3:40 p.m. PDT, July 26, 2012 SAN DIEGO -- Researchers from San Diego State University's Heart Institute rejuvenated damaged cardiac tissue removed from older heart-failure patients, using modified stem cells, the university announced Thursday. University officials said the research could eventually lead to new treatments for heart-failure patients. "Since patients with heart failure are normally elderly, their cardiac stem cells aren't very healthy,'' said Sadia Mohsin, a post-doctoral research scholar and one of the study's authors. "We modified these biopsied stem cells and made them healthier. It's like turning back the clock so these cells can thrive again.'' Researchers used stem cells modified with a protein called PIM-1 to increase the activity of the enzyme telomerase, which can lengthen telomeres. Telomeres --- DNA sequences on the ends of chromosomes -- keep the chromosomes from losing DNA base pairs during cellular replication but lose base pairs themselves during the process. If telomeres become too short, the chromosome can't replicate. According to Moshin, modifying aged cardiac cells added to the cells' ability to regenerate damaged heart muscle. "This is an especially exciting finding for heart failure patients,'' Moshin said in a statement. "Right now we can only offer medication, heart transplantation or … Continue reading
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