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OPKO Health and The Scripps Research Institute Announce Global License Agreement for a Novel Compound That Blocks …

Posted: Published on March 10th, 2012

MIAMI & JUPITER, Fla.--(BUSINESS WIRE)-- OPKO Health, Inc. (NYSE: OPK - News) and The Scripps Research Institute today announced a global agreement for the development and commercialization of SR 3306, a novel compound discovered by scientists from the Florida campus of The Scripps Research Institute that blocks the destruction of brains cells in animal models of Parkinsons disease. Under the terms of the agreement, The Scripps Research Institute has granted to OPKO Health exclusive worldwide rights to develop, manufacture and commercialize SR 3306 and related compounds that inhibit a class of enzymes called jun-N-terminal kinsases (JNK) that play an important role in neuron survival. The new compound, a small molecule known as SR-3306, would potentially be the first to protect the brain from the ravages of Parkinson's disease. This licensing agreement will help insure that the development of this promising compound keeps moving forward, said Scripps Research Professor Philip LoGrasso, whose laboratory has led the research on the compound to date. This is one of the best opportunities we have for the development of an effective neuroprotective treatment for Parkinsons patients. We are excited to be working with Dr. LoGrasso and The Scripps Research Institute to develop this important compound … Continue reading →

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Parkinson's drug research closely monitored: UBC

Posted: Published on March 10th, 2012

The deaths of four monkeys at the University of B.C., now under investigation by the BC SPCA, resulted from a small dose of a designer drug being tested in Parkinson's disease research and was completely unexpected, the university says. And that research was fully overseen by UBC's Animal Care Committee, despite claims to the contrary by animal rights activists, the committee chairman says. A spokeswoman for research animal watchdog group STOP UBC Animal Research, Anne Birthistlem, said she was concerned UBC researcher Doris Doudet's experiment did not receive full scrutiny by the ACC because it was a "pilot project." But ACC chairman Marcel Bally said that Doudet's work was not done as a pilot project. UBC spokesman Randy Schmidt said the committee reviewed the proposed research and the protocol for the treatment of those animals. Committee members also conducted annual inspections of UBC's animal research facilities. As well, veterinarians paid monthly visits to each facility and were involved on-site during significant procedures. Schmidt added that those veterinarians were required to report any breaches of the research's protocol or any perceived abuse of the animals to the Animal Care Committee. As well, a national organization, the Canadian Council on Animal Care, … Continue reading →

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Aggressive Care Best for Brain Trauma, Study Shows

Posted: Published on March 10th, 2012

FRIDAY, March 9 (HealthDay News) -- Aggressive treatment of patients with traumatic brain injury improves chances of recovery and reduces long-term care costs, according to a new study. University of Pennsylvania School of Medicine researchers analyzed data from 1,000 patients with traumatic brain injury and found that aggressive care was much more costly than routine care or comfort care. But it was also much more effective and led to better results, improved quality of life and lower long-term care costs, the researchers said. Aggressive care includes invasive intracranial pressure monitoring and decompressive hemicraniectomy, a procedure in which part of the skull is removed to allow a swelling brain to expand. The investigators found that aggressive care was cost-effective in patients of all ages, but especially in younger patients. The study, published online March 6 in the Journal of Neurosurgery, is the first to show the cost-effectiveness of aggressive care for these patients, the authors said. "This study clearly shows that aggressive care, for both young and older patients who suffer a severe traumatic brain injury, provides patients the best chance at surviving and recovering, and also reduces lifetime costs associated with TBI [traumatic brain injury] treatment," lead author and neurosurgery … Continue reading →

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Fly Research Gives Insight Into Human Stem Cell Development

Posted: Published on March 10th, 2012

Newswise CHICAGO, IL March 8, 2012 Stem cells provide a recurring topic among the scientific presentations at the Genetics Society of Americas 53rd Annual Drosophila Research Conference, March 7-11 at the Sheraton Chicago Hotel & Towers. Specifically, researchers are trying to determine how, within organs, cells specialize while stem cells maintain tissues and enable them to repair damage and respond to stress or aging. Four talks, one on Thursday morning and three on Sunday morning, present variations on this theme. For a fertilized egg to give rise to an organism made up of billions or trillions of cells, a precise program of cell divisions must unfold. Some divisions are asymmetric: one of the two daughter cells specializes, yet the other retains the ability to divide. Chris Q. Doe, Ph.D., professor of biology at the University of Oregon, compares this asymmetric cell division to splitting a sundae so that only one half gets the cherry. The cherries in cells are the proteins and RNA molecules that make the two cells that descend from one cell different from each other. This collecting of different molecules in different regions of the initial cell before it divides is termed "cell polarity." Dr. Doe and … Continue reading →

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StemCells, Inc. Announces Webcast to Discuss 2011 Financial Results and Business Update

Posted: Published on March 10th, 2012

NEWARK, Calif., March 9, 2012 (GLOBE NEWSWIRE) -- StemCells, Inc. (Nasdaq:STEM - News), a leading stem cell company developing and commercializing novel cell-based therapeutics and tools for use in stem cell-based research and drug discovery, announced today that it will release financial results for the fourth quarter and year ended December 31, 2011 after the market close on Tuesday, March 13. In connection with this announcement, StemCells will host a conference call and webcast to discuss its results and an update on its business at 1:30 p.m. Pacific Time (4:30 p.m. Eastern Time) the same day. Interested parties are invited to listen to the call over the Internet by accessing the Investors section of the Company's website at http://www.stemcellsinc.com. Webcast participants should allot extra time before the webcast begins to register and, if necessary, download and install audio software. An archived version of the webcast will also be available for replay on the Company's website beginning approximately two hours following the conclusion of the live call and continuing for a period of 30 days. About StemCells, Inc. StemCells, Inc. is engaged in the research, development, and commercialization of cell-based therapeutics and tools for use in stem cell-based research and drug … Continue reading →

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Heart Disease Stem Cell Therapies – Development Must Come From Several Specialties

Posted: Published on March 10th, 2012

Editor's Choice Academic Journal Main Category: Heart Disease Also Included In: Cardiovascular / Cardiology;Stem Cell Research Article Date: 09 Mar 2012 - 4:00 PST email to a friend printer friendly opinions Current Article Ratings: 5 (1 votes) The paper's lead author, Kenneth Chien from Harvard University in the USA explains: Until now, clinical trials have been based on heart attacks, chronic heart failure as well as dilated cardiomyopathy, but regardless of the fact that regenerative therapies that are based on various non-cardiac cell types seem to be safe, their efficacy has not yet been tested in a clinical trial. However, possible new targets and treatment strategies are now emerging due to recent progress in cardiac stem cell research and regenerative biology. Scientists used to think that the heart only has a minimal capacity for self-renewal and saw no prospect in reversing the loss of healthy heart muscle and function. This perception has been altered because of recent findings, such as the discovery of several distinct embryonic progenitor cell types of which some are found in the heart. A certain number of these cells can be activated in people with cardiac injuries and are now targeted by scientists to develop novel … Continue reading →

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Weld Co. woman claims Walgreen’s pharmacy botched prescriptions

Posted: Published on March 10th, 2012

Posted on: 9:08 pm, March 9, 2012, by Tammy Vigil, updated on: 10:42pm, March 9, 2012 FIRESTONE, Colo. A woman in Firestone claims a Walgreens pharmacy made three medication mistakes that could have harmed her family. There are about 1.5 million medication errors every year that result in injuries. So, Kristi Warner counts herself as lucky. They messed up three times in two weeks with me, she says. Warner says it started two weeks ago, when the pharmacy didnt give her enough anti-depressant. They gave her enough to cover just one pill a day, instead of one-and-a-half pills. So I ran out. And I had to go, I had to go a week without my medication. When I go without that, I get sick, she says. Then on Friday, she says there were two mistakes. The pharmacy gave her 11-year-old son time-release Ritalin instead of the short-acting type of the drug prescribed by his doctor. It also gave her 3-year-old a more potent antibiotic than he was supposed to get. Read the original here: Weld Co. woman claims Walgreen’s pharmacy botched prescriptions … Continue reading →

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Court: Hospital improperly held pharmacy audit

Posted: Published on March 10th, 2012

Broadlawns Medical Center improperly kept secret an audit of its pharmacy done in the wake of drug thefts there, the Iowa Supreme Court ruled Friday. Broadlawns, which is owned and financed by Polk County taxpayers, has fought to prevent release of the audit since The Des Moines Register requested a copy in 2009. The audit was performed by the pharmacys director after a pharmacist who worked there admitted she stole addictive narcotics. Pharmacy Director Mark Hall and hospital executives contended that the report should not be made public because they gave a copy of it to the Iowa Board of Pharmacy, whose investigative files generally are confidential. A district judge ruled in favor of the hospital in 2010, but the Supreme Court disagreed on Friday. The court said public officials may not automatically make documents confidential by giving copies to a regulatory board. In this case, the justices said, the newspaper should have been given the audit. The public interest in information related to the theft of drugs from a pharmacy at a hospital funded by taxpayers is compelling, the justices wrote in a ruling released Friday morning. By Friday afternoon, Broadlawns still had not released the audit. The hospitals … Continue reading →

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New Industry Partnership to Strengthen Regenerative Medicine Industry in Canada

Posted: Published on March 10th, 2012

TORONTO, ONTARIO--(Marketwire -03/09/12)- The newest player in the regenerative medicine (RM) field in Canada is taking a collaborative approach to commercializing stem cell and biomaterials products. The Centre for Commercialization of Regenerative Medicine (CCRM) has created an industry consortium that is working together to address real-life bottlenecks in their RM product pipelines. CCRM's scientific leadership is recognized by the global RM community as being world-leading. According to Michael May, CEO of CCRM, partnering with industry completes the puzzle. "By working with industry, CCRM captures business expertise that informs product development and commercialization. We already had access to some of the best scientific minds in the field and now we have access to seasoned industry experts. This is key to our success and will accelerate product development." The members of the industry consortium represent the key sectors of the RM industry: therapeutics, devices, reagents, and cells as tools. CCRM has built three core development platforms: reprogramming, cell manufacturing, and biomaterials and tissue mimetics. The intellectual property and infrastructure of CCRM's six research institution partners and support from 20 leading RM companies will enhance Canada's already strong leadership role in the RM field. "CCRM is uniquely positioned to meet the needs of … Continue reading →

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Newburgh Man Dies While Receiving Stem Cell Treatment in Florida

Posted: Published on March 10th, 2012

A homicide investigation in Florida has some far reaching ties to the Tri-State. A Newburgh man was there for stem cell treatment and died during the procedure. Richard Poling, 77, went to Florida for treatment of a lung disease he's battled for more than ten years, but he didn't make it through the procedure. Now the doctor he chose, Dr. Zannos Grekos, is at the heart of a homicide investigation. But his isn't the first story about Dr. Grekos that ends poorly. Barb Neuman's husband was diagnosed with a different lung disease, but went to the same doctor, in 2009. They mortgaged their home to afford more than $50,000 for the treatment. Unfortunately Neuman's husband died nine months later. But other patients speak highly of Dr. Grekos. Grekos' license had been restricted in 2011 for performing undisclosed stem cell research on a woman with breast cancer who later died. Neuman says she hopes her story can teach others a valuable lesson. No one has been arrested in the three deaths. The Florida State Surgeon General has issued an emergency suspension on Grekos' license, and Lee County Sheriff's Deputies are investigating the deaths. Visit link: Newburgh Man Dies While Receiving Stem … Continue reading →

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