sports injuries and chronic pains. Go said the treatment allows the patient to continue the normal routine even after the treatment. He said the therapy is non-surgical and has a healing period of only three days. The modalities in extracting stem cells in the therapy are either through the Platelet Rich Plasma (PRP) and through Bone Marrow Aspiration Concentrate. Go said autologous means that the stem cells will be extracted from the patient himself and will be regenerated through an equipment. The hospital uses the Harvest technologies from the United States which introduced the SmartPrePtm2. SmartPrePtm2 is used to redefine platelet concentrate systems. Its latest innovation will further expand and enhance the use of autologous bioactive proteins as well as help optimize the condition for healing. Go said that the therapy session depends on the severeness of the patient's condition. He added that most patients had 3 sessions but some had once or twice. He said the technology was first … Continue reading →

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Industry Leaders Team Up to Educate Patients on StemCellLipo™ Cryopreservation of Stem Cells after Liposuction

Posted: Published on May 30th, 2013

Tucson, AZ and San Juan Capistrano, CA (PRWEB) May 29, 2013 Liposuction.com, the largest website dedicated to liposuction education, and AdiCyte, the nations leading cryobank for adipose [fat] derived tissue and stem cells, have partnered to educate consumers about StemCellLipo and the value of banking adipose tissue and stem cells following liposuction. StemCellLipo is a new add-on procedure that enables liposuction patients to collect and preserve their youngest stem cells for use in the future in regenerative medicine or tissue engineering. Oddly, fat is the largest source of mesenchymal stem cells [MSC] in the human body. These stem cells can replicate into other types of cells such as bone, nerve, cartilage and muscle. Doctors have already successfully regenerated knee cartilage in arthritic patients, and engineered new blood vessels and whole organs such as a bladder, using a patients own MSCs. Since regenerative medicine with MSCs is the focus of over 100 clinical trials for things like recovery after a heart attack and spinal disc regeneration, banking the cells has been referred to as a type of biological insurance in case of future need. We think http://www.liposuction.com is the quintessential online resource for patients interested in liposuction and every single one … Continue reading →

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Igniting woman's sexual desire is more than popping pill

Posted: Published on May 30th, 2013

Lori Brotto, psychologist, and one of the world's leading experts on sexual dysfunction and arousal disorders, has been married 12 years, has children aged eight, seven and three, and could be forgiven if - how to put this delicately? - she wasn't as ready to jump in the sack with her husband as she used to be. She did not say if that were the case, and I didn't ask. But all fires cool with time, even, presumably, for the director of the University of B.C.'s Sexual Health Laboratory. Those first years of intense sexual combustion fade to a slower burn for most of us. "It's normal," Brotto said. "That lustful desire that really lives within the novelty of a new relationship in mystery and romance does wane for both men and women over time." It wanes much more frequently, research shows, for women than it does for men. For some women, that lack of sexual desire is so great and so emotionally distressing it meets the clinical criteria for hypoactive sexual-desire disorder, or HSDD. "We're not talking about the normal waning of desire that happens over time," Brotto said. "We're talking about disorders that are clinically significant, that interfere … Continue reading →

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