London, January 21 (ANI): In one of the first genome-wide studies to hunt for both genes and their regulatory "tags" in patients suffering from a common disease, scientists have found a clear role for the tags in mediating genetic risk for rheumatoid arthritis (RA), an immune disorder that afflicts millions of adults. By teasing apart the tagging events that result from RA from those that help cause it, the scientists say they were able to spot tagged DNA sequences that may be important for the development of RA. And they suspect their experimental method can be applied to predict similar risk factors for other common, noninfectious diseases, like type II diabetes and heart ailments. The researchers at Johns Hopkins and the Karolinska Institutet say their study bridges the gap between whole-genome genetic sequencing and diseases that have no single or direct genetic cause. Most genetic changes associated with disease do not occur in protein-coding regions of DNA, but in their regulatory regions, explained Andrew Feinberg, M.D., M.P.H., a Gilman scholar, professor of molecular medicine and director of the Center for Epigenetics at the Johns Hopkins University School of Medicine's Institute for Basic Biomedical Sciences. "Our study analyzed both and shows … Continue reading →

Jan. 20, 2013 In one of the first genome-wide studies to hunt for both genes and their regulatory "tags" in patients suffering from a common disease, researchers have found a clear role for the tags in mediating genetic risk for rheumatoid arthritis (RA), an immune disorder that afflicts an estimated 1.5 million American adults. By teasing apart the tagging events that result from RA from those that help cause it, the scientists say they were able to spot tagged DNA sequences that may be important for the development of RA. And they suspect their experimental method can be applied to predict similar risk factors for other common, noninfectious diseases, like type II diabetes and heart ailments. In a report published in Nature Biotechnology Jan. 20, the researchers at Johns Hopkins and the Karolinska Institutet say their study bridges the gap between whole-genome genetic sequencing and diseases that have no single or direct genetic cause. Most genetic changes associated with disease do not occur in protein-coding regions of DNA, but in their regulatory regions, explains Andrew Feinberg, M.D., M.P.H., a Gilman scholar, professor of molecular medicine and director of the Center for Epigenetics at the Johns Hopkins University School of Medicine's … Continue reading →

--Johns Hopkins scientists identify epigenetic changes that referee genetic risk Newswise In one of the first genome-wide studies to hunt for both genes and their regulatory tags in patients suffering from a common disease, researchers have found a clear role for the tags in mediating genetic risk for rheumatoid arthritis (RA), an immune disorder that afflicts an estimated 1.5 million American adults. By teasing apart the tagging events that result from RA from those that help cause it, the scientists say they were able to spot tagged DNA sequences that may be important for the development of RA. And they suspect their experimental method can be applied to predict similar risk factors for other common, noninfectious diseases, like type II diabetes and heart ailments. In a report published in Nature Biotechnology Jan. 20, the researchers at Johns Hopkins and the Karolinska Institutet say their study bridges the gap between whole-genome genetic sequencing and diseases that have no single or direct genetic cause. Most genetic changes associated with disease do not occur in protein-coding regions of DNA, but in their regulatory regions, explains Andrew Feinberg, M.D., M.P.H., a Gilman scholar, professor of molecular medicine and director of the Center for Epigenetics … Continue reading →

Public release date: 20-Jan-2013 [ | E-mail | Share ] Contact: Carrie Strehlau media@stjude.org 901-595-2295 St. Jude Children's Research Hospital (MEMPHIS, Tenn. January 20, 2013) Research led by St. Jude Children's Research Hospital scientists has identified a possible lead in treatment of two childhood leukemia subtypes known for their dramatic loss of chromosomes and poor treatment outcomes. The findings also provide the first evidence of the genetic basis for this high-risk leukemia, which is known as hypodiploid acute lymphoblastic leukemia (ALL). Normal human cells have 46 chromosomes, half from each parent, but hypodiploid ALL is characterized by fewer than 44 chromosomes. Chromosomes are highly condensed pieces of DNA, the molecule that carries the inherited instructions for assembling and sustaining a person. The research appears in the January 20 advance online edition of the scientific journal Nature Genetics. The study, the largest ever focused on hypodiploid ALL, confirmed that this tumor has distinct subtypes distinguished by the number of chromosomes lost and the submicroscopic genetic alterations they harbor. Researchers found evidence suggesting more than one-third of patients with a subtype known as low hypodiploid ALL have Li-Fraumeni syndrome. Families with Li-Fraumeni syndrome harbor inherited mutations in the TP53 tumor suppressor gene … Continue reading →

Stem Cell Diabetes Stem Cell Treatment in Thailand CD34+ Protocol Type 2 Client Testimonial Stem Cell Treatment for Diabetes in Thailand: thaimedicalvacation.com Recent Testimonial from Thai Medical client Osi from Australia who came to Thailand 6 months ago in hopes of treating his Diabetes Type 2. After 6 months we asked him to share his experience with the Thai Medical Vacation Stem Cell Treatment Protocol. To learn more please contact us for more information about stem cell treatment for Diabetes type 1 or Type 2 or for any other surgical and non-surgical medical solutions we offer please contact us now email: help@thaimedicalvacation.com SKYPE: Thai.MedicalVacation Telephone THAILAND +66 02 402 6566 AUSTRALIA: 02 8006 1094 EUROPE: +44 20 7979 1977 NORTH AMERICA: 1-888-497-3485 By: thaimedicalvacation … Continue reading →

Springhill Medical Group-What is Stem Cell Therapy? springhillmedgroup.com We have been hearing about this stem cell lately but does everyone know about what this really is? According to medical researchers, stem cell treatments have the potential to change the face of human disease and alleviate suffering. There are already many stem treatments nowadays but they are not usually used because they tend to be experimental and they are very expensive. Medical researchers foresee being able to use technologies derived from stem cell research to treat cancer, spinal cord injuries, and muscle damage, amongst a number of other diseases and impairments. This stem cell therapy is established in order to treat disease or injury by introducing new adult stem cells into damaged tissue. Stem cell therapy is an intervention strategy. The good thing about stem cell is that there are minimal risk of rejection and side effects. They have the ability to self-renew and give rise to subsequent generations with variable degrees of differentiation capacities. They also offer significant potential for generation of tissues that can potentially replace diseased and damaged areas in the body. It has been said that there are already a number of stem-cell therapies that exist but … Continue reading →