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University of Maryland School of Medicine scientists develop stem cell model for hereditary disease

Posted: Published on October 16th, 2012

Public release date: 15-Oct-2012 [ | E-mail | Share ] Contact: Karen Robinson karobinson@som.umaryland.edu 410-706-7590 University of Maryland Medical Center A new method of using adult stem cells as a model for the hereditary condition Gaucher disease could help accelerate the discovery of new, more effective therapies for this and other conditions such as Parkinson's, according to new research from the University of Maryland School of Medicine. Scientists at the University of Maryland School of Medicine reprogrammed stem cells to develop into cells that are genetically similar to and react to drugs in a similar way as cells from patients with Gaucher disease. The stem cells will allow the scientists to test potential new therapies in a dish, accelerating the process toward drug discovery, according to the paper published online in the journal the Proceedings of the National Academy of Sciences (PNAS) on Oct. 15 (Panicker et.al.). The study was funded with $1.7 million in grants from the Maryland Stem Cell Research Fund; researchers received a start-up grant for $200,000 in 2007 and a larger, five-year grant for $1.5 million in 2009. "We have created a model for all three types of Gaucher disease, and used stem cell-based tests to … Continue reading

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Realizing the potential of stem cell therapy

Posted: Published on October 16th, 2012

Public release date: 15-Oct-2012 [ | E-mail | Share ] Contact: Kat Snodgrass 202-962-4090 Society for Neuroscience NEW ORLEANS New animal studies provide additional support for investigating stem cell treatments for Parkinson's disease, head trauma, and dangerous heart problems that accompany spinal cord injury, according to research findings released today. The work, presented at Neuroscience 2012, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news about brain science and health, shows scientists making progress toward using stem cell therapies to repair neurological damage. The studies focused on using stem cells to produce neurons essential, message-carrying cells in the brain and spinal cord. The loss of neurons and the connections they make for controlling critical bodily functions are the chief hallmarks of brain and spinal cord injuries and of neurodegenerative afflictions such as Parkinson's disease and ALS (amyotrophic lateral sclerosis), also known as Lou Gehrig's disease. Today's new findings show that: Other recent findings discussed show that: "As the fields of developmental and regenerative neuroscience mature, important progress is being made to begin to translate the promise of stem cell therapy into meaningful treatments for a range of well-defined neurological problems," said press conference … Continue reading

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AMA Warns of Pradaxa Bleeding as Lawsuits Grow

Posted: Published on October 16th, 2012

The Pradaxa Resource Center is the Webs largest source for information on Pradaxa legal news, research and side effects. Visit http://www.Pradaxa-lawsuits.org Orlando, FL (PRWEB) October 16, 2012 The news comes after an FDA warning last December that it would investigate the blood thinner Pradaxa after receiving more injury or death reports than expected. USA Today reported on August 19th that the FDA received 3,781 reports of side effects and 542 deaths among Pradaxa users last year, leading all other medications in 2011. Anyone affected by internal bleeding or the loss of a loved one after using Pradaxa is urged to speak with a lawyer about their legal rights as soon as possible. Pradaxa is a popular blood thinner prescribed to prevent strokes and blood clots in patients with atrial fibrillation. According to The Wall Street Journal on April 24, 2012, Boehringer Ingelheim has earned more than $1 billion from the drug so far in more than 70 countries. Due to the number of Pradaxa lawsuits expected, a central court was recently established in Illinois to handle the claims. The case is known as MDL No. 2385, IN RE: Pradaxa Product Liability Litigation, Southern District of Illinois. On September 5, 2012, … Continue reading

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H. D. Smith To Acquire Northern California-based Valley Wholesale Drug

Posted: Published on October 16th, 2012

SPRINGFIELD, Ill., Oct. 15, 2012 /PRNewswire/ --H. D. Smith, among the nation's largest pharmaceutical wholesalers, today announced plans to acquire Valley Wholesale Drug in a merger agreement transaction. The acquisition provides H. D. Smith with an increased customer base in California, reaching more than 1,000 independent pharmacy customers in the state approximately half of the California market. Additionally, Valley Wholesale Drug customers will benefit from access to H. D. Smith's broader product, service and solutions portfolio through its national network of distribution facilities and sales teams. The acquisition also provides H. D. Smith the opportunity to expand into the Pacific Northwest, an underserved region and marketplace for the company. (Logo: http://photos.prnewswire.com/prnh/20121015/NY93014LOGO ) "Today's announcement serves as an important building block in our national customer service vision to continue our commitment to meeting the needs of independent community pharmacies and serve a growing number of these customers throughout the important state of California," said Dale Smith, chairman and chief executive officer, H. D. Smith. "As we have since our founding in 1954, H. D. Smith will continue to focus on exceptional service to our core customers the Retail Independent Pharmacy. This acquisition confirms our commitment to assisting this vital link in … Continue reading

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More drugs linked to fungal meningitis outbreak

Posted: Published on October 16th, 2012

By Val Brickates Kennedy, MarketWatch BOSTON (MarketWatch) Two more drugs have linked to a deadly outbreak of fungal meningitis around the country, the Centers for Disease Control reported Monday. The CDC said it has received reports that a patient with possible fungal meningitis, an infection of the protective membranes of the brain and spinal cord, was recently injected with the steroid drug triamcinolone acetonide. In addition, two transplant patients who received the medication cardioplegic solution have been diagnosed with fungal infections. All of three infections involve the fungus aspergillus. The agency said it is investigating whether the two drugs were manufactured by New England Compounding Center, or NECC, which has been implicated in the ongoing outbreak. The company recalled all of its products from the market on Oct. 6. Why do some some people explode at little annoying things and others don't, like dealing with customer-service people or someone who cuts in line at the grocery store? Elizabeth Bernstein and Weill Cornell psychology professor Stephen Josephson discuss. Photo: AP. Earlier this month, reports surfaced that patients injected with the steroid methylprednisolone acetate had developed a rare form of meningitis associated with fungus aspergillus. Investigators suspect the cases were caused by … Continue reading

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FDA: Injectible drugs from Mass. facility suspect

Posted: Published on October 16th, 2012

The New England Compounding Center recalled all its products earlier this month following an outbreak of fungal meningitis. STORY HIGHLIGHTS (CNN) -- More issues have been reported with drugs from a Massachusetts compounding pharmacy linked to a deadly multistate outbreak of fungal meningitis, federal officials said Monday. Fifteen people have died from the non-contagious meningitis associated with injections of a contaminated steroid produced by the New England Compounding Center. As part of the ongoing investigation into the center, a patient with possible meningitis has been identified who received injection of another NECC product, triamcinolone acetonide, the Food and Drug Administration said. And fungus infections from Aspergillis, one fungus linked to the meningitis outbreak, were reported in two transplant patients who received cardioplegic solution from NECC, the FDA said. Cardioplegic solution is used to induce paralysis of the heart during open-heart surgery. The other fungus linked to the meningitis outbreak is Exserohilum, which the CDC says may not be easily detectable. A patient with a negative fungal test is not in the clear, officials have said. The NECC on October 6 announced a recall of all its products. The FDA said Monday it has not confirmed the three infections were caused … Continue reading

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FDA: More drugs in meningitis scare

Posted: Published on October 16th, 2012

The New England Compounding Center recalled all its products earlier this month following an outbreak of fungal meningitis. STORY HIGHLIGHTS (CNN) -- More issues have been reported with drugs from a Massachusetts compounding pharmacy linked to a deadly multistate outbreak of fungal meningitis, federal officials said Monday. Fifteen people have died from the non-contagious meningitis associated with injections of a contaminated steroid produced by the New England Compounding Center. As part of the ongoing investigation into the center, a patient with possible meningitis has been identified who received injection of another NECC product, triamcinolone acetonide, the Food and Drug Administration said. And fungus infections from Aspergillis, one fungus linked to the meningitis outbreak, were reported in two transplant patients who received cardioplegic solution from NECC, the FDA said. Cardioplegic solution is used to induce paralysis of the heart during open-heart surgery. The other fungus linked to the meningitis outbreak is Exserohilum, which the CDC says may not be easily detectable. A patient with a negative fungal test is not in the clear, officials have said. The NECC on October 6 announced a recall of all its products. The FDA said Monday it has not confirmed the three infections were caused … Continue reading

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2 New Drugs Tied to Fungal Meningitis Outbreak

Posted: Published on October 16th, 2012

Health officials have now identified two more drugs that may be linked to the recent outbreak of fungal meningitis. All meningitis cases were previously tied to methylprednisolone acetate a steroid injection used as treatment for back pain. Two additional cases of fungal infections in people's joints were linked with the same drug. But now, one case of suspected meningitis has been linked to a drug called triamcinolone acetonide, another type of steroid injection, according to the Food and Drug Administration. Both drugs were made by the New England Compounding Center in Framingham, Mass. In addition, two patients undergoing organ transplants developed fungal infections after surgeries that used a NECC drug. The drug, called cardioplegic solution, is administered to paralyze the heart during surgery. It is not clear whether the fungal infections seen in these two patients were caused by the cardioplegic solution, or by something else, the FDA noted. So far, the outbreak has affected 214 people in 15 states, and caused five deaths, according to the Centers for Disease Control and Prevention. Patients who received any injectable drug made by NECC including drugs used in eye surgery or who received cardioplegic solution should be alerted about their potential risk … Continue reading

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More drugs may be linked to meningitis outbreak: FDA

Posted: Published on October 16th, 2012

CHICAGO/NEW YORK (Reuters) - Two other drugs made by the Massachusetts pharmacy at the center of a deadly meningitis outbreak may be linked to the disease, U.S. health regulators said on Monday, potentially widening the scope of the health crisis. The Food and Drug Administration said it was looking into reports of a patient with possible meningitis who received an injection of a different steroid than the one found to have caused 15 deaths. It also said two transplant patients were infected with the rare fungus linked to the meningitis outbreak after receiving a heart drug also made by the New England Compounding Center (NECC) of Framingham, Massachusetts. Nine more people have been diagnosed with fungal meningitis linked to possibly tainted vials of the injected steroid methylprednisolone, bringing the number of cases to 212, according to the U.S. Centers for Disease Control and Prevention (CDC). A Tennessee woman among these cases filed a lawsuit on Monday against NECC seeking $15 million in damages. The patient identified by the FDA as potentially having meningitis received an injection for pain of the steroid triamcinolone, also supplied by NECC. The FDA said its investigation of that patient and the two who received the … Continue reading

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More drugs implicated in fungal meningitis outbreak

Posted: Published on October 16th, 2012

The FDA is urging doctors who administer any injectable product, drug used in eye surgery or cardiac solution, to contact their patients out of an abundance of caution. NBC's Lisa Myers reports. By Maggie Fox, NBC News Two more drugs have been implicated in the ongoing outbreak of fungal meningitis linked to contaminated pain injections, federal health officials said Monday. Both come from the same pharmacy, New England Compounding Center, that distributed the steroids suspected of sickening at least 214 people and killing 15 of them, the Food and Drug Administration said in a statement. One is a steroid called triamcinolone acetonide and another is a product used during heart surgery. While the FDA hasnt confirmed that the two products are to blame, its issued a warning. A patient with possible meningitis potentially associated with epidural injection of an additional NECC product, triamcinolone acetonide, has been identified through active surveillance and reported to FDA, the agency said in a statement. Triamcinolone acetonide is a type of steroid injectable product made by NECC. The cases of meningitis identified to date have been associated with methylprednisolone acetate, another similar steroid injectable product. Both can be injected into the spine. The FDA didn't … Continue reading

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