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Nationwide Children's CEO to Co-Chair Parent Project Muscular Dystrophy Event

Posted: Published on June 21st, 2012

Newswise Nationwide Childrens Hospital CEO Steve Allen, MD, will serve as co-chair of the first Transforming Duchenne Care workshop to be held June 27 and 28, 2012, in Ft. Lauderdale, FL. The national symposium, held by Parent Project Muscular Dystrophy, will gather leadership from top medical institutions, neuromuscular experts and patient representatives with the ultimate goal of establishing a network of centers of excellence for the care and treatment of children with Duchenne muscular dystrophy. In addition to Dr. Allen, Nationwide Childrens will be represented by Jerry Mendell, MD; Kevin Flanigan, MD; and Linda H. Cripe, MDthree prominent pediatric specialists in the Neuromuscular Disorders program. Dr. Mendell is an attending neurologist, Director of the Center for Gene Therapy at The Research Institute at Nationwide Childrens and Director of the Paul D. Wellstone Muscular Dystrophy Cooperative Research Center. He is also Co-director of the Muscular Dystrophy Association Clinic at Nationwide Childrens and serves as Professor of Pediatrics, Neurology, Pathology, and Physiology and Cell Biology at The Ohio State University College of Medicine. Dr. Flanigan, also a neurologist at Nationwide Childrens, is a principal investigator in the Center for Gene Therapy in The Research Institute and Professor of Pediatrics at The Ohio … Continue reading

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Epilepsy Organizations Award Funding for New Devices to Treat, Detect and Monitor Epilepsy Conditions

Posted: Published on June 21st, 2012

Announce Fall Grant Application Cycle is Now Open WASHINGTON, June 21, 2012 /PRNewswire-USNewswire/ -- The Epilepsy Therapy Project (ETP) and the Epilepsy Foundation (EF) today announced the latest grant recipients of their New Therapy Grants Program, a unique joint venture of the two non-profit epilepsy organizations to advance clinical development and commercialization of promising epilepsy therapies.The grant awards will support the development of four important new technologies: "We are continuing to support new technologies to detect, monitor and treat epilepsy through the New Therapy Grants award program," said Warren Lammert, Chairman of the Epilepsy Therapy Project. "In this grant cycle, we have selected four projects that may prove critical to managing and treating epilepsy and to accelerating the development of future new therapies. With these grants and the support and guidance our organizations can offer, we are advancing important new products to market and so to people with epilepsy." For a comprehensive list of all epilepsy therapies in development including past projects supported by the New Therapy Grants program, please visit http://www.epilepsy.com/etp/pipeline_new_therapies.The epilepsy pipeline identifies the most promising products from early-stage development to commercial-stage, and whether a product is currently available in the US or internationally. "The mission of this … Continue reading

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Study Uncovers New Tools for Targeting Genes Linked to Autism

Posted: Published on June 21st, 2012

Newswise UCLA researchers have combined two tools gene expression and the use of peripheral blood -- to expand scientists arsenal of methods for pinpointing genes that play a role in autism. Published in the June 21 online edition of the American Journal of Human Genetics, the findings could help scientists zero in on genes that offer future therapeutic targets for the disorder. Technological advances now allow us to rapidly sequence the genome and uncover dozens of rare mutations, explained principal investigator Dr. Daniel Geschwind, the Gordon and Virginia MacDonald Distinguished Professor of Human Genetics and a professor of neurology at the David Geffen School of Medicine at UCLA. But just because a particular genetic mutation is rare doesnt mean its actually causing disease. We used a new approach to tease out potential precursors of autism from the occasional genetic glitch. Geschwind and his colleagues studied DNA contained in blood samples from 244 families with one healthy child and one child on the autism spectrum. The team used a hybrid method that blended tests that read the order of DNA bases with those that analyze gene expression, the process by which genes make cellular proteins. Monitoring gene expression provides us with … Continue reading

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Autism Speaks awards nearly $2.9 million to fund autism research

Posted: Published on June 21st, 2012

Public release date: 21-Jun-2012 [ | E-mail | Share ] Contact: Jane E. Rubinstein jrubinstein@rubenstein.com 212-843-8287 Autism Speaks New York, N.Y. (June 21, 2012) Autism Speaks, the world's leading autism science and advocacy organization, today announced the award of new research grants totaling nearly $2.9 million in funding to support autism research. "Suzanne and I are extraordinarily proud of Autism Speaks, not only for funding research projects which have tremendous potential to open new avenues to understanding autism," said Autism Speaks Co-founder Bob Wright, "but in supporting predoctoral and postdoctoral fellows who are the next generation of leaders in autism research." The projects approved include a Suzanne and Bob Wright Trailblazer Award, ten Weatherstone Predoctoral Fellowships and nine Postdoctoral Fellowships in Translational Research. In addition, five targeted research studies which support research across a range of high-priority areas were funded. These include environmental risk factors, understanding the impact of DSM-5 on autism diagnosis, the development of medicines, new behavioral treatments across the lifespan, improved access to early intervention in minority communities and a deeper understanding of autism biology. "We are extremely gratified by the high quality of these research projects. These projects focus on issues that directly affect the lives … Continue reading

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Autism Speaks provides strategies to help a child with autism shows difficult behaviors

Posted: Published on June 21st, 2012

Public release date: 21-Jun-2012 [ | E-mail | Share ] Contact: Jane E. Rubinstein jrubinstein@rubenstein.com 212-843-8287 Autism Speaks NEW YORK, N.Y. (June 21, 2012) Autism Speaks, the world's leading autism science and advocacy organization, today released An Introduction to Behavioral Health Treatments, Applied Behavior Analysis and Toilet Training parent's guides. These latest tool kits, all developed as part of the work of the Autism Treatment Network through its participation as the HRSA-funded Autism Intervention Research Network on Physical Health (AIR-P), are available for free download on Autism Speaks Tool Kits webpage. Behavioral challenges are a common problem for children with an autism spectrum disorder (ASD). Many children with ASD have challenges managing certain behaviors such as aggression or not following directions in addition to experiencing limitations in communication or social skills. The experts of the Autism Speaks Autism Treatment Network (ATN) and the AIR-P have addressed how parents and families can help improve their child's behavior with The Introduction to Behavioral Health Treatment which provides an overview of in-home strategies as well as tips to teach and increase desirable behaviors and decrease behavior problems. This tool kit also provides an overview of professional behavioral treatments families can seek out from … Continue reading

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Treating strokes with cholesterol drugs

Posted: Published on June 21st, 2012

Eyewitness News NEW YORK (WABC) -- You probably know someone who's taking a statin drug to lower their cholesterol, to try and prevent a stroke or heart attack. But now, the statins are part of treatment, not just prevention. Statins and another drug, progesterone, have been reported in several recent studies to make survival from strokes and other brain damage events more likely. But the statins have moved into current treatment fastest. Now, if patients are not already taking a statin, one will likely be started if doctors suspect a stroke. Fifty-three year old Joe Lipton noticed some disturbing symptoms earlier this year while raking his yard. Joe was having a T-I-A, the warning sign of a stroke. Tests at the hospital showed damage to the brain's blood supply. He had an emergency procedure to prevent a stroke. Immediately, doctors gave him a statin drug. "Within twenty-four hours, I was on Lipitor," Lipton said. Lipitor and other statins given during the hospital stay for a stroke can improve survival and recovery. Stroke patients already on these drugs had better survivals than if statins were stopped after hospitalization. All this from pills meant to prevent strokes and heart attacks. The idea … Continue reading

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Pfizer’s Lyrica Gains U.S. Approval for Spinal Pain

Posted: Published on June 21st, 2012

By Drew Armstrong and Catherine Larkin - 2012-06-21T20:28:38Z Pfizer Inc. (PFE)s second-best selling drug, Lyrica, was approved by U.S. regulators today for use against pain caused by spinal cord injuries. The Food and Drug Administration cleared the expanded use of Lyrica, already backed to treat nerve pain from fibromyalgia, diabetic nerve pain and pain after shingles, New York-based Pfizer, said today in a statement. Pfizer estimates a potential patient population size of about 100,000 people. Until now, no FDA approved treatment options were available in the U.S. for people with neuropathic pain associated with spinal cord injury, a condition which can be extremely disabling, said Steven J. Romano, senior vice president and head of Pfizers medicines development group, Global Primary Care business unit, in the statement. Lyrica is Pfizers best-selling drug after cholesterol pill Lipitor, which lost patent protection in November. It had $3.39 billion in revenue last year. The treatment has patent protection until 2018, and Pfizer is working to expand its use. Pfizer declined less than 1 percent to $22.60 at the close in New York. To contact the reporters on this story: Drew Armstrong in New York at darmstrong17@bloomberg.net; Catherine Larkin in Denver at clarkin4@bloomberg.net To contact … Continue reading

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Pfizer Reveals Lyrica Capsules Were Granted FDA Approval For Neuropathic Pain

Posted: Published on June 21st, 2012

(RTTNews.com) - Pfizer Inc (PFE) Thursday announced that U.S. Food and Drug Administration, or the FDA, has granted approval for the use of Lyrica capsules for the management of neutopathic pain associated with spinal cord injury. The company stated that Lyrica has been given priority review designation by the FDA for the new indication. Pfizer further stated that neuropathic pain can be experienced above, at or below the level of the spinal cord injury, and is typically not confined to one area in the body. Approximately one-third of spinal cord injury patients report below-level neuropathic pain that is severe or excruciating. Patients may experience neuropathic pain associated with spinal cord injury as early as two weeks after injury and it may persist for up to 25 years. "Until now, no FDA approved treatment options were available in the U.S. for people with neuropathic pain associated with spinal cord injury, a condition which can be extremely disabling," said Steven J. Romano, MD, senior vice president and head, medicines development group, Global Primary Care Business Unit, Pfizer. "The approval of Lyrica for this indication is a significant milestone, exemplifying Pfizer's commitment to pursue scientific advancements that address unmet medical needs." For comments … Continue reading

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InVivo Therapeutics’ CEO Frank Reynolds Scheduled to Appear on WAWS-TV (FOX)/WTEV-TV (CBS) in Jacksonville and KNSD-TV …

Posted: Published on June 21st, 2012

CAMBRIDGE, Mass.--(BUSINESS WIRE)-- InVivo Therapeutics Holdings Corp. (NVIV), a developer of groundbreaking technologies for the treatment of spinal cord injuries (SCI), today announced that CEO Frank Reynolds is scheduled to appear on WAWS-TV (FOX)/WTEV-TV (CBS) in Jacksonville, Florida on Monday June 25, 2012 at 7:45 am EDT. He is also scheduled to appear on KNSD-TV (NBC) in San Diego, California on Tuesday June 26, 2012 at 12:00pm PDT. InVivo Therapeutics has pioneered a new treatment using a biocompatible polymer-based scaffold to provide structural support to a damaged spinal cord. The device sparesspinal cordtissue from scarring while improving functional recovery after a traumatic SCI. In addition to the scaffold and its application for acute and chronic SCI, Reynolds will discuss new hydrogel technologies under development by InVivo. Our technology is a true platform that can be leveraged to create many neurotrauma products. InVivo is developing technologies to treat both acute and chronic injuries, as well as therapies for other nervous system conditions such as pain due to nerve compression and other peripheral nerve injuries. Were currently under review at FDA for our first SCI treatment, and we look forward to receiving approval to begin those human studies in 2012, said Reynolds. … Continue reading

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FDA Approves Pfizer's Lyrica for Some Spinal Cord Injury Patients

Posted: Published on June 21st, 2012

By Tess Stynes Pfizer Inc. (PFE) said the U.S. Food and Drug Administration approved its Lyrica drug for nerve pain for use by some spinal-cord-injury patients. The pharmaceutical giant said about 40% of 270,000 patients in the U.S. with spinal cord injuries suffer from neuropathic pain, which can hinder rehabilitation efforts. "Until now, no FDA approved treatment options were available in the U.S. for people with neuropathic pain associated with spinal cord injury, a condition which can be extremely disabling," said Steven J. Romano, head of the medicines development group at Pfizer's Global Primary Care Business Unit. In 12-week and 16-week studies, Lyrica was shown to significantly reduce nerve pain compared to a placebo. In addition, more patients taking Lyrica saw pain reduced by 30% and 50% , respectively, than those that received a placebo. In addition to efforts to refill product pipelines, pharmaceutical companies like Pfizer have been looking to expand uses of current drugs in an effort to head off the loss of patents on key drugs. Pfizer, which has posted weaker results lately amid the loss of U.S. market exclusivity for its anticholesterol drug Lipitor, has been studying the potential use of Lyrica to treat other diseases. … Continue reading

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