KANSAS CITY, Mo. Childrens Mercy Hospital has received a large grant to help fund a one-of-a-kind facility to help diagnose and treat genetic diseases in children, the hospital announced on Monday. The hospital received a $1,000,000 gift from the William T. Kemper Foundation to fund the Center for Pediatric Genomic Medicine at Childrens Mercy. Officials say that the facility which the hospital says is the first genome center in the world to be located in a childrens hospital will focus on the diagnosis of inherited pediatric diseases, and to improving health care for children. The Childrens Mercy Center for Pediatric Genomic Medicine will secure Kansas Citys place as a center of biotechnology, but more than anything, it will benefit the children born with genetic diseases, said Samuel Bennett, Foundation Program Manager at Commerce Bank, in a statement released Monday morning. At this time, there is no other facility like this in a clinical setting. For all of these reasons, the William T. Kemper Foundation wanted to be at the forefront of this effort. The hospital says that the grant will allow the Center to have their critically ill patients in their Neonatal Intensive Care Unit (NICU) the opportunity to have … Continue reading →

Washington, Jan 28 (IANS) Even though healthy men and women have similarly structured hearts, the US researchers have discovered genetic differences in diseased hearts. The new genetic differences found by researchers from Washington University in St. Louis in diseased hearts could pave the way to personalised treatment of various heart ailments. Generally, men are more susceptible to developing atrial fibrillation, an irregular, rapid heartbeat that may lead to stroke, while women are more likely to develop long-QT syndrome, a rhythm disorder that can cause rapid heartbeats and sudden cardiac death, the journal Public Library of Science ONE reports. Igor Efimov, professor of biomedical engineering at the Washington University School of Engineering & Applied Science, and former doctoral student Christina Ambrosi analysed 34 human hearts, looking for genetic differences that might explain gender differences in heart disease, according to a Washington statement. The team screened for 89 major genes in electrophysiology, ion channel subunits, calcium handling proteins and transcription factors important in cardiac conduction and in the development of arrhythmia (irregular heartbeats) and the left atria (upper chambers) and ventricles (lower chambers) in human hearts. "What was striking in this study is that we expected very large gender differences in expression … Continue reading →

Every cancer patient could soon have a genetic profile made of their tumour so they can be treated with new smart drugs that can dramatically improve their survival. Scientists at the Institute of Cancer Research believe the technique will prove so effective that it will turn cancer into a chronic disease that people live with, rather than die from. Work at the institute's new Tumour Profiling Unit will begin this year to analyse patients' cancer cells for changes to their DNA. These mutations allow the tumour to grow out of control and even develop resistance to chemotherapy. By identifying key genetic changes, researchers hope to target specific drugs at individual patients. Breast cancer patients are already beginning to benefit from such personalised medicine. The drug Herceptin is highly effective - but only in women who have tumours positive for a protein called HER2. Other cancer patients are now set to benefit. Professor Alan Ashworth, from the institute, said: "None of this is science fiction. "One would think in five or 10 years this will be absolutely routine practice for every cancer patient, and that's what we're aiming to bring about." Tumour profiling has been made possible by the rapid advances … Continue reading →

ELSC-ICNC Seminar: Tamir Ben-Hur A lecture given by: Tamir Ben-Hur Department of Neurology, Hadassah -- Hebrew University Medical Center On the topic of: "Cell therapy for multiple sclerosis" January 3, 2013 Abstract: Neural stem cell therapy was originally thought as a means of cell replacement therapy for achieving brain repair in neurological disorders. While this still holds partly true, the discovery of their strong immunomodulatory and neurotrophic properties, has shifted the rationale for their therapeutic transplantation into using these functional properties. We will discuss the basic biology of the bi-directional interactions between stem cells and the nervous system, and clinical application of cell therapy in particular for multiple sclerosis. In addition we will present and discuss our recent findings on the functional limitations of neural stem cells which need to be considered in clinical translation. By: elscvideo … Continue reading →

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