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Scripps Research Institute Scientists Find Antibody that Transforms Bone Marrow Stem Cells Directly into Brain Cells

Posted: Published on April 23rd, 2013

LA JOLLA, Calif., April 22, 2013 /PRNewswire-USNewswire/ -- In a serendipitous discovery, scientists at The Scripps Research Institute (TSRI) have found a way to turn bone marrow stem cells directly into brain cells. Current techniques for turning patients' marrow cells into cells of some other desired type are relatively cumbersome, risky and effectively confined to the lab dish. The new finding points to the possibility of simpler and safer techniques. Cell therapies derived from patients' own cells are widely expected to be useful in treating spinal cord injuries, strokes and other conditions throughout the body, with little or no risk of immune rejection. "These results highlight the potential of antibodies as versatile manipulators of cellular functions," said Richard A. Lerner, the Lita Annenberg Hazen Professor of Immunochemistry and institute professor in the Department of Cell and Molecular Biology at TSRI, and principal investigator for the new study. "This is a far cry from the way antibodies used to be thought ofas molecules that were selected simply for binding and not function." The researchers discovered the method, reported in the online Early Edition of the Proceedings of the National Academy of Sciences the week of April 22, 2013, while looking for … Continue reading

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Method makes it easier to separate useful stem cells from 'problem' ones for therapies

Posted: Published on April 23rd, 2013

Public release date: 22-Apr-2013 [ | E-mail | Share ] Contact: Shaun Mason smason@mednet.ucla.edu 310-206-2805 University of California - Los Angeles Pluripotent stem cells can turn, or differentiate, into any cell type in the body, such as nerve, muscle or bone, but inevitably some of these stem cells fail to differentiate and end up mixed in with their newly differentiated daughter cells. Because these remaining pluripotent stem cells can subsequently develop into unintended cell types bone cells among blood, for instance or form tumors known as teratomas, identifying and separating them from their differentiated progeny is of utmost importance in keeping stem cellbased therapeutics safe. Now, UCLA scientists have discovered a new agent that may be useful in strategies to remove these cells. Their research was published online April 15 in the journal Developmental Cell and will appear in an upcoming print edition of the journal. The study was led by Carla Koehler, a professor of chemistry and biochemistry at UCLA, and Dr. Michael Teitell, a UCLA professor of pathology and pediatrics. Both are members of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at UCLA and UCLA's Jonsson Comprehensive Cancer Center. In work using … Continue reading

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OHSU teams with Intel to decode the root causes of cancer and other complex diseases

Posted: Published on April 23rd, 2013

Public release date: 22-Apr-2013 [ | E-mail | Share ] Contact: Elisa Williams 503-494-8231 Oregon Health & Science University PORTLAND, Ore. Oregon Health & Science University (OHSU) and Intel Corp. are teaming up to develop next-generation computing technologies that advance the field of personalized medicine by dramatically increasing the speed, precision and cost-effectiveness of analyzing a patient's individual genetic profile. Through a multi-year research and engineering collaboration announced today, engineers and scientists from the two institutions will develop hardware, software and workflow solutions for Intel's extreme-scale, high-performance computing solutions. This new level of computational horsepower seeks to make strides in addressing one of the biggest challenges in personalized medicine: how to cope with the unprecedented volume of complex biomedical data it generates. The collaboration combines Intel's strengths in extreme-scale computing capable of handling billions of complex computations simultaneously with OHSU's innovative four-dimensional approach in imaging and analyzing the molecular-level drivers of cancer and other diseases. OHSU's imaging techniques work like a Google map for cancer by providing a highly detailed view of how cells change over time at the molecular level along with a big-picture analysis of how the cells behave as a system. The team's approach will be to … Continue reading

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Life Technologies' Ion Proton(TM) to Power Stratified Medicine Scotland Innovation Centre

Posted: Published on April 23rd, 2013

- Innovation Centre's ambitious approach to treatment of disease to dramatically improve patient outcomes whilst reducing overall healthcare costs. GLASGOW, Scotland, April 23, 2013 /PRNewswire/ -- Life Technologies( http://www.lifetechnologies.com/us/en/home.html ) Corporation (LIFE) today announces that it is a lead commercial partner along with Aridhia,( http://www.aridhia.com ) a bio-medical informatics company, in the Stratified Medicine Scotland Innovation Centre (SMS-IC). The Ion Proton( http://www.invitrogen.com/site/us/en/home/Products-and-Services/Applications/Sequencing/Semiconductor-Sequencing/proton.html )(TM) sequencing platform will be the primary tool to drive discovery and genetic analysis as SMS-IC aspires to be a world-class centre of research, innovation and commercialisation in stratified medicine. The SMC-IC is a unique collaboration bringing together excellence in the academic, industrial and NHS( http://www.show.scot.nhs.uk/introduction.aspx ) communities to create an infrastructure that will act as a springboard to allow Scotland to be at the forefront of the field. The First Minister of Scotland, Alex Salmond said: "Scotland has always been a world leader in innovation and this new funding for the Stratified Medicine Scotland Innovation Centre reinforces the Scottish Government's commitment to the Life Sciences securing Scotland's place as a world leader in innovative health technology. The pioneering research carried out by the innovation centres will not only improve the healthcare of patients but also, by way … Continue reading

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Francois Jacob, Nobel winner for genetic work, dies at 92

Posted: Published on April 23rd, 2013

PARIS, April 22 (UPI) -- French biologist Francois Jacob, who won a Nobel Prize for work on the genetic mechanisms in bacteria, had died, his family said. He was 92. Jacob died Friday, his family said in a Radio France Internationale report. Jacob shared the 1956 Nobel Prize for medicine with researchers Andre Lwoff and Jacques Monod for their work on the genetic mechanisms in bacteria and "discoveries concerning genetic control of enzyme and virus synthesis." Born in 1920 in Nancy in eastern France, in 1940 Jacob joined the French 2nd Armored Division in London, working to free France from Nazi occupation. For his wartime service, during which he was injured in a German air attack in 1944, he was awarded France's highest World War II decoration for valor, the Cross of Liberation. After World War II Jacob completed his medical degree but was unable to practice as a surgeon because his war injuries meant he couldn't stand for long periods to perform operations. Instead he turned to biological research, joining the Pasteur Institute in Paris in 1950 and spending the rest of his career there. Read more from the original source: Francois Jacob, Nobel winner for genetic work, dies … Continue reading

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Life Technologies' Ion Proton™ to Power Stratified Medicine Scotland Innovation Centre

Posted: Published on April 23rd, 2013

Innovation Centre's ambitious approach to treatment of disease to dramatically improve patient outcomes whilst reducing overall healthcare costs. GLASGOW , Scotland, April 23, 2013 /CNW/ - Life Technologies Corporation (LIFE) today announces that it is a lead commercial partner along with Aridhia, a bio-medical informatics company, in the Stratified Medicine Scotland Innovation Centre (SMS-IC). The Ion Proton sequencing platform will be the primary tool to drive discovery and genetic analysis as SMS-IC aspires to be a world-class centre of research, innovation and commercialisation in stratified medicine. The SMC-IC is a unique collaboration bringing together excellence in the academic, industrial and NHS communities to create an infrastructure that will act as a springboard to allow Scotland to be at the forefront of the field. The First Minister of Scotland, Alex Salmond said: "Scotland has always been a world leader in innovation and this new funding for the Stratified Medicine Scotland Innovation Centre reinforces the Scottish Government's commitment to the Life Sciences securing Scotland's place as a world leader in innovative health technology. The pioneering research carried out by the innovation centres will not only improve the healthcare of patients but also, by way of the unique advanced process of diagnosis, could … Continue reading

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Pre-clinical results on naproxcinod in models of muscular dystrophy presented at MDA Scientific Conference

Posted: Published on April 23rd, 2013

SOPHIA ANTIPOLIS, FRANCE--(Marketwired - Apr 23, 2013) - Nicox S.A. (EURONEXT PARIS: COX) today announced promising pre-clinical results on naproxcinod, a CINOD (Cyclooxygenase-Inhibiting Nitric Oxide-Donating) anti-inflammatory candidate, in models of muscular dystrophies. The data were presented by Nicox and the Center for Genetic Medicine Research(1), a center within the Children's Research Institute, Children's National Medical Center, in a poster session on April 22(nd) at the Muscular Dystrophy Association (MDA) Scientific Conference in Washington, DC. The research study data were presented in a poster entitled "Long-term treatment with naproxcinod significantly improves skeletal and cardiac disease phenotype in mdx mouse model of dystrophy" (poster #175). In this study, the effects of naproxcinod were investigated on skeletal and cardiac muscle function in mdx mice. Three doses of naproxcinod (10, 21 and 41 mg/kg) were given orally to 4-week-old mdx mice (a reference model for Duchenne Muscular Dystrophy, DMD) for 9 months and compared to 0.9 mg/kg of prednisolone. The results of the study suggest that naproxcinod may have potential as a safe therapeutic option for the treatment of muscular dystrophies. Naproxcinod treatment at 10 and 21mg/kg resulted in significant improvements in hind limb grip strength as well as an approximately 25-30% decrease in … Continue reading

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Special Report: The Genetic Revolution

Posted: Published on April 23rd, 2013

Image: Yakobchuk/iStockphoto Sixty years ago this month, researchers James Watson and Francis Crick described the double helix shape of DNA. This breakthrough allowed geneticists to study how an organisms physical characteristics are encoded in the DNA molecule, and how living creatures pass down traits to their offspring. Ten years ago this month, researchers completed sequencing the human genome, putting the roughly 3 billion letters that make up a molecule of human DNA in order. The Human Genome Project took more than a decade and cost about US $3 billion. With this comprehensive map, researchers can more easily study how our genes determine our medical fates. On April 25, researchers celebrate DNA Day to mark the accomplishments of the past, and to marvel at the progress made since those historic milestones. Today, fast and cheap machines enable scientists to sequence the genomes of thousands of people in research projects devoted to complex diseases like cancer and heart disease. Soon, such whole-genome scans may be a routine part of medicine. IEEE Spectrum explores the new field of personalized genetic medicine with a package of articles, radio pieces, and blog posts. Happy DNA Day! Storified by IEEE Spectrum Thu, Apr 11 2013 12:32:05 … Continue reading

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Stem Cell – Drive for Jayden Roll – Video

Posted: Published on April 23rd, 2013

Stem Cell - Drive for Jayden Roll NEW YORK, NEW YORK-- Stem Cell Drive. Jayden Roll is a playful, energetic 4-year old girl who loves life. She was recently diagnosed with myelodysplastic syn... By: JaydenDrive … Continue reading

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Stem Cell Lift (Liposuction) Does it Hurt – Video

Posted: Published on April 23rd, 2013

Stem Cell Lift (Liposuction) Does it Hurt Video 4 in the Series: In this video, Dr Newman is performing liposuction on Eva's thigh. As he does so, both he and Eva share details about the sedative. Dr... By: nathannewmanmd … Continue reading

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