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Drug destroys human cancer stem cells but not healthy ones

Posted: Published on May 27th, 2012

ScienceDaily (May 24, 2012) A team of scientists at McMaster University has discovered a drug, thioridazine, successfully kills cancer stem cells in the human while avoiding the toxic side-effects of conventional cancer treatments. "The unusual aspect of our finding is the way this human-ready drug actually kills cancer stem cells; by changing them into cells that are non-cancerous," said Mick Bhatia, the principal investigator for the study and scientific director of McMaster's Stem Cell and Cancer Research Institute in the Michael G. DeGroote School of Medicine. Unlike chemotherapy and radiation, thioridazine appears to have no effect on normal stem cells. The research, published May 24 in the science journal Cell, holds the promise of a new strategy and discovery pipeline for the development of anticancer drugs in the treatment of various cancers. The research team has identified another dozen drugs that have good potential for the same response. For 15 years, some researchers have believed stem cells are the source of many cancers. In 1997, Canadian researchers first identified cancer stem cells in certain types of leukemia. Cancer stem cells have since been identified in blood, breast, brain, lung, gastrointestinal, prostate and ovarian cancer. To test more than a dozen … Continue reading

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Making a connection

Posted: Published on May 27th, 2012

Helping doctors connect with Generation X and Y. MEN from Generation X and Y are at a critical point in their lives. They are in their 20s to their 40s, the period when they are making crucial choices that influence their lifestyles, such as their eating habits, activity levels and stress levels. What they do and how they live now, during these two to three decades of their lives, will determine their risk for chronic diseases, and even life-threatening events later in life. Unfortunately, many men from Gen X and Y are not even aware that they are on the cusp of this turning point in their lives, and are making many unhealthy choices that they will live to regret later. Many of these poor choices are rooted in mens lack of awareness and knowledge about certain health basics. Generation gap Many men in Malaysia still have a lot of misconceptions about general health and male sexual issues. For instance, there are men who think that erectile dysfunction (ED) is caused by too much masturbation, or confuse ED with premature ejaculation (PE). Some men think that eating a healthy diet means buying expensive foods, while others see exercise as a … Continue reading

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Fears about medicine pose health risk

Posted: Published on May 27th, 2012

Fears about medicine pose health risk Olivia Olarte-Ulherr / 27 May 2012 Misconceptions about the side effects of lipid-lowering drugs, statin, are stalling many patients from reaching their cholesterol goals, putting them at risk of heart diseases and stroke, said a cardiologist. According to Dr Joseph Kurian, head of cardiology at Lifeline Hospital, patients are deterred from taking high doses of statin because of the side effects they read on the Internet. He explained that some of the side effects are not very serious compared to the risk of heart attack. The side effects are blown out of proportion, he stated, citing increase in muscle and liver enzymes as some of the side effects. When you give a statin, there could be a little increase in the liver enzyme and thats not a serious problem at all. That just shows you that the drug is working well. Nobody has died due to a liver failure from statin despite millions of people using it, he pointed out. He was speaking to Khaleej Times on the sidelines of the Lifeline Hospitals first International Annual Conference in the Capital on Thursday. Citing the results of the CEPEUS study or Centralised Pan-European survey on … Continue reading

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Drug destroys human cancer stem cells but not healthy ones

Posted: Published on May 27th, 2012

ScienceDaily (May 24, 2012) A team of scientists at McMaster University has discovered a drug, thioridazine, successfully kills cancer stem cells in the human while avoiding the toxic side-effects of conventional cancer treatments. "The unusual aspect of our finding is the way this human-ready drug actually kills cancer stem cells; by changing them into cells that are non-cancerous," said Mick Bhatia, the principal investigator for the study and scientific director of McMaster's Stem Cell and Cancer Research Institute in the Michael G. DeGroote School of Medicine. Unlike chemotherapy and radiation, thioridazine appears to have no effect on normal stem cells. The research, published May 24 in the science journal Cell, holds the promise of a new strategy and discovery pipeline for the development of anticancer drugs in the treatment of various cancers. The research team has identified another dozen drugs that have good potential for the same response. For 15 years, some researchers have believed stem cells are the source of many cancers. In 1997, Canadian researchers first identified cancer stem cells in certain types of leukemia. Cancer stem cells have since been identified in blood, breast, brain, lung, gastrointestinal, prostate and ovarian cancer. To test more than a dozen … Continue reading

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Three Sixty Pharmacy nips BNK in Inter- Merchant

Posted: Published on May 27th, 2012

Cebu Daily News THE Three Sixty Pharmacy-Online nipped BNK Auto Shop, 89-88, Thursday night in the Inter-Merchant-2012 basketball tournament at the Pope John gym in Mabolo, Cebu City. BNK Auto Shop looked headed for an easy win when it took a, 30-10 lead in the first period but Three Sixty responded with a 26-16 run in the second to trail, 36-46 at the half. The Pharmacians then whipped up a furious, 31-14 storm in the 3rd period to grab a, 67-60 lead going to the final quarter where the two protagonists engaged in an air-tight battle resulting in an, 88-all tie with 13 seconds remaining. In the return play, BNK fouled a driving Christian Fajardo that sent him to the stripe where he sank one of his two freethrows for Three Sixty Pharmacys one-point win. Barok Ceniza led Three Sixty with 16 points while Dodong Rivera paced BNK Auto Shop with 22 markers. BOX SCORES THREE SIXTY (89)- Ceniza 16, Espina 14, Rosal 14, Denisson 14, Densay 8, Teyam 6, Fajardo 6, Caete 5, Tallo 4, Tan 2. BNK (88)- Rivera 22, Sobrio 16, Layones 13, Gornez 7, Halop 6, Paquibot 6, Lanonigo 6, Abaquita 6, Dela Serna 6. /Correspondent … Continue reading

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Methodist Medical Center receives Get With The Guidelines-Stroke Silver Plus Quality Achievement Award

Posted: Published on May 27th, 2012

Methodist Medcial Center has received the American Heart Association/American Stroke Associations Get With The Guidelines-Stroke Silver Plus Quality Achievement Award. The award recognizes Methodists commitment and success in implementing a higher standard of stroke care by ensuring that stroke patients receive treatment according to nationally accepted standards and recommendations. To receive the Get With The Guidelines-Stroke Silver Plus Quality Achievement Award, Methodist achieved at least 12 consecutive months of 85 percent or higher adherence to all Get With The Guidelines-Stroke Quality Achievement indicators and achieved at least 75 percent or higher compliance with six of 10 Get With The Guidelines-Stroke Quality Measures during that same period of time, which are reporting initiatives to measure quality of care. These measures include aggressive use of medications, such as antithrombotics, anticoagulation therapy, DVT prophylaxis, cholesterol reducing drugs and smoking cessation, all aimed at reducing death and disability and improving the lives of stroke patients In addition to the Get With The Guideline-Stroke award, Methodist has also been recognized as a recipient of the associations Target: Stroke Honor Roll, for improving stroke care. Over the past quarter, at least 50 percent of the hospitals eligible ischemic stroke patients have received tissue plasminogen activator, or … Continue reading

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SD scientists get $18 million in stem cell funds

Posted: Published on May 27th, 2012

San Diego scientists will receive about $18.1 million in the latest round of funding from the California Institute of Regenerative Medicine (CIRM), the agency that's distributing $3 billion in stem cell research money made available through Proposition 71. Since funding began, San Diego County researchers have been awarded at least $258 million, making the region one of the largest stem cell research clusters in the country. Extended U-T science coverage on Facebook Here's a sample of the latest grants: Mark Tuszynski, UC San Diego, $4.7 million for research on novel stem cell therapies to treat spinal cord injuries. Peter Schutlz, The Scripps Research Institute, $4.3 million for research to treat multiple sclerosis. Juan Carlos Izpisua Belmonte, Salk Institute, $2.3 million for research that would help repair damaged blood vessels. Yang Xu, UC San Diego, $1.8 million for research that would help treat heart failure. Eric Adler, UC San Diego, $1.7 million for research to help treat Danon disease, which causes major abnormalities in heart and skeletal muscles. David Schubert, Salk Institute, $1.7 million for research aimed at treating Alzheimer's disease Read the original post: SD scientists get $18 million in stem cell funds … Continue reading

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Nnew genetic method developed to pinpoint individuals' geographic origin

Posted: Published on May 27th, 2012

ScienceDaily (May 24, 2012) Understanding the genetic diversity within and between populations has important implications for studies of human disease and evolution. This includes identifying associations between genetic variants and disease, detecting genomic regions that have undergone positive selection and highlighting interesting aspects of human population history. Now, a team of researchers from the UCLA Henry Samueli School of Engineering and Applied Science, UCLA's Department of Ecology and Evolutionary Biology and Israel's Tel Aviv University has developed an innovative approach to the study of genetic diversity called spatial ancestry analysis (SPA), which allows for the modeling of genetic variation in two- or three-dimensional space. Their study is published online this week in the journal Nature Genetics. With SPA, researchers can model the spatial distribution of each genetic variant by assigning a genetic variant's frequency as a continuous function in geographic space. By doing this, they show that the explicit modeling of the genetic variant frequency -- the proportion of individuals who carry a specific variant -- allows individuals to be localized on a world map on the basis of their genetic information alone. "If we know from where each individual in our study originated, what we observe is that some … Continue reading

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Rutgers studies genetic link to military suicides

Posted: Published on May 27th, 2012

Rutgers University will study the genetic makeup of soldiers at risk for suicide or psychological issues, thanks in part to a national grant that the school has received. The Rutgers Cell and DNA Repository was awarded $2.4 million by the Henry M. Jackson Foundation for the Advancement of Military Medicine to conduct the study, which is part of the Army STARRS (Study to Assess Risk and Resilience in Servicemembers) initiative. Army STARRS will survey 55,000 active-duty soldiers though June 2014. It is the largest study of military personnel of its kind. Blood samples have been sent to the Rutgers repository, the largest university-based one in the world providing analyzing services for DNA, RNA, cell lines, and genetics, the university said. Rutgers officials hope the research will help determine whether there is a genetic predisposition to mental-health disorders and why some soldiers are at risk for suicide and post-traumatic stress disorder while others are more resilient. The suicide rate of active-duty military increased 80 percent between 2004 and 2008, according to a study by the U.S. Army Public Health Command. - Angelo Fichero Read more here: Rutgers studies genetic link to military suicides … Continue reading

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Owens plans to open 9th pharmacy at former Blockbuster store

Posted: Published on May 26th, 2012

Independent pharmacies are no different from your neighborhood supermarket or dress shop. Whether it's the big-box discounter down the block or the Internet, it's tough to survive in today's retail environment. But Owens Healthcare has faced the challenge and is growing. The Redding-based company will open its ninth retail pharmacy this summer on Lake Boulevard just north of the Raley's-ShopKo shopping center. John Friesen, whose father, Royce, bought the pharmacy business more than 40 years ago, said Owens has grown from a tiny drugstore to a company that has found its mark. "We are what I would consider a niche," said Friesen, Owens' chief executive officer. "We are not small like a one-store operation, but we also are not a 5,000-store Walgreens. We are kind of in between." Over the past few years, Owens has opened new locations on Churn Creek Road, inside a former scooter shop across from Four Corners, and on Continental Street in downtown Redding. Royce Friesen bought Owens from founders Harold and Gertrude Owens in 1971. The business had two pharmacies in Redding and eight employees. Owens today has about 125 employees. With eight retail pharmacies, Friesen said that affords Owens buying clout to compete against … Continue reading

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