TORONTO - Some cholesterol-lowering drugs called statins appear to put users at an elevated risk of developing diabetes, a new study reports. The work, by Toronto scientists, suggests that higher potency statins increase the diabetes risk, while for lower dose statin brands the elevated risk is not seen. At the end of the day, the cholesterol-lowering benefits of the drugs may outweigh the diabetes risks in many cases, said senior author Dr. Muhammad Mamdani. But he suggested it makes sense to try to use a lower dose statin when possible. "If a patient has a really high LDL" the dangerous form of cholesterol "then maybe you do need the high powered stuff like Lipitor and rosuvastatin or Crestor and you can actually go a bit higher on the dose," said Mamdani, director of the applied health research centre at the St. Michael's Hospital's Li Ka Shing Knowledge Institute. "But for most of the patients you could probably get away with using something like pravastatin or even lovastatin.... I'd say for the vast majority of patients, those would be just fine." Pravastatin, which is sold as Pravachol or Selektine, has actually been shown to be protective against diabetes in some studies. … Continue reading
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