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Twice Given, Twice Used: Infusion of Stem Cells and Specially Generated T-Cells From Same Donor Improves Leukemia …

Posted: Published on February 28th, 2013

NEWS RELEASE EMBARGOED FOR RELEASE Until 2 p.m. ET, Feb. 27, 2013 TWICE GIVEN, TWICE USED: INFUSION OF STEM CELLS AND SPECIALLY GENERATED T-CELLS FROM SAME DONOR IMPROVES LEUKEMIA SURVIVAL Newswise SEATTLE In a significant advance for harnessing the immune system to treat leukemias, researchers at Fred Hutchinson Cancer Research Center for the first time have successfully infused large numbers of donor T-cells specific for a key anti-leukemic antigen to prolong survival in high-risk and relapsed leukemia patients after stem cell transplantation. Both the stem cells for transplant and the T-cells came from the same matched donors. Reporting results of a pilot clinical trial in the Feb. 27 issue of the journal Science Translational Medicine, researchers describe the use of T-cells that were taken from a donor, programmed in the lab to recognize the Wilms Tumor Antigen 1 (WT1) and kill leukemia cells, grown in large numbers, and then infused into patients to promote anti-leukemic activity. The WT1 protein is overexpressed in leukemias and is in part responsible for why the cells have become leukemic. The best results were achieved when some of the patients received T-cell clones that were exposed to interleukin 21 (IL-21) during the programming and growth … Continue reading

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Crowd-sourced funding provides missing help for rare genetic diseases

Posted: Published on February 28th, 2013

Public release date: 27-Feb-2013 [ | E-mail | Share ] Contact: George Hunka ghunka@aftau.org 212-742-9070 American Friends of Tel Aviv University Tel Aviv For the estimated 250 million people worldwide who suffer from rare diseases, there is little hope for diagnosis or treatment. Because each individual disease impacts so few people, hardly any funding is allocated to research, leaving many without medical options. The US-based non-profit organization Rare Genomics Institute (RGI) is working to address this problem by "crowd-funding" allowing people to donate on the Internet towards genetic testing for individual children who are struggling with a rare disease. Now, thanks to Dr. Noam Shomron of Tel Aviv University's Sackler Faculty of Medicine, RGI's vital mission has come to Israel the first international branch of the organization. Its online home is http://raregenomics.org/world_Israel.php, and it has launched its first appeal for two Israeli children at http://raregenomics.org/donors.php. Based at the TAU-affiliated Sourasky Medical Center and Rabin Medical Center, RGI-Israel will help families with children impacted by rare genetic diseases find support and care through advanced genetic testing. The Israeli branch is run in collaboration with three of Israel's top geneticists, Drs. Lina Basel, Shay Ben-Shachar, and Hagit Baris. The services that the … Continue reading

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Genetic tricks put a date on Homer's 'Iliad'

Posted: Published on February 28th, 2013

Biblioteca Ambrosiana via LGPN This codex of Homer's "Iliad" was produced in the late fifth century or early sixth century. By Joel N. Shurkin Inside Science News Service Scientists who decode the genetic history of humans by tracking how genes mutate have applied the same technique to one of the Western world's most ancient and celebrated texts to uncover the date it was first written. The text is Homer's "Iliad," and Homer if there was such a person probably wrote it in 762 B.C., give or take 50 years, the researchers found. The "Iliad" tells the story of the Trojan War if there was such a war with Greeks battling Trojans. The researchers accept the received orthodoxy that a war happened and someone named Homer wrote about it, said Mark Pagel, an evolutionary theorist at the University of Reading in England. His collaborators include Eric Altschuler, a geneticist at the University of Medicine and Dentistry of New Jersey, in Newark, and Andreea S. Calude, a linguist also at Reading and the Santa Fe Institute in New Mexico. They worked from the standard text of the epic poem. The date they came up with fits the time most scholars think the … Continue reading

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Dr. Mahajan’s Interview on Hitguj – Video

Posted: Published on February 28th, 2013

Dr. Mahajan's Interview on Hitguj Dr Mahajan's Interview about Stem Cell Treatment on Marathi News Chanel. explaining about Stem Cell treatment the usefulness facts about stem cell treatment. By: StemRx BioScience … Continue reading

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Part 15, after stem cell treatment, Big drop in energy, 20fev2013 – Video

Posted: Published on February 28th, 2013

Part 15, after stem cell treatment, Big drop in energy, 20fev2013 My name is Carole St-Laurent, I am from Rimouski, Quebec, Canada. I have a Spinal Muscular Atrophy from birth, it's in the family of Muscular Dystrophy. I received a stem cell treatment on the 28th of November 2012 at the "Integra Medical Center" in Nuevo Progresso Mexico, by Dr. Omar Gonzalez. This is a follow-up video. By: Kina Diamond … Continue reading

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MIT’s Dr. Robert Langer Joins Nanobiosym Scientific Advisory Board

Posted: Published on February 28th, 2013

CAMBRIDGE, Mass.--(BUSINESS WIRE)-- Nanobiosym, a leading nanotechnology firm, has announced that M.I.T. professor Dr. Robert Langer, winner of the Lemelson-M.I.T. Innovation Prize, has joined the companys Scientific Advisory Board. Dr. Langer was recently awarded the National Medal of Innovation and Technology by President Obama and has served as chairman of the FDAs highest advisory board. Nanobiosym creates and commercializes breakthrough technologies at the nexus of physics, biomedicine and nanotechnology. Nanobiosyms product platform, Gene-RADAR, is a mobile device that detects DNA/RNA biomarkers in real time, enabling individuals to personalize their diagnosis and monitor their response to treatment. I am delighted to welcome Dr. Langer to our team, said Nanobiosym Chairman and CEO, Dr. Anita Goel, a Harvard-M.I.T. physicist-physician and internationally renowned nanotechnology scientist and entrepreneur. Dr. Langer has been pioneering the precision delivery of drugs and novel therapeutics and we at Nanobiosym have been developing mobile platforms that quantify molecular fingerprints in real time. In collaboration with forward-thinking pharmaceutical companies, we are developing companion nanodiagnostics that will enable novel medicines and therapies to reach patients faster. Our goal is to make medicine less toxic, more precise, more affordable and more effective by personalizing it for each individual. We call this Personalized … Continue reading

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Experts develop nanoparticles for tumour-targeted response

Posted: Published on February 28th, 2013

Bangalore, Feb. 27 -- In a major scientific breakthrough, Indian researchers have collaborated to develop peptide nanoparticles that may be used as vehicles for targeted drug delivery for tumours. The study - Modified dipeptide based nanoparticles: Vehicles for targetted tumour drug delivery published in the journal Nanomedicine says that different nanoparticles have been investigated to deliver chemotherapeutic agents but complex synthetic procedures and biocompatibility issues raise concerns in developing them for safe human usage. The research was done collectively by the scientists at the International Center for Genetic Engineering and Biotechnology (ICGEB), Institute of Nuclear Medicine and Allied Sciences and National Center for Cell Science, Pune. "Conventional treatment methods such as chemotherapy and radiation therapy are not fully safe and free from side effects despite all the progress made in this area. Peptides-based nanoparticles are attracting attention of the scientific community due to their wide potential and have also been investigated to deliver chemotherapeutic agents. The present research may prove a milestone in the development of more stable, non-toxic simple peptide-based nanostructure for effective drug delivery system for cancer," Prof V S Chauhan, director ICGEB and one of the authors of the study told HT. The in-vivo studies for evaluating … Continue reading

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Verastem Cofounders to Present at MIT Technology Breakfast on Breakthrough Discoveries in Cancer Stem Cells

Posted: Published on February 27th, 2013

CAMBRIDGE, Mass.--(BUSINESS WIRE)-- Verastem, Inc., (VSTM) a clinical-stage biopharmaceutical company focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, announced that Robert Weinberg, Ph.D., Verastem scientific cofounder and chair of the Scientific Advisory Board, and Christoph Westphal, M.D., Ph.D., Verastem cofounder, Chairman and CEO, will present at the MIT Technology Breakfast on February 28, 2013, at 8am ET. The Technology Breakfast series features breakthrough discoveries from research at MIT and brings together the researchers and entrepreneurs who accelerate and commercialize the technology. Drs. Weinberg and Westphal will speak on how they are changing the landscape of the current treatment paradigm in cancer. Verastem was founded on work in the laboratories of Dr. Weinberg and Dr. Eric Lander, of the Broad Institute of MIT and Harvard, that describes the underlying mechanisms of cancer stem cell development and methods to identify drugs that preferentially target them. Cancer stem cells have been implicated as a cause of tumor resistance to chemotherapy and driver of disease progression. Verastem has advanced the discoveries made by Drs. Weinberg and Lander into clinical development and is currently testing lead compound, VS-6063, in a Phase 1/2 clinical trial for ovarian … Continue reading

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Stem cells cruise to clinic

Posted: Published on February 27th, 2013

Induced pluripotent stem cells could soon be used in human trials in Japan. Kathrin Plath lab, Univ. Calif. Los Angeles/CIRM In the seven years since their discovery, induced pluripotent stem (iPS) cells have transformed basic research and won a Nobel prize. Now, a Japanese study is about to test the medical potential of these cells for the first time. Made by reprogramming adult cells into an embryo-like state that can form any cell type in the body, the cells will be transplanted into patients who have a debilitating eye disease. Masayo Takahashi, an ophthalmologist at the RIKEN Center for Developmental Biology in Kobe, Japan, plans to submit her application for the study to the Japanese health ministry next month, and could be recruiting patients as early as September. Stem-cell researchers around the world hope that if the trial goes forward, it will allay some of the safety concerns over medical use of the cells. And the Japanese government hopes that its efforts to speed iPS cells to the clinic by generously funding such work will be vindicated (see Nature 493, 465; 2013). The entire field is very dependent on this group and the Japanese regulatory agencies to ensure that preclinical … Continue reading

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Rasheda Ali on National and Local News: BrainStorm’s ALS Clinical Trial Results Exceeded Expectations

Posted: Published on February 27th, 2013

NEW YORK & PETACH TIKVAH, Israel--(BUSINESS WIRE)-- BrainStorm Cell Therapeutics (BCLI), a leading developer of adult stem cell technologies for neurodegenerative diseases, announced that the company was recently featured on national and local news, as well as Fox News. Rasheda Ali, a member of BrainStorms advisory board and revered author and daughter of renowned boxer Muhammad Ali, discussed BrainStorms promising ALS clinical trials last week on NBC NY and Current TVs Viewpoint. She was also interviewed on Fox News Geraldo at Large and Neil Cavuto shows. In her various interviews, Ms. Ali stated that BrainStorms Phase I/II ALS clinical trial results with its NurOwn stem cell candidate exceeded scientists expectations, surpassing the goal of confirming safety by also showing initial signs of clinical improvement. She also discussed BrainStorms recent acceleration to a Phase IIa trial by the Israeli Ministry of Health. Ms. Alis interviews can be viewed at the following links: NBC NY: http://bit.ly/Xam0rG. Current TV Viewpoint: http://bit.ly/13VDZRY About BrainStorm Cell Therapeutics, Inc. BrainStorm Cell Therapeutics Inc. is a biotechnology company engaged in the development of first-of-its-kind adult stem cell therapies derived from autologous bone marrow cells for the treatment of neurodegenerative diseases. The Company holds the rights to develop … Continue reading

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