NEWS RELEASE EMBARGOED FOR RELEASE Until 2 p.m. ET, Feb. 27, 2013 TWICE GIVEN, TWICE USED: INFUSION OF STEM CELLS AND SPECIALLY GENERATED T-CELLS FROM SAME DONOR IMPROVES LEUKEMIA SURVIVAL Newswise SEATTLE In a significant advance for harnessing the immune system to treat leukemias, researchers at Fred Hutchinson Cancer Research Center for the first time have successfully infused large numbers of donor T-cells specific for a key anti-leukemic antigen to prolong survival in high-risk and relapsed leukemia patients after stem cell transplantation. Both the stem cells for transplant and the T-cells came from the same matched donors. Reporting results of a pilot clinical trial in the Feb. 27 issue of the journal Science Translational Medicine, researchers describe the use of T-cells that were taken from a donor, programmed in the lab to recognize the Wilms Tumor Antigen 1 (WT1) and kill leukemia cells, grown in large numbers, and then infused into patients to promote anti-leukemic activity. The WT1 protein is overexpressed in leukemias and is in part responsible for why the cells have become leukemic. The best results were achieved when some of the patients received T-cell clones that were exposed to interleukin 21 (IL-21) during the programming and growth … Continue reading
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