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Novelos Therapeutics Presents Diapeutic Technology Platform At EMIT: Targeted Radiotherapy International Conference

Posted: Published on February 1st, 2013

MADISON, Wis., Jan. 31, 2013 /PRNewswire/ -- Novelos Therapeutics, Inc. (NVLT), a pharmaceutical company developing novel drugs for the treatment and diagnosis of cancer, today announced that an oral presentation on research conducted by Novelos and its collaborators is being made by Dr. Christopher Pazoles at the EMIT: Targeted Radiotherapy international conference taking place January 29 to 31, in Washington, D.C. This presentation by invitation from EMIT describes the mechanistic foundation for Novelos' diapeutic (diagnostic + therapeutic) technology platform together withanimal data and initial findings in advanced cancer patients that demonstrate selective and prolonged accumulation of Novelos' PET imaging I-124-CLR1404 (LIGHT), therapeutic I-131-CLR1404 (HOT) and optical imaging CLR1502 (GLOW2) compounds in a range of tumor types. Dr. Pazoles is the Senior Vice President of Research and Development for Novelos. "LIGHT, HOT and GLOW2 were designed to exploit a feature shared by most, if not all, cancer cells including cancer stem cells, which results in the selective uptake and prolonged accumulation of our proprietary, small-molecule delivery vehicle in a wide range of malignant tumors compared with normal tissues," said Dr. Pazoles. "By incorporating a unique functional property in each PET imaging, radiotherapy or optical imaging we have generated an array of … Continue reading

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Research to boost stem cell production

Posted: Published on February 1st, 2013

A Melbourne researcher is working to boost the number of stem cells drawn from umbilical cord blood, offering hope for easier bone marrow transplants. The work has the potential to help people who require bone marrow transplants but struggle to find an exact match. Associate Professor Louise Purton from St Vincent's Institute in Melbourne will use compounds derived from vitamin A to increase the number and quality of cord blood stem cells. Stem cells from cord blood are becoming increasing popular for bone marrow transplants around the world. But often there are not enough stem cells from a single unit for a successful transplant for an adult, although some patients are infused with two unrelated cord blood units with varying degrees of success. Cord blood cells can be slow to mature into platelets and red and white blood cells, which can leave the patient exposed to a greater risk of infection. Donor, or allogeneic, cord blood also carries the risk of graft versus host disease, where the recipient's immune system responds to the foreign cells by attacking the body's organs. Assoc Prof Purton has proven her method works in mice and will now move to test the compounds on human … Continue reading

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ICMR giving final touches to stem cell research guidelines

Posted: Published on February 1st, 2013

While the stem cells market witnessed a high growth in 2011, more therapies are expected to be launched in the next five years The Indian Council of Medical Research (ICMR) is giving the final touches to the much-awaited document on Guidelines for Stem Cell Research. This document will provide ethical and scientific directions to scientists and clinicians working in the field of stem cell research, B.R. Jagashetty, State Drugs Controller, said here on Thursday. He was speaking at the inauguration of the ninth annual stem cell conference, Stem 2013, organised by the Society for Regenerative Medicine and Tissue Engineering (SRMTE). Pointing out that stem cell research had come under the scanner of stringent regulatory oversight, in the backdrop of socio-religious and clinical concerns, Dr. Jagashetty said that the draft guidelines for stem cell research were issued in March 2012. I will find out more about the final document during the Drugs Consultative Committee meeting scheduled on February 4 and 5 in Delhi, he said. New therapies While the stem cells market witnessed a high growth in 2011, more therapies are expected to be launched in the next five years. With the liberalisation of stem cell research in the U.S., more … Continue reading

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Controversial Stem-Cell Company Moves Treatment out of U.S.

Posted: Published on February 1st, 2013

Celltex Therapeutics of Houston ceased treatment patients in the U.S. last year after a warning from regulators, and will now send patients for treatments to Mexico By David Cyranoski and Nature magazine Relations have soured between Celltex and RNL Bio since December 2011 when they launched their stem-cell bank in Sugar Land, Texas. Pictured: human neural stem cells from fetal cortex. Image: Flickr/GE Healthcare US citizens who had pinned their hopes on a company being able to offer stem-cell treatments close to home will now need to travel a little farther. Celltex Therapeutics of Houston, Texas, stopped treating patients in the United States last year following a warning from regulators. A 25 January e-mail to Celltex customers indicates that the firm will now follow in the footsteps of many other companies offering unproven stem-cell therapies and send its patients abroad for treatment but only to Mexico. The stem-cell treatments offered by Celltex involved extracting adult stem cells from a patient, culturing them and then reinjecting them in a bid to replenish damaged tissue. It had been offering the treatment for more than a year with one of its high-profile customers being Texas governor, Rick Perry when the US Food and … Continue reading

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Arteriocyte Receives FDA Approval to Initiate Cellular Therapy Trial for Treatment of Thermal Burn Wounds in Wounded …

Posted: Published on February 1st, 2013

CLEVELAND, Jan. 31, 2013 /PRNewswire/ -- Arteriocyte, a leading biotechnology company with offices in Cleveland, Ohio and Hopkinton, Massachusetts announced today approval from the Food and Drug Administration (FDA) to initiate a Phase I clinical trial using its Magellan System technology in the treatment of thermal burn wounds. The FDA Investigational Device Exemption (IDE-15140) allows Arteriocyte and its clinical partners to initiate evaluation of autologous platelet gel (APG) (using the Magellan Autologous Platelet Separator technology) as an adjunctive therapy for autologous skin grafting in patients with thermal injuries. This treatment has been developed in partnership with the United States Telemedicine and Advanced Technology Research Center (TATRC), and the University of Utah Health Science Center and Intermountain Burn Center. Arteriocyte is initiating a series of investigations employing Arteriocyte's Magellan Autologous Platelet Rich Plasma and Bone Marrow Derived Stem Cell Based Therapies for Burn Wounds as part of Arteriocyte's Cellular Therapies for Battlefield Wounds Program. The Magellan System is an FDA 510(k) cleared medical device for the rapid production of Platelet Rich Plasma from blood and bone marrow that can be applied to a surgical site as surgeons deem necessary for their clinical use requirements. Magellan MAR01a technology enables the rapid Operating … Continue reading

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Arunachal Pradesh helps find stem cells where dormant TB bacteria hide

Posted: Published on February 1st, 2013

Washington, January 31 (ANI): The Idu-Mishmi community of Arunachal Pradesh and RIWATCH (Research Institute of World's Ancient Traditions Cultures and Heritage) have made a great contribution in studying dormant Mycobacterium in TB that has affected nearly 4 billion people in the world and causing 1.9 million deaths yearly. TB is a huge problem in India. The incidence of this infectious disease is much more higher in Northeast of India and especially Arunachal Pradesh than rest of India. The doctors prescribe drug treatment for months together to the TB patients, however TB recurs leading to death and suffering. It was not clear as to how the bacteria of TB hide in the body from months of drug treatment. Now a new study has reported that the dormant TB hide in bone marrow stem cells to escape from drug treatment. The finding that could help develop better therapy to target the dormant TB bacteria. Dr. Bikul Das, who hails from Sualkuchi in Assam and engaged in doing research on stem cells in Stanford University California is known to RIWATCH and its' parent organization ICCS (International Center for Cultural Studies US) since long. When he was working as a Doctor in Bhutan, he … Continue reading

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Bone marrow stem cells (from young Russians!)–the new fountain of youth?

Posted: Published on February 1st, 2013

By Alex Y. Vergara DR. VICKI Belo ARNOLD ALMACEN Is the elusive search for the fountain of youth over? Vicki Belo, one of the countrys leading beauty doctors, thinks so, as she recently unveiled her latest weapons in the fight against aging: intradermal (ID) and intravenous (IV) stem cell treatments. Developed by Russian doctors in Moscow after more than a decade of research, ID treatment, much like Botox, is injected directly on specific points of the face and neck to supposedly facilitate faster skin regeneration, tighten sagging muscles and promote the production of collagen and elastin, two of the skins most important building blocks. As we age, our skin tends to lose elasticity, said Belo. Since we dont produce as much collagen and elastin as we used to, our faces soon lose fat and become hollow. Wrinkles also start to deepen and permanently set in. This may sound a bit scary, but the stem cells Belo uses, unlike those used in a number of clinics abroad, including a famous one in Germany, dont come from animals like sheep. They are not sourced from embryos either. In a way, we pioneered stem cell therapy in the Philippines by using a persons … Continue reading

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TB hideout found inside stem cells

Posted: Published on February 1st, 2013

New Delhi, Jan. 31: Scientists, using bone marrow samples from members of the Idu Mishmi tribe in Arunachal Pradesh, have discovered the hideout in the human body where tuberculosis bacteria can lie dormant for years. A collaborative study by Indian and US scientists has identified stem cells in the bone marrow that seem to serve as a "protective niche" for TB germs to evade the drugs' action and the human immune system. The study, published yesterday in the journal Science Translational Medicine, relied on samples of bone marrow provided by volunteers among Idu Mishmi tribals who live in a remote mountain range in Arunachal's Lower Dibang Valley. By volunteering to participate in the study, scientists say, this indigenous community has contributed to efforts to resolve a long-standing medicine mystery. While effective antibiotics have been available to treat and cure TB for more than 50 years, TB bacilli remain in the body despite a successful course of treatment and can cause the disease to recur after years or even decades. Now Bikul Das, at the Stanford University Medical Centre, and his collaborators have found that cells called mesenchymal stem cells (MSCs) in the bone marrow appear to provide a "long-term protective" … Continue reading

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Duchenne Muscular Dystrophy Drug Could Unlock Huge Potential For This Pharmaceutical

Posted: Published on February 1st, 2013

By Jordo Bivona - January 31, 2013 | Tickers: CELG, GILD, SRPT | 0 Comments Jordo is a member of The Motley Fool Blog Network -- entries represent the personal opinions of our bloggers and are not formally edited. Presentingat the 31st Annual JPMorgan Healthcare Conference, Sarepta Therapeutics (NASDAQ: SRPT) CEO Christopher Garabedian focused primarily on the company's Duchenne muscular dystrophy program. Duchenne Muscular Dystrophy is a disease that is characterized by patients being unable to produce the essential protein Dystrophin. Because of this lack of Dystrophin, patients end up on a progressive track towards losing the ability to walk by their pre-teen years, and have a life expectancy into their 20s, rarely living beyond the age of 30. Dystrophin is the shock absorber of the muscles and allows people to maintain good muscle function into their adult lives. The company's drug, Eteplirsen, is an anti-sense Oligonucleotide with a very different backbone structure than seen in any other RNA therapeutics. The drug is made by manipulating RNA, or ribonucleic acid, which controls protein synthesis. The company is working on using its technology to direct alternative splicing to repair the RNA mutation and restore the translation to produce the protein. The … Continue reading

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Study finds parasites and poor antenatal care are main causes of epilepsy in Africa

Posted: Published on February 1st, 2013

Public release date: 30-Jan-2013 [ | E-mail | Share ] Contact: Jen Middleton j.middleton@wellcome.ac.uk 44-207-611-7262 Wellcome Trust The largest study of epilepsy in sub-Saharan Africa to date reveals that programmes to control parasitic diseases and access to better antenatal care could substantially reduce the prevalence of the disease in this region. Epilepsy is one of the most common neurological conditions worldwide and it is well known that it is significantly more prevalent in poorer countries and rural areas. The study of over half a million people in five countries of sub-Saharan Africa is the first to reveal the true extent of the problem and the impact of different risk factors. The study, conducted at International Network for the Demographic Evaluation of Populations and Their Health (INDEPTH) demographic surveillance sites in Kenya, South Africa, Uganda, Tanzania and Ghana, screened 586,607 residents and identified 1711 who were diagnosed as having active convulsive epilepsy. These individuals, along with 2033 who did not have epilepsy, were given a questionnaire to complete about their lifestyle habits. The team also took blood samples to test for exposure to malaria, HIV and four other parasitic diseases that are common in the developing world. The team found that … Continue reading

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