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Cellular Biomedicine Group Achieves 50% Enrollment Milestone in Phase I Clinical Trial for Knee Osteoarthritis

Posted: Published on May 17th, 2013

PALO ALTO, Calif., May 17, 2013 /PRNewswire/ --Cellular Biomedicine Group (CBMG) today announced that it has achieved 50% enrollment of the total projected enrollment required for its Phase I trial to evaluate the safety and preliminary efficacy of the medical technology haMPC (Human Adipose-derived Mesenchymal Progenitor Cells) therapy for Knee Osteoarthritis (KOA). To date the trial has had no Severe Adverse Effect (SAE) reported. The Phase I open label clinical research trial for KOA, registered with the U.S. National Institutes of Health (NIH) under number NCT01809769 (click here to view), tests the safety and efficacy of intra-articular injections of autologous (patient's own) haMPC in order to reduce inflammation and regenerate damaged joint tissues. This trial is conducted at Shanghai Renji Hospital, one of the largest teaching hospitals in China. "This patient enrollment achievement in our clinical trial is an exciting milestone for CBMG. We anticipate that enrollment will continue to move quickly and the study is on schedule to complete its Phase I clinical trial," said Dr. William Cao, President of Cellular Biomedicine Group. About Cellular Biomedicine GroupCellular Biomedicine Group, Inc. develops proprietary cell therapies for the treatment of certain degenerative diseases and cancers. Our developmental stem cell, progenitor cell, … Continue reading

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TaiGen Biotechnology Announces Submission of New Drug Application for Nemonoxacin in Taiwan and Mainland China

Posted: Published on May 16th, 2013

TAIPEI, Taiwan, May 16, 2013 /PRNewswire/ --TaiGen Biotechnology Company, Limited ("TaiGen") today announced that they have submitted New Drug Application (NDA) for the oral formulation of nemonoxacin with the Taiwan Food and Drug Administration (TFDA) and China Food and Drug Administration (CFDA). Approval is expected in the first half of 2014. Nemonoxacin is the first pharmaceutical product to fall under the Cross-Strait Cooperation Agreement on Medicine and Public Health Affairs of the Economic Cooperation Framework Agreement (ECFA) between Taiwan and mainland China. It is also the first new drug from Taiwan to meet the requirements of CFDA's Category 1.1 New Drug. Drugs under this classification have to be new chemical entities (NCEs) that have not been marketed in any country in the world. Nemonoxacin, thus, represents a landmark in the continued development of cross-strait relationship between the pharmaceutical industry and regulatory agencies. Nemonoxacin is a NCE, broad spectrum antibiotic with excellent efficacy and safety profile. The NDA submission for nemonoxacin is supported by a pivotal Phase 3 trial with 532 patients in community-acquired pneumonia (CAP). The trial was conducted in both Taiwan and mainland China (441 patients from mainland China and 91 patients from Taiwan) that met all primary and … Continue reading

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Embryonic Stem Cells: Advance In Medical Human Cloning

Posted: Published on May 16th, 2013

Human cloning has been used to produce early embryos, marking a "significant step" for medicine, say US scientists. The cloned embryos were used as a source of stem cells, which can make new heart muscle, bone, brain tissue or any other type of cell in the body. The study, published in the journal Cell, used methods like those that produced Dolly the sheep in the UK. However, researchers say other sources of stem cells may be easier, cheaper and less controversial. Opponents say it is unethical to experiment on human embryos and have called for a ban. Stem cells are one of the great hopes for medicine. Being able to create new tissue might be able to heal the damage caused by a heart attack or repair a severed spinal cord. There are already trials taking place using stem cells taken from donated embryos to restore people's sight. However, these donated cells do not match the patient so they would be rejected by the body. Cloning bypasses this problem. The technique used - somatic cell nuclear transfer - has been well-known since Dolly the sheep became the first mammal to be cloned, in 1996. Skin cells were taken from an … Continue reading

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Is Ireland is danger of being left behind due to lack of stem cell research laws?

Posted: Published on May 16th, 2013

Photo issued by Cell Press showing how scientists have succeeded in obtaining stem cells from human embryos cloned from skin. Photograph: Eric Baker/OHSU/PA Embryonic stem cells are highly-prized because they can turn into any type of cell in the body, like heart cells, muscles or neurons. However, the research is controversial because it can involve destroying embryos and raises the vexed question of when life begins . As a result, successive governments have failed to grapple with this area of stem cell research and the wider field of assisted human reproduction. This is despite the recommendations of advisory groups and State bodies over the course of a decade or more. Ireland is one of the few European countries that does not have legislation or meaningful regulation to guide this kind of research. This gap leaves scientists caught in a web of ethical uncertainty at a time when the States official policy is to promote research and development in these kinds of cutting-edge fields. Ironically, theres no law or Constitutional obstacle standing in the way of embryonic stem cell research. In 2009 the Supreme Court ruled in Roche vs Roche an embryo custody case that the Constitution did not offer protection … Continue reading

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Stem Cell Therapeutics to Begin Trading on the U.S. OTCQX Marketplace

Posted: Published on May 16th, 2013

TORONTO, ONTARIO--(Marketwired - May 16, 2013) - Stem Cell Therapeutics Corp. (TSX VENTURE:SSS), a biopharmaceutical company developing cancer stem cell-related technologies, today announced that the Company's stock will trade on OTCQX International under the symbol "SCTPF" starting May 20. OTCQX is the premier U.S. Over-The-Counter marketplace, allowing international companies increased access and exposure to the U.S. market. Roth Capital Partners will be the market maker for Stem Cell Therapeutics' stock and will also serve as the Company's Principal American Liaison (PAL) on OTCQX, responsible for providing guidance on OTCQX requirements and U.S. securities laws. Roth Capital Partners is an investment banking firm dedicated to the small-cap public market and has been an innovator in this market since its inception in 1984. "The U.S. capital markets are critically important in assuring viability of life sciences companies internationally and we undertake this step as part of a deliberate and long-term strategy," commented Stem Cell Therapeutics' Chairman David Allan. "The admission to the OTCQX is one of several undertakings that the company committed to complete this year. The acquisition of Trillium, the in-licensing of the tigecycline program and the recent completion of dosing in the interstitial cystitis trial are among the others." About … Continue reading

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Cell Cure Neurosciences awarded $1.5m Chief Scientist grant

Posted: Published on May 16th, 2013

Stem cell company Cell Cure Neurosciences has been awarded a NIS 5.34 million (about $1.5 million) grant for 2013 from Israels Chief Scientist at the Ministry of the Economy (formerly Industry, Trade and Labor). The grant will help finance the development of OpRegen, a cell-based therapeutic product being developed by Cell Cure Neurosciences for the treatment of age-related macular degeneration. The company plans completing preclinical testing of OpRegen and filing an application to commence human clinical trials in 2014. Cell Cure CEO Dr. Charles Irving said, "The dry form of age-related macular degeneration is one of the leading diseases of aging and is estimated to afflict over 7.3 million people in the US alone. We anticipate that OpRegen will make a real difference in the quality of life of the aging baby-boom generation in many industrialized countries, and hence it is a strategic investment for the world as a whole. Cell Cure is developing therapeutic cells for the treatment of retinal and neural degenerative disease. Founded in 2005, the company's technology platform is based on manufacturing diverse cell products sourced from clinical grade human embryonic stem cells. In 2010, BioTime acquired a majority interest in Cell Cure and has made … Continue reading

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Stem Cell Therapeutics Announces Completion of Dosing in Phase I Study of TTI-1612 in Patients With Interstitial …

Posted: Published on May 16th, 2013

TORONTO, ONTARIO--(Marketwired - May 16, 2013) - Stem Cell Therapeutics Corp. (TSX VENTURE:SSS), a biopharmaceutical company developing cancer stem cell-related technologies, today announced that its wholly owned subsidiary Trillium Therapeutics has completed dosing in its Phase I study of TTI-1612 in patients with interstitial cystitis/bladder pain syndrome (IC/BPS). The study was designed to assess the safety and tolerability of single ascending doses of TTI-1612 in IC/BPS patients. Pharmacokinetics and changes in disease symptoms were also evaluated. A total of 28 patients were enrolled at four urology clinics in Southern Ontario. Preliminary data indicate that the drug is well tolerated and exhibits a favourable pharmacokinetic profile. Full results are expected to be published at a later date. IC/BPS, also known as Painful Bladder Syndrome, is a chronic, debilitating and poorly treated bladder disease affecting millions of people. The disease is believed to develop as a result of dysfunction in the protective epithelial layer lining the bladder. TTI-1612, a locally-delivered recombinant growth factor, is being developed to correct the dysfunction and restore the bladder epithelium to a normal, healthy state. This urology program, acquired by Stem Cell Therapeutics through its recent merger with Trillium Therapeutics, targets an indication of high unmet need … Continue reading

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Reading firefighters will hit streets to give muscular dystrophy the boot

Posted: Published on May 16th, 2013

Reading firefighters will be out at prominent city intersections Friday asking motorists to help "Fill the Boot" for the Muscular Dystrophy Association. Every dollar that motorists pitch into the firefighters' boots helps the firefighters union and its members assist Berks County families living with neuromuscular diseases get medical treatment and support services. Firefighters will be collecting at 11th and Rockland streets and Third and Washington streets from 10:30 a.m. to 5 p.m. The International Association of Fire Fighters has been a national MDA partner for more than 50 years and remains committed to the fight to end neuromuscular diseases. "We know the money we raise definitely makes a difference in the lives of people affected by neuromuscular diseases, and that it helps them get the care they need," said Mike Shoumlisky, president of IAFF Local 1803, the Reading firefighters union. "Fill the Boot is a proud tradition for us, and it's a great way for firefighters to be out in the community reminding residents that we are here, always ready to help." Continued here: Reading firefighters will hit streets to give muscular dystrophy the boot … Continue reading

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Scientists discover a link between epilepsy and autism for the first time

Posted: Published on May 16th, 2013

Many adults with epilepsy showed autistic traits Epileptic seizures disrupt the neurological function that affects social functioning in brains This results in the same traits seen in autism, such as impaired social interaction and communication By Anna Hodgekiss PUBLISHED: 18:35 EST, 15 May 2013 | UPDATED: 18:35 EST, 15 May 2013 A link between epilepsy and autism has been discovered for the first time. Breakthrough research from the University of Bath found adults with epilepsy have higher traits of autism and Asperger syndrome. It found epileptic seizures disrupt the neurological function that affects social functioning in brains, resulting in the same traits seen in autism. These characteristics include impairment in social interaction and communication as well as restricted and repetitive interests. Researchers found that epileptic seizures disrupt the neurological function that affects social functioning in brains, resulting in the same traits seen in autism SallyAnn Wakeford, a PhD student at the university's Department of Psychology, said the traits could be 'severe' and go unnoticed for many years, having a great impact on the lives of those experiencing them. Dr Wakeford said: 'The social difficulties in epilepsy have been so far under-diagnosed and research has not uncovered any underlying theory to … Continue reading

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Wait lists for autism services setting Durham families back

Posted: Published on May 16th, 2013

This is part three of a three-part series looking at autism in Durham Region, including the services available and the experience of Durham families who have children with an autism spectrum disorder diagnosis. DURHAM - With early intervention touted as key to the success of autism therapy, Durham children may be missing out as they languish on wait lists. In Durham, children with autism spectrum disorders (ASD) wait about six months for an assessment, one year for applied behaviour analysis (ABA) therapy and up to four years for intensive behaviour intervention (IBI) therapy. IBI consist of up to 40 hours a week of one-on-one treatment with a therapist and teaches children through positive reinforcement and repetition. ABA is less intensive, offered in weekly sessions over a two to six-month period. "The prime age for IBI is between two and six years old; when kids are older it may not be helpful," said Frances Donovan, program director for autism services at Kinark Child and Youth Services, which delivers IBI services in Durham. Launched in 2000, the Central East IBI program, which covers Durham, initially had capacity for 50 children. With the provincial government quadrupling autism spending to $186 million over the … Continue reading

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