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New treatment for Parkinson’s – Video

Posted: Published on April 24th, 2012

22-04-2012 15:49 This piece first broadcast on 13 Apr 2012. Televised on UK's satellite television Sky News. Read the original: New treatment for Parkinson's - Video … Continue reading

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Treating Parkinson’s Disease at Rhode Island Hospital – Video

Posted: Published on April 24th, 2012

23-04-2012 08:05 Chief of neurosurgery G. Rees Cosgrove, MD, discusses the signs and symptoms of Parkinson's Disease and treatment options. Learn more about neurosciences at Rhode Island Hospital: Link: Treating Parkinson's Disease at Rhode Island Hospital - Video … Continue reading

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Cynapsus Therapeutics Appoints Dr. Abraham Lieberman to Clinical Advisory Board

Posted: Published on April 24th, 2012

TORONTO, ONTARIO--(Marketwire -04/23/12)- Cynapsus Therapeutics (TSX-V: CTH.V - News), a specialty pharmaceutical company developing an improved dosing formulation of an approved drug used to treat the symptoms of Parkinson's disease, today announced that it has appointed Dr. Abraham Lieberman to its Clinical Advisory Board (CAB). Dr. Lieberman is the Director of the Muhammad Ali Parkinson Center and Movement Disorder Clinic of the Barrow Neurological Institute at St. Joseph's Hospital and Medical Center. The news follows completion of the Company's first human clinical study of APL- 130277, a reformulation of an approved drug (Apomorphine), for the treatment of motor fluctuation in Parkinson's disease. The new appointment enhances the range and depth of expertise of the CAB, which provides medical, clinical and strategic guidance for the Company's product development and commercialization activities. "Cynapsus is very pleased to have Dr. Lieberman join our Clinical Advisory Board. His vast knowledge and commitment to improving treatments and outcomes for Parkinson's patients will be especially valuable as we advance APL -130277 towards clinical practice," said Anthony Giovinazzo, President and Chief Executive Officer of Cynapsus. "Dr. Lieberman joins an international group of Clinical Advisory Board members, including Dr. Warren Olanow and Dr. Fabrizio Stocchi. Collectively their experience … Continue reading

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Wockhardt launches authorized generic of Parkinson’s drug

Posted: Published on April 24th, 2012

Kolkata, Apr 24 : Pharmaceutical and biotechnology major Wockhardt has launched an authorized generic version of four strengths (50mg, 75mg, 125mg and 200mg) of the triple-drug combination product containing Levodopa, Carbidopa and Entacapone, which are used in treatment of Parkinsons disease. The Levodopa + Carbidopa + Entacapone tablet is the generic name for the brand Stalevo, owned by Orion Corporation and marketed in the United States by Novartis. Wockhardt launched the product on Monday and is entitled to 180-days of exclusivity. Wockhardt was the first-to-file with paragraph-IV certification on four out of six strengths of this product, said Wockhardt Chairman Dr. Habil Khorakiwala. Pursuant to a settlement of the litigation between Wockhardt and Orion Corporation, Finland, the holder of the NDA, Wockhardt came to an arrangement to launch an authorized generic version with 180-days of exclusivity. The product involved development of a complex API as well as a triple-drug combination formulation, he said. Incidence of Parkinsons disease is increasing worldwide. According to IMS Health, the total market for this product in the US is about USD 55 million for the above four strengths and even after the 180-days exclusivity the number of competitors to enter the market is expected to … Continue reading

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Wockhardt launches generic Parkinson’s treatment drug in US

Posted: Published on April 24th, 2012

New Delhi, Apr 24: Wockhardt said on Tuesday that it has launched a generic version of Orion Corporations Parkinsons treatment drug Stalevo in the US, with 180 days of marketing exclusivity. The company said its generic copy is of four strengths (50mg, 75mg, 125mg and 200mg) of the triple drug combination product containing levodopa, carbidopa and entacapone. Wockhardt was the firsttofile with paragraph IV certification on four out of six strengths of this product, Wockhardt Chairman, Mr Habil Khorakiwala, said in a statement. Pursuant to a settlement of the litigation between Wockhardt and Orion Corporation, Finland, the two parties came to an arrangement to launch an authorised generic version with 180 days of exclusivity, he added. Wockhardt launched the product on April 23, 2012 and is entitled to 180 days of exclusivity, the company said. The combination of levodopa, carbidopa and entacapone tablet is the generic name for the brand Stalevo, owned by Orion Corporation and marketed in the US by Novartis. Citing IMS Health, Wockhardt said the total market for this product in the US is about $ 55 million for the above four strengths and even after the 180 days exclusivity the number of competitors to enter the … Continue reading

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Nano-Devices That Cross Blood-Brain Barrier Open Door to Treatment of Cerebral Palsy, Other Neurologic Disorders

Posted: Published on April 24th, 2012

-Studies in rabbits hold promise for people Newswise A team of scientists from Johns Hopkins and elsewhere have developed nano-devices that successfully cross the brain-blood barrier and deliver a drug that tames brain-damaging inflammation in rabbits with cerebral palsy. A report on the experiments, conducted at Wayne State University in collaboration with the Perinatology Research Branch of the National Institute of Child Health and Human Development, before the lead and senior investigators moved to Johns Hopkins, is published in the April 18 issue of Science Translational Medicine. For the study, researchers used tiny, manmade molecules laced with N-acetyl-L-cysteine (NAC), an anti-inflammatory drug used as antidote in acetaminophen poisoning. The researchers precision-targeted brain cells gone awry to halt brain injury. In doing so they improved the animals neurologic function and motor skills. The new approach holds therapeutic potential for a wide variety of neurologic disorders in humans that stem from neuro-inflammation, including Alzheimers disease, stroke, autism and multiple sclerosis, the investigators say. The scientists caution that the findings are a long way from human application, but that the simplicity and versatility of the drug-delivery system make it an ideal candidate for translation into clinical use. In crossing the blood-brain barrier and … Continue reading

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Nano-devices that cross blood-brain barrier open door to treatment of cerebral palsy

Posted: Published on April 24th, 2012

Public release date: 23-Apr-2012 [ | E-mail | Share ] Contact: Ekaterina Pesheva epeshev1@jhmi.edu 410-502-9433 Johns Hopkins Medical Institutions A team of scientists from Johns Hopkins and elsewhere have developed nano-devices that successfully cross the brain-blood barrier and deliver a drug that tames brain-damaging inflammation in rabbits with cerebral palsy. A report on the experiments, conducted at Wayne State University in collaboration with the Perinatology Research Branch of the National Institute of Child Health and Human Development, before the lead and senior investigators moved to Johns Hopkins, is published in the April 18 issue of Science Translational Medicine. For the study, researchers used tiny, manmade molecules laced with N-acetyl-L-cysteine (NAC), an anti-inflammatory drug used as antidote in acetaminophen poisoning. The researchers precision-targeted brain cells gone awry to halt brain injury. In doing so they improved the animals' neurologic function and motor skills. The new approach holds therapeutic potential for a wide variety of neurologic disorders in humans that stem from neuro-inflammation, including Alzheimer's disease, stroke, autism and multiple sclerosis, the investigators say. The scientists caution that the findings are a long way from human application, but that the simplicity and versatility of the drug-delivery system make it an ideal candidate … Continue reading

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Estrogen hormone reveals protective ability after traumatic brain injury

Posted: Published on April 24th, 2012

ScienceDaily (Apr. 22, 2012) With more than 1.7 million people sustaining a traumatic brain injury each year, the need to identify processes to limit inflammation and subsequent damage is critical. Approximately 275,000 people are hospitalized annually with traumatic brain injury, leaving 85,000 with long-term disabilities and taking the lives of more than 50,000. More than 5 million people live with disabilities caused by traumatic brain injuries, often the result of car accidents and falls. Direct and indirect costs exceed $75 billion. Dr. Joshua Gatson, Assistant Professor of Surgery at the University of Texas Southwestern Medical Center in Dallas, investigates biomarkers and novel therapies for traumatic brain injury. His previous work has shown that estrone, one of the three naturally occurring estrogen hormones in the body, has shown some promise in reducing inflammation and cell death in the brain. His latest study is the first to demonstrate estrone provides those anti-inflammatory and antioxidant capabilities after traumatic brain injury. It is likewise the first to reveal the cellular pathways that are involved. His findings were presented April 22, 2012 during Experimental Biology 2012 in San Diego, CA. The study, conducted in male rats, compared 0.5 mg of estrone to a placebo, both … Continue reading

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Multiple Sclerosis: Symptoms and Treatment – Video

Posted: Published on April 24th, 2012

22-04-2012 22:54 Go here to read the rest: Multiple Sclerosis: Symptoms and Treatment - Video … Continue reading

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Gilenya Successfully Treated Relapsing MS Patients For Up To 7 Years

Posted: Published on April 24th, 2012

Editor's Choice Main Category: Multiple Sclerosis Article Date: 24 Apr 2012 - 0:00 PDT email to a friend printer friendly opinions Current Article Ratings: 1 (1 votes) Gilenya (fingolimod) is the only oral therapy approved to treat relapsing forms of multiple sclerosis (MS)1,2. It is the first in a new class of sphingosine 1-phosphate receptor (S1PR) modulating compounds and has demonstrated superior efficacy over Avonex (interferon-beta-1a IM), a commonly prescribed treatment. In a pivotal head-to-head trial in patients with relapsing- remitting multiple sclerosis at one year, Gilenya achieved both its primary and secondary endpoints, i.e. a 52% relative reduction of the yearly relapse rate and a 40% relative reduction in the rate of brain atrophy. A recent sub-analysis at one year revealed that in comparison to interferon-beta-1a (IM), Gilenya achieved a 61% relative reduction in the rate of yearly relapses in patient subgroups with highly active relapsing-remitting MS patients who previously received interferon therapy. Gilenya has no label restrictions specific to treatment duration and was generally well tolerated during clinical trials with a manageable safety profile. Since February 2012, over 36,000 patients have been treated with Gilenya in clinical trials and in the post-marketing setting, which confirms Gilenya's long- term … Continue reading

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