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Realizing the potential of stem cell therapy: Studies report progress in developing treatments for diseases and injuries

Posted: Published on October 16th, 2012

ScienceDaily (Oct. 15, 2012) New animal studies provide additional support for investigating stem cell treatments for Parkinson's disease, head trauma, and dangerous heart problems that accompany spinal cord injury, according to research findings released today. The work, presented at Neuroscience 2012, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news about brain science and health, shows scientists making progress toward using stem cell therapies to repair neurological damage. The studies focused on using stem cells to produce neurons -- essential, message-carrying cells in the brain and spinal cord. The loss of neurons and the connections they make for controlling critical bodily functions are the chief hallmarks of brain and spinal cord injuries and of neurodegenerative afflictions such as Parkinson's disease and ALS (amyotrophic lateral sclerosis), also known as Lou Gehrig's disease. Today's new findings show that: Other recent findings discussed show that: "As the fields of developmental and regenerative neuroscience mature, important progress is being made to begin to translate the promise of stem cell therapy into meaningful treatments for a range of well-defined neurological problems," said press conference moderator Jeffrey Macklis, MD, of Harvard University and the Harvard Stem Cell Institute, an … Continue reading

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New findings could help speed recovery, alleviate pain associated with spinal cord injury

Posted: Published on October 16th, 2012

ScienceDaily (Oct. 15, 2012) Research released today demonstrates how new scientific knowledge is driving innovative treatments for spinal cord injuries. Spinal cord damage is debilitating and life-altering, limiting or preventing movement and feeling for millions worldwide, and leading to chronic health conditions and pain. The new studies suggest potential therapies for managing the aftermath of pain and pressure sores, repairing nervous system damage, and speeding recovery. The findings were presented at Neuroscience 2012, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news about brain science and health. In the United States, approximately 12,000 people are hospitalized for spinal cord injury (SCI) each year, and at least 270,000 people live with it. The initial injury is usually compounded by a wave of immune activity that can extend the initial nervous system damage, and complications of SCI may include pain and pressure sores that compromise the quality of life. New research is tackling all of these dimensions of SCI. Today's new findings show that: "While the damage of SCI can appear to be immediate and dramatic, the biological events that lead to extensive nerve and tissue damage are complex, and injuries evolve over time," said … Continue reading

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UAB Team Sets Sights on Neuroprotective Treatment for Parkinson's Disease

Posted: Published on October 16th, 2012

Newswise BIRMINGHAM, Ala. For decades, patients with Parkinsons disease (PD) have had the same experience. Their hands start to shake uncontrollably, their limbs become rigid and they lose their balance. Years before those movement problems set in, many begin struggling with fainting, incontinence, sexual dysfunction, anxiety and depression. Many patients are still treated with a 42-year-old drug called L-DOPA, which temporarily staves off symptoms but can itself cause heart arrhythmias, stomach bleeding and hallucinations. This punishing experience may explain in part why patients with PD die at twice the rate of those without the disease in the years after their diagnosis. In this light, its best to tread carefully when talking about early study results that promise something better. That said, a team of researchers at the University of Alabama at Birmingham is excited. The UAB team has identified a set of experimental drugs called LRRK2 inhibitors that may go beyond symptom relief to directly counter the inflammation and nerve cell death at the root of Parkinsons. At least, these effects have been suggested in mouse and cell culture studies meant to approximate human disease. UAB researchers reported on these findings today in a presentation at Neuroscience 2012, the annual … Continue reading

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Joseph O'Reggio: £6million payout for boy starved of oxygen at birth which caused cerebral palsy

Posted: Published on October 16th, 2012

Joseph OReggio, 11, has been left unable or speak or feed himself Maternity staff failed to act swiftly enough when his heart rate dropped Delay caused him to be starved of oxygen which led to brain damage Ten year battle for parents Julian and Rachel to get the hospital to accept liability By Daniel Miller PUBLISHED: 13:20 EST, 15 October 2012 | UPDATED: 16:22 EST, 15 October 2012 The family of a boy who developed severe cerebral palsy after a hospital blunder led to him being starved of oxygen at birth have received a 6million payout. Joseph OReggio, 11, has been left unable or speak or feed himself after staff at Wolverhampton's New Cross Hospital failed to act swiftly enough when his heart rate dropped. His mother Rachel O'Reggio, now 40, had gone into labour after a healthy pregnancy on the morning of April 13, 2001. Injury: Joesph O'Reggio has been left unable to speak or feed himself after maternity staff failed to act swiftly enough when his heart rate dropped at birth which led to brain damage But the following day, from late morning, her unborn baby's heart rate dropped. Although he was being monitored, it wasnt until around … Continue reading

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The ghoulish facts about Halloween candy and your dog

Posted: Published on October 16th, 2012

Halloween is just around the corner and what do dogs like more than getting into the cupboard and sniffing out the Halloween candy? Most pet owners know that chocolate is toxic to dogs, but did you know that xylitol-containing gum/candy/baked goods, macadamia nuts and raisins are also potentially toxic to dogs? What is xylitol and why is it bad for dogs? Xylitol is a common sweetener used in sugar-free gum, candy, mints, baked goods and oral-care products. While safe in humans, xylitol causes an unsafe drop in blood sugar in animals. Xylitol tricks the pancreas into releasing a large surge of insulin which causes a sudden drop in blood glucose. In large doses, xylitol can cause liver toxicity/failure and death. How much does my dog have to ingest in order to be dangerous? A 10 pound (4.5 kg) dog can eat as little as a stick and a half of gum to become hypoglycemic. The dose of xylitol that can cause hypoglycemia is anything greater than 0.1 grams per kilogram of body weight. A typical stick of gum will contain 0.3 to 0.4 grams of xylitol. Anything above 0.5 grams per kilogram of body weight of xylitol may potentially cause … Continue reading

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Stem cell model for hereditary disease developed

Posted: Published on October 16th, 2012

ScienceDaily (Oct. 15, 2012) A new method of using adult stem cells as a model for the hereditary condition Gaucher disease could help accelerate the discovery of new, more effective therapies for this and other conditions such as Parkinson's, according to new research from the University of Maryland School of Medicine. Scientists at the University of Maryland School of Medicine reprogrammed stem cells to develop into cells that are genetically similar to and react to drugs in a similar way as cells from patients with Gaucher disease. The stem cells will allow the scientists to test potential new therapies in a dish, accelerating the process toward drug discovery, according to the paper published online in the journal the Proceedings of the National Academy of Sciences (PNAS) on Oct. 15. "We have created a model for all three types of Gaucher disease, and used stem cell-based tests to evaluate the effectiveness of therapies," says senior author Ricardo Feldman, Ph.D., associate professor of microbiology and immunology at the University of Maryland School of Medicine, and a research scientist at the University of Maryland Center for Stem Cell Biology and Regenerative Medicine. "We are confident that this will allow us to test more … Continue reading

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Illumina Launches Infinium® HumanCore Arrays for Economical Large-Scale Genetic Studies

Posted: Published on October 16th, 2012

SAN DIEGO--(BUSINESS WIRE)-- Illumina, Inc. (ILMN) today launched the Infinium HumanCore BeadChip family of products. With content developed in collaboration with several leading research institutions, the customizable Infinium HumanCore and Infinium HumanCoreExome BeadChips support cost-effective, large-scale genotyping and screening studies such as those performed by biobanks, genome centers, and core labs. Based on Illuminas proven Infinium assay, the BeadChips enable genotyping of markers found across diverse populations, making them ideal for researchers engaged in population genetics studies around the world. These powerful, cost-effective arrays were specifically designed to make genotyping accessible to a wider range of researchers and laboratories, said Christian Henry, Senior Vice President and General Manager, Genomic Solutions at Illumina. Infinium HumanCore BeadChips combine affordability and high-throughput sample processing using the industrys best multi-sample array. The high-quality, genome-wide information they deliver can be used for a variety of downstream applications. Both customizable arrays include content important for disease research, including association studies and copy number variant discovery and analysis. The Infinium HumanCore BeadChip features highly-informative, genome-wide tag SNPs and additional high value markers such as indels and updated exome-focused content. The higher density Infinium HumanCoreExome BeadChip provides that same valuable core content, along with informative markers from the … Continue reading

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Genetic protection against arsenic

Posted: Published on October 16th, 2012

16.10.2012 - (idw) Schwedischer Forschungsrat - The Swedish Research Council Evolution has not only controlled human development over millions of years, it also has an impact on modern man. This is one of the conclusions of a study of Argentinian villagers in the Andes, where the water contains high levels of arsenic. A gene variant that produces efficient and less toxic metabolism of arsenic in the body was much more common among the villagers than among other indigenous groups in South or Central America. The study was a collaborative effort by Karin Broberg from Lund University and Carina Schlebusch and Mattias Jakobsson from Uppsala University in Sweden. We know that many bacteria and plants have genes that increase resistance to arsenic, a highly toxic substance that is found in soil and water in many parts of the world. There has been no previous research on whether the people in these regions also have protective genes against arsenic, says Karin Broberg. High levels of arsenic in drinking water are linked to a range of health problems. Increased child morbidity and an increased risk of cancer, heart disease and diabetes are some examples. In many places this is a relatively new problem, … Continue reading

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Realizing the potential of stem cell therapy

Posted: Published on October 16th, 2012

Public release date: 15-Oct-2012 [ | E-mail | Share ] Contact: Kat Snodgrass 202-962-4090 Society for Neuroscience NEW ORLEANS New animal studies provide additional support for investigating stem cell treatments for Parkinson's disease, head trauma, and dangerous heart problems that accompany spinal cord injury, according to research findings released today. The work, presented at Neuroscience 2012, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news about brain science and health, shows scientists making progress toward using stem cell therapies to repair neurological damage. The studies focused on using stem cells to produce neurons essential, message-carrying cells in the brain and spinal cord. The loss of neurons and the connections they make for controlling critical bodily functions are the chief hallmarks of brain and spinal cord injuries and of neurodegenerative afflictions such as Parkinson's disease and ALS (amyotrophic lateral sclerosis), also known as Lou Gehrig's disease. Today's new findings show that: Other recent findings discussed show that: "As the fields of developmental and regenerative neuroscience mature, important progress is being made to begin to translate the promise of stem cell therapy into meaningful treatments for a range of well-defined neurological problems," said press conference … Continue reading

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Beauty salon ‘offers’ stem cell therapy

Posted: Published on October 16th, 2012

With all the publicity about the miraculous effects of stem cell therapy, the Department of Health (DOH) should prepare itself for the possibility that the new procedure would be performed by unqualified, and completely clueless, people. I passed a beauty parlor recently and saw a huge poster on its door announcing the arrival of stem cell therapy. I was instantly reminded of botched breast enhancement and nose jobs performed by salon personnel who seemed to think it was as easy to learn complicated surgical procedures as it was to train to cut hair or do manicures and pedicures. The DOH should start warning the public not to fall for these special offers just because they are available at giveaway rates. Modern lifestyle problem Experts have repeatedly talked about problems brought about by modern lifestyles. Changing diets and stress are two of the best known. Dr. Jaime G. Ignacio, section chief of gastroenterology at Veterans Hospital and head of the Digestive Malignancy Council of the Philippine Society of Gastroenterology, said constipation could be one of the consequences of the combination of these two factors. Speaking at an event hosted by Boehringer Ingelheim, maker of Dulcolax (generic name Bisacodyl), a formulation for … Continue reading

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