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Canadian Lab Study for Stroke Drug Accurately Predicts Outcomes in Human Clinical Trials

Posted: Published on October 4th, 2012

Newswise Toronto October 3, 2012 Scientists at the Krembil Neuroscience Centre, located at the Toronto Western Hospital, University Health Network have developed the first lab study in the world to accurately predict the outcomes of a human clinical for their drug that protects the brain against the damaging effects of stroke. The study, A translational paradigm for the preclinical evaluation of the stroke neuroprotectant Tat-NR2B9c in gyrencephalic non-human primates, published online today in Science Translational Medicine was conducted concurrently with a human clinical trial called ENACT. The purpose of the animal study was to test whether the Toronto team could predict benefits of the stroke drug Tat-NR2B9c in a larger, multi-center trial conducted in humans. This study builds on work previous published in the journal Nature earlier this year, which showed the ability of this drug to reduce brain damage caused by stroke. Several previous attempts at developing stroke drugs have suggested that certain drugs were effective in reducing stroke damage in small animals such as rats. However, none have shown efficacy in patients suffering from stroke, leaving an unexplained gap between results of studies in animals and those in humans. The landmark research conducted by the Toronto team provides … Continue reading

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Common medicine helps repair brain after stroke, study in rats suggests

Posted: Published on October 4th, 2012

ScienceDaily (Oct. 3, 2012) Strokes often cause loss or impairment of vital brain functions -- such as speech, movement, vision or attention. Restoration of these functions is often possible, but difficult. One of the factors impeding brain plasticity is inflammation. A study on rats, carried out at the Nencki Institute in Warsaw, suggests that effectiveness of neurorehabilitation after a stroke can be improved by anti-inflammatory drugs. Post-stroke inflammation slows down recovery and impairs brain plasticity, reveal the results from the lab of Professor Magorzata Kossut at the Nencki Institute in Warsaw. The popular anti-inflammatory drug ibuprofen restores the ability of brain cortex to reorganize -- a process necessary for recovery of stroke-damaged functions. "Our research was conducted on rats, but we have good reasons to suppose that in future our results will help improve effectiveness of rehabilitation of stroke patients," says Prof. Kossut. The Nencki Institute team stresses that so far there are no proofs that the treatment will be effective in humans and that they did not investigate if the ibuprofen therapy prevents strokes, but concentrated on post-stroke recovery. The most frequent cause of stroke is blocking of brain arteries. Without supply of oxygen, neurons die quickly. In the … Continue reading

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Spaulding Selected by NIDRR as both TBI and Burn Injury Model System Sites

Posted: Published on October 4th, 2012

BOSTON, Oct. 3, 2012 /PRNewswire-USNewswire/ -- Spaulding Rehabilitation Hospital announced today that both its Traumatic Brain Injury (TBI) Program and Burn Injury Rehabilitation Program have been selected as Model System sites by the National Institute on Disability and Rehabilitation Research (NIDRR). These selections combined with last year's selection of Spaulding as a Spinal Cord Injury Model System Site make Spaulding one of only two providers nationally to be selected as a Model System in all three specialties at the same time. These grants are awarded in five year cycles by NIDRR through an extremely selective process with only 21 national sites for TBI and only 5 for Burn Injury. NIDRR awards Model Systems grants to institutions that are national leaders in medical research and patient care. Each site provides the highest level of comprehensive specialty services, from the point of injury through rehabilitation and community reentry. Dr. Joe Giacino will serve as Program Director for the TBI Model System Site and Dr. Jeffrey Schneider will serve as Program Director for the Burn Injury Model System site. Dr. Ross Zafonte will serve as Administrative Co-Director for both. "Our selection by NIDRR as only the second provider in the nation to serve … Continue reading

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Infertility Treatment May Worsen MS Symptoms

Posted: Published on October 4th, 2012

Oct. 3, 2012 -- There is growing evidence that infertility treatments raise relapse rates in women with multiple sclerosis. In a new study, 3 out of 4 women with MS had increased disease activity following assisted reproductive technology (ART) infertility treatments. The study was small, with just 16 infertile MS patients getting the treatments. But a second study with twice as many patients, published just a few months ago, also suggested that infertility treatments can bring on or worsen MS symptoms. Timothy Coetzee, PhD, who is chief research officer for the National MS Society, says it is increasingly clear that hormones -- particularly sex hormones -- play an important role in MS. This research highlights an issue that needs further study, he says. When we manipulate hormones to achieve a pregnancy, there may be a significant impact on MS symptoms. Multiple sclerosis is an autoimmune disease that affects about 400,000 people in the U.S. and 2.5 million people worldwide. Twice as many women as men are diagnosed.Women are often diagnosed in their childbearing years. Most women with MS are no more likely to suffer from infertility as other women. But fertility can be affected in women treated with certain MS … Continue reading

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First Presentation of Pooled Phase III Data Supporting Europe´s Newest Partial Epilepsy Treatment

Posted: Published on October 4th, 2012

HATFIELD, England, October 4, 2012 /PRNewswire/ -- New results for Fycompa(R) (perampanel) presented today at leading epilepsy conference New data shared today with Europes epilepsy community at the 10th European Congress on Epileptology (ECE) in London, demonstrate the efficacy of once-daily Fycompa(R) (perampanel) in reducing partial-onset seizures, the most common form of epilepsy, and its effectiveness and flexibility of use as add-on therapy. The successful treatment of partial-onset seizures (the most common form of epilepsy) remains a significant challenge in some patients and the incidence of uncontrolled partial epilepsy remains high, despite many existing anti-epileptic drugs (AEDs); between 20 - 40% of patients with epilepsy have remained poorly controlled despite these treatments.[1] The new data supports the use of perampanel as a new therapeutic option for this hard-to-treat patient population. Results from two separate analyses of pooled data from the perampanel pivotal Phase III clinical trial programme endorse the efficacy and safety of the new AED at clinically relevant doses.[2] In addition, the results show that perampanel decreased the frequency of both complex partial seizures and secondarily generalised seizures.[3] In a third analysis of the pooled trial data, patients with uncontrolled partial-onset seizures taking any of the five most commonly-used … Continue reading

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People's Pharmacy: Contradictory medical advice frustrates patients

Posted: Published on October 4th, 2012

Q: I am fed up with medical flip-flops. Whether it is hormone replacement therapy, calcium supplements, eggs or salt, first we get told one thing, and then doctors change their minds. In the meantime, we consumers are left wondering what to believe and whom to trust. I am still baffled by whether salt is as bad as I have always been told. A: We understand how hard it is to make sense of contradictory evidence from medical research. You are right that there have been major reversals regarding eggs, calcium and salt. For decades, Americans were told to avoid eggs to control cholesterol and decrease the risk of heart disease. Current science does not support this belief (Advances in Nutrition, September 2012). Salt is another hot-button issue. An analysis of 167 randomized controlled trials found that reducing sodium intake lowers blood pressure modestly (American Journal of Hypertension, January 2012). Sodium restriction also raises cholesterol, triglycerides and stress hormones. An eight-year study of 3,500 people found that those consuming the least sodium were at the highest risk of dying during the study (Journal of the American Medical Association, May 4, 2011). This isn't to suggest that people should be increasing their … Continue reading

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Doctors Buzzing About New Hormone Therapy Study

Posted: Published on October 4th, 2012

Medical experts are buzzing about a new hormone therapy study that shows short-term estrogen and progesterone treatment is safe for some menopausal women -- and the study data isn't even out yet. Results from the Kronos Early Estrogen Prevention Study, or KEEPS, will be presented tonight at the North American Menopause Society's annual meeting in Orlando. Researchers reported finding that hormone pills and patches relieved patients' symptoms, such as hot flashes and night sweats, but didn't necessarily increase their risk of heart problems, as other studies have shown. "We're so excited about results that are going to be released in just a few hours," NAMS Executive Director Dr. Margery Gass said from Orlando. She said the KEEPS data is preliminary and the paper hasn't been written yet, but doctors all around her are talking about the summary they've seen. "This study, however, is looking more at the immediate effects of hormones on quality of life issues and then markers of chronic disease... It's not the final results, such as broken bone, a heart attack or a stroke because those things don't really happen that much in this age group." Findings released to the media this week in a press release … Continue reading

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Hormone Therapy Study Has Doctors Buzzing

Posted: Published on October 4th, 2012

Medical experts are buzzing about a new hormone therapy study that shows short-term estrogen and progesterone treatment is safe for some menopausal women -- and the study data isn't even out yet. Results from the Kronos Early Estrogen Prevention Study, or KEEPS, will be presented tonight at the North American Menopause Society's annual meeting in Orlando. Researchers reported finding that hormone pills and patches relieved patients' symptoms, such as hot flashes and night sweats, but didn't necessarily increase their risk of heart problems, as other studies have shown. "We're so excited about results that are going to be released in just a few hours," NAMS Executive Director Dr. Margery Gass said from Orlando. She said the KEEPS data is preliminary and the paper hasn't been written yet, but doctors all around her are talking about the summary they've seen. "This study, however, is looking more at the immediate effects of hormones on quality of life issues and then markers of chronic disease... It's not the final results, such as broken bone, a heart attack or a stroke because those things don't really happen that much in this age group." Findings released to the media this week in a press release … Continue reading

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New study points to benefits from hormone replacement therapy

Posted: Published on October 4th, 2012

Healthy middle-aged women who take hormones to ease the misery of hot flashes and night sweats have fewer depressive symptoms, less anxiety and tension, and better and more sex than those who do not, according to a new study. Though the long-term effects of hormone replacement therapy could not be measured by the new research, it did offer some reassuring findings. It suggested that some women's cholesterol profiles and metabolic function might improve on hormone replacement therapy and that blood pressure did not rise during or after a relatively brief stay on hormone replacement. Participants taking oral hormone replacement pills reported, on average, a slight improvement in their ability to recall printed materials they had read. But for women who received hormones through a transdermal patch, subjective reports of memory problems increased slightly, as did their severity. As expected, women who got hormone replacement maintained more bone density than those who did not. The results from the Kronos Early Estrogen Prevention Study, known as KEEPS, were presented Wednesday at the North American Menopause Society's annual meeting in Orlando, Fla. The study is likely to fuel a growing willingness among American women and their physicians to turn to replacement hormones, after … Continue reading

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Provocative Biotech Exposition Reveals Significant Advancements in Stem Cell Research, Immunotherapy, Targeted …

Posted: Published on October 4th, 2012

STAMFORD, CT--(Marketwire - Oct 3, 2012) - Noble Financial Capital Markets (Noble) announced today that it has released a full high definition video catalog of its Life Sciences Exposition, BIOX, an investor exposition that was held at the University of Connecticut in Stamford, CT on September 24-25, 2012. In addition to the participation of more than two dozen biotechnology companies, the event featured world renowned key opinion leaders Dr. Mark Noble (University of Rochester), R. Phil Greenberg (Fred Hutchinson Cancer Research Center), Dr. Jeffrey Infante (Sarah Cannon Research Institute), and Dr. Charles Vacanti (Harvard Medical School). Opening remarks were provided by Dr. Sharon White, Director of the UCONN Stamford campus and Richard Blumenthal, United States Senator for Connecticut. "Washington is dysfunctional and broken," Blumenthal said. "The good news is that scientific advancements and research offer a real opportunity to reach across the aisle; this is an area that should inspire bipartisan cooperation." Overwhelmingly, the message coming from the Exposition was one of encouragement that we are making great strides in the effective treatment of catastrophic disease, in particular cancers. Determining genetic differences in tumors, which has posed challenges for biomarkers, has improved significantly with advancements in molecular biology. Novel and … Continue reading

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