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Resistance to Backup Tuberculosis Drugs Increases

Posted: Published on August 30th, 2012

In countries such as South Africa, drugs commonly used to treat tuberculosis are becoming less effective as strains of the diseases develop resistance. Image: Tom Fox/Dallas Morning News/Corbis Showcasing more than fifty of the most provocative, original, and significant online essays from 2011, The Best Science Writing Online 2012 will change the way... Read More From Nature magazine More than 40% of tuberculosis infections that are resistant to front-line treatments are also resistant to some common backup drugs, according to research published this week in The Lancet1. Efforts to control tuberculosis are being hampered by the emergence of multidrug-resistant (MDR) strains of the disease, which resist treatment with two front-line antibiotics, rifampicin and isoniazid. In some parts of the world, as many as 50% of tuberculosis cases are resistant to these drugs2. Alternative treatment options are toxic and expensive, relying on second-line drugs that are not as effective and must be given in lengthy courses. Unfortunately, the majority of MDRtuberculosis cases occur in developing countries that cant afford the several billion dollars that the global Stop TB Partnershipestimates3 will be required to combat the disease. More recently, strains of tuberculosis have emerged that are resistant not only to front-line antibiotics, … Continue reading

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Deaths fall from misuse of drugs

Posted: Published on August 30th, 2012

30 August 2012 Last updated at 02:23 ET The number of deaths from drugs misuse in Wales fell in 2011, according to the Office for National Statistics (ONS). However, the overall trend has shown a sharp rise in the death rate over the past two decades. Last year 137 people died, but that compared with 33 in 1993 and 89 in 2005. The death rate peaked in 2010 with 152 deaths, and the rate still remains higher in Wales compared with every other region in England, said the ONS. However, Ifor Williams, chief executive of the Swansea Drugs Project, was encouraged by last year's fall in deaths and said it showed education and prevention projects were working. "I think it's important that we take the positive rather than seeing the figures from the last 20 years," he said. There's no real evidence to show there are fewer people taking drugs, but this does show us that education and prevention is taking effect Mr Williams said the Welsh government has been "focused" in the last couple of years on preventing deaths and users have been able to carry the antidote naloxone. Naloxone works by temporarily blocking the effect of the opiate … Continue reading

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Nanoparticles Could Lead to Stronger Drugs, Fewer Side Effects for Cancer Patients

Posted: Published on August 30th, 2012

A biotech company called Cerulean says its nanoparticle-delivered cancer drugs are better at attacking tumors. One result of the side effects of cancer treatments is that patients often can't tolerate or survive a combination of different drugs at the same timewhich can limit a doctor's ability to knock out the disease. The head of a Boston-area biotech called Cerulean Pharmathinks the solution is nanoparticle-delivered drugs, which have fewer and less severe side effects. They could make it easier for doctors to mount a multipronged attack on tumors and kill the cells before they can develop a resistance to any one compound. Cancer cells can develop resistance to individual drugs very quickly, says Oliver Fetzer, CEO of Cerulean. And he points to recent studies showing that different cells within the same tumor can have different genetic mutations. In some cases, that means that a drug that kills cancer cells in one part of a tumor may not work in other parts. This tumor diversity suggests that it would be best to hit cancer cells with multiple drugs at once to make it extremely difficult for the tumor to develop resistance to all therapies. Nanoparticles could help achieve this goal. The nanoparticles … Continue reading

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URI's new pharmacy building to formally open

Posted: Published on August 30th, 2012

SOUTH KINGSTOWN, R.I.The University of Rhode Island is preparing to formally open its new $75 million pharmacy building, which has tripled the capacity of its College of Pharmacy. University officials next week are marking the opening of the five-story, 144,000 square-foot building, the largest academic building on the South Kingstown campus. Officials say the building was funded through $65 million in bonds and $10 million in private donations and university money. A ribbon-cutting is planned for Tuesday with URI President David Dooley, U.S. Rep. James Langevin (LAN'-jih-vin) and others. A new $42 million, 429-bed residence hall is also being built. It had initially been expected to open to students next month but a university spokeswoman says it will be ready in October. She says all students have been accommodated with temporary housing. Copyright 2012 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed. Read this article: URI's new pharmacy building to formally open … Continue reading

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Sacred Heart Medical Center Deploys Talyst's Pharmacy Automation for Inventory Control and Improved Patient Safety

Posted: Published on August 30th, 2012

KIRKLAND, Wash., Aug 30, 2012 /PRNewswire/ -- Providence Sacred Heart Medical Center, a member of the Providence Health & Services, has utilized Talyst's innovative pharmacy automation, AutoPharm, three AutoCarousel, and AutoLabel, for five years. The technologies provide the hospital with greater inventory control and improved patient safety. With AutoCarousel, the hospital is able to consolidate its drug inventory in a compact footprint. The vertical design provides secure, automated storage and accurate retrieval. In addition, AutoLabel has improved Sacred Heart's patient safety by barcoding and labeling all medications, ensuring virtually 100% of medications are scan-ready at the bedside. "Talyst's pharmacy automation has dramatically improved our inventory control and processes," said John Woon, Pharm.D., FASHP, Manager, Pharmacy Informatics at Providence Sacred Heart Medical Center & Children's Hospital. "Sacred Medical is now more efficient and has better control of our drug inventories, while ensuring patient safety." "Our products help our customers minimize storage footprint, and increase efficiencies within the pharmacy," said Carla Corkern, Chief Executive Officer at Talyst."This is critical in a time of drug shortages." About Talyst Talyst is a leader in pharmacy automation and engineers the safer pharmacy. Our solutions provide enterprise-wide medication management across your entire health system to offer … Continue reading

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Stem cells power implants

Posted: Published on August 30th, 2012

Stem cell-powered implant set to revolutionise orthopaedic surgery Scientists at the University of Glasgow are working to harness the regenerative power of stem cells to improve orthopaedic implant surgery. They are collaborating with surgeons at Glasgows Southern General Hospital to develop a new type of orthopaedic implant which could be considerably stronger and more long-lived than the current generation of products. Currently, implants are commonly made from materials such as polyethylene, stainless steel, titanium or ceramic and have a limited lifespan due to loosening, requiring replacement after 15 or 20 years of use. In hip replacement surgery, the head of the thigh bone is removed and replaced with an implant which is held in place by a rod fixed inside the marrow along the length of the bone. Marrow is a rich source of mesenchymal stem cells, which have the potential to divide, or differentiate, into other types of cells such as skin, muscle or bone which can improve the process of healing. However, stem cells can also differentiate into cells which have no use in therapy. Artificially controlling the final outcome to ensure the desired type of cells are created is very difficult, even under laboratory conditions. When traditional … Continue reading

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Clinic Day for muscular dystrophy

Posted: Published on August 30th, 2012

GREEN BAY - When you live with a disease like muscular dystrophy every day can bring new challenge. Patients in Northeast Wisconsin have a place to go for regular check-ups on certain days. It's called Clinic Day. One of the doctors in the area who helps care for patients is Dr. Terence Edgar with Prevea Clinic in Green Bay. Edgar says a team of medical professionals come together to bring different skills directly to the patients. They monitor everything from heart to lungs, all the way to the patients body functions. Edgar says treatment has come a long way in the last ten years. So the advances we have now, now we don't just look at can we cure - but how can we make your heart function the best and so there is a multitude of different strategies that we use, said Dr. Edgar. MDA raises money to support treatment and research to find cures for some 40 neuromuscular diseases. Be sure to join us for the MDA Show of Strength on Sunday night from 7 until 10. More: Clinic Day for muscular dystrophy … Continue reading

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Developmental Delays, Autism Often Missed in Hispanic Children

Posted: Published on August 30th, 2012

By Janice Wood Associate News Editor Reviewed by John M. Grohol, Psy.D. on August 29, 2012 Hispanic children often have undiagnosed developmental delays, according to new research that also found that large numbers of all children who were first thought to have developmental delays actually had autism. Our study raises concerns about access to accurate, culturally relevant information regarding developmental milestones and the importance of early detection and treatment, said Virginia Chaidez, Ph.D., the lead author and a postdoctoral researcher in the University of California Davis when the study was conducted. Autism and developmental delay tend to go undiagnosed when parents are not aware of the signs to look for, and the conditions are often misdiagnosed when parents dont have access to adequate developmental surveillance and screening. The researchers used data from the Childhood Autism Risk from Genetics and the Environment (CHARGE) Study, a population-based study of factors that increase the risks for autism or developmental delay. The study included 1,061 children living in California who were between 24 and 60 months of age. They were divided into three groups: Children with autism, children with developmental delay but not autism, and children with typical development. The evaluations of Hispanic children … Continue reading

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Riding waves to treat autism

Posted: Published on August 30th, 2012

Last year Kate Wells family went through six TVs in six months nine-year-old Aidan destroyed them all. Aidan, who has limited vocabulary and motor skills due to autism, experiences what Ms. Wells calls severe meltdowns. Afterward, he returns to his usual sweet self, saying quietly, I sorry, his mom said. Like many kids with autism, Aidans fits are triggered by his senses loud noises like babies crying or dogs barking. Even though it has been a difficult year, Aidan recently found an activity that has left him calm and relaxed: surfing. California-based non-profit called Surfers Healing offers free surf camps to children with autism. The group, run by former pro-surfer Israel (Izzy) and wife Danielle Paskowitz, believe that surfing can provide long-term therapeutic benefits to kids with autism. Aidan attended their first-ever surf camp in Canada this past weekend as part of a fundraising event called Aloha Toronto. Surfers Healing runs about 20 camps each year all over the U.S., with the help of donors and volunteers instructors, many of who are pro surfers. The Paskowitzes have even been featured in their own reality show, The Swell Life , on the Oprah Winfrey Network. Researchers remain skeptical. Dr. Wendy Roberts, … Continue reading

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Chocolate: A sweet method for stroke prevention in men?

Posted: Published on August 30th, 2012

ScienceDaily (Aug. 29, 2012) Eating a moderate amount of chocolate each week may be associated with a lower risk of stroke in men, according to a new study published in the August 29, 2012, online issue of Neurology, the medical journal of the American Academy of Neurology. "While other studies have looked at how chocolate may help cardiovascular health, this is the first of its kind study to find that chocolate, may be beneficial for reducing stroke in men," said study author Susanna C. Larsson, PhD, with the Karolinska Institute in Stockholm, Sweden. For the study, 37,103 Swedish men ages 49 to 75 were given a food questionnaire that assessed how often they consumed various foods and drinks and were asked how often they had chocolate. Researchers then identified stroke cases through a hospital discharge registry. Over 10 years, there were 1,995 cases of first stroke. Men in the study who ate the largest amount of chocolate, about one-third of a cup of chocolate chips (63 grams) per week, had a lower risk of stroke compared to those who did not consume any chocolate. Those eating the highest amount of chocolate had a 17-percent lower risk of stroke, or 12 … Continue reading

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