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Nationwide Children's Hospital neuromuscular disorder podcasts now available on iTunes

Posted: Published on March 2nd, 2012

Public release date: 1-Mar-2012 [ | E-mail | Share ] Contact: Erin Pope Erin.Pope@NationwideChildrens.org 614-355-0495 Nationwide Children's Hospital In 2010, the Center for Gene Therapy at Nationwide Children's Hospital launched a monthly podcast entitled, "This Month in Muscular Dystrophy," featuring internationally known scientists discussing the latest research in muscular dystrophy and other neuromuscular disorders. Now, these podcasts will be available for users on iTunes and at http://www.NationwideChildrens.org/muscular-dystrophy-podcast. The podcasts are geared toward patients, their families and primary care physicians who take care of patients with neuromuscular diseases. Hosted by Kevin Flanigan, MD, an attending physician in Neurology at Nationwide Children's Hospital, and a principal investigator in the Center for Gene Therapy in The Research Institute at Nationwide Children's, the programs include interviews with authors of recent scientific publications discussing how their work improves understanding of inherited neuromuscular diseases and what their findings might mean for treatment. New programs available for download on iTunes include: Podcasts from previous months have also been uploaded to iTunes and are available for download. "There is a lot of exciting work going on in the field of neuromuscular disease, and for patients and their families, it may be hard to get access to information about … Continue reading →

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'Parent Training' May Help Kids With Autism Behave Better

Posted: Published on March 2nd, 2012

THURSDAY, March 1 (HealthDay News) -- Children with autism often display challenging behaviors, but new research suggests that parents can learn to better handle tantrums and aggression, which may improve their child's overall functioning. "Parent training is one of the best, evidence-supported treatment interventions in child psychiatry for other conditions, such as for children with ADHD or children with oppositional defiant disorder," said senior study author Lawrence Scahill, a professor at Yale University School of Nursing and Child Study Center in New Haven, Conn. "But strangely enough, it had never really been tried with children with autism or with developmental disabilities, so we had to make our own manual." The study involved 124 children aged 4 to 13 with an autism spectrum disorder and serious behavioral issues, including daily, prolonged tantrums, aggression or self-injurious behavior. The children were prescribed risperidone (Risperdal), an antipsychotic drug approved by the U.S. Food and Drug Administration for treating severe behavioral problems in children with autism. Half the children and their parents were also assigned to a six-month, structured "parent training" program. Parents were asked to identify the most difficult, disruptive behaviors and to think about what preceded the incidents and why the child might … Continue reading →

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Experimental drug holds post-stroke promise

Posted: Published on March 2nd, 2012

TORONTO Newly reported Canadian research is holding out hope that a treatment for minimizing the damage done by the most common type of stroke could be on the horizon. A Toronto-based research team is reporting that an experimental drug significantly reduced brain damage and post-stroke impairment when used in macaque monkeys in which strokes were induced. The report, in the journal Nature, makes no reference to use of the drugs in humans. But at an international stroke conference in New Orleans in early February, the team presented preliminary data of a Phase II human trial in which the drug was reported to be quite favourable. Larger and more expensive Phase III trials are needed to gain regulatory approval to bring drugs to market. The new report, which lays out data from a series of experiments in monkeys, is being greeted with enthusiasm laced with caution. Researchers have tried for more than half a century to find a drug or therapy to protect the brain from the cascade of damage seen after an ischemic stroke, the type caused by a blockage of blood to the brain. About 85 per cent of strokes are the result of clots blocking blood flow, depriving … Continue reading →

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UCLA researchers stop Parkinson's progression in animal tests

Posted: Published on March 2nd, 2012

Raleigh Neurology/Flickr Flexibility testing at a Parkinson's clinic. A possible breakthrough has happened in the treatment of Parkinsons disease. UCLA researchers have found a way to stop the progression of the disease in animal tests. Parkinsons is a disease that strikes the nervous system, affecting ones movements. So far, there are no treatments to stop its progression. Medical professionals aren't even sure what actually causes it. But researchers do believe one particular protein in the brain plays a role. Its found in clumps in all Parkinson's patients. Researchers at UCLA have created a compound that prevents the protein from clumping. They call it a "molecular tweezer." In live animal tests, the compound binds to that protein, prevents it from aggregating and even breaks up existing clumps. Most importantly, the compound did this without appearing to harm normal brain cells. The study was done with transparent zebrafish. Now the findings are being applied to mice. Human trials, they hope, will be next. Read more: UCLA researchers stop Parkinson's progression in animal tests … Continue reading →

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Assistive Mobility Devices Designed by Mobility Research Now Offered by Rehabmart.com

Posted: Published on March 2nd, 2012

This experienced team of educators, clinicians, researchers and engineers work to provide education, products and rehabilitation solutions for adult and pediatric populations with motor control-related disabilities. They design and manufacture the LiteGait collection of products, used in treating stroke, spinal cord injury, multiple sclerosis, cerebral palsy, head injury, amputation, orthopedic problems, arthritis, balance issues and chronic pain. Elberton, GA (PRWEB) March 02, 2012 The LiteGait mobility frames are mutually beneficial for rehabilitation facilities, therapists and patients. Facilities can increase efficiency and revenue by growing the number of patients receiving gait therapy, by reducing the risk of back injuries to staff and the risk of falls to patients, and by offering therapy to patients not previously eligible for gait therapy due to the complexity or severity of their conditions or cognitive levels. Therapists can provide more efficient treatment, without the risk of injury to themselves or their patients, and more properly and effectively facilitate a wide variety of gait, balance and alignment therapies. And patients can experience a sense of accomplishment with this supported suspension, learning to walk in an environment free from falls. The LiteGait allows the patient to begin training earlier in the rehabilitation process, and at a lower … Continue reading →

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From monkeys to medication: New research into helping people with MS

Posted: Published on March 2nd, 2012

More than 400,000 Americans are living with Multiple Sclerosis, a chronic, unpredictable disease that attacks the central nervous system. Now, new discoveries could help scientists come up with better treatments for the disease and even prevent its onset. Whether parachuting, fishing, or enjoying the beach, Susan Dobroff has always pictured herself as an outdoors woman. Susan Dobroff, Living with MS, explains why she enjoys the outdoors so much, "It's like being in touch with God." Not even Multiple Sclerosis could dampen her active lifestyle. Two years after being diagnosed, she started law school. Dobroff explains how she decided to go to law school, "I realized, you know, you've been thinking about going to law school for a long time so got to do it sooner rather than later." 10 years after her diagnosis, Susan began to lose her ability to walk. Eventually, her legal career came to a grinding halt, too. Dobroff explains how she struggle after awhile with her job, "Lawyers don't need to walk and run in order to practice law but we do have to think." Now Japanese Macaques could hold the key to helping people like Susan. Scientists at the Oregon National Primate Center have discovered … Continue reading →

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Planarian genes that control stem cell biology identified

Posted: Published on March 2nd, 2012

Public release date: 1-Mar-2012 [ | E-mail | Share ] Contact: Nicole Giese Rura rura@wi.mit.edu 617-258-6851 Whitehead Institute for Biomedical Research FINDINGS: Devising a novel method to identify potential genetic regulators in planarian stem cells, Whitehead Institute scientists have determined which of those genes affect the two main functions of stem cells. Three of the genes are particularly intriguing because they code for proteins similar to those known to regulate mammalian embryonic stem cells. Such genetic similarity makes planarians an even more attractive model for studying stem cell biology in vivo. RELEVANCE: Stem cells may hold the promise to regrow damaged, diseased, or missing tissues in humans, such as insulin-producing cells for diabetics and nerve cells for patients with spinal cord injuries. With its renowned powers of regeneration and more than half of its genes having human homologs, the planarian seems like a logical choice for studying stem cell behavior. Yet, until now, scientists have been unable to efficiently identify the genes that regulate the planarian stem cell system. CAMBRIDGE, Mass. Despite their unassuming appearance, the planarian flatworms in Whitehead Institute Member Peter Reddien's lab are revealing powerful new insights into the biology of stem cellsinsights that may eventually help … Continue reading →

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Cell and signaling pathway that regulates the placental blood stem cell niche identified

Posted: Published on March 2nd, 2012

ScienceDaily (Mar. 1, 2012) UCLA stem cell researchers have discovered a critical placental niche cell and signaling pathway that prevent blood precursors from premature differentiation in the placenta, a process necessary for ensuring proper blood supply for an individual's lifetime. The placental niche, a stem cell "safe zone," supports blood stem cell generation and expansion without promoting differentiation into mature blood cells, allowing the establishment of a pool of precursor cells that provide blood cells for later fetal and post-natal life, said study senior author Dr. Hanna Mikkola, an associate professor of molecular cell and developmental biology and a researcher at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA. Mikkola and her team found that PDGF-B signaling in trophoblasts, specialized cells of the placenta that facilitate embryo implantation and gas and nutrient exchanges between mother and fetus, is vital to maintaining the unique microenvironment needed for the blood precursors. When PDGF-B signaling is halted, the blood precursors differentiate prematurely, creating red blood cells in the placenta, Mikkola said. The study, done in mouse models, appears March 1, 2012, in the peer-reviewed journal Developmental Cell. "We had previously discovered that the placenta provides a … Continue reading →

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Cord Blood Registery Helps Families Use Stem Cells – Video

Posted: Published on March 2nd, 2012

29-02-2012 17:57 Learn more at http://www.cordblood.com CBR's team of dedicated professionals is prepared to guide you through every step of the banking process and beyond. Meet Sherry, CBR's transplant coordinator. As Sherry says, her employer is CBR, but she works for the families who need newborn stem cell medicine. She is the voice parents hear over the phone when they need to use their stored cord blood stem cells. Sherry's dedication and passion to deliver exceptional customer service to clients is one example of the many people at Cord Blood Registry who are committed to helping families live longer, healthier lives. Visit link: Cord Blood Registery Helps Families Use Stem Cells - Video … Continue reading →

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UCLA Scientists Identify Cell and Signaling Pathway that Regulates the Placental Blood Stem Cell Niche

Posted: Published on March 2nd, 2012

Newswise UCLA stem cell researchers have discovered a critical placental niche cell and signaling pathway that prevent blood precursors from premature differentiation in the placenta, a process necessary for ensuring proper blood supply for an individuals lifetime. The placental niche, a stem cell safe zone, supports blood stem cell generation and expansion without promoting differentiation into mature blood cells, allowing the establishment of a pool of precursor cells that provide blood cells for later fetal and post-natal life, said study senior author Dr. Hanna Mikkola, an associate professor of molecular cell and developmental biology and a researcher at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA. Mikkola and her team found that PDGF-B signaling in trophoblasts, specialized cells of the placenta that facilitate embryo implantation and gas and nutrient exchanges between mother and fetus, is vital to maintaining the unique microenvironment needed for the blood precursors. When PDGF-B signaling is halted, the blood precursors differentiate prematurely, creating red blood cells in the placenta, Mikkola said. The study, done in mouse models, appears March 1, 2012, in the peer-reviewed journal Developmental Cell. We had previously discovered that the placenta provides a home for a … Continue reading →

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