Editor's Choice Main Category: Stroke Article Date: 24 May 2012 - 15:00 PDT Current ratings for: 'Is Alteplase Safe For Stroke Patients Over 80? Researchers Say Yes' Although the drug can be used in several conditions including ischemic stroke, heart attacks and pulmonary embolism, the time window in which the drug can be administered safely and effectively after a stroke is still debated. Two studies published in The Lancet reveal the benefits of alteplase in stroke patients age 80+ and also confirm the benefits of rapid treatment. The first study reports the results of the third International Stroke Trial (IST-3). In the trial, Professor Peter Sandercock, University of Edinburgh and Western General Hospital, Edinburgh, UK, evaluated 3,035 patients at 156 hospitals in 12 countries in order to determine whether stroke patients treated within 6 hours in clinical trials might benefit (ie, be alive and independent in daily living). 53% of study participants were older than 80 years of age. At present, thrombolysis is known to benefit individuals under the age of 80 who are treated within 4-5 hours of acute ischemic stroke. The researchers assigned 1,515 participants to receive alteplase and 1,520 to the control group. At 6 months, the … Continue reading
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