MELBOURNE, AUSTRALIA--(Marketwire - Mar 6, 2013) - Prana Biotechnology ( NASDAQ : PRAN ) ( ASX : PBT ) today announced that PBT434, Prana's lead drug candidate for Parkinson's Disease (PD) and movement disorders, will be presented at two international conferences in March. The key finding to be reported is that PBT434 reduces the aggregation and accumulation of a key protein (alpha-synuclein) in multiple transgenic animal models of the disease. The alpha-synuclein (s.n.) protein aggregates inside the nerve cells of the substantia nigra, the part of the brain that is progressively damaged in the disease. The substantia nigra is responsible for controlling movement. The (s.n.) protein aggregates are associated with the onset and progression of Parkinson's Disease and in three different Parkinson's Disease animal models, PBT434 significantly prevented the death of substantia nigra brain cells. "A treatment for Parkinson's Disease and other movement diseases that actually modifies the course of the diseases remains a major unmet medical need. Our data suggests that PBT434 intervenes in metal dependent pathways which otherwise promote the aggregation of alpha-synuclein. Thus, PBT434 prevents the death of substantia nigra cells. We have observed marked improvements in motor function and coordination with PBT434," commented Associate Professor Robert … Continue reading
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