A team of Harvard Stem Cell Institute scientists have discovered a protein that circulates in blood that can turn old hearts young, causing a mouses heart that has thickened and enlarged with age to revert back to a more youthful state. The researchers hope that the discovery will lay a foundation for a new approach to therapy for a common form of heart failure that strikes elderly people, although much more research is needed before it could be tested in people. The change was unbelievably obvious, said Dr. Richard T. Lee, a cardiologist at Brigham and Womens Hospital and one of the leaders of the study, published Thursday in the journal Cell. Usually we do quite sophisticated quantitative analyses of hearts and the shapes of the cells and things like that. ... You could see what happened from the very first experiment. Outside researchers praised the study, which used a decades-old technique of stitching together the circulatory systems of two mice, called parabiosis. In this case, an old mouse was connected to a young mousea technique that co-author Amy Wagers, a Harvard stem cell scientist, has utilized to examine the effect of blood on aging in various tissues. The researchers … Continue reading
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