Newswise Toronto October 3, 2012 Scientists at the Krembil Neuroscience Centre, located at the Toronto Western Hospital, University Health Network have developed the first lab study in the world to accurately predict the outcomes of a human clinical for their drug that protects the brain against the damaging effects of stroke. The study, A translational paradigm for the preclinical evaluation of the stroke neuroprotectant Tat-NR2B9c in gyrencephalic non-human primates, published online today in Science Translational Medicine was conducted concurrently with a human clinical trial called ENACT. The purpose of the animal study was to test whether the Toronto team could predict benefits of the stroke drug Tat-NR2B9c in a larger, multi-center trial conducted in humans. This study builds on work previous published in the journal Nature earlier this year, which showed the ability of this drug to reduce brain damage caused by stroke. Several previous attempts at developing stroke drugs have suggested that certain drugs were effective in reducing stroke damage in small animals such as rats. However, none have shown efficacy in patients suffering from stroke, leaving an unexplained gap between results of studies in animals and those in humans. The landmark research conducted by the Toronto team provides … Continue reading
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