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Today's top stories

Posted: Published on March 9th, 2013

7:37am, Sat 9 Mar 2013 - last updated Sat 9 Mar 2013 Scientists have come a step closer to replacing missing teeth with implants grown from stem cells. Researchers managed to engineer hybrid human-mouse teeth coated in enamel with developing roots. It could mean that in future dentures are replaced by real substitute molars grown from "seeds" planted into a patient's jaw. Two kinds of cell were used to make the bioengineered teeth. Epithelial "surface lining" cells were taken from the gum tissue and mesenchymal cells from the mouse embryos. Mesenchymal stem cells can develop into a range of different tissues, including bone, cartilage and fat. Epithelial cells derived from adult human gum tissue are capable of responding to tooth-inducing signals from embryonic tooth mesenchyme in an appropriate way to contribute to tooth crown and root formation and give rise to relevant differentiated cell types, following in-vitro (in a living body) culture. These easily accessible epithelial cells are thus a realistic source for consideration in human biotooth formation. The next major challenge is to identify a way to culture adult human mesenchymal cells to be tooth-inducing, as at the moment we can only make embryonic mesenchymal cells do this. The … Continue reading

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New 'teeth' grown from mouse cells

Posted: Published on March 9th, 2013

New 'teeth' grown from mouse cells 4:59am Saturday 9th March 2013 in National News Press Association 2013 Scientists have come a step closer to replacing missing teeth with implants grown from stem cells. Researchers succeeded in engineering hybrid human-mouse teeth coated in enamel with developing roots. In future, it is hoped the work will lead to dentures being replaced by real substitute molars grown from "seeds" planted into a patient's jaw. The technique involved growing cells from human gum tissue and combining them with tooth stem cells from mouse embryos. The combination cell clusters were transplanted into adult mouse kidneys where they grew into recognisable tooth structures. Examination showed that they contained dentin - the main structural material of teeth - as well as hard protective enamel. There was also evidence of viable root formation. Two kinds of cell were used to make the bioengineered teeth. Epithelial "surface lining" cells were taken from the gum tissue and mesenchymal cells from the mouse embryos. Mesenchymal stem cells can develop into a range of different tissues, including bone, cartilage and fat. Professor Paul Sharpe, who led the research at King's College London's Dental Institute, said: "Epithelial cells derived from adult human gum … Continue reading

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Research and Markets: PharmaPoint Drug Evaluation Report – Ganaxolone ( Epilepsy ) – Forecast and Market Analysis to 2022

Posted: Published on March 9th, 2013

DUBLIN--(BUSINESS WIRE)-- Research and Markets (http://www.researchandmarkets.com/research/smv8q8/ganaxolone) has announced the addition of GlobalData's new report "Ganaxolone (Epilepsy) - Forecast and Market Analysis to 2022" to their offering. PharmaPoint Drug Evaluation report, Ganaxolone (Epilepsy) - Forecast and Market Analysis to 2022. Epilepsy is a brain disorder characterized by spontaneously occurring and recurrent seizures. The market is heavily driven by the sales of antiepileptic drugs (AEDs) targeted at seizure reduction. The AED market is currently dominated by UCB's Keppra and GlaxoSmithKline's Lamictal. Although both drugs have experienced significant generic erosion, they form the mainstay of epilepsy treatment in the nine markets and will continue to have significant market share during the forecast period. Other key drugs include older generation AEDs such as Pfizer's Dilantin, Abbott's Depakote, and Novartis' Tegretol and Trileptal which still have significant usage due to their longevity in the market. However, the AED dominance landscape will continue to shift towards newer generation drugs particularly following the recent market entry of GlaxoSmithKline's Trobalt/Potiga and Eisai's Fycompa which both offer first-in-class mechanisms of action. Ganaxolone is a first-in-class synthetic neurosteroid analog of the endogenous neurosteroid allopregnanolone. It has novel GABA-A receptor modulation and unique broad-spectrum protective efficacy, and is under development for … Continue reading

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Research and Markets: PharmaPoint Drug Evaluation Report – Keppra ( Epilepsy ) – Forecast and Market Analysis to 2022

Posted: Published on March 9th, 2013

DUBLIN--(BUSINESS WIRE)-- Research and Markets (http://www.researchandmarkets.com/research/b9qggc/keppra_epilepsy) has announced the addition of GlobalData's new report "Keppra (Epilepsy) - Forecast and Market Analysis to 2022" to their offering. PharmaPoint Drug Evaluation report, Keppra (Epilepsy) - Forecast and Market Analysis to 2022. Epilepsy is a brain disorder characterized by spontaneously occurring and recurrent seizures. The market is heavily driven by the sales of antiepileptic drugs (AEDs) targeted at seizure reduction. The AED market is currently dominated by UCB's Keppra and GlaxoSmithKline's Lamictal. Although both drugs have experienced significant generic erosion, they form the mainstay of epilepsy treatment in the nine markets and will continue to have significant market share during the forecast period. Other key drugs include older generation AEDs such as Pfizer's Dilantin, Abbott's Depakote, and Novartis' Tegretol and Trileptal which still have significant usage due to their longevity in the market. However, the AED dominance landscape will continue to shift towards newer generation drugs particularly following the recent market entry of GlaxoSmithKline's Trobalt/Potiga and Eisai's Fycompa which both offer first-in-class mechanisms of action. Keppra (levetiracetam) is an approved first-in-class AED developed and marketed by UCB. The drug received FDA approval in November 1999, and EU approval in September 2000. Levetiracetam is … Continue reading

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Research and Markets: PharmaPoint: Epilepsy – Germany Drug Forecast and Market Analysis to 2022

Posted: Published on March 9th, 2013

DUBLIN--(BUSINESS WIRE)-- Research and Markets (http://www.researchandmarkets.com/research/v7xkm4/pharmapoint) has announced the addition of GlobalData's new report "PharmaPoint: Epilepsy - Germany Drug Forecast and Market Analysis to 2022" to their offering. GlobalData has released its new Country report, PharmaPoint: Epilepsy - Germany Drug Forecast and Market Analysis to 2022. Epilepsy is a brain disorder characterized by spontaneously occurring and recurrent seizures. The market is heavily driven by the sales of antiepileptic drugs (AEDs) targeted at seizure reduction. The AED market is currently dominated by UCB's Keppra and GlaxoSmithKline's Lamictal. Although both drugs have experienced significant generic erosion, they form the mainstay of epilepsy treatment in the nine markets and will continue to have significant market share during the forecast period. Other key drugs include older generation AEDs such as Pfizer's Dilantin, Abbott's Depakote, and Novartis' Tegretol and Trileptal which still have significant usage due to their longevity in the market. However, the AED dominance landscape will continue to shift towards newer generation drugs particularly following the recent market entry of GlaxoSmithKline's Trobalt/Potiga and Eisai's Fycompa which both offer first-in-class mechanisms of action. The main factor for the decline in this market is the launch of generics and the high rate of generic substitution … Continue reading

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Research and Markets: PharmaPoint Drug Evaluation Report – Brivaracetam ( Epilepsy ) – Forecast and Market Analysis to …

Posted: Published on March 9th, 2013

DUBLIN--(BUSINESS WIRE)-- Research and Markets (http://www.researchandmarkets.com/research/48jdq7/brivaracetam) has announced the addition of GlobalData's new report "Brivaracetam (Epilepsy) - Forecast and Market Analysis to 2022" to their offering. PharmaPoint Drug Evaluation report, Brivaracetam (Epilepsy) - Forecast and Market Analysis to 2022. Epilepsy is a brain disorder characterized by spontaneously occurring and recurrent seizures. The market is heavily driven by the sales of antiepileptic drugs (AEDs) targeted at seizure reduction. The AED market is currently dominated by UCB's Keppra and GlaxoSmithKline's Lamictal. Although both drugs have experienced significant generic erosion, they form the mainstay of epilepsy treatment in the nine markets and will continue to have significant market share during the forecast period. Other key drugs include older generation AEDs such as Pfizer's Dilantin, Abbott's Depakote, and Novartis' Tegretol and Trileptal which still have significant usage due to their longevity in the market. However, the AED dominance landscape will continue to shift towards newer generation drugs particularly following the recent market entry of GlaxoSmithKline's Trobalt/Potiga and Eisai's Fycompa which both offer first-in-class mechanisms of action. Brivaracetam (BRV), which is an analog of the AED levetiracetam (Keppra), is being developed by UCB as an adjunctive therapy for the treatment of epilepsy, partial-onset seizures, and … Continue reading

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Research and Markets: PharmaPoint Drug Evaluation Report – VX-765 ( Epilepsy ) – Forecast and Market Analysis to 2022

Posted: Published on March 9th, 2013

DUBLIN--(BUSINESS WIRE)-- Research and Markets (http://www.researchandmarkets.com/research/qssnjh/vx765_epilepsy) has announced the addition of GlobalData's new report "VX-765 (Epilepsy) - Forecast and Market Analysis to 2022" market research report to their offering. PharmaPoint Drug Evaluation report, VX-765 (Epilepsy) - Forecast and Market Analysis to 2022. Epilepsy is a brain disorder characterized by spontaneously occurring and recurrent seizures. The market is heavily driven by the sales of antiepileptic drugs (AEDs) targeted at seizure reduction. The AED market is currently dominated by UCB's Keppra and GlaxoSmithKline's Lamictal. Although both drugs have experienced significant generic erosion, they form the mainstay of epilepsy treatment in the nine markets and will continue to have significant market share during the forecast period. Other key drugs include older generation AEDs such as Pfizer's Dilantin, Abbott's Depakote, and Novartis' Tegretol and Trileptal which still have significant usage due to their longevity in the market. However, the AED dominance landscape will continue to shift towards newer generation drugs particularly following the recent market entry of GlaxoSmithKline's Trobalt/Potiga and Eisai's Fycompa which both offer first-in-class mechanisms of action. VX-765 is a first-in-class CASP1 inhibitor being developed by Vertex for the treatment of epilepsy. It represents a novel approach of using anti-inflammatory compounds for … Continue reading

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Research and Markets: Lyrica ( Epilepsy ) – Forecast and Market Analysis to 2022

Posted: Published on March 9th, 2013

DUBLIN--(BUSINESS WIRE)-- Research and Markets (http://www.researchandmarkets.com/research/5qlwpl/lyrica_epilepsy) has announced a new report "Lyrica (Epilepsy) - Forecast and Market Analysis to 2022" to their offering. Epilepsy is a brain disorder characterized by spontaneously occurring and recurrent seizures. The market is heavily driven by the sales of antiepileptic drugs (AEDs) targeted at seizure reduction. The AED market is currently dominated by UCB's Keppra and GlaxoSmithKline's Lamictal. Although both drugs have experienced significant generic erosion, they form the mainstay of epilepsy treatment in the nine markets and will continue to have significant market share during the forecast period. Other key drugs include older generation AEDs such as Pfizer's Dilantin, Abbott's Depakote, and Novartis' Tegretol and Trileptal which still have significant usage due to their longevity in the market. However, the AED dominance landscape will continue to shift towards newer generation drugs particularly following the recent market entry of GlaxoSmithKline's Trobalt/Potiga and Eisai's Fycompa which both offer first-in-class mechanisms of action. Lyrica is a compound with both analgesic and anticonvulsant properties that was developed by Pfizer as a more potent successor to gabapentin (Neurontin). Pregabalin is the active pharmaceutical ingredient in Lyrica, and it binds with high affinity to the alpha2-delta site (an auxiliary subunit … Continue reading

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Autism Research Group to Train San Diego Professionals on Effective Autism Behavioral Intervention Techniques

Posted: Published on March 9th, 2013

The one-day event features an exceptional collection of autism experts presenting the latest state-of-the-art methods of applied behavior analysis (ABA) for teaching perspective-taking and executive function skills to individuals with autism. San Diego, CA (PRWEB) March 08, 2013 The workshop, sponsored by the Center for Autism and Related Disorders (CARD), will be held at the Catamaran Resort and Spa from 9:00 am to 4:00 pm. It is designed for professionals, practitioners, family members, caregivers, and educators who work with children with autism. Attendees must register online at http://workshop.autismresearchgroup.org. The workshop will focus on the application of the state-of-the-art treatment of applied behavior analysis (ABA) for teaching advanced skills to children diagnosed with autism spectrum disorders. According to the Centers for Disease Control and Prevention (CDC), 1 in every 88 children in the U.S. is diagnosed with an autism spectrum disorder, making it more prevalent than juvenile diabetes, pediatric cancer, and childhood AIDS combined. We conducted a similar workshop in the Los Angeles area and received an overwhelming response. Whats exciting about this event is that we are dedicating a full day to cutting-edge training on how to teach advanced skills to individuals with autism, says workshop presenter Adel Najdowski, PhD, … Continue reading

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DNA Sequencing Giant Illumina Joins Hunt for Autism Blood Test

Posted: Published on March 9th, 2013

Illumina will work with SynapDxs to find a blood-test that could allow treatment to start earlier. Massachusetts startup SynapDx announced on Wednesday that it will work with DNA sequencer manufacturer Illumina to develop early detection tools for autism spectrum disorders, according to a release. SynapDx is trying to develop a blood-based test that will catch most cases of autism spectrum disorders in children earlier than current methods (see Can a Blood Test Detect Autism Early?). The advantage would be that treatments seem to work better the sooner they start. The challenge is that there arent clear biomarkers or genetic signals for the disorder, which is most likely a mix of many different conditions. But that doesnt seem to deter sequencing giant Illumina, which has been growing the diagnostic side of its business over the last few months (see A Brave New World of Prenatal DNA Sequencing). According to the release: SynapDx and Illumina share a vision of better pediatric care through the use of advanced molecular assays and sequencing technologies, said Stanley Lapidus, SynapDxs CEO. We look forward to broadly collaborating on multiple joint initiatives. SynapDx is currently recruiting participants into a clinical study of gene expression and autism in … Continue reading

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