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Stanford researchers first to determine entire genetic sequence of individual human sperm

Posted: Published on July 20th, 2012

Public release date: 19-Jul-2012 [ | E-mail | Share ] Contact: Krista Conger kristac@stanford.edu 650-725-5371 Stanford University Medical Center STANFORD, Calif. The entire genomes of 91 human sperm from one man have been sequenced by Stanford University researchers. The results provide a fascinating glimpse into naturally occurring genetic variation in one individual, and are the first to report the whole-genome sequence of a human gamete the only cells that become a child and through which parents pass on physical traits. "This represents the culmination of nearly a decade of work in my lab," said Stephen Quake, PhD, the Lee Otterson Professor in the School of Engineering and professor of bioengineering and of applied physics. "We now have devices that will allow us to routinely amplify and sequence to a high degree of accuracy the entire genomes of single cells, which has far-ranging implications for the study of cancer, infertility and many other disorders." Quake is the senior author of the research, which will be published July 20 in Cell. Graduate student Jianbin Wang and former graduate student H. Christina Fan, PhD, now a senior scientist at ImmuMetrix, share first authorship of the paper. Sequencing sperm cells is particularly interesting because … Continue reading →

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HIV Injection Could Someday Replace Daily Pill Regimen

Posted: Published on July 20th, 2012

Newswise This has been a good week for breakthroughs in HIV/AIDS. Earlier this week, the Food and Drug Administration approved a daily pill, Truvada, which reduces the risk of HIV infection. Today, a University of Nebraska Medical Center research teams progress toward developing weekly or twice-monthly injectable antiretroviral therapy (ART) nanomedicines for patients with human immunodeficiency virus (HIV) infection will be highlighted as the cover story in the Journal of Infectious Diseases. A long-acting, nanoformulated ART (nanoART) would be a substantive improvement over daily and sometimes more complex regimen of pills, said Howard Gendelman, M.D., the lead investigator on the development of nanoART for HIV/AIDS and professor and chairman of the department of pharmacology and experimental neuroscience (PEN) at UNMC. The journal article hails the successful testing of UNMCs ART injectables as treatment of HIV-infected mice and in preventing new infections. We actually followed the process exactly as we would with a person and it worked, Dr. Gendelman said. This is all very exciting. Although there are clear pitfalls ahead and the medicines are not yet ready for human use, the progress is undeniable. Dr. Gendelman said one of the projects real advantages is in the nanoformulations. NanoART is cell … Continue reading →

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Plug Pulled On Grum, Responsible for 18 Percent of All Internet Spam

Posted: Published on July 20th, 2012

Have you stopped receiving unsolicited emails about penis enlargement surgery? There's a good reason for that. Grum, the world's third-largest spam botnet, has been taken down by computer security experts. Grum is essentially a network of infected computers used by cyber criminals to send spam to millions of people, the New York Times reported. Security experts say that Grum is responsible for 18 percent of global spam. Before Grum was killed, it was sending 18 billion spam messages each day. Grum's control servers were based in Panama, Russia and Ukraine, BBC News reported. Atif Mushtaq, the senior staff scientist at security firm FireEye, announced in a blog post Wednesday that after a long struggle, Grum had finally died. "Grum's takedown resulted from the efforts of many individuals," Mushtaq wrote. "This collaboration is sending a strong message to all the spammers: 'Stop sending us spam. We don't need your cheap Viagra or fake Rolex.'" To shut Grum down, FireEye collaborated with security experts across the globe. The experts had to pressure local ISPs to help them suspend the operation, the BBC said. But given how advanced Grum was, is it possible that it can come back to life? Not in its … Continue reading →

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Doubt over the worth of prostate surgery

Posted: Published on July 20th, 2012

"The whole problem is selecting the ones which need to be operated on" ... Cancer Council chief executive Ian Olver. Photo: Natalie Boog A LANDMARK study of prostate cancer surgery has found it does not appear to save the lives of men with early-stage disease and causes high rates of incontinence and erectile dysfunction. In what has been described by experts as ''game changing'' research, American researchers tracked the progress of 731 men with prostate cancer over 12 years to see how surgical removal of the prostate compared with continuing observation of the cancer to see if it becomes more active or spreads. The largest clinical trial comparing the two approaches to date found surgery did not significantly change the survival rate between the groups. After 10 years, 21 men or 5.8 per cent of those who received surgery had died from prostate cancer or its treatment, compared to 31 or 8.4 per cent of those whose doctors watched their progress. However, in the surgery group, one in five men suffered a complication from the surgery called a radical prostatectomy. Two years on from the procedure, one man had died from it, 81 per cent suffered erectile dysfunction, 17 per … Continue reading →

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Surgery for early-stage prostate cancer 'not saving lives'

Posted: Published on July 20th, 2012

A study of prostate cancer surgery has found it does not appear to save lives of men with early stage disease. Photo: Gabriele Charotte A LANDMARK study of prostate cancer surgery has found it does not appear to save the lives of men with low-risk disease and causes high rates of incontinence and erectile dysfunction. In what has been described by experts as a ''game changing'' finding, American researchers tracked the progress of 731 men with prostate cancer over 12 years to see how surgical removal of the prostate compared with ongoing observation of the cancer to see if it became more active or spread. The largest clinical trial comparing the two approaches to date found surgery did not significantly change the survival rate between the groups. After a decade, 21 men or 5.8 per cent of those who received surgery had died from prostate cancer or its treatment compared with 31 or 8.4 per cent of those whose doctors watched their progress. The researchers said the difference could have been due to chance and not significant enough for surgery to be advised. The number of Australian men having PSA (prostate specific antigen) tests and surgery for prostate cancer has … Continue reading →

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No more antihistamines

Posted: Published on July 20th, 2012

Im not saying antihistamines are bad for everyone but there are some nasty side effects, especially if you have to take a lot of them or long term. My latest medication caused my liver enzymes to climb and turned me into Godzilla. On top of that, I was still congested and sneezing my head off. I did some research and found out that antihistamines cause more than the common drowsiness, difficulty concentrating, slow reaction time, and dry mouth, nose and eyes. Some lesser known side effects include: appetite loss or gain confusion constipation or diarrhea poor coordination depression impairment of thinking altered taste or smell irritability or anxiety Here are some antihistamine-free treatments that may provide relief. Vegan/Vegetarian Diet If you suffer from allergies, adopting a vegetarian or vegan diet may offer some relief. Researchers have found that those who exclude animal products from their diet in favor of plant-based foods are less likely to need treatment for allergies or asthma. A vegetarian is someone who does not eat meat, poultry and seafood but instead consumes a plant-based diet, including seeds, nuts, legumes, grains, fruits and vegetables. Some vegetarians will eat dairy and eggs but some do not. A vegan … Continue reading →

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Court orders $730,000 in restitution in dependency cure scheme

Posted: Published on July 20th, 2012

TALLAHASSEE, Fla. - Florida's attorney general and the Federal Trade Commission were granted a court order requiring more than $730,000 in restitution from Jacksonville company offering a bogus alcoholism cure. The order also bans the Alcoholism Cure Foundation and Robert Douglas Krotzer, its owner, from marketing or selling any treatment or cure for alcoholism, drug addiction or any other human health-related problem. "The fact that this company deceived consumers and threatened to reveal their personal information is abhorrent," said Attorney General Pam Bondi. "I am grateful to the FTC for their partnership in stopping this company from exploiting consumers and providing refunds for those harmed by this companys actions." The complaint alleged that the company prescribed concoctions of dietary supplements claiming they could cure alcoholism. Robert Douglas Krotzer, owner of the company, purportedly charged consumers about $350 for the supplements and services and falsely claimed that the consumers could cancel any time. When consumers attempted to cancel their memberships, Krotzer threatened to publicly reveal the consumers' alcoholism. The company operated under the names Enjoy a Few and Guilt Free Drinking. According to the attorney general's office, the company boasted that their team of doctors would create customized, low-cost and permanent … Continue reading →

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Diet drugs could be scarce

Posted: Published on July 20th, 2012

FDA The Food and Drug Administration has approved two new diet drugs, but both have restrictions about who can -- or should -- take them. By Maggie Fox, NBC News The Food and Drug Administration has approved two new diet pills in a week -- the first new obesity drugs to be approved in 13 years. The agency, usually dry about its approvals, practically gushed about the pent-up demand for new obesity treatments in a country where more than two-thirds of the population is overweight or obese and steadily getting fatter. These prescription medications would be taken for the rest of a persons life, the FDA says on its website. For many people, obesity is a life-long condition, but we dont always think of it -- or treat it -- as such, said Dr. Amy Egan, deputy director for safety in FDAs Division of Metabolism and Endocrinology Products But dont expect to be able to get either drug easily.Each ofthe new drugs -- Belviq and Qsymia -- is being restricted in a different way. And consumer advocates say dieters should think twice about taking either. The FDA was so worried about Belviq, approved last week, that it has asked for … Continue reading →

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United Pharmacy Partners (UPPI) Signs Agreement with Novation for Low and High (PET) Energy Radioisotopes

Posted: Published on July 20th, 2012

SUWANEE, Ga.--(BUSINESS WIRE)-- United Pharmacy Partners (UPPI) is pleased to announce the signing of a 5-year agreement with Novation, a leading health care supply chain expertise and contracting company, to offer both low and high (PET) radiopharmaceuticals. UPPI radiopharmacies have the ability to supply a full scope of radiopharmaceutical products for both diagnostic and therapeutic uses to assist members in servicing their patients needs. Novation provides sourcing services, as well as information and data services to a broad range of healthcare providers in the United States. In addition to providing both low and high radioisotopes to the member sites served by Novation, UPPI will offer a host of support options to those members. UPPI will offer quality programs in the areas of Continuing Education and Reimbursement Support which can include hotline support, webinars, facility audits, Healthcare Reform Consulting and Accreditation assistance. BioDose Patient Management Systems, the exceptional, easy to use patient management system which allows the technologists to capture key patient data, manage patient studies, electronically order/fax doses plus many more tasks is also available to members. Perry Polsinelli, President of UPPI, stated We are excited about this radiopharmaceutical contract award and the opportunity to provide exceptional value, products, service … Continue reading →

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New studies show spinal cord injury and ALS respond to cell transplantation

Posted: Published on July 20th, 2012

Public release date: 18-Jul-2012 [ | E-mail | Share ] Contact: David Eve cellmedicinect@gmail.com Cell Transplantation Center of Excellence for Aging and Brain Repair Tampa, Fla. (July. 18 , 2012) Two studies published in a recent issue of Cell Medicine [2(2)] report on the therapeutic efficacy of stem cell transplantation in animal models of amyotrophic lateral sclerosis (ALS) and spinal cord injury (SCI). Cell Medicine is freely available on-line at http://www.ingentaconnect.com/content/cog/cm. Mensenchymal stem cell transplantation in spinal cord injured rats promotes functional recovery Transplantation of mesenchymal stem cells (MSCs), multipotent stem cells with the ability to differentiate into a variety of cell types with renewal capacities, has been found to enhance laboratory animal function after induced spinal cord injury. However, the biological mechanism of the functional enhancement has not been clearly defined. In an attempt to gain a clearer picture of the mechanism, a team of Korean researchers transplanted MSCs derived from human umbilical cord blood into the tail veins of laboratory rats immediately after spinal cord injury. The intravenous route was selected because the researchers felt that injection into the damaged site could further traumatize the injured spinal cord, although intravenously injected MSCs risk being eliminated by the host … Continue reading →

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