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BIND Biosciences and Amgen Sign Agreement For The Worldwide Development and Commercialization of a Kinase Inhibitor …

Posted: Published on January 8th, 2013

CAMBRIDGE, Mass.--(BUSINESS WIRE)-- BIND Biosciences, a clinical-stage biopharmaceutical company developing a new class of highly selective targeted and programmable therapeutics called AccurinsTM,announced today that it has entered into a global collaboration agreement with Amgen Inc. to develop and commercialize a kinase inhibitor nanomedicine for treating a range of solid tumors. The collaboration will develop a novel Accurin based on BINDs platform for targeted and programmable nanomedicines and Amgens undisclosed proprietary kinase inhibitor. The collaboration aims to create a kinase inhibitor nanomedicine with optimized therapeutic properties, applying for the first time tissue targeting to molecularly targeted drugs. Under the terms of the agreement, Amgen will have the exclusive right to pursue development and commercialization of the Accurin kinase inhibitor against solid tumor targets to be selected by Amgen. Both companies will work together on preclinical development and Amgen will assume responsibility for future development and commercialization. BIND could receive up-front and development milestone payments totaling $46.5 million, and BIND could receive up to an additional $134 million in regulatory and sales milestone payments for the first therapeutic indication and is eligible for additional payments. BIND will receive tiered royalties on potential future sales. BINDs technology is well aligned with Amgens focus … Continue reading

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Nanomedicine: Stealth bombs to target cancer

Posted: Published on January 8th, 2013

The dreaded C word will grip one in eight Indians within the next two decades. What's scary is that many won't be able to afford the expensive treatment. But nanoparticles -- 1/500th the diameter of human hair -- could well change this dismal scenario. Being so miniscule, they can go anywhere in the human body, leading to greater drug efficacy. And they can be guided to be precise, quite like stealth bombs. Chemotherapy and radiation leave behind a toxic trail which can damage healthy tissues. Nanomedicine, on the other hand, is targeted therapy and can evade the immune system by mimicking the body. Being in the cusp of this exciting phase led Indian researchers and doctors from prestigious schools such as Harvard, Cornell and John Hopkins to come back to India and design nanoparticles which can be loaded to chemo drugs. It's cheaper to develop them in India than abroad. In fact, it's hoped that eventually they will be sold at one-tenth the cost in the US and be made commercially viable within the next 5-6 years. "These nanoparticles are engineered from chemo drugs that recognise each other in the body where they assemble together like LEGO blocks to become … Continue reading

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Owner hopes stem cell therapy will get dog’s life back

Posted: Published on January 8th, 2013

REHOBOTH, Mass. -- A first of its kind procedure is being performed in Massachusetts Monday. Its a stem cell therapy on a dog. "He can't get comfortable, can't lay down, because of the pain, so he sits up and stares at the wall all night, which is tough to watch," said Bob Cook, Bubbas owner. Cook of Taunton is talking about his 2-year-old English Bulldog Bubba, who suffers from hip dysplasia. He said his condition has gotten worse in the last several months. After doing research, he found out about a regenerative stem cell therapy and has been hopeful. He brought Bubba to the Abbot Animal Hospital in Rehoboth. "Hopefully we can give these animals relief and increase quality of life and their life span as well, said Dr. Ashraf Gomaa. Gomaa is the only doctor in our area certified by MediVet America, the company that developed this technology. After extracting fat from Bubba, it is processed in a machine that basically breaks down the cells to get to the healthy stem cells. The cells are then injected back into Bubba into the area of concern. "Replacing the bad cells with new cells, pretty advanced technology," Gomaa said. Continue reading … Continue reading

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Owner hopes stem cell therapy will get dog's life back

Posted: Published on January 8th, 2013

REHOBOTH, Mass. -- A first of its kind procedure is being performed in Massachusetts Monday. Its a stem cell therapy on a dog. "He can't get comfortable, can't lay down, because of the pain, so he sits up and stares at the wall all night, which is tough to watch," said Bob Cook, Bubbas owner. Cook of Taunton is talking about his 2-year-old English Bulldog Bubba, who suffers from hip dysplasia. He said his condition has gotten worse in the last several months. After doing research, he found out about a regenerative stem cell therapy and has been hopeful. He brought Bubba to the Abbot Animal Hospital in Rehoboth. "Hopefully we can give these animals relief and increase quality of life and their life span as well, said Dr. Ashraf Gomaa. Gomaa is the only doctor in our area certified by MediVet America, the company that developed this technology. After extracting fat from Bubba, it is processed in a machine that basically breaks down the cells to get to the healthy stem cells. The cells are then injected back into Bubba into the area of concern. "Replacing the bad cells with new cells, pretty advanced technology," Gomaa said. Continue reading … Continue reading

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Elsevier Selected to Publish Cytotherapy: The Journal of Cell Therapy

Posted: Published on January 8th, 2013

AMSTERDAM, January 7, 2013 /PRNewswire/ -- Official journal of the International Society for Cellular Therapy (ISCT) to be published by Elsevier beginning January 2013 Elsevier, a world-leading provider of scientific, technical and medical information products and services, is pleased to announce that the International Society for Cellular Therapy (ISCT) has selected Elsevier to publish Cytotherapy: The Journal of Cell Therapy effective January 2013. "Elsevier presented ISCT with unsurpassed reach into the global medical community, top class publishing services, and significant experience in this field. We are extremely confident that our collaboration with Elsevier will not only help Cytotherapy grow for the benefit of our members and readers, but also for the benefit of all scientists, technologists, regulators, manufacturing experts and others dedicated to translational development of safe and effective cell therapies," said ISCT President, Kurt Gunter, MD, FASCP. Cytotherapy is a highly influential publication in the mainstream of the rapidly expanding field of cell-based treatments for cancer, degenerative disorders, immunotherapy and stem cell transplantation. Cytotherapy publishes cutting edge findings, clinical trials of cell-based therapies, and news and opinion on all aspects of these disciplines. The journal focuses especially on the practical translation of scientific developments in the laboratory into clinical … Continue reading

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Bioheart to Present at Cell Therapy for Cardiovascular Disease Conference in New York

Posted: Published on January 8th, 2013

SUNRISE, Fla., Jan. 7, 2013 /PRNewswire/ --Bioheart, Inc. (BHRT.QB) will present an update on 12 years of clinical data on MyoCell for treating heart failure at the 8th Annual Conference on Cell Therapy for Cardiovascular Disease January 23-25th, 2013 @ Columbia University Medical Center - http://celltherapy.crf.org/register.html - Course Director, Warren Sherman, M.D. (Logo: http://photos.prnewswire.com/prnh/20130107/FL37699LOGO ) Howard J. Leonhardt, Founder and Chief Technology Officer of Bioheart, will present data from clinical trials sponsored by the company since 2001. In Phase II/III clinical trials stage in the U.S. for muscle stem cells for treating advanced heart failure, Bioheart's MyoCell is believed to be the only cell type able to create new contractile muscle in heart scar tissue.Phase II/III Part I interim results demonstrated 95.7 meters improvement in exercise capacity in Bioheart MyoCell patients over placebo (-4 meters) in a double blind randomized study.This compares to -4 meters for CHF drugs, 16 meters for CRT pacers, 53 meters for cardiac stem cells, 52 meters for adipose derived cells and 10 meters allogeneic bone marrow derived cells. Leonhardt will also provide a look at new generation improvements brought forward to enhance cell transplantation by Bioheart which include:SDF-1 gene transfection, electrical stimulation see http://www.myostimpacers.com, repeat … Continue reading

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NeoStem’s Subsidiary, Progenitor Cell Therapy, and Hackensack University Medical Center Enter Into a Cell Processing …

Posted: Published on January 8th, 2013

ALLENDALE, N.J. and HACKENSACK, N.J., Jan. 7, 2013 (GLOBE NEWSWIRE) -- NeoStem, Inc. (NYSE MKT:NBS) and its subsidiary, Progenitor Cell Therapy, LLC ("PCT"), an internationally recognized contract development and manufacturing organization (CDMO), and Hackensack University Medical Center ("HackensackUMC"), part of the Hackensack University Health Network and a hub of healthcare for the Northern New Jersey and New York metropolitan areas, announced today that HackensackUMC has renewed its engagement of PCT's services for processing and storage of a variety of cell types used therapeutically by the hospital. HackensackUMC will use the services of PCT for processing and storage services for peripheral blood progenitor cells, donor leukocytes, bone marrow and cord blood, as well as for further assays, storage, retrieval and transportation. HackensackUMC was recently voted one of the best hospitals by U.S. News and World Report 2012-2013, placing it fourth out of the 184 hospitals in the New York Metropolitan Area and number 1 in New Jersey. HackensackUMC has grown to be a preeminent cancer treatment facility with one of the largest blood and bone marrow transplant programs in the world. "We are very excited to continue our relationship with HackensackUMC, whose engagement of PCT began in 1999, thirteen years ago," … Continue reading

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NeoStem's Subsidiary, Progenitor Cell Therapy, and Hackensack University Medical Center Enter Into a Cell Processing …

Posted: Published on January 8th, 2013

ALLENDALE, N.J. and HACKENSACK, N.J., Jan. 7, 2013 (GLOBE NEWSWIRE) -- NeoStem, Inc. (NYSE MKT:NBS) and its subsidiary, Progenitor Cell Therapy, LLC ("PCT"), an internationally recognized contract development and manufacturing organization (CDMO), and Hackensack University Medical Center ("HackensackUMC"), part of the Hackensack University Health Network and a hub of healthcare for the Northern New Jersey and New York metropolitan areas, announced today that HackensackUMC has renewed its engagement of PCT's services for processing and storage of a variety of cell types used therapeutically by the hospital. HackensackUMC will use the services of PCT for processing and storage services for peripheral blood progenitor cells, donor leukocytes, bone marrow and cord blood, as well as for further assays, storage, retrieval and transportation. HackensackUMC was recently voted one of the best hospitals by U.S. News and World Report 2012-2013, placing it fourth out of the 184 hospitals in the New York Metropolitan Area and number 1 in New Jersey. HackensackUMC has grown to be a preeminent cancer treatment facility with one of the largest blood and bone marrow transplant programs in the world. "We are very excited to continue our relationship with HackensackUMC, whose engagement of PCT began in 1999, thirteen years ago," … Continue reading

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Research Sheds New Light On How Popular Diabetes Drug Metformin Works

Posted: Published on January 8th, 2013

January 7, 2013 redOrbit Staff & Wire Reports Your Universe Online Metformin, the drug most frequently prescribed by doctors to treat Type 2 Diabetes, works differently than previously believed a discovery which could lead to new treatments that have fewer side effects. Lead researcher Dr. Morris J. Birnbaum, a professor at the University of Pennsylvanias Institute for Diabetes, Obesity, and Metabolism (IDOM), and an international team of scientists have discovered that, in mice, metformin suppresses the liver hormone glucagons ability to generate a key signaling molecule. Their findings have been published online in the journal Nature. One of the main reasons that a diabetics blood sugar levels become high is because of the inability of insulin to limit liver glucose output. Metformin lowers blood glucose by decreasing the livers production, Birnbaum said, but until now the medical community was uncertain exactly how it was able to do so. Previously, scientists believed that it reduced glucose synthesis by activating an enzyme known as AMPK. However, in 2010, Marc Foretz and Benoit Viollet from Inserm, CNRS and Universit Paris Descartes both of whom also worked with Birnbaum on this latest study discovered that metformin still worked in mice that lacked AMPK, suggesting … Continue reading

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The US Drug Watchdog Now Urges Users Of The Birth Control Pills Yaz-Yasmin to Contact The Johnson Law Group For a …

Posted: Published on January 8th, 2013

The US Drug Watchdog says, "If you, or a friend were using birth control pills called Yaz, Yasmin, or their generic version Ocella, and severe side effects have occurred, such as a heart attack, a stroke a pulmonary embolism, or other severe medical conditions please contact the Johnson Law Group immediately at 1-800-996-9900 before time runs out to get you identified." http://www.johnsonlawgroup.com/ (PRWEB) January 08, 2013 Possible Side Effects Yaz/Yasmin The US Drug Watchdog says, "One of the biggest problems we have with respect to our drug initiative work, is the average US consumer never hears about a drug recall, or serious side effects related to a specific drug's use. We are attempting to change this very sad fact with aggressive initiatives focused on increasing public awareness, and hopefully suggesting possible help for victims." http://USDrugWatchdog.Com MDL No. 2100 (3:09-md-02100-DRH-PMF) M Thomas Martin Americas Watchdog 866-714-6466 Email Information Read the original post: The US Drug Watchdog Now Urges Users Of The Birth Control Pills Yaz-Yasmin to Contact The Johnson Law Group For a ... … Continue reading

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