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Accelerated Cure Project for Multiple Sclerosis Partners with Leading Organizations in an Alliance to Find New MS …

Posted: Published on March 4th, 2013

WALTHAM, Mass.--(BUSINESS WIRE)-- Accelerated Cure Project for Multiple Sclerosis (ACP-MS) today announced the launch of Orion Bionetworks, a multi-institution cooperative alliance that is unlocking the power of shared data and predictive modeling to help transform our understanding of diseases such as multiple sclerosis (MS) and accelerate the search for cures. Orion Bionetworks is a program of the Marin Community Fund, a nonprofit 501(c)(3) corporation, and is funded by Janssen Research & Development, LLC, a New Jersey-based pharmaceutical company, which has provided a $5.4 million scientific sponsorship as part of its Healthy Minds program for the first phase of this effort. Initially, this cooperative alliance will focus on integrating clinical, biomarker and imaging data with rich real-world patient data from existing, independent databases of over 7,000 people with MS into a causal computational disease model. We are delighted to collaborate with such a dynamic group of innovators to launch Orion Bionetworks, said Robert McBurney, Chief Executive Officer of ACP-MS. Orion is demonstrating that a predictive disease modeling alliance that uses real-world patient data can have an unprecedented ability to drive toward better treatments and, ultimately, cures for multiple sclerosis and other devastating brain disorders. Our involvement in the alliance is a … Continue reading →

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HRT patches 'treat prostate cancer'

Posted: Published on March 4th, 2013

Oestrogen skin patches used to control menopausal symptoms in women may provide a safe alternative therapy for prostate cancer, research has shown. Hormone replacement therapy (HRT) patches prevent the growth of prostate tumours by drastically lowering levels of testosterone. Prostate cancer that is starting to spread is known to be fuelled by the male hormone. Current treatments include injected drugs called LHRH agonists, such as Zoladex, which interfere with testosterone production, resulting in chemical castration but they can have serious long-term side effects, including the bone thinning disease osteoporosis and diabetes. Oestrogen - the female sex hormone - taken in a pill form also blocks testosterone production, but can lead to dangerous blood clots and strokes. The new findings, from a Phase II trial involving more than 250 men with locally advanced or spreading prostate cancer, show that the patches lower testosterone as effectively as LHRH agonists. Importantly, they do not cause the same blood clotting problems seen with oestrogen tablets. Nor do they have the side effects associated with LHRH agonist injections. Lead researcher Dr Ruth Langley, from the Medical Research Council Clinical Trials Unit in London, said: "These promising new findings suggest that we might be able to … Continue reading →

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HRT Patches Could Treat Prostate Cancer

Posted: Published on March 4th, 2013

Oestrogen skin patches used to control menopausal symptoms in women may provide a safe alternative therapy for prostate cancer, research has shown. Hormone replacement therapy (HRT) patches prevent the growth of prostate tumours by drastically lowering levels of testosterone. Prostate cancer that is starting to spread is known to be fuelled by the male hormone. Current treatments include injected drugs called LHRH agonists, such as Zoladex, which interfere with testosterone production, resulting in chemical castration. However, they can have serious long-term side effects, including the bone thinning disease osteoporosis and diabetes. Oestrogen - the female sex hormone - taken in a pill form also blocks testosterone production, but can lead to dangerous blood clots and strokes. Did you read about these breakthroughs last year? This year, the U.S. Preventive Services Task Force recommended against routine prostate cancer screening for men of all ages, noting its small benefits compared to the harms, published in the Annals of Internal Medicine. "We think the benefit is very small," Dr. Michael LeFevre, a member of the task force, told NPR's Shots blog. "Our range is between zero and one prostate cancer death avoided for every thousand men screened," which is minuscule compared to lives … Continue reading →

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Stem Cell Proposal (Animation) – Video

Posted: Published on March 4th, 2013

Stem Cell Proposal (Animation) "E. Pluribus UNUM" By Jef.Thornton and Steven Bellettini This is an animation project me and My classmate steve did for a class assignment. It is in support of the michigan stem cell research proposal. enjoy :^) By: jeffypoo8 … Continue reading →

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Young Turks YT@11 Episode 18 Part 1 – RMS Regrow – Video

Posted: Published on March 4th, 2013

Young Turks YT@11 Episode 18 Part 1 - RMS Regrow RMS Regrow: Making stem cell regeneration accessible to all Stem cell research and treatment have been gaining ground over the last few years. The idea behind stem cell research and treatments is a type of intervention which introduces new adult stem cells into damaged tissue to treat disease or an injury. Many medical researchers believe that stem cell treatments have the potential to be a game changer in the world of medicine. This treatment is particularly relevant to India and can help Indians diagnosed with blood cancer and children with Thalassemia. According to the Indian Stem Cell Transplant Registry the number of blood stem cell transplants done in India till 2011 stands at a measly 4015. This means it is imperative to move towards making blood stem cell treatments more cost effective and affordable to more patients. Contributing to this cause is 26 year old Satyen Sanghavi whose venture Regenerative Medical Services makes both stem cell banking and bone and cartilage regeneration accessible to Indians. Sanghavi has done his Masters in Stem Cell Technology from UK. The 26 year old who loves traveling, sports and reading is helping patients regrow. … Continue reading →

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Obama: science should trump politics

Posted: Published on March 4th, 2013

President Obama, lifting an eight-year limit on federal funding of stem cell research, today portrayed his decision as part of a broader move to focus on science instead of politics. Besides signing an executive order (read it here) reversing the Bush administration restrictions, Obama is also issuing a presidential memorandum (read it here) directing the head of the White House Office of Science and Technology Policy to develop a strategy for restoring scientific integrity to government decision making. The goal, the president said: "To ensure that in this new administration, we base our public policies on the soundest science; that we appoint scientific advisers based on their credentials and experience, not their politics or ideology; and that we are open and honest with the American people about the science behind our decisions." On embryonic stem cell research in particular, Obama acknowledged the religious-based opposition. But he said there is an ethical way to do such research. "Rather than furthering discovery, our government has forced what I believe is a false choice between sound science and moral values," he said in the East Room of the White House, filled with advocates of stem cell research who cheered and applauded his annoucement. … Continue reading →

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Stephen Epstein, MD To Head Scientific & Medical Advisory Board For Stemedica’s Cardiology Division

Posted: Published on March 4th, 2013

Stemedica Cell Technologies, Inc., a leader in adult allogeneic stem cell manufacturing, research and development, announced today that cardiologist Stephen E. Epstein, MD, Director of Translational Research of the MedStar Heart Institute, Washington Hospital Center, has accepted the position of Chairman of Stemedicas Scientific and Medical Advisory Board for the Companys Cardiology Division. Dr. Epstein served for over 30 years as Chief of the Cardiology Branch of the National Heart, Lung and Blood Institute (NHLBI) in Bethesda, Maryland. San Diego, CA (PRWEB) March 04, 2013 With more than 500 publications in peer-reviewed medical journals, Dr. Epstein is a recognized international authority on angiogenesis and the role of infection in atherosclerosis. He and his colleagues recently developed stem cell strategies for enhancing collateral development (new blood vessel growth) and are currently focused on understanding and treating cardiovascular disease at the molecular level by identifying the molecular mechanisms responsible for development of vulnerable plaques. These efforts have included examining possible genetic polymorphisms and of circulating biomarkers as indicators that a given patient is at risk of plaque rupture. Dr. Epstein has also explored how aging leads to collateral dysfunction and the related molecular mechanisms. One of Dr. Epsteins current primary areas of … Continue reading →

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Life Technologies Signs License and Collaborative Stem Cell Research Agreement with Harvard University

Posted: Published on March 4th, 2013

CARLSBAD, Calif., March 4, 2013 /PRNewswire/ --Life Technologies Corporation (LIFE) announced today that it has signed a collaborative research agreement and related license with Harvard University under which it has acquired exclusive rights to develop a panel of characterization assays designed to rapidly evaluate human pluripotent stem (hPS) cells for their utility in a variety of discovery and translational research applications. The license expands Life's growing portfolio of stem cell research products and deepens its commitment to customers in the field. The panel, which will be offered on the company's market-leading semiconductor sequencing and PCR-based genetic analysis platforms, will help overcome major hurdles that impede stem cell technology from moving into the clinic. Current methods for evaluating pluripotency the potential for induced pluripotent stem (iPS) cells to differentiate into any cell type are laborious, costly and can produce ambiguous results. Standardizing the way researchers characterize iPS cells will allow them to quickly identify the most promising cell lines and avoid wasting time and resources on cells that do not possesses the appropriate characteristics. Such efficiency could accelerate applications ranging from development of "disease-in-a-dish" models from patient-derived cells and drug screening, to the eventual use of pluripotent cells as a renewable … Continue reading →

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Scientists Identify 'Clean-Up' Snafu That Kills Brain Cells in Parkinson's Disease

Posted: Published on March 4th, 2013

Newswise March 3, 2013 (Bronx, NY) Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered how the most common genetic mutations in familial Parkinsons disease damage brain cells. The study, which published online today in the journal Nature Neuroscience, could also open up treatment possibilities for both familial Parkinsons and the more common form of Parkinsons that is not inherited. Parkinsons disease is a gradually progressing disorder of the nervous system that causes stiffness or slowing of movement. According to the Parkinsons Disease Foundation, as many as one million Americans are living with the disease. The most common mutations responsible for the familial form of Parkinsons disease affect a gene called leucine-rich repeat kinase-2 (LRRK2). The mutations cause the LRRK2 gene to code for abnormal versions of the LRRK2 protein. But it hasnt been clear how LRRK2 mutations lead to the defining microscopic sign of Parkinsons: the formation of abnormal protein aggregates inside dopamine-producing nerve cells of the brain. Our study found that abnormal forms of LRRK2 protein disrupt an important garbage-disposal process in cells that normally digests and recycles unwanted proteins including one called alpha-synuclein the main component of those protein aggregates that gunk up nerve … Continue reading →

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New Guidance Issued on Genetic Testing of Children

Posted: Published on March 4th, 2013

Newswise For the first time, the American Academy of Pediatrics (AAP) and the American College of Medical Genetics and Genomics (ACMG) spoke with one voice and released a set of recommendations and guidelines on best practices for genetic testing and screening of children. Genetic screening is done more on children than on any other group, with about 4 million newborns screened every year for nearly 40 metabolic and endocrine disorders including phenylketonuria, cystic fibrosis and hypothyroidism, as well as hemoglobinopathies, such as sickle cell disease. Most states have adopted the uniform panel, although some states include a variety of additional conditions. Despite gains in technology and the study of genetics, such guidelines had not been updated by either group in at least a decade. We now have geneticists, pediatricians and ethicists all in consensus about what are the best guidelines for genetic testing and screening of children, said pediatrician Lainie Ross, MD, PhD, Carolyn and Matthew Bucksbaum professor and associate director at the MacLean Center for Clinical Medical Ethics at the University of Chicago. Ross is the lead author of the policy statement, published by AAP, and the companion technical paper, published by the ACMG. The new guidelines were released … Continue reading →

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