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Gold nanoparticle cancer treatment in dogs has no observed side effects

Posted: Published on October 17th, 2012

We have witnessed the devastating side effects of current cancer therapies for far too many years -- we might be able to shrink or destroy cancerous masses or cells, but the effects of blasting an individual with localised radiation or injecting toxic chemicals into their bloodstream are, in themselves, deadly. We're due to wait until till as long as 2030 to see graphene become a drug delivery tool that targets only cancerous cells, but now, a collaborative team at the University of Missouri has proven that radioactive gold nanoparticles are an effective and side effect-free cancer treatment -- at least, that is, in dogs with aggressive prostate cancer. "Dogs represent such a good model because they develop the disease naturally," explains Sandra Axiak-Bechtel, an assistant professor of oncology at the University of Missouri (MU) College of Veterinary Medicine. "It's a disease that normally we don't have a particularly good treatment for so it offers us as veterinarians the opportunity to better and more aggressively treat the disease while preserving their quality of life, and in the future hopefully it will give us a better way of treating men with prostate cancer more aggressively as well." Previous research by Stanford University … Continue reading →

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Study Shows Young People Driving Epidemic of Prescription Drug Abuse; Abuse of Nonmedical Analgesics up 40 percent

Posted: Published on October 17th, 2012

A new study by the University of Colorado Denver reveals that todays adolescents are abusing prescription pain medications like vicodin, valium and oxycontin at a rate 40 percent higher than previous generations. Denver, CO (PRWEB) October 16, 2012 That makes it the second most common form of illegal drug use in the U.S. after marijuana, according to Richard Miech, Ph.D., lead author of the study and professor of sociology at CU Denver. Prescription drug use is the next big epidemic, Miech said. Everyone in this field has recognized that there is a big increase in the abuse of nonmedical analgesics but our study shows that it is accelerating among todays generation of adolescents. The study was published Tuesday in the Journal of Adolescent Health. It drew on data from the National Survey on Drug Use and Health, a series of annual, nationally representative, cross-sectional surveys of U.S. drug use. The analysis used data from 1985 through 2009. According to Miech, the prevalence of prescription pain medication abuse among the current generation of youth is higher than any generation ever measured. This finding was present among subgroups of men, women, non-Hispanic whites, non-Hispanic blacks and Hispanics. Miech and his co-authors said … Continue reading →

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Young people driving epidemic of prescription drug abuse

Posted: Published on October 17th, 2012

Public release date: 15-Oct-2012 [ | E-mail | Share ] Contact: David Kelly david.kelly@ucdenver.edu 303-315-6374 University of Colorado Denver DENVER (Oct. 16, 2012) A new study by the University of Colorado Denver reveals that today's adolescents are abusing prescription pain medications like vicodin, valium and oxycontin at a rate 40 percent higher than previous generations. That makes it the second most common form of illegal drug use in the U.S. after marijuana, according to Richard Miech, Ph.D., lead author of the study and professor of sociology at CU Denver. "Prescription drug use is the next big epidemic," Miech said. "Everyone in this field has recognized that there is a big increase in the abuse of nonmedical analgesics but our study shows that it is accelerating among today's generation of adolescents." The study was published Tuesday in the Journal of Adolescent Health. It drew on data from the National Survey on Drug Use and Health, a series of annual, nationally representative, cross-sectional surveys of U.S. drug use. The analysis used data from 1985 through 2009. According to Miech, the prevalence of prescription pain medication abuse among the current generation of youth is "higher than any generation ever measured." This finding was … Continue reading →

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Drugs Help Cholesterol Declines in U.S. as Obesity Rises

Posted: Published on October 17th, 2012

Drugs like Pfizer Inc. (PFE)s Lipitor and healthier diets containing fewer trans fats have led to lower cholesterol levels in the U.S. in the past two decades, even as obesity rates soared, a study found. Total cholesterol declined 5 percent on average between 1988 and 2010, while bad cholesterol, or LDL, dropped 10 percent and good cholesterol, or HDL, rose 3.4 percent, according to research published today in the Journal of the American Medical Association. The number of people using cholesterol-lowering medicines rose to 16 percent in 2007-2010 from 3 percent in 1988-1994. High cholesterol is a major risk factor for heart disease and stroke, according to the American Heart Association. Less smoking, better diets and widely prescribed cholesterol-lowering medicines have all helped to lower levels in the U.S., the authors said. About one-third of American adults are obese. Even though weve had this increase in obesity, some of those negative consequences have been balanced by the reductions of smoking and trans fats in our diet, said Donna Arnett, president of the Dallas-based American Heart Association, in a telephone interview yesterday. In the U.S., we have been improving our cholesterol levels and improving our cardiovascular health and thats good news. … Continue reading →

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Drugs Hint At Potential Reversal Of Autism

Posted: Published on October 17th, 2012

MedicalRF.com/Corbis A mutation, called Fragile X, on the X chromosome can cause retardation and autism. Seen here, a microscopic visualization of X chromosomes. Roger Diehl, a college freshman with Asperger's and depression, and his mother, Sita Diehl, answer questions about what parents and education specialists can do to help kids with learning disabilities or mental illness make a strong transition to college. Read the Q&A Scientific researchers can spend years in the lab on obscure topics, like how a sea slug remembers or how a fruit fly sees color. But every now and then, a basic scientist makes a discovery that changes human lives. Mark Bear, who directs the Picower Institute for Learning and Memory at MIT, is one of those basic scientists. He's discovered a system in the brain that could change the lives of thousands of people with the genetic disorder known as Fragile X Syndrome. Fragile X is a mutation on the X chromosome that can cause mental retardation and autism. Until now, there has been no treatment. But Bear discovered that the mutation responsible for Fragile X appears to disrupt a system in the brain that regulates synapses the connections between brain cells. He says the … Continue reading →

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Pharmacy In Outbreak Is Raided

Posted: Published on October 17th, 2012

Federal criminal investigators on Tuesday searched the New England Compounding Center, which supplied drugs tied to the deadly meningitis outbreak. A spokeswoman for the U.S. Food and Drug Administration said criminal investigators from the agency were at the NECC, based in Framingham, Mass., on Tuesday. U.S. Attorney Carmen M. Ortiz of Massachusetts said her office is investigating allegations concerning the compounding center but didn't provide further details. Paul R. Cirel, a lawyer for the New England Compounding Center said in a statement late Tuesday: "It is difficult to understand the purpose of this search, since we have been clear that New England Compounding Center would provide, and has provided, anything requested. We've been clear that warrants weren't needed; asking would have produced the same result. Nevertheless, we continue to offer our cooperation." Also on Tuesday, federal health officials updated treatment guidelines for doctors dealing with the outbreak, saying oral medicine can be used to treat mild cases of meningitis. The Centers for Disease Control and Prevention said there is growing evidence that the fungus Exserohilum rostratum, " a brown-black mold," is the predominant pathogen behind the fungal-meningitis outbreak associated with tainted steroid injections made by NECC. As of Tuesday, the … Continue reading →

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Beauty salon ‘offers’ stem cell therapy

Posted: Published on October 16th, 2012

With all the publicity about the miraculous effects of stem cell therapy, the Department of Health (DOH) should prepare itself for the possibility that the new procedure would be performed by unqualified, and completely clueless, people. I passed a beauty parlor recently and saw a huge poster on its door announcing the arrival of stem cell therapy. I was instantly reminded of botched breast enhancement and nose jobs performed by salon personnel who seemed to think it was as easy to learn complicated surgical procedures as it was to train to cut hair or do manicures and pedicures. The DOH should start warning the public not to fall for these special offers just because they are available at giveaway rates. Modern lifestyle problem Experts have repeatedly talked about problems brought about by modern lifestyles. Changing diets and stress are two of the best known. Dr. Jaime G. Ignacio, section chief of gastroenterology at Veterans Hospital and head of the Digestive Malignancy Council of the Philippine Society of Gastroenterology, said constipation could be one of the consequences of the combination of these two factors. Speaking at an event hosted by Boehringer Ingelheim, maker of Dulcolax (generic name Bisacodyl), a formulation for … Continue reading →

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NICE recommends treatment with alteplase is started as early as possible, within 4.5 hours of onset of ischaemic …

Posted: Published on October 16th, 2012

BRACKNELL, UK--(BUSINESS WIRE)-- Indication Acute Ischaemic Stroke Product Actilyse (alteplase, rt-PA) NICE has issued final guidance on the use of alteplase (Actilyse) for the treatment of acute ischaemic stroke[1], which recommends initiation of treatment within 4.5 hours of onset of ischaemic stroke symptoms. This will give more patients access to thrombolytic therapy, though it remains crucial that doctors treat stroke patients as early as possible. This recommendation comes as the result of a review of existing NICE guidance for Actilyse in stroke, prompted by an extension to the marketing authorisation which allows the initiation of Actilyse from 3 to 4.5 hours from the onset of ischaemic stroke symptoms. The NICE Appraisal Committee concluded that Actilyse administered between 0 and 4.5 hours after onset of stroke symptoms was a cost-effective treatment for acute ischaemic stroke as it decreases the probability of disability, death or dependence. Data suggests that extension of the licence has the potential to make alteplase treatment available to between 2-4.7% more people who suffer an acute ischaemic stroke[2, 3]. The recommendation made by NICE that treatment should be started as early as possible within 4.5 hours of onset of stroke symptoms is vitally important. An extended treatment window … Continue reading →

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Exeter Hospital doctor reprimanded for stroke treatment

Posted: Published on October 16th, 2012

CONCORD An Exeter Hospital emergency room physician has agreed that she delivered improper care to a 38-year-old patient who suffered a severe stroke in 2008, state medical officials announced. As part of an agreement between Dr. Jan Vanderlinde and the New Hampshire Board of Medicine, Vanderlinde keeps her license of 15 years. But she must obtain eight continuing medical education credits through Harvard Medical School, pay a $1,000 administrative fee and inform potential employers for a year about the case. In its settlement agreement, Vanderlinde admitted to misconduct when she treated the patient, who was rushed to Exeter Hospital from a tanning bed on Sept. 22, 2008. Despite the symptoms of stroke, Vanderlinde did not consider administering clot-busting drugs, and she did not calculate the patients health stroke score, the agreement said. The following day, an MRI detected a large stroke on the left side of the brain. A lawsuit filed over the matter was eventually dropped by the patient. Websites such as Angies list, healthgrades.com and ucomparehealthcare.com list Vanderlinde as an emergency medicine physician at Exeter Hospital. The rest is here: Exeter Hospital doctor reprimanded for stroke treatment … Continue reading →

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Acorda Therapeutics Announces Hatch-Waxman Extension of AMPYRA® (dalfampridine) Sustained-Release Formulation Patent

Posted: Published on October 16th, 2012

ARDSLEY, N.Y.--(BUSINESS WIRE)-- Acorda Therapeutics, Inc. (ACOR) today announced that theU.S. Patent and Trademark Office (USPTO) has determined that U.S. Patent No. 5,540,938 (the 938 patent) is entitled to a full five year patent term extension under the patent restoration provisions of the Hatch Waxman Act. The claims of the 938 patent relate to methods for treating a neurological disease, such as multiple sclerosis (MS), and cover the use of a sustained release dalfampridine formulation, such as AMPYRA (dalfampridine) Extended Release Tablets, 10 mg for improving walking in people with MS.With a five year patent term extension, the 938 patent wouldexpire in 2018. Acorda also has a granted U.S. patent and an allowed U.S. patent application covering the use of AMPYRA in improving walking in people with MS.The granted U.S. patent will expire in 2027, and the allowed U.S. patent application, once granted, is expected to expire in 2025 plus any additional term determined by the USPTO based on patent term adjustment provisions. AMPYRA is approved by the U.S. Food and Drug Administration (FDA) as a treatment to improve walking in patients with MS. This was demonstrated by an improvement in walking speed. Important Safety Information Do not take AMPYRA … Continue reading →

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