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Autism: Don't look now — I'm trying to think

Posted: Published on March 8th, 2012

ScienceDaily (Mar. 7, 2012) Children with autism look away from faces when thinking, especially about challenging material, according to new research from Northumbria University. Although generally encouraged to maintain eye contact as a means of enhancing their social skills, researchers found autistic children follow the same patterns as other children when processing complex information or difficult tasks. Typically developing children and adults look away when asked difficult questions and gaze aversion has been proven in the past to improve the accuracy of responses. Prof Gwyneth Doherty-Sneddon, Associate Dean for Research in the School of Life Sciences at Northumbria University, will present her findings in next month's Journal of Child Psychology and Psychiatry. In the first study of its kind, researchers asked 20 children with autism -- characterised by reduced sociability -- and 18 with William's Syndrome -- associated with hypersociability -- to carry out mental arithmetic tests. Both groups engaged in gaze aversion while thinking and increased their gaze aversion as question difficulty increased. Prof Doherty-Sneddon said: "Previous research found that children and adults tend to avert their gaze when thinking something through and this principle can now be applied to children with autism too. "Although social skills training is … Continue reading

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Wayzata HS student takes stem cell research to national competition

Posted: Published on March 8th, 2012

by Tom Crann, Minnesota Public Radio March 7, 2012 Audio player code: St. Paul, Minn. A Minnesota teen will be one of 40 high school students nationwide competing for a top prize of $100,000 at the annual Intel Science Talent Search in Washington D.C. Thursday. Evan Chen, a student at Wayzata High School, focused his research on a type of stem cell that could help replace and regenerate muscle lost by people suffering from muscular dystrophy. Chen told Tom Crann of All Things Considered that he was inspired to do the research after meeting three boys from Taiwan who were in Minnesota seeking treatment for the disease. "They left after the experiment; the treatment didn't work," Chen said. "I was pushed not only by my experience with them, but also my fascination with stem cells." The advanced research Chen envisioned couldn't be done in a high school laboratory, so Chen approached local scientists for help. "Eventually one sat down with me and we talked about the research I wanted to do," Chen said. "He was like, 'Sure, you can use my lab for this.'" Chen and the other students will be judged by a panel of scientists. Other projects in … Continue reading

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Fly research gives insight into human stem cell development and cancer

Posted: Published on March 8th, 2012

Public release date: 8-Mar-2012 [ | E-mail | Share ] Contact: Phyllis Edelman pedelman@genetics-gsa.org 301-351-0896 Genetics Society of America CHICAGO, IL March 8, 2012 Stem cells provide a recurring topic among the scientific presentations at the Genetics Society of America's 53rd Annual Drosophila Research Conference, March 7-11 at the Sheraton Chicago Hotel & Towers. Specifically, researchers are trying to determine how, within organs, cells specialize while stem cells maintain tissues and enable them to repair damage and respond to stress or aging. Four talks, one on Thursday morning and three on Sunday morning, present variations on this theme. For a fertilized egg to give rise to an organism made up of billions or trillions of cells, a precise program of cell divisions must unfold. Some divisions are "asymmetric": one of the two daughter cells specializes, yet the other retains the ability to divide. Chris Q. Doe, Ph.D., professor of biology at the University of Oregon, compares this asymmetric cell division to splitting a sundae so that only one half gets the cherry. The "cherries" in cells are the proteins and RNA molecules that make the two cells that descend from one cell different from each other. This collecting of different … Continue reading

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Scientists unlock genetic code for gorillas – and show the human link

Posted: Published on March 8th, 2012

Despite the evolutionary split with gorillas around 10 million years ago, we still share a remarkable number of genes with the great ape. Photo: AFP HUMANS and gorillas last shared a common ancestor 10 million years ago, according to an analysis of the first full sequence of the gorilla genome. The gorilla is the last of the living great apes - humans, chimpanzees, gorillas and orangutans - to have its complete genetic code catalogued. Scientists, led by researchers from the Wellcome Trust Sanger Institute near Cambridge, England, and Baylor College of Medicine in Houston, Texas, also found that 15 per cent of the gorilla's genetic code is closer between humans and gorillas than it is between humans and chimpanzees, our closest animal relative. The genomes of all three species are, in any case, highly similar: humans and chimpanzees share more than 98 per cent of their genes, while humans and gorillas share more than 96 per cent. The genetic sequence was taken from a female western lowland gorilla named Kamilah and published in the science journal Nature. Advertisement: Story continues below ''Gorillas are an interesting animal in their right but the main reason they are of particular interest is because … Continue reading

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Tumor's Genetic Identity Not Revealed By Single Biopsy

Posted: Published on March 8th, 2012

Featured Article Academic Journal Main Category: Cancer / Oncology Also Included In: Genetics;Urology / Nephrology Article Date: 08 Mar 2012 - 2:00 PST email to a friend printer friendly opinions Current Article Ratings: 3 (1 votes) Professor Peter Johnson, chief clinician at Cancer Research UK said in a statement that the study highlights "important differences that exist within tumours and suggest a way to improve the success rate of personalised cancer medicines". The lead author of the study is Professor Charles Swanton, who works at Cancer Research UK's London Research Institute and the UCL Cancer Institute. He and his colleagues analyzed the genetic variation among different regions of the same cancer tumor, using samples donated by patients with advanced kidney cancer. This is the first time genome-wide analysis has been used for this. Swanton told the press that scientists have known for a while that a tumor is a "patchwork" of faults, but this is the first time, thanks to cutting edge genomic sequencing technology, scientists have been able to map the genetic landscape of a tumor in such "exquisite detail". For the study, he and his colleagues compared the genetic variations in samples taken from different regions of four … Continue reading

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Nuvilex Points Toward Cell Encapsulation Technology Future to Expand Stem Cell Use for Late Stage Cancer Treatments

Posted: Published on March 8th, 2012

SILVER SPRING, Md.--(BUSINESS WIRE)-- Nuvilex, Inc. (OTCQB:NVLX), an emerging biotechnology provider of cell and gene therapy solutions, today discussed the potential use of the companys cell encapsulation technology with modified stem cells to treat late stage cancers. Stem cell therapy is not new to physicians dealing with blood and bone cancers, with stem cell transplants being an important treatment for growing new bone marrow since the 1970s. Recent studies have indicated the potential for using stem cells across a much broader range of cancers is becoming a reality, mostly a result of advances in cell and molecular biology techniques. Traditional chemotherapy works by targeting the fast-growing cells common to cancer tumors. Unfortunately, chemotherapeutics dont differentiate between healthy and cancerous cells. Patients suffering from metastatic cancers, where tumors have spread to multiple areas of the body, often have substantial difficulties with the chemotherapy needed to treat their disease. In one case, researchers at City of Hope and St. Jude Children's Research Hospital may have found a way to treat cancers that have spread throughout the body more effectively. They used genetically modified stem cells to activate chemotherapeutic drugs at the tumor sites, so that normal tissue surrounding the tumor and throughout … Continue reading

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Circassia’s Ragweed Allergy Therapy Achieves Positive Phase II Clinical Results

Posted: Published on March 8th, 2012

OXFORD, England, March 8, 2012 /PRNewswire/ -- Circassia Ltd, a specialty biopharmaceutical company focused on allergy, today announced that its ragweed allergy therapy has achieved positive results in a key phase II clinical trial. In the study, patients with more severe symptoms achieved a significantly greater improvement following treatment with the ToleroMune T-cell vaccine than those on placebo (p0.05). The results were presented at the 2012 Annual Meeting of the American Academy of Allergy, Asthma and Immunology*. "The results of this key phase II study are highly encouraging, because they show our ToleroMune ragweed allergy vaccine can reduce patients' symptoms after just a short course of treatment and, most importantly, offers the greatest improvement to those who can benefit most," said Steve Harris, Circassia's CEO. "We have now achieved successful phase II results with four of our allergy T-cell vaccines, which validate our scientific approach and give us the confidence to progress our lead programmes into the final phase of development." Circassia's latest phase II study was designed to assess the T-cell vaccine's efficacy and tolerability and to identify the optimal treatment regime. The trial was conducted in Canada in 275 ragweed allergy patients. During the randomised, double-blind, placebo-controlled trial, … Continue reading

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Circassia's Ragweed Allergy Therapy Achieves Positive Phase II Clinical Results

Posted: Published on March 8th, 2012

OXFORD, England, March 8, 2012 /PRNewswire/ -- Circassia Ltd, a specialty biopharmaceutical company focused on allergy, today announced that its ragweed allergy therapy has achieved positive results in a key phase II clinical trial. In the study, patients with more severe symptoms achieved a significantly greater improvement following treatment with the ToleroMune T-cell vaccine than those on placebo (p0.05). The results were presented at the 2012 Annual Meeting of the American Academy of Allergy, Asthma and Immunology*. "The results of this key phase II study are highly encouraging, because they show our ToleroMune ragweed allergy vaccine can reduce patients' symptoms after just a short course of treatment and, most importantly, offers the greatest improvement to those who can benefit most," said Steve Harris, Circassia's CEO. "We have now achieved successful phase II results with four of our allergy T-cell vaccines, which validate our scientific approach and give us the confidence to progress our lead programmes into the final phase of development." Circassia's latest phase II study was designed to assess the T-cell vaccine's efficacy and tolerability and to identify the optimal treatment regime. The trial was conducted in Canada in 275 ragweed allergy patients. During the randomised, double-blind, placebo-controlled trial, … Continue reading

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FDA mulls widely used drugs being available sans prescriptions

Posted: Published on March 8th, 2012

Some of the most widely used prescription drugs, including those to treat cholesterol and high blood pressure, could be freely available over the counter under a new proposal being weighed by government regulators. Food and Drug Administration officials said Wednesday they are considering waiving prescription requirements for certain drugs used to treat ailments such as diabetes, asthma and migraine. Driving the move is a wave of computer technology, including touch-screen kiosks found in pharmacies, designed to help patients self-diagnose common diseases. FDA regulators told reporters that easing access to obtain certain medications could help address undertreated epidemics like diabetes, a leading cause of heart disease and stroke. Of the more than 25 million Americans with diabetes, an estimated 7 million are not diagnosed and therefore are not treated. These are discussions that need to start happening as we think about peoples health needs and how to improve access, said FDA Commissioner Dr. Margaret Hamburg said. The over-the-counter switch is one of several FDA proposals aimed at increasing access to established drugs or speeding up approval of experimental medications. After years of high-profile drug safety cases in which the FDA restricted access to certain medications, the agency is increasingly highlighting its … Continue reading

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Sen. Hinojosa: HMO shift forcing pharmacies out of business

Posted: Published on March 8th, 2012

PHARR A low reimbursement rate for Medicaid patients is crippling independent pharmacies in the Rio Grande Valley to the point that most will go out of business, state Sen. Juan Chuy Hinojosa said Wednesday while standing inside a small drugstore that closed its doors last week. About a dozen Valley pharmacies went out of business since the Health and Human Services Commission placed 400,000-plus Medicaid beneficiaries into its managed care program March 1 in an effort to more efficiently deliver health care to the poor and to those with disabilities. But Hinojosa, D-McAllen, said the profit-driven companies that are now managing Medicaid dramatically cut reimbursement rates for small, independent pharmacies while paying a higher fee to the chains. Quite frankly, the dispensing fee and the reimbursement rates are unacceptable, Hinojosa said at a news conference surrounded by dozens of pharmacists at Sam Houston Pharmacy, a Pharr-based drugstore that shut down the first day of managed care. They were never intended to be that low. The Valley made the long-delayed switch to managed care March 1 despite opposition from local legislators, who successfully delayed its rollout here for about a decade. Under managed care, the state contracts the coverage for its … Continue reading

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