Two scientists who discovered the developmental clock could be turned back in mature cells, transforming them into immature cells with the ability to become any tissue in the body pluripotent stem cells are being honored with the Nobel Prize in Physiology or Medicine. The Nobel Prize honoring Sir John B. Gurdon and Shinya Yamanaka was announced today (Oct. 8) by the Royal Swedish Academy of Sciences. Th duo's work revealed what scientists had thought impossible. Just after conception, an embryo contains immature cells that can give rise to any cell type such as nerve, muscle and liver cells in the adult organism; these are called pluripotent stem cells, and scientists believed once these stem cells become specialized to carry out a specific body task there was no turning back. Gurdon, now at the Gurdon Institute in Cambridge, England, found this wasn't the case when in 1962 he replaced the nucleus of a frog's egg cell with the nucleus taken from a mature intestinal cell from a tadpole. And voila, the altered frog egg developed into a tadpole, suggesting the mature nucleus held the instructions needed to become all cells in the frog, as if it were a young unspecialized cell. … Continue reading →

8 October 2012 Last updated at 09:58 ET By James Gallagher Health and science reporter, BBC News Please turn on JavaScript. Media requires JavaScript to play. British scientist John Gurdon told a news conference he still keeps a bad report given to him by his school science teacher Two pioneers of stem cell research have shared the Nobel prize for medicine or physiology. John Gurdon from the UK and Shinya Yamanaka from Japan were awarded the prize for changing adult cells into stem cells, which can become any other type of cell in the body. Prof Gurdon used a gut sample to clone frogs and Prof Yamanaka altered genes to reprogramme cells. The Nobel committee said they had "revolutionised" science. The prize is in stark contrast to Prof Gurdon's first foray into science when his biology teacher described his scientific ambitions as "a waste of time". "I believe Gurdon has ideas about becoming a scientist; on his present showing this is quite ridiculous; if he can't learn simple biological facts he would have no chance of doing the work of a specialist, and it would be a sheer waste of time, both on his part and of those who would … Continue reading →

Shinya Yamanaka of Japan and John Gurdon of Britain won the Nobel Prize on Monday for work in cell programming, a frontier that has nourished dreams of replacement tissue for people crippled by disease. The two scientists found that adult cells can be transformed back to an infant state called stem cells, the key ingredient in the vision of regenerative medicine. "Their findings have revolutionised our understanding of how cells and organisms develop," the Nobel jury declared. "By reprogramming human cells, scientists have created new opportunities to study diseases and develop methods for diagnosis and therapy." Among those who acclaimed the award were Britain's Royal Society, Ian Wilmut, "father" of Dolly the cloned sheep, and a leading ethicist, who said it eased a storm about the use of embryonic cells. Stem cells are precursor cells which differentiate into the various organs of the body. They have stirred huge excitement, with hopes that they can be coaxed into growing into replacement tissue for victims of Alzheimer's, Parkinson's and other diseases. Gurdon, 79, said he was grateful but also surprised by the honour, since his main research was done a half-century ago. In 1962, he discovered that the DNA code in the … Continue reading →

John Gurdon (left) and Shinya Yamanaka showed how to reprogram cells into their embryonic states. J. Player/Rex Features; Aflo/Rex Features The discovery that cells can be reprogrammed to an embryonic-like state has won this years Nobel Prize in Physiology or Medicine for two leading lights of stem-cell research: John Gurdon and Shinya Yamanaka. Reprogrammed cells regain pluripotency, the potential to differentiate into many mature cell types. Many researchers hope that cells created in this way will eventually be used in regenerative medicine, providing replacement tissue for damaged or diseased organs. The field has become one of the hottest in biology, but the prizewinners discoveries were not without controversy when they were made. Gurdon, who is based at the Gurdon Institute in Cambridge, UK, was the first person to demonstrate that cells could be reprogrammed, in work published 50years ago1. At the time, scientists believed that cellular specialization was a one-way process that could not be reversed. Gurdon overturned that dogma by removing the nucleus from a frog egg cell and replacing it with the nucleus from a tadpoles intestinal cell. Remarkably, the process was able to turn back the cellular clock of the substitute nucleus. Although it had already committed … Continue reading →