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'Smart Bomb' Cancer Drug Announced at Chicago Conference – Video

Posted: Published on June 5th, 2012

03-06-2012 19:04 An experimental cancer drug successfully shrank tumors in patients with different kinds of cancer, including typically hard-to-treat lung cancers, according to a new study. Oncologists said the research was encouraging, but more study was needed to know whether the drug would prolong life for cancer patients. The study, led by Dr. Suzanne Topalian, was presented today at the Super Bowl of cancer professionals, a meeting of the American Society of Clinical Oncology, and published in the New England Journal of Medicine. In a small, early phase study, researchers used a drug targeting a portion of the body's immune system, a pathway called PD-1, which usually works to stop the body from fighting cancerous tumors. By shutting down the pathway, the drug stokes the body's immune system to fight tumor cells. Researchers gave the drug to nearly 240 patients with advancedmelanoma, colorectal, prostate, kidney and lung cancers. All the patients had tried up to five other treatments, which failed. After up to two years on the drug, tumors shrank in 26 of 94 patients with melanoma, nine of 33 patients with kidney cancer and 14 of 76 patients with lung cancer. For more on this story: Here is the … Continue reading →

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Investigational Diabetes Drug May Have Fewer Side Effects

Posted: Published on June 5th, 2012

Newswise Drugs for type 2 diabetes can contribute to weight gain, bone fractures and cardiovascular problems, but in mice, an investigational drug appears to improve insulin sensitivity without those troublesome side effects, researchers at Washington University School of Medicine in St. Louis have shown. The experimental medicine works through a different pathway, which could provide additional molecular targets for treating insulin resistance and diabetes. The new study appears online in the Journal of Biological Chemistry. Current diabetes medications activate a receptor that improves insulin sensitivity, but unfortunately also contributes to side effects that make some people discontinue the medication, contributing to other health problems, says principal investigator Brian N. Finck, PhD. So even though these drugs are effective, wed really like to find new insulin-sensitizing therapies that would avoid activating the same receptor. Finck, a research assistant professor of medicine in the Division of Geriatrics and Nutritional Science, worked with colleagues at the University of Michigan and at the drug discovery company Metabolic Solutions Development Co., LLC. The scientists studied one of the companys investigational drugs, MSD-0602, focusing on its effects in obese mice. The drug improved blood glucose levels and insulin tolerance in the mice, as did the two … Continue reading →

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Costco to pay $3.6 million in hazardous waste settlement

Posted: Published on June 5th, 2012

Sacramento County District Attorney Jan Scully joins Alameda County District Attorney Nancy E. O'Malley, and 28 other California district attorneys in announcing the settlement of a civil law enforcement action against Costco Wholesale Corporation. The civil action was filed in Alameda County Superior Court, and the settlement resolves allegations that Costco violated California laws for the safe storage, handling and disposal of pharmaceutical, and pharmacy waste as well as other hazardous waste. The Alameda County District Attorney's Office teamed up with the other DA offices as part of a joint investigation and prosecution to address statewide violations of law after San Joaquin County inspectors found evidence of improper storage, handling and disposal of hazardous waste, and pharmaceutical waste products at Costco stores. Upon notification of the investigation, Costco officials cooperated with prosecutors and quickly came into compliance with hazardous waste management regulations. The violations occurred over a five-year period at numerous Costco stores and distribution stores statewide, including 5 stores in Sacramento County. District Attorney Jan Scully states, "Improper handling and disposal of hazardous waste creates a health and safety risk to the citizens of Sacramento County and our environment. The District Attorney's Consumer Environment Protection Unit remains aggressive in … Continue reading →

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Costco agrees to $3.6 million settlement of Alameda pharmaceutical waste suit

Posted: Published on June 5th, 2012

OAKLAND, Calif. Costco has agreed to pay $3.6 million in civil penalties and costs to settle a state-wide lawsuit over alleged violations of environmental laws involving the safe storage, handling and disposal of pharmaceutical and pharmacy waste, Alameda County prosecutors announced Monday. Alameda County District Attorney Nancy OMalley announced that her office together with 28 other California District Attorneys had reached the settlement with Costco Wholesale Corporation. The civil action was filed in Alameda County Superior Court and the settlement resolves allegations that Costco violated California laws for the safe storage, handling and disposal of pharmaceutical and pharmacy waste as well as other hazardous waste. The Alameda County District Attorneys Office teamed up with the other DA offices as part of a joint investigation and prosecution to address statewide violations of law after San Joaquin County inspectors found evidence of improper storage, handling and disposal of hazardous waste and pharmaceutical waste products at Costco stores. Upon notification of the investigation, Costco officials cooperated with prosecutors and quickly came into compliance with hazardous waste management regulations. The violations occurred over a five-year period at numerous Costco stores and distribution stores statewide, including five stores in Alameda County. My Offices Environmental Protection … Continue reading →

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New Drugs Unleash Immune System to Attack Tumors

Posted: Published on June 5th, 2012

Lung, Skin, Kidney Tumors Shrink in Early-Stage Trials June 4, 2012 (Chicago) -- Two experimental drugs that recharge the body's immune system to seek out and attack tumors are showing promise for the treatment of certain advanced lung, skin, and kidney cancers. The drugs disable a molecular shield that tumors put up to block attacks from the immune system. In early-stage studies, the drugs shrank tumors in some people with certain types of lung, skin, and kidney cancers who had not been helped by other treatments. Researcher Julie Brahmer, MD, associate professor of oncology at Johns Hopkins Kimmel Cancer Center, tells WebMD that she is optimistic because "in some patients, tumors did not grow back even after treatment was stopped." "These patients had been through several types of therapy and were very ill," she says. It's too soon to say whether the drugs will extend lives and whether they are safe in the long run. A larger, longer study is planned to test that. But the early studies suggest the drugs work at least as well as chemotherapy drugs currently in use, and possibly with fewer side effects, Brahmer says. The research was presented here at the annual meeting of … Continue reading →

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Pharmacy college to add athletic facility to Albany campus

Posted: Published on June 5th, 2012

ALBANY The Albany College of Pharmacy and Health Sciences is adding a $2.5 million athletic facility to its campus. The facility will take two years to complete. The project includes a new synthetic turf soccer field and a rubberized six-lane running track. The soccer field will now meet NCAA guidelines. The first phase has begun and is to be completed by the fall. The second phase includes new lights and a scoreboard, a long-jump pit, bleachers, press box, entrance and signs. It is to be completed in 2013. "This much anticipated renovation will be a tremendous asset to our student athletes and coaches for both practice and games," college President James Gozzo said. "It will also benefit the rest of the campus and the neighboring community by giving the college the ability to host a wider range of athletic and social events." The school has transformed and expanded considerably in recent years, transitioning from a trade school into a more traditional college campus. Dorms have been built or renovated to house students and older campus buildings have been modernized, including a new dining hall. In November, the school launched a $50 million capital campaign. The money will be used to … Continue reading →

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Mature liver cells may be better than stem cells for liver cell transplantation therapy

Posted: Published on June 5th, 2012

Public release date: 4-Jun-2012 [ | E-mail | Share ] Contact: David Eve celltransplantation@gmail.com Cell Transplantation Center of Excellence for Aging and Brain Repair Tampa, Fla. (June 4, 2012) After carrying out a study comparing the repopulation efficiency of immature hepatic stem/progenitor cells and mature hepatocytes transplanted into liver-injured rats, a research team from Sapporo, Japan concluded that mature hepatocytes offered better repopulation efficiency than stem/progenitor cells. Until day 14 post-transplantation, the growth of the stem/progenitor cells was faster than the mature hepatocytes, but after two weeks most of the stem/progenitor cells had died. However, the mature hepatocytes continued to survive and proliferate one year after their implantation. The study is published in Cell Transplantation (21:1), now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/. "Cell-based therapies as an alternative to liver transplantation to treat liver disease have shown promise," said study corresponding author Dr. Toshihiro Mitaka of the Cancer Research Institute of the Sapporo Medical University School of Medicine, Sapporo, Japan. "However, the repopulation efficiency of two candidate cell sources - hepatic progenitor/stem cells and mature hepatocytes - had not been comprehensively assessed and questions concerning the efficiency of each needed to be resolved." The researchers noted that the shortage of cell … Continue reading →

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Cell transplantation of lung stem cells has beneficial impact for emphysema

Posted: Published on June 5th, 2012

Public release date: 4-Jun-2012 [ | E-mail | Share ] Contact: David Eve Celltransplantation@gmail.com Cell Transplantation Center of Excellence for Aging and Brain Repair Tampa, Fla. (June 4, 2012) When autologous (self-donated) lung-derived mensenchymal stem cells (LMSCs) were transplanted endoscopically into 13 adult female sheep modeled with emphysema, post-transplant evaluation showed evidence of tissue regeneration with increased blood perfusion and extra cellular matrix content. Researchers concluded that their approach could represent a practical alternative to conventional stem cell-based therapy for treating emphysema. The study is published in Cell Transplantation (21:1), now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/. "Mensenchymal stem cells are considered for transplantation because they are readily available, highly proliferative and display multi-lineage potential," said study corresponding author Dr. Edward P. Ingenito of the Brigham and Women's Hospital Division of Pulmonary and Critical Care Medicine. "Although MSCs have been isolated from various adult tissues - including fat, liver and lung tissues - cells derived from bone marrow (BM) have therapeutic utility and may be useful in treating advanced lung diseases, such as emphysema." However, according to the authors, previous transplantation studies, many of which used an intravenous delivery method, have shown that BM-MSCs have been only marginally successful in treating … Continue reading →

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TELUS investing $840 million in Quebec over the next three years

Posted: Published on June 4th, 2012

TELUS expanding wireless and wireline networks, connecting rural communities and building its advanced Internet Data Centre in Rimouski MONTREAL , June 4, 2012 /CNW/ - TELUS will invest $840 million in Quebec over the next three years to expand and enhance its wireless and wireline networks. This major announcement coincides with TELUS' 85th anniversary in Quebec and brings the company's investments in the province to $12.3billion since 2000. "TELUS is an employer of choice and leader in the telecommunications sector in Qubec. We are committed to contribute to the prosperity and well-being of the province and all its regions as we believe leading edge technologies and robust infrastructure can be the foundation of a stronger economy. That's why we will continue to invest in cutting-edge technology and infrastructure for consumer, business and healthcare markets," said Franois Ct, President of TELUS Qubec and TELUS Health Solutions. "This year, TELUS will further extend our 4G LTE - the fastest wireless technology in the world - to the Montreal Metropolitan region and the Quebec City area, while bringing new wireless and broadband services to even more rural communities. Our significant growth in Quebec has been made possible because of our customers' trust and … Continue reading →

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Medistem Achieves Important ERC Stem Cell Clinical Trial Milestone

Posted: Published on June 4th, 2012

SAN DIEGO, CA--(Marketwire -06/04/12)- Medistem Inc. (MEDS) announced today positive safety data from the first 5 patients enrolled in the Non-Revascularizable IschEmic Cardiomyopathy treated with Retrograde COronary Sinus Venous DElivery of Cell TheRapy (RECOVER-ERC) trial. The clinical trial uses the company's "Universal Donor" Endometrial Regenerative Cells (ERC) to treat Congestive Heart Failure (CHF). According to the study design, after 5 patients enter the trial, they must be observed for a two month time period before additional patients are allowed to enter the study. Patient data was analyzed by the study's independent Data Safety Monitoring Board (DSMB), which concluded that based on lack of adverse effects, the study be allowed to continue recruitment. "Medistem is developing a treatment for CHF that uses a 30-minute catheter-based procedure to administer the ERC stem cell into the patients' hearts. The achievement of 2 month patient follow-up with no adverse events is a strong signal for us that our new approach to this terrible condition is feasible," said Thomas Ichim, CEO of Medistem. The RECOVER-ERC trial will treat a total of 60 patients with end-stage heart failure with three concentrations of ERC stem cells or placebo. The clinical trial is being conducted by Dr. Leo … Continue reading →

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