Washington, November 8 (ANI): Regular use of ibuprofen may help reduce risk of bladder cancer, especially in those with certain genetic marker, a new study has found. In a 2012 collaborative project with the National Cancer Institute, Margaret Karagas, PhD, co-director, Cancer Epidemiology and Chemoprevention program at Norris Cotton Cancer Center, and Professor of Community and Family Medicine at the Geisel School of Medicine at Dartmouth, and Richard Waddell, D.Sc, Research Assistant Professor of Medicine at the Geisel School of Medicine, looked for connections between ibuprofen use and bladder cancer. Karagas did an earlier study on the relationship between bladder cancer and nonsteroidal anti-inflammatory drugs (NSAIDs) usage in New Hampshire. The new study included patients in Vermont and Maine. Researchers enrolled 1,171 participants newly diagnosed with bladder cancer and 1,418 participants who did not have bladder cancer. Karagas also added a genetic component looking at thirty-nine genes related to NSAID metabolism and studied a new class of NSAIDs known as selective cyclooxygenase (COX-2) inhibitors, such as celecoxib (Celebrex). The findings in the recent study suggested that "regular use of nonaspirin nonselective NSAIDs, particularly ibuprofen, may reduce bladder cancer risk, especially among regular users for 10 years or more." However, the … Continue reading →

Public release date: 7-Nov-2012 [ | E-mail | Share ] Contact: Bonnie Davis bdavis@wakehealth.edu 336-716-4977 Wake Forest Baptist Medical Center WINSTON-SALEM, N.C. Nov. 7, 2012 World-renowned scientists are taking what they've learned from their multicenter research collaboration studying the health impact of fatty acids on diverse populations to set up a genetics center in India. Wake Forest Baptist Medical Center researchers Floyd H. "Ski" Chilton, Ph.D., and Avinash K. "Avi" Shetty, M.D., are studying genetic differences in populations related to how they convert certain dietary fats known as polyunsaturated fatty acids (PUFAs). "Given that one third of all severely malnourished children are in India, it is vital to understand the distribution of gene variants that impact long-chain PUFA synthesis in this country," Chilton said. "We're particularly interested in PUFAs because they are so critical for brain and immune development early in life." With new grant funding from the National Institutes of Health, they will take their research to the coastal city of Mangalore in the state of Karnataka in Southern India to study its diverse populations and their genetic capacity to make PUFAs that are critical for brain, eye and immune system development. The collaboration brings together Wake Forest Baptist, … Continue reading →

SAN DIEGO, Nov. 8, 2012 /PRNewswire/ -- Sequenom, Inc. (SQNM), a life sciences company providing innovative genetic analysis solutions, today reported revenue of $22.9 million for the third quarter of 2012, an increase of 25% from revenue of $18.3 million in the second quarter of 2012 and a 68% increase compared to revenue of $13.6 million for the third quarter of 2011. Revenues from the Sequenom Center for Molecular Medicine (Sequenom CMM) diagnostic testing services operating segment grew to $12.5 million in the third quarter of 2012, while revenues from the genetic analysis operating segment were $10.4 million in the third quarter of 2012. Also during the third quarter of 2012, Sequenom CMM established a number of new agreements with networks and insurance providers, increasing the number of lives covered with in-network access to the MaterniT21 PLUS laboratory developed test (LDT) from 26 million to 46 million. "The results from this quarter illustrate the impact of the Company's strategic approach, as we have focused on maintaining our leadership position within our markets," said Harry Hixson, Jr., Ph.D., Chairman and CEO of Sequenom. "Overall, the last year has been an exciting time as Sequenom CMM introduced the MaterniT21 PLUS LDT and … Continue reading →

ScienceDaily (Nov. 8, 2012) Alcohol use during adolescence is harmful on multiple levels, including an increased risk for developing alcohol use disorders (AUDs) later in life. Recent research suggests that genetic influences are moderated by environmental factors. A new study of gene-environment interactions between a functional single nucleotide polymorphism (SNP) of the -opioid receptor (OPRM1) gene (A118G) and the risk for developing an AUD during adolescence, with a specific focus on the influence of parenting practices or affiliation with deviant peers, has confirmed that environmental factors can moderate this association. Results will be published in the February 2013 issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View. "The harmful effects of underage drinking are well documented," said Robert Miranda, associate professor in the department of psychiatry and human behavior at Brown University and corresponding author for the study. "They include injury-related death, suicide, victimization, academic failure and dropout, and possibly irreversible damage to the developing brain." "Consuming alcohol during adolescence confers different health risks, some are similar to adults, others have particular significance for this stage of human development," said John F. Kelly, associate professor in psychiatry at Harvard Medical School, and associate director of … Continue reading →

ORLANDO, Fla., Nov. 8, 2012 /PRNewswire/ -- A coalition of leaders in hemophilia advocacy and treatment today announced a nationwide program that will offer free genetic testing to people with hemophilia and their families. The partnership will be officially unveiled this evening at the 64th National Hemophilia Foundation (NHF) Annual Meeting in Orlando, Florida. To view the multimedia assets associated with this release, please click: http://www.multivu.com/mnr/59068-my-life-our-future-genotyping-for-progress-in-hemophilia The initiative, called My Life, Our Future: Genotyping for Progress in Hemophilia, is a partnership of the NHF, the American Thrombosis and Hemostasis Network (ATHN), Puget Sound Blood Center (PSBC), and Biogen Idec (BIIB). It is designed to help uncover genetic information that can be used by physicians to individualize the care of people with hemophilia, as well as generate data that may lead to new scientific discoveries. Genetic testing, or genotyping, is used to identify the genetic mutation that causes hemophilia, a rare inherited disorder that impairs blood clotting. Research has shown that certain mutations are associated with an increased risk for severe bleeding and inhibitors, a major complication that involves an immune response to treatment. Healthcare providers can tailor treatment to the individual needs of patients when these risks are understood. In … Continue reading →

Variants thought to be behind inherited conditions prove difficult to pin down By Tina Hesman Saey Web edition: November 8, 2012 SAN FRANCISCO Rare tweaks in single letters of DNA are not as powerful a force in health and in common diseases as scientists hoped, new work suggests. Common genetic variants contribute only a tiny bit to a persons risk of developing particular diseases, so researchers have turned to rare variants as a possible explanation for why some people inherit a propensity for heart disease, diabetes or other common ailments. These rare variants, present in a small percentage of people, are thought to affect how genes work. Two separate attempts to link rare variants with disease suggest that they may not affect disease risk more than common variants do. We have learned that the effect size of these very rare variants is quite small, statistical geneticist Suzanne Leal of Baylor College of Medicine in Houston said November 6 during the annual meeting of the American Society of Human Genetics. Leal and her colleagues have assembled excerpts of genetic instruction manuals, or genomes, for about 6,700 people of European or African American heritage. Instead of determining the makeup of the entire … Continue reading →

PURTIER Live Stem Cell Therapy - 4th Edition (English Version).mp4 PURTIER Live Stem Cell Therapy - 4th Edition (English Version) Please contact Pearly @ +65 9338 9541 for more detailsFrom:PurtierPearlyViews:8 0ratingsTime:09:00More inPeople Blogs See the rest here: PURTIER Live Stem Cell Therapy - 4th Edition (English Version).mp4 - Video … Continue reading →

Govt. Appoints Task Force To Explore Stem Cell Research Minister of Health Hon. Dr. Perry Gomez announced that the government has appointed a 10 member task force, charged with making recommendations to the government to explore stem cell therapy in The Bahamas.From:ZNSNetworkViews:5 0ratingsTime:03:27More inNews Politics View post: Govt. Appoints Task Force To Explore Stem Cell Research - Video … Continue reading →