The reputation of bisphosphonates, the most widely prescribed osteoporosis drugs on the market, has taken a beating lately. Last month, a study in the New England Journal of Medicine by the U.S. Food and Drug Administration found inconsistencies in the ability of bisphosphonates to reduce fractures and suggested the drugs may not have much benefit for many women. In an accompanying article, researchers questioned whether women who are at a high risk for fractures and are currently taking the drugs would be better off only using them for a short period. The same month, a study in the Archives of Internal Medicine found women taking bisphosphonates appear to actually face a higher risk of suffering rare, but very serious, atypical femoral fractures which account for less than 1 per cent of all hip and femur fractures. Unlike most fractures, atypical femoral fractures arent usually the result of a fall or other trauma; the thigh bone appears to snap for no reason. Healing can take months or years and the fractures may lead to complications. Last December, Health Canada announced it was updating the warning label on bisphosphonate drugs in light of evidence they are linked to a higher risk of … Continue reading
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