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3-D biomimetic scaffolds support regeneration of complex tissues from stem cells

Posted: Published on January 11th, 2013

Jan. 10, 2013 Stem cells can be grown on biocompatible scaffolds to form complex tissues such as bone, cartilage, and muscle for repair and regeneration of damaged or diseased tissue. However, to function properly, the cells must often grow in a specific pattern or alignment. An innovative method for creating a stretched polymer scaffold that can support complex tissue architectures is described in an article in Tissue Engineering, Part C, Methods. Zu-yong Wang and a team of researchers from National University of Singapore, Nanyang Technological University, KK Women's and Children's Hospital, and Duke-NUS Graduate Medical School, in Singapore, developed a reproducible method that involves stretching a polymer thin film to produce scaffolds that can support the growth of human mesenchymal stem cells. The stretching process creates orientated 3-dimensional micro-grooves on the surface of the films, and these formations promote consistent alignment and elongation of stem cells as they grow and develop into tissues on and around the resorbable scaffold. The authors present their work in the article, "Biomimetic 3D anisotropic geometries by uniaxial stretch of poly(?-caprolactone) films for mesenchymal stem cell proliferation, alignment and myogenic differentiation." "The researchers developed a very elegant method to promote cell behavior," says John Jansen, … Continue reading

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Bullying causes significant short-term emotional and physical consequences for children with autism

Posted: Published on January 10th, 2013

Jan. 10, 2013 Nearly 70 percent of children with autism spectrum disorders (ASD) experience emotional trauma as a result of being bullied, according to findings published today in the Journal of Developmental & Behavioral Pediatrics, while a significant portion were concerned for their own safety at school. The study also found that children with ASD who presented with pre-existing psychiatric diagnoses were at increased risk for involvement in bullying, with children diagnosed with ASD and attention deficit hyperactivity disorder (ADHD) or depression at highest risk of being victimized over a one month period. This study was led by researchers from the Interactive Autism Network, a project of the Kennedy Krieger Institute that is the nation's first online autism registry with participants from 47 states, making it the largest collection of autism data in the world. "Recent research indicates that children receiving special education services are at risk of being victimized at higher rates than regular education students," says Dr. Paul Law, senior study author and director of the Interactive Autism Network at Kennedy Krieger. "Our findings show that not only are these children being bullied more, but they are also experiencing significant short-term, and likely long-term, effects of being bullied." … Continue reading

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English In Medicine – U7 – Task 3 – Video

Posted: Published on January 10th, 2013

English In Medicine - U7 - Task 3 Unit 7: Treatment Task 3 1 A hypertensive 50-year-old director of a small company DOCTOR: The condition you have requires to be controlled to prevent future damage to the body, especially the blood vessels. If it's not controlled, you can have certain serious illnesses such as a heart attack or a stroke. Treatment is therefore to prevent illness developing because I'm sure that you don't feel ill at the moment. You'll have to take tablets, or medicine, but you'll also have to modify some of your habits. For instance, you must stop smoking. 2 An insulin-dependent 11-year-old girl accompanied by her parents DOCTOR: Now Elizabeth, the trouble with you is that you're not making a substance that you need to control the amount of sugar in your blood. If you have too much sugar or too little sugar, it'll make you feel very ill and we'll have to replace this each day. It means that you'll have to have a jab because it doesn't work properly if we give it to you in a tablet. Now your mother here will go with … Continue reading

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Martin Stephen: I had a stroke of good luck with my stroke

Posted: Published on January 10th, 2013

I was lucky. Not in the hospital I was sent to; my wife and I watched a comatose old man in the opposite bed have a sandwich left on his tray by one orderly every mealtime, to be picked up an hour later, unopened, by another one. After a day and a half, when we reported that the old man was apparently being starved to death, my wife offered to feed him. No you cant, she was told; youre not trained. No, I was lucky because my family had found out about pioneering research in the States: it showed that, provided there had simply been a clot in the brain, and not a bleed into it, you could reprogramme your brain so that speech, writing and physical movement assumed their old levels. The plasticity of the brain means it can reroute signals round the burnt-out channels, but the devil in it is that you have to start within three and a half weeks, we read, or for some reason the brain closes down the regenerative capacity, like a computer erasing a program that hasnt been used for a long time. To do the reprogramming you have to do endless hours … Continue reading

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Andrew Marr 'talking and responding to treatment' after suffering stroke aged just 53 but 'too soon to know long term …

Posted: Published on January 10th, 2013

BBC spokesman said: 'Andrew Marr is responding to medication' Keen runner was taken to hospital on Tuesday, corporation revealed Politicians and other prominent people send their good wishes He and his family are 'touched by the warmth' of the messages By Leon Watson, Paul Revoir and Liz Thomas PUBLISHED: 14:25 EST, 9 January 2013 | UPDATED: 17:02 EST, 10 January 2013 Stroke victim Andrew Marr is a keen long-distance runner. Here he is pictured in Blackpool Andrew Marr is conscious and 'responding to medication' while 'continuing to progress' as he recovers in hospital following a stroke, the BBC said tonight. The 53-year-old, one of the BBC's most prominent and well-loved broadcasters, was taken ill on Tuesday. A BBC spokesman said: 'Andrew Marr is responding to medication and continuing to progress. 'He is conscious and eating. He and his family are touched by all the warm wishes and support flooding in.' Colleagues were left stunned and concerned when the BBC issued a statement at around 7pm yesterday which revealed Marr's illness. The corporation said: 'Andrew Marr was taken ill yesterday and taken to hospital. The hospital confirmed he has had a stroke. Read more from the original source: Andrew Marr 'talking … Continue reading

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BBC Presenter Andrew Marr Suffers Stroke, Recovering in Hospital

Posted: Published on January 10th, 2013

Andrew Marr quizzed David Cameron on his Sunday morning politics show just last week (Reuters) Journalist and TV presenter Andrew Marr has been hospitalised after suffering a stroke yesterday. The presenter, who fronts the BBC's Andrew Marr Show and has produced an acclaimed series charting the history of Britain, was taken to hospital after falling ill. He was later diagnosed with a stroke. Doctors say he is responding to treatment and his family have asked for privacy. A statement from the BBC said: "The hospital confirmed he has had a stroke. His doctors say he is responding to treatment. "His family have asked for their privacy to be respected as he recovers. "His colleagues and the whole BBC wish him a speedy recovery." Marr, 53, joined the BBC as its political editor in 2000. On his Sunday morning politics show last week, he quizzed David Cameron on the UK's relationship with Europe and his decision over child benefit cuts. James Landale, the deputy political editor for BBC News, will be presenting the forthcoming episode of The Andrew Marr Show. Outpour of sympathy More: BBC Presenter Andrew Marr Suffers Stroke, Recovering in Hospital … Continue reading

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Signs of Recovery – BBC’s Andrew Marr Responds To Treatment After Stroke

Posted: Published on January 10th, 2013

The BBC presenter Andrew Marr has suffered a stroke, though is said to be responding to treatment, according to a statement released by the corporation. Marr was taken ill on Tuesday (January 8, 2013) and was taken to hospital, where it was confirmed that he had suffered a stroke. According to The Mirror, a source close to Marr said that it was a scary time for him and his family, though thankfully, the 53 year-old TV presenter and political expert is responding well to treatment. It is believed that he is still able to speak, which is a good indicator that a patient will recover from a stroke. His family sound positive and he seems to be recovering well, said the source. His wife Jackie and three children have been with him for the past 48 hours, whilst he recovers in hospital. A statement from the BBC read We will continue to broadcast The Andrew Marr Show and [his Radio 4 programme] Start The Week with guest presenters in his absence. Colleagues and the whole BBC wish him a speedy recovery. An unnamed source at the BBC told them With strokes it is difficult to know the full prognosis for … Continue reading

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Andrew Marr 'talking and responding to treatment' after suffering stroke aged just 53

Posted: Published on January 10th, 2013

BBC spokesman said: 'Andrew Marr is responding to medication' Keen runner was taken to hospital on Tuesday, corporation revealed Politicians and other prominent people send their good wishes He and his family are 'touched by the warmth' of the messages By Leon Watson, Paul Revoir and Liz Thomas PUBLISHED: 14:25 EST, 9 January 2013 | UPDATED: 17:02 EST, 10 January 2013 Stroke victim Andrew Marr is a keen long-distance runner. Here he is pictured in Blackpool Andrew Marr is conscious and 'responding to medication' while 'continuing to progress' as he recovers in hospital following a stroke, the BBC said tonight. The 53-year-old, one of the BBC's most prominent and well-loved broadcasters, was taken ill on Tuesday. A BBC spokesman said: 'Andrew Marr is responding to medication and continuing to progress. 'He is conscious and eating. He and his family are touched by all the warm wishes and support flooding in.' Colleagues were left stunned and concerned when the BBC issued a statement at around 7pm yesterday which revealed Marr's illness. The corporation said: 'Andrew Marr was taken ill yesterday and taken to hospital. The hospital confirmed he has had a stroke. More: Andrew Marr 'talking and responding to treatment' after … Continue reading

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Scientists uncover potential drug target to block cell death in Parkinson's disease

Posted: Published on January 10th, 2013

Jan. 10, 2013 Oxidative stress is a primary villain in a host of diseases that range from cancer and heart failure to Alzheimer's disease, Amyotrophic Lateral Sclerosis and Parkinson's disease. Now, scientists from the Florida campus of The Scripps Research Institute (TSRI) have found that blocking the interaction of a critical enzyme may counteract the destruction of neurons associated with these neurodegenerative diseases, suggesting a potential new target for drug development. These findings appear in the January 11, 2013 edition of The Journal of Biological Chemistry. During periods of cellular stress, such as exposure to UV radiation, the number of highly reactive oxygen-containing molecules can increase in cells, resulting in serious damage. However, relatively little is known about the role played in this process by a number of stress-related enzymes. In the new study, the TSRI team led by Professor Philip LoGrasso focused on an enzyme known as c-jun-N-terminal kinase (JNK). Under stress, JNK migrates to the mitochondria, the part of the cell that generates chemical energy and is involved in cell growth and death. That migration, coupled with JNK activation, is associated with a number of serious health issues, including mitochondrial dysfunction, which has long been known to contribute … Continue reading

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Saliva gland test for Parkinson's disease?

Posted: Published on January 10th, 2013

Jan. 10, 2013 New research suggests that testing a portion of a person's saliva gland may be a way to diagnose Parkinson's disease. The study was released January 10 and will be presented at the American Academy of Neurology's 65th Annual Meeting in San Diego, March 16 to 23, 2013. "There is currently no diagnostic test for Parkinson's disease," said study author Charles Adler, MD, PhD, with the Mayo Clinic Arizona and a Fellow of the American Academy of Neurology. "We have previously shown in autopsies of Parkinson's patients that the abnormal proteins associated with Parkinson's are consistently found in the submandibular salivary glands, under the lower jaw, and this is the first study demonstrating the value of testing a portion of the saliva gland to diagnose a living person for Parkinson's disease. Making a diagnosis in living patients is a big step forward in our effort to understand and better treat patients." The study involved 15 people with an average age of 68 who had Parkinson's disease for an average of 12 years, responded to Parkinson's medication and did not have known salivary gland disorders. Biopsies were taken of two different salivary glands: the gland under the lower jaw … Continue reading

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