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Bigger nanoparticles for better treatment of brain tumours

Posted: Published on September 7th, 2012

Nanoparticles larger than 100nm in diameter that have been coated with a polymer can penetrate brain tissue, according to new work by researchers in the US. The result will be important for designing new strategies to deliver drugs into the brain for treating tumours, neuroinflammation and other diseases that are difficult to treat with conventional therapies. One of the main goals of nanomedicine is to encapsulate drugs inside nanoparticles and deliver them to specific, diseased targets in the body. Size is all-important when it comes to nanoparticle-mediated delivery because small increases in particle radius translate into huge improvements in drug loading and prolonged release kinetics. There is a problem, however; the brain is a very challenging delivery environment in part because of the bloodbrain barrier and the tightly regulated space between cells. These barriers protect us by preventing harmful substances from the bloodstream entering our brains and also limit how they are distributed within the brain. Now, Justin Hanes and colleagues at the Johns Hopkins University School of Medicine in Baltimore have found that much larger particles can quickly pass through brain tissue provided they are coated with a dense layer of poly(ethylene glycol) a harmless, hydrophilic polymer routinely used … Continue reading →

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Research and Markets: Nanomedicine: Technologies and Applications

Posted: Published on September 7th, 2012

DUBLIN--(BUSINESS WIRE)-- Research and Markets (http://www.researchandmarkets.com/research/svn5wb/nanomedicine_tech) has announced the addition of Woodhead Publishing Ltd's new book "Nanomedicine: Technologies and applications" to their offering. Nanotechnology is at the forefront of advances in medicine. Nanomedicine: Technologies and applications provides an important review of this exciting technology and its growing range of applications. After an introduction to nanomedicine, part one discusses key materials and their properties, including nanocrystalline metals and alloys, nanoporous gold and hydroxyapatite coatings. Part two goes on to review nanomedicine for therapeutics and imaging, before nanomedicine for soft tissue engineering is discussed in part three, including organ regeneration, skin grafts, nanotubes and self-assembled nanomaterials. Finally, nanomedicine for bone and cartilage tissue engineering is the focus of part four, with electrically active biocomposites for smart scaffolds investigated alongside cartilage and bone tissue engineering, regeneration and replacement. With its distinguished editor and international team of expert contributors, Nanomedicine: Technologies and applications is an indispensible guide for all those involved in the research, development and application of this exciting technology, whilst providing a comprehensive introduction for students and academics interested in this field. Key Topics Covered: PART 1 MATERIALS, PROPERTIES AND CONSIDERATIONS Introduction to nanomedicine Trends in nanomedicine Biomedical nanocrystalline metals and alloys: … Continue reading →

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Cedars-Sinai Heart Institute awarded $1.3 million to study cardiac stem cells

Posted: Published on September 7th, 2012

Public release date: 6-Sep-2012 [ | E-mail | Share ] Contact: Sally Stewart Sally.stewart@cshs.org 310-248-6566 Cedars-Sinai Medical Center LOS ANGELES Sept. 6, 2012 A team of Cedars-Sinai Heart Institute stem cell researchers today was awarded a $1.3 million grant from the California Institute of Regenerative Medicine to continue study of an experimental stem cell therapy that treats heart attack patients with heart-derived cells. Earlier this year, data from the first clinical trial of the stem cell treatment showed the therapy helped damaged hearts regrow healthy muscle. To date, this cell therapy, developed by Eduardo Marbn, MD, PhD, director of the Cedars-Sinai Heart Institute and Mark S. Siegel Family Professor, is the only treatment shown to regenerate the injured human heart. In this therapy, human heart tissue is used to grow specialized heart stem cells, which then are injected back into the patient's heart. The new research will focus on understanding the cellular mechanisms that have produced favorable outcomes. "We have seen encouraging results in patients with this treatment, and it has the potential to revolutionize how we treat heart attack patients," Marbn said. "This further study will allow us to better understand how it works, which we hope will lead … Continue reading →

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Albert Martinez claims stem cell therapy cleared wife Liezl Martinez of breast cancer

Posted: Published on September 7th, 2012

Laking pasasalamat ni Albert Martinez at ng kanyang pamilya na cleared na sa breast cancer ang asawa niyang si Liezl Martinez. Kuwento ni Albert sa PEP.ph (Philippine Entertainment Portal), sa tulong daw ng stem cell therapy ay naging cancer-free ang asawa. Ok naman, so far with Gods blessing,. Its all cleared. So, were very, very happy. Dealing with cancer is a struggle from day one, and Im really thankful that theres such a thing as stem cell na naging solusyon sa recovery ni Liezl." EXTENSIVE RESEARCH. Ayon kay Albert ay pinag-aralan niya ang lahat ng puwedeng maging solusyon sa sakit ng asawa. Pero sa huli, ang stem cell pa rin ang naging solusyon. Marami akong pinagdaanan kasi ni-research ko lahat yan. Kailangang alamin mo kung ano ba ang mga dapat gawin. Lahat pinag-aralan natin And nag-end up talaga, na ang pinakamaganda is stem cell. I took the risk, researched on the possibilities of doing it, availability niya. Link: Albert Martinez claims stem cell therapy cleared wife Liezl Martinez of breast cancer … Continue reading →

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Stem-cell-protecting drug could prevent the harmful side effects of radiation therapy

Posted: Published on September 7th, 2012

ScienceDaily (Sep. 6, 2012) Radiation therapy is one of the most widely used cancer treatments, but it often damages normal tissue and can lead to debilitating conditions. A class of drugs known as mammalian target of rapamycin (mTOR) inhibitors can prevent radiation-induced tissue damage in mice by protecting normal stem cells that are crucial for tissue repair, according to a preclinical study published by Cell Press in the September issue of the journal Cell Stem Cell. "We can exploit the emerging findings for the development of new preventive strategies and more effective treatment options for patients suffering this devastating disease," says senior study author J. Silvio Gutkind of the National Institute of Dental and Craniofacial Research. In response to radiation therapy, cancer patients often develop a painful condition called mucositis -- tissue swelling in the mouth that can leave these patients unable to eat or drink and force them to rely on opioid-strength pain killers. Radiation therapy may cause this debilitating condition by depleting normal stem cells capable of repairing damaged tissue. In the new study, Gutkind and his team found that the mTOR inhibitor rapamycin protects stem cells taken from the mouths of healthy individuals (but not cancer cells) … Continue reading →

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Pills That Lead Double Lives

Posted: Published on September 7th, 2012

We usually view side effects as a bad thing, but sometimes they point the way to a whole new use for a drug. "We think of...drugs as being specific to [a] task," says Harvard University medical historian Dr. Jeremy Greene. In fact, he says, "drugs are very complex objects." As research and development costs have climbed, drug companies are more interested than ever in finding ways to repurpose their products. Often they seek to simply market an existing drug for a new condition, but in some cases they give the drug a whole new name and face. Here are eight drugs that lead double lives. Prozac and Sarafem When Eli Lilly's patent on Prozac (fluoxetine) expired in 2001, the company saw sales of the blockbuster drug plummet as the market opened up to competition from cheaper generic versions. In what some experts saw as a move to stem losses, Lilly began marketing fluoxetine for premenstrual dysphoric disorder, a severe form of PMS. With the new use came a new brand: Sarafem. Pink-and-purple capsules in sunflower-bedecked packaging replaced the gender-neutral green and white of Prozac. A Lilly rep said the makeover helped give women "a treatment with its own identity," but … Continue reading →

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Drugs accused granted anonymity

Posted: Published on September 7th, 2012

7 September 2012 Last updated at 08:23 ET Two alleged drug dealers have been granted anonymity at a court in Londonderry because of a possible threat from "third parties". The defendants, two women aged 27 and 19, were arrested after drugs were found in the Waterside area of the city on Wednesday. Both women are charged with having cannabis and having the drug with intent to supply. The older of the two is also charged with having the Class A drug ecstasy. Before the women were brought from the dock, the judge granted an application by defence not to have their names and addresses read out in court. They were identified only by their court numbers during the hearing. The judge said he accepted the application on the basis that there could be threats made to the lives of both women by "third parties". The women were released on their own bail of 500 with 750 sureties each. As part of their bail conditions they must not contact one another and must not use or have a mobile phone. Read more: Drugs accused granted anonymity … Continue reading →

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Synthetic drugs seized in Santa Clarita undercover drug sting

Posted: Published on September 7th, 2012

An undercover operation aimed at ensuring that Santa Clarita businesses are complying with laws regarding the sale of illegal substances led to the arrest this week of a retailer on charges that he sold synthetic drugs known as"bath salts" and "spice," authorities said. Information obtained by the Santa Clarita Valley Sheriffs Station indicated that some local businesses might be selling the illegal substances to children and adults, authorities said in a statement. So the Santa Clarita Sheriffs Station Juvenile Intervention Team joined forces with deputies from the stations Crime Prevention Unit and launched a sting Wednesday. The statement explained that spice, also known as synthetic cannabis, is a psychoactive designer drug made from natural herbs sprayed with synthetic chemicals. When consumed, it can mimic the effects of other illegal drugs, authorities said. The term bath salt represents a family of designer drugs that contain chemicals that can provide intoxication similar to amphetamine and cocaine, officials said. While the white crystals resemble legal bathing products, such as Epsom salts, the products are not chemically related, officials said. Officials said selling, dispensing, distributing, offering to sell, or possessing synthetic cannabinoid compound or synthetic cannabinoid derivative in order to sell them, is a … Continue reading →

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Albert Martinez claims stem cell therapy cleared wife Liezl Martinez of breast cancer

Posted: Published on September 7th, 2012

Laking pasasalamat ni Albert Martinez at ng kanyang pamilya na cleared na sa breast cancer ang asawa niyang si Liezl Martinez. Kuwento ni Albert sa PEP.ph (Philippine Entertainment Portal), sa tulong daw ng stem cell therapy ay naging cancer-free ang asawa. Ok naman, so far with Gods blessing,. Its all cleared. So, were very, very happy. Dealing with cancer is a struggle from day one, and Im really thankful that theres such a thing as stem cell na naging solusyon sa recovery ni Liezl." EXTENSIVE RESEARCH. Ayon kay Albert ay pinag-aralan niya ang lahat ng puwedeng maging solusyon sa sakit ng asawa. Pero sa huli, ang stem cell pa rin ang naging solusyon. Marami akong pinagdaanan kasi ni-research ko lahat yan. Kailangang alamin mo kung ano ba ang mga dapat gawin. Lahat pinag-aralan natin And nag-end up talaga, na ang pinakamaganda is stem cell. I took the risk, researched on the possibilities of doing it, availability niya. Excerpt from: Albert Martinez claims stem cell therapy cleared wife Liezl Martinez of breast cancer … Continue reading →

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CIRM's latest round of funding

Posted: Published on September 7th, 2012

>>UC Irvine photos The California Institute for Regenerative Medicine awarded $63 million in CIRM Disease Team Therapy Development Awards to four research teams. UCLA's Stanley Nelson and collaborators also are recipients, for research on Duchenne muscular dystrophy. CIRM also granted Basic Biology IV awards to a number of UC researchers: UC Berkeley: Robert Tjian UC Davis: Deborah Lieu UCLA: Kathrin Plath, Owen Witte UC San Diego: George Sen, Gene Yeo, Maike Sander, Ananda Goldrath, Miles Wilkinson, David Traver UC San Francisco: Jeremy Reiter, Barbara Panning, Miguel Ramalho-Santos >>CIRM press release IRVINE Efforts to begin human clinical trials using stem cells to treat Alzheimer's disease and retinitis pigmentosa received a $37.3 million boost from the California Institute for Regenerative Medicine during its most recent round of funding on Wednesday (Sept. 5). UC Irvine scientists will be part of two research teams garnering CIRM Disease Team Therapy Development Awards, which are designed to accelerate collaborative translational research leading to human clinical trials. In one, Dr. Henry Klassen, an associate professor of ophthalmology in UC Irvine's Sue & Bill Gross Stem Cell Research Center, and his collaborators at UC Santa Barbara and Cedars-Sinai Medical Center, received $17.3 million to cultivate therapeutically potent retinal … Continue reading →

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