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Neutron Crystallography Aids Drug Design

Posted: Published on October 10th, 2012

Precisely tailored pharmaceuticals could reduce medical side effects LOS ALAMOS, N.M., Oct. 9, 2012 /PRNewswire-USNewswire/ --Researchers at Los Alamos National Laboratory have used neutron crystallography for the first time to determine the structure of a clinical drug in complex with its human target enzyme. Seeing the detailed structure of the bonded components provides insights into developing more effective drugs with fewer side effects for patients. (Photo: http://photos.prnewswire.com/prnh/20121009/DC89923 ) The atomic details of drug binding have been largely unknown due to the lack of key information on specific hydrogen atom positions and hydrogen bonding between the drug and its target enzyme. In this research, scientists used the drug acetazolamide (AZM) -- a sulfonamide drug that has been used for decades to treat a variety of diseases such as glaucoma, altitude sickness, and epilepsy. But when the drug binds with the wrong form (called an isoform) of the target enzyme for the disease, it can produce unpleasant side effects in patients (so called "off-target" drug binding). Enter neutron crystallography the use of neutron scattering to paint a picture of these bonds. By providing precise information on hydrogen bonding between target enzymes and the treatment drugs (carbon anhydrase II targeted by AZM in … Continue reading →

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Fosamax Side Effects Make Drug a Poor Choice for Women with Osteopenia, According to Consumer Reports.

Posted: Published on October 10th, 2012

Fosamax femur fractures, along with the risk for other Fosamax side effects, leads to a Consumer Reports recommendation that the drug not be used by women with osteopenia, Bernstein Liebhard LLP reports. New York, New York (PRWEB) October 09, 2012 Consumer Reports is to be commended for its clear recommendation against the use of Fosamax for women with osteopenia, says Bernstein Liebhard LLP, a nationwide law firm that represents victims of defective drugs and medical devices. Given the mounting evidence linking Fosamax to femur fractures and other serious side effects, this is wise advice. Fosamax Side Effect Lawsuits Fosamax is an oral bisphosphonate used to prevent fractures in people who have bone weakening diseases like osteoporosis and Pagets disease. In October 2010, the U.S. Food & Drug Administration (FDA) warned that people taking Fosamax and other bisphosphonates for osteoporosis are at risk of suffering atypical femur fractures.** Just this past May, an FDA-commissioned analysis published in the New England Journal of Medicine found that there was little benefit in taking Fosamax and similar drugs for longer than five years. The report cited serious Fosamax side effects, including femur fractures and osteonecrosis of the jaw (ONJ, or dead jaw syndrome).*** Fosamax … Continue reading →

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Meningitis outbreak sparks call for regulation

Posted: Published on October 10th, 2012

An outbreak of fungal meningitis has infected 91 people in the US and killed nine. The US Centers for Disease Control and Prevention said this week that 13,000 people could be at risk. The outbreak has been linked to contamination of a steroid drug sold across 23 states. The New England Compounding Center (NECC) in Framingham, Massachusetts, which produces the steroid, has recalled 17,676 vials and is working with the US Food and Drug Administration (FDA) to identify the source of contamination. Meningitis is a potentially fatal inflammation of the brain or spinal cord, most often caused by bacteria or viruses. In the current outbreak, however, it appears two fungal species are to blame. Compounding pharmacies normally combine drugs prepared elsewhere to create bespoke versions for individual patients. But some, like the NECC, have moved on to produce drugs on a larger scale. They are exempt from standard FDA regulations. The FDA has sought to restrict such pharmacies from advertising their products but the Supreme Court overturned this in 2002. "Clearly, there are disturbing questions as to whether, how and why this business was engaged in the wholesale manufacture and sale of a prescription drug product, rather than the filling … Continue reading →

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Madison County leaders move forward to privatize drug and alcohol treatment services

Posted: Published on October 10th, 2012

Madison County leaders began the process of outsourcing the countys alcohol and drug treatment program Tuesday, a transition officials said could be complete by Jan. 1. Earlier this year, county officials issued a request for proposals for the Alcohol and Drug Abuse Prevention and Treatment program, known as ADAPT, which provides psychiatric evaluation and treatment for individuals and families. On Tuesday, the board agreed to enter into contract negotiations with Family Counseling Services of Cortland County, one of four vendors who replied to the countys call for bids. The administrative and financial pressures placed on Madison Countys chemical dependency treatment program by the federal and state government under Medicare and Medicaid have become increasingly burdensome, read the resolution that supervisors approved Tuesday. There are increasing taxpayer concerns and expectations about the public sectors fiscal viability, productivity and accountability, especially as the state and nation moved toward managed health and behavioral healthcare, the resolution read. The move followed last years sale of the countys 44-employee certified home health agency to Home Care of Rochester Inc. a transition that will save county taxpayers $750,000 in next years budget, said Madison County Administrator Mark Scimone. When supervisors voted to privatize, the home health … Continue reading →

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Consumer Energy Solutions Connects with Law Enforcement to Help Protect Honest People

Posted: Published on October 10th, 2012

Consumer Energy Solutions has sponsored a free Drug Education program in their company and they are using it to keep a Drug Free workplace as well as promote to other businesses the importance of a drug free environment. Clearwater, FL (PRWEB) October 10, 2012 Bringing the effective drug education materials of Foundation for a Drug-Free World to our society is their passion. Connecting with others who work to protect the lives of honest people is a natural partnership. Law enforcement groups welcome their educational materials because they know full well how dangerous drugs are to the individual, how much of crime is caused by drug use and dependency, and indeed what a large percentage of crimes are actually committed by people who are high or intoxicated. To offer help, Consumer Energy Solutions (CES) attended several key law enforcement events. National School Safety Conference Orlando, Florida This national conference is held for school police officers, principals and superintendents from around the United States. Attendees are presented new ideas and technology to keep their schools safe. We signed up 100 schools from over 30 states around the country, for the Foundation for a Drug-Free Worlds Educators Program. Each of these has approximately … Continue reading →

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Lawmakers seek more regulation of compounded drugs

Posted: Published on October 10th, 2012

WASHINGTON (AP) -- Two Democratic lawmakers on Tuesday called for stricter federal oversight of compounding pharmacies in the wake a deadly meningitis outbreak linked to contaminated injections made by a Massachusetts specialty pharmacy. Representatives Rosa DeLauro and Edward Markey said in separate statements that they will draft legislation to give the Food and Drug Administration more authority to police the safety of custom-mixed medicines, known as compounded drugs. Compounding pharmacies traditionally supply products that are not available commercially, based on an individual doctor's prescription. But some pharmacies have grown into larger businesses, operating across state lines and supplying drugs to thousands of hospitals, clinics and physicians. As many as 13,000 people received steroid shots from the New England Compounding Center of Framingham, Mass, according to The Centers for Disease Control and Prevention. The contaminated shots have now been associated with 119 cases of meningitis, including 11 deaths, the agency said Tuesday. The company has recalled the fungus-contaminated steroid, which was shipped to 23 states. Meningitis is an inflammation of the lining of the brain and spinal cord. Symptoms include severe headache, nausea, dizziness and fever. Unlike drugs manufactured by large pharmaceutical companies, compounded drugs have never been reviewed for safety … Continue reading →

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Latin America Leads Way in Decriminalizing Drugs

Posted: Published on October 10th, 2012

Even as Latin American countries are at the forefront of the war against narcotraffickers, they are also pushing alternative strategies including the legalization of drugs, particularly marijuana HECTOR GUERRERO / AFP / Getty Images A Mexican soldier pulls up marijuana plants found in a field of blue agave in Hostotipaquillo, Jalisco state, on Sept. 27, 2012. Members of the Mexican military conducted an operation in the area, where so far they have destroyed 40 hectares of marijuana plantations and burned more than 50 tons of plants Guatemalan President Otto Prez Molina has never been soft on crime. The 30-year military veteran rose to power last year on the wings of his law-and-order platform, crystallized in his campaign slogan: Iron fist, head and heart. And he recently approved the creation of two military bases, outfitted with 2,500 soldiers, to guard against the growing presence of drug cartels that have turned Guatemala into a trafficking corridor and fueled some of the worlds highest murder rates. Since February, though, Prez has coupled his tough talk on crime with calls for a drastic change in crime-fighting tactics centered on the legalization and decriminalization of drugs. Legalization, he insists, should supplement military buildup to stem … Continue reading →

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Global Human Growth Hormone Drugs Industry

Posted: Published on October 10th, 2012

NEW YORK, Oct. 10, 2012 /PRNewswire/ --Reportlinker.com announces that a new market research report is available in its catalogue: http://www.reportlinker.com/p01010194/Global-Human-Growth-Hormone-Drugs-Industry.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_and_Medication This report analyzes the worldwide markets for Human Growth Hormone Drugs in US$ Million. The report provides separate comprehensive analytics for the US, Japan, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2009 through 2018. Also, a six-year historic analysis is provided for these markets. The report profiles 37 companies including many key and niche players such as Eli Lilly and Company, Ferring Pharmaceuticals A/S, Genentech, Inc., GeneScience Pharmaceuticals Co., Ltd., Merck Serono SA, Sandoz International GmbH, Novo Nordisk A/S, Pfizer, Inc., and Teva Pharmaceutical Industries Limited. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based upon search engine sources in the public domain. To order this report:Drug_and_Medication Industry: Global Human Growth Hormone Drugs Industry CONTACT: Nicolas Bombourg Reportlinker Email: nicolasbombourg@reportlinker.com US: (805)652-2626 Intl: +1 805-652-2626 Read more here: Global Human Growth Hormone Drugs Industry … Continue reading →

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Pharmacy linked to outbreak issues wide recall – Video

Posted: Published on October 10th, 2012

08-10-2012 05:29 he pharmacy that distributed a steroid linked to an outbreak of fungal meningitis has issued a voluntary recall of all of its products, calling the move a precautionary measure. Read more here: Pharmacy linked to outbreak issues wide recall - Video … Continue reading →

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Total Therapeutic Management, Inc. Invites Directors Of Pharmacy To Learn Strategies Of Medicare Part D STAR Ratings …

Posted: Published on October 10th, 2012

KENNESAW,Ga., Oct. 9, 2012 /PRNewswire/ -- As the healthcare landscape continues to rapidly evolve, pharmacy and medical directors are increasingly challenged to demonstrate improvement in quality and outcomes to reap the rewards that come with these changes. TTM is attentive to this ever-changing environment and is introducing the second webinar in their Quality Improvement Series in which it will focus on Medicare Part D STARS improvement. "Improvement in STAR ratings are critical to the success of Medicare Advantage Health Plans and we are pleased to provide meaningful and timely education to our clients and prospects in this arena," said Barry Patel, Pharm.D. President and Co-Founder of TTM. Dr. Mitzi Wasik, Pharm.D., Director of Medicare Pharmacy Programs at Coventry Healthcare, will lead this timely discussion. Dr. Wasik has extensive experience on quality initiatives for Medicare Part D STAR ratings. Dr. Wasik will describe the quality-based bonus opportunity in the Medicare Advantage STAR ratings program relative to the triple-weighted pharmacy quality measures, the barriers to overcome while improving STAR ratings: member and provider engagement; and identify the strategies to improve STAR ratings. The webinar will benefit medical, quality and pharmacy directors, as well as other clinical leaders looking to develop better communication … Continue reading →

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