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Brain stimulation for Parkinson’s disease offers improvements

Posted: Published on June 29th, 2012

June 28, 2012 WASHINGTON, DC Patients with Parkinsons disease who undergo deep brain stimulation (DBS) a treatment in which a pacemaker-like device sends pulses to electrodes implanted in the brain can expect stable improvement in muscle symptoms for at least three years, according to a Department of Veterans Affairs study appearing in the most recent issue of the journal Neurology. VA was proud to partner with the National Institutes of Health in this research, said Secretary of Veterans Affairs Eric K. Shinseki. Our research on Parkinsons helps ensure we continue to provide the best care possible for veterans with this debilitating disease. VA cares for approximately 40,000 veterans with the condition. In DBS, surgeons implant electrodes in the brain and run thin wires under the skin to a pacemaker-like device placed at one of two locations in the brain. Electrical pulses from the battery-operated device jam the brain signals that cause muscle-related symptoms. Thousands of Americans have seen successful results from the procedure since it was first introduced in the late 1990s. But questions have remained about which stimulation site in the brain yields better outcomes, and over how many years the gains persist. Initial results from the study appeared … Continue reading

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Research and Markets: Handbook of Parkinson's Disease – Blue-Ribbon Guide

Posted: Published on June 29th, 2012

DUBLIN--(BUSINESS WIRE)-- Research and Markets (http://www.researchandmarkets.com/research/lb6wfj/handbook_of_parkin) has announced the addition of the "Handbook of Parkinson's Disease" book to their offering. This blue-ribbon guide has long prevailed as one of the leading resources on Parkinson's Disease (PD). Fully updated with practical and engaging chapters on pathology, neurochemistry, etiology, and breakthrough research, this source spans every essential topic related to the identification, assessment, and treatment of PD. Reflecting the many advances that have taken place in the management of PD, this source promotes a multidisciplinary approach to care and supplies new sections on the latest pharmacologic, surgical, and rehabilitative therapies, as well as essential diagnostic, imaging, and nonmotor management strategies for PD. Key Topics Covered: Early Iconography of Parkinson's Disease Epidemiology of Parkinsonism Differential Diagnosis of Parkinsonism Pathophysiology and Clinical Assessment of Parkinsonian Symptoms and Signs Autonomic Dysfunction and Management Sleep Dysfunction in Parkinson's Disease Continue reading here: Research and Markets: Handbook of Parkinson's Disease - Blue-Ribbon Guide … Continue reading

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Cord Blood Reversing Cerebral Palsy: Medicine’s Next Big Thing?

Posted: Published on June 29th, 2012

BACKGROUND: Cerebral palsy (CP) is a group of disorders that can impair brain and nervous system functions. Patients may have issues with movement, learning, hearing, seeing, and thinking. CP is caused by injuries or abnormalities in the brain. Most of these problems happen as the baby grows in the womb, but they can also happen at any time during the first two years of life when the babys brain is still developing. In some patients, parts of the brain are injured because of low levels of oxygen. Premature infants have a slightly higher risk of developing CP. Other conditions like bleeding in the brain, brain infections, head injuries, infections during pregnancy and severe jaundice can cause CP. (SOURCE: U.S. National Library of Medicine - The World's Largest Medical Library) SYMPTOMS OF CP: Symptoms of CP may vary, depending on the severity of the disorder, but they usually are present before a child is 2 years old. Some of these symptoms include: muscle tightness, abnormal gait, joint tightness, muscle weakness or loss of muscle movement, abnormal movements, tremors, unsteady gait, loss of coordination, speech problems, hearing or vision problems, seizures, pain, problems with swallowing, and floppy muscles. (SOURCE: U.S. National Library … Continue reading

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Stem cell bank at UMass to close at year's end

Posted: Published on June 29th, 2012

SHREWSBURY, Mass.The stem cell bank at the University of Massachusetts is set to run out of cash and close at the end of this year. State and university officials tell The Boston Globe (http://bo.st/LQi71Z ) that changes in technology and federal policies around stem cell research have made obsolete the facility at the U-Mass Medical Center's Shrewsbury campus. The stem cell bank was established in 2008 with the help of $8.6 million state funding, part of Gov. Deval Patrick's effort to boost the life sciences industry in Massachusetts. Human stem cells were kept and distributed to researchers working on potential cures for diseases and spinal cord injuries. Experts say new technologies for producing stem cells and the loosening of federal restrictions on research have significantly altered the need for facilities like the one at U-Mass. Information from: The Boston Globe, http://www.boston.com/globe Copyright 2012 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed. The rest is here: Stem cell bank at UMass to close at year's end … Continue reading

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Human model of Huntington's disease created from skin's stem cells

Posted: Published on June 29th, 2012

ScienceDaily (June 28, 2012) An international consortium of Huntington's disease experts, including several from the Sue & Bill Gross Stem Cell Research Center at UC Irvine, has generated a human model of the deadly inherited disorder directly from the skin cells of affected patients. The re-created neurons, which live in a petri dish, will help researchers better understand what disables and kills brain cells in people with HD and let them gauge the effects of potential drug therapies on cells that are otherwise locked deep in the brain. UCI scientists were part of a consortium that in 1993 identified the autosomal dominant gene mutation responsible for HD, but there is still no cure, and no treatments are available to even slow its onset or progression. The research, published online June 28 in the journal Cell Stem Cell, is the work of the Huntington's Disease iPSC Consortium. Participants examined several other cell lines and control cell lines to ensure that their results were consistent and reproducible in different labs. "Our discovery will enable us for the first time to test therapies on human Huntington's disease neurons," said Leslie Thompson, UCI professor of psychiatry & human behavior and neurobiology & behavior, one … Continue reading

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International Stem Cell Corporation Reports Reaching Milestone in Its Cornea Program

Posted: Published on June 29th, 2012

CARLSBAD, CA--(Marketwire -06/28/12)- International Stem Cell Corporation (ISCO) http://www.internationalstemcell.com today announced that its Research and Development team has advanced its program to create a functional and transplantable human cornea by developing a new method to derive corneal endothelium-like cells from human pluripotent stem cells. This work represents a significant step towards the creation of complete cornea tissue that can be used for transplantation and supports prior data showing indications of corneal endothelium generated by ISCO's collaborators at Sankara Nethralaya Eye Hospital, India. Such cells by themselves may potentially promote wound healing and regeneration of the cornea and therefore could be used as a standalone medical treatment. Development and commercialization of ISCO's stem cell-derived cornea tissue along with manufacturing of Lifeline Cell Technology's media and cellular products are the foundation for our expansion to the Asian markets and for clinical collaboration with Indian biomedical organizations including Sankara Nethralaya Eye Hospital and All-India Institute for Medical Sciences. Asia represents a huge potential growth market for ISCO's Cornea program. For example, in India alone there are more than 4 million people suffering from corneal vision impairment with limited access to corneal tissue. ISCO's intention is to work with our clinical affiliate in India … Continue reading

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My Life. My Medicine. – Luke’s Story – Video

Posted: Published on June 29th, 2012

28-06-2012 02:51 Luke is an eighteen-year-old medical marijuana patient in California. He has been suffering from a rare genetic skin disorder his whole life that causes his skin can to blister and tear with just slight contact. He is required to have hand and throat surgery every few years in order to live more comfortably. At age sixteen, Luke first tried medical marijuana to help aid his symptoms. These symptoms include pain, night terrors, loss of appetite, insomnia, and isolation. Since then, Luke has seen improvements in all areas. Because of their higher potency, Luke has found that medical marijuana concentrates help him sleep better. He discovered the G-Pen personal vaporizer for it's ease of use compared to traditional methods of ingestion. Luke has now taken his crusade for the legalization of medical marijuana to new heights as he visits with the WeedMaps team to get the message out. Please take a moment and listen to Luke tell you his story of bravery and achievement over all odds. His story will inspire you. The G Pen - Vaporizer Pen Original post: My Life. My Medicine. - Luke's Story - Video … Continue reading

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I may finally be able to quit smoking. Vaccine stops nicotine from reaching the brain, may prevent addiction.

Posted: Published on June 29th, 2012

This is great news for me! Ive been wanting to quit smoking for years and this vaccine may be the answer for me to finally put down this addiction that Ive had in years. CBS News reports: Dr. Ronald G. Crystal, chairman and professor of Genetic Medicine at Weill Cornell Medical College in New York City. Crystals team has announced theyve successfully tested a new vaccine that may treat nicotine addiction. Much like vaccines for diseases that create antibodies to fight infection, the vaccine creates antibodies against nicotine. However, previous attempts at similar vaccines have failed because within a few weeks the antibodies are gone, which wont exactly help people stay smoke-free. Crystals team developed a vaccine that contains a virus consisting of a genetic sequence they engineered from a nicotine antibody, and injected it into the liver of mice. The injection genetically modifies the liver to churn out nicotine antibodies, along with other cells it typically makes, thus providing a nicotine antibody factory in the body. That suggests the effect wont diminish over time like that of other antibodies. The antibodies then work by targeting the nicotine cells within seconds of exposure and preventing them from reaching receptors in … Continue reading

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Millennium Laboratories Launches Innovative Pharmacogenetic Test, Paving the Way for Personalized Medicine in the …

Posted: Published on June 29th, 2012

SAN DIEGO, June 28, 2012 /PRNewswire/ --Millennium Laboratories, the leading research-based clinical diagnostic company dedicated to improving the lives of people suffering from pain, announced today the introduction of Millennium Pharmacogenetic Testing (PGT). Millennium PGT is saliva-based testing to detect genetic variations in enzymes associated with the metabolism of medications commonly prescribed to patients suffering from debilitating chronic pain and pain-related effects. This testing will help clinicians identify patients who may benefit from modifying the drug selection or dosing of certain prescribed opioids including methadone, benzodiazepines, tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and serotonin norepinephrine reuptake inhibitors (SNRIs). (Logo: http://photos.prnewswire.com/prnh/20120516/LA07836LOGO) "This novel testing provides insight into whether or not a patient will experience the anticipated effect of a prescribed medication or be at increased risk for additional side effects," said Howard Appel, President of Millennium Laboratories. Medication metabolism differs greatly among individuals and may partly be the result of genetic variations in metabolizing enzymes. These genetic variations can result in clinically significant differences in response to prescribed medications. By identifying genetic variations in drug-metabolizing enzymes, clinicians can more effectively personalize each patient's treatment. Incorporating pharmacogenetic testing into clinical practice has significant potential to improve the efficacy of drug … Continue reading

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Diabetes breakthrough: UBC scientists reverse disease in mice using stem-cell transplants

Posted: Published on June 29th, 2012

VANCOUVER -- For the first time ever, University of B.C. scientists have used human embryonic stem cell transplants to reverse Type 1 diabetes in mice with the disease, giving hope to about 300 million people around the world who suffer from the chronic disease. A 13-member team, whose milestone work is published in the journal Diabetes, shows that after transplantation, the stem cells matured into insulin-secreting, pancreatic beta-cells. The cells automatically sensed blood sugar levels to release the right amount of insulin and a few dozen diabetic mice were gradually weaned off insulin given to them over a period of months. Insulin is produced by beta-cells to to help the body absorb sugar and use it for energy. Essentially, the mice were cured of their diabetes by placing the body back in charge of regulated insulin production as it is in healthy, non-diabetics, said lead author Timothy Kieffer. It took about four to five months for the [stem] cells to become functional in our experiments and the mice were able to maintain good blood glucose levels even when fed a high-glucose diet, said Kieffer, a UBC professor in the department of cellular and physiological sciences. Type 1 diabetes otherwise known … Continue reading

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