Ryan Ethan McCormack ALD diagnosis. Awareness fundraising support http://www.facebook.com Two brothers recently diagnosed with Adrenoleukodystrophy (ALD) share their zest for life and will to fight for their lives. As Ryan and his mum Caroline prepare for their journey to Minnesota where he will undergo intense chemotherapy and a Bone marrow transplant, Ethan will stay at home with Ryan's twin Jack and begin hormone replacement therapy for his malfunctioning adrenal gland. ALD is a major battle and much love and support will be needed. (From en.wikipedia.org Adrenoleukodystrophy (also known as X-Linked Adrenoleukodystrophy, ALD, X-ALD, Adrenomyeloneuropathy,AMN, Siemerling-Creutzfeldt Disease or Bronze Schilder Disease) is a disorder of peroxisomal fatty acid beta oxidation which results in the accumulation of very-long chain fatty acids in tissues throughout the body. The most severely affected tissues are the myelin in the central nervous system, the adrenal cortex and the Leydig cells in the testes. Clinically, ALD is a heterogenous disorder, presenting with several distinct phenotypes, and no clear pattern of genotype-phenotype correlation. As an X-linked disorder, ALD presents most commonly in males, however approximately 50% of heterozygote females show some symptoms later in life. Approximately one-third of ALD patients will present with the childhood cerebral form … Continue reading
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