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Autonomic Technologies Initiates European Study of Novel Neurostimulator for the Treatment of Severe Migraine

Posted: Published on February 28th, 2012

REDWOOD CITY, Calif.--(BUSINESS WIRE)-- Autonomic Technologies, Inc. (ATI), the developer of a novel miniaturized implantable stimulator for severe headaches, today announced initiation of a study in Europe to evaluate the safety and efficacy of the company’s investigational neurostimulation system for the treatment of high frequency, high disability migraine. The multi-center, randomized Pathway M-1 study will enroll 30 patients initially at leading headache centers in Denmark, Belgium, Spain, France and Germany. Migraine is the most common disabling headache, affecting 11% of the population in Western Europe and the United States.1 It is marked by pulsating, moderate to severe pain lasting from 4-72 hours, and may be associated with nausea and sensitivity to light or sound. According to the World Health Organization, severe migraine is associated with the highest level of disability (Class VII), higher than that of Congestive Heart Failure, Parkinson’s and Alzheimer diseases.2 “Current migraine treatments include preventive and acute abortive drugs, but these are not effective for all migraine sufferers,” said Prof. Dr. Rigmor Hoejland Jensen, Director of the Danish Headache Center at Glostrup Hospital in Denmark and study Principal Investigator. “Some patients cannot use these medications because of cardiovascular risk factors or side effects, and others do not … Continue reading

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Santanu Mitra

Posted: Published on February 28th, 2012

Thanks for allowing rape victim find a voice I would like to convey my thanks to STAR Ananda for providing a solid platform to the Park Street rape victim to air her torment and gather enough courage to defend her stand despite her efforts being repeatedly brushed off as a ?conspiracy to malign the government?. The initiative of the channel may have woken the confused administration out of its slumber to launch a belated damage-control measure, allowing its police force a free hand to live up to its abilities and skills. The case has been cracked with speed under the aegis of a determined leadership, proving once again that politics has a lot to do with people?s gradual loss of faith in the police. People of Bengal were truly in a dilemma in the absence of a suitable alternative to the Left Front, considering the air of unpredictability surrounding the prospective chief minister. Anti-establishment furore and disenchantment, coupled with her honest and persistent endeavour, however, have paved the way for one-person governance, replacing the party-centric model. But, even after ascending the coveted throne, our chief minister has failed to shed her image of a street fighter, either crying conspiracy at … Continue reading

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US trip holds hope for city boy

Posted: Published on February 28th, 2012

Blaise Wyatt, with his mother Dawn Mackenzie Wyatt, will spend his third birthday in the US, receiving the revolutionary cerebral palsy treatment his parents have been raising funds for. Claudia Baxter BLAISE Wyatt is $3000 away from spending his third birthday in the United States undergoing revolutionary new cerebral palsy treatments. The brave Ipswich youngster suffers from spastic quadriplegia, a severe form of cerebral palsy that affects all his limbs. He will celebrate his April 1 birthday in the US, and will spend a month undergoing therapies not available in Australia. Parents Dawn and Cameron have fundraised and saved $17,000 of the $20,000 necessary to pay for the trip and therapies, and launched a Facebook auction to raise the remaining funds. "The support we got after the story we had in the QT last year was amazing, and we've had Xact Radiology and a couple of other businesses help out with the fundraising, and I've hosted auctions and sold Christmas decorations on Facebook," Dawn Mackenzie-Wyatt said. Ms Mackenzie-Wyatt is currently tallying the money raised by the auction, which featured 52 items donated from local and Queensland businesses. As the March 31 trip draws closer, Dawn said she was feeling a … Continue reading

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Health Canada launches investigation of oral MS drug

Posted: Published on February 28th, 2012

carly weeks From Tuesday's Globe and Mail Published Monday, Feb. 27, 2012 4:23PM EST Last updated Monday, Feb. 27, 2012 4:29PM EST Serious safety concerns over a popular oral medication used to treat multiple sclerosis have prompted Health Canada to launch a full investigation. The department made the announcement on Monday after reports of 11 deaths worldwide that have been linked to the drug fingolimod. When fingolimod, sold under the brand name Gilenya, was approved in Canada last March, it was known the drug could increase the risk of heart problems, such as a decreased or abnormal heart rate, after the first dose. But Health Canada and many other regulators around the world ruled that the benefits of the drug outweighed the risks. More related to this story None of the deaths linked to Gilenya occurred in Canada. But Health Canada has received 52 reports of adverse events linked to fingolimod since last April. At least 14 reports came from patients who experienced a decreased heart rate after taking the drug. Other reported problems include blood pressure fluctuation, fatigue and dizziness. Gilenya, marketed by Novartis, is the first oral medication approved for treatment of relapsing-remitting MS, the most common form … Continue reading

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Health Canada reviewing MS drug Gilenya, linked to 11 deaths outside Canada

Posted: Published on February 28th, 2012

TORONTO - Health Canada is reviewing a new multiple sclerosis drug that has been linked to 11 deaths. There have been no reports of deaths in Canada of people taking the Novartis drug, which is sold under the brand name Gilenya. Health Canada says that of the deaths outside the country, it's not clear whether the drug itself caused them, or whether other factors played a role. Both the U.S. Food and Drug Administration and the European Medicines Agency had earlier announced that they were undertaking reviews of Gilenya. Gilenya is used for treatment of relapsing-remitting MS to reduce the frequency of attacks and to delay physical disability; it is generally recommended when other MS treatments have not been effective or cannot be tolerated. At the time the drug was authorized, it was known that certain types of heart rhythm disturbances can be seen with Gilenya use and the Canadian labelling contains several warnings to this effect. But Health Canada says it felt the drug's benefits outweighed its risks. Of the 11 reported deaths, four involved serious heart-related events — three were heart attacks and another a disturbance of the heart rhythm. The seven other deaths are unexplained, including one … Continue reading

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Safety of MS pill Gilenya reviewed after deaths

Posted: Published on February 28th, 2012

Health Canada is reviewing a new multiple sclerosis drug that has been linked to 11 deaths. There have been no reports of deaths in Canada of people taking the Novartis drug, which is sold under the brand name Gilenya. Gilenya, also called fingolimod, is taken once a day for people with the relapsing-remitting form of MS. (Novartis) Health Canada says that of the deaths outside the country, it's not clear whether the drug itself caused them, or whether other factors played a role. Both the U.S. Food and Drug Administration and the European Medicines Agency had earlier announced that they were undertaking reviews of Gilenya. Gilenya is used for treatment of relapsing-remitting MS to reduce the frequency of attacks and to delay physical disability; it is generally recommended when other MS treatments have not been effective or cannot be tolerated. At the time the drug was authorized, it was known that certain types of heart rhythm disturbances can be seen with Gilenya use and the Canadian labelling contains several warnings to this effect. But Health Canada says it felt the drug's benefits outweighed its risks. Of the 11 reported deaths, four involved serious heart-related events — three were heart attacks … Continue reading

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Scientists urged to share data on stem cells research

Posted: Published on February 28th, 2012

By Noimot Olayiwola Staff Reporter Researchers and scientists in the field of both embryonic and adult stem cells research in the Middle East were yesterday urged to be more open to collaboration and networking among themselves in order to build on their already acquired and existing strengths for the betterment of the future use of stem cells in curing genetic diseases in the region. Stem cells are ‘unspecialised’ cells that are able to divide and produce copies of themselves and having the potential to differentiate, that is, to produce other cell types in the body. Speaking on how to further expand the scope of stem cell research in the region during a panel discussion yesterday at the ongoing Qatar International Conference on Stem Cell Science and Policy, Weill Cornell Medical College in Qatar’s Dr Jeremie Arash Rafii Tabrizi said there was the need for the region’s researchers in the field of stem cells to know each other and come together to network and form collaborations. “I believe that each and everyone in the field within this region has built some sort of strength while conducting their individual researches, so I will suggest that we all come together to put heads … Continue reading

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Stem cell fertility treatments could be risky for older women

Posted: Published on February 28th, 2012

Harvard scientists are challenging traditional medical logic that dictates that women are born with a finite amount of eggs.  The scientists said they have discovered the ovaries of young women harbor rare stem cells that are in fact capable of producing new eggs. If properly harnessed, those stem cells may someday lead to new treatments for women suffering from infertility due to cancer or other diseases – or for those who are simply getting older, according to the researchers.  Lead researcher Jonathan Tilly of Harvard's Massachusetts General Hospital has co-founded a company, OvaScience Inc., to try to develop the findings into fertility treatments. The idea that women are born with all the egg cells – called oocytes – they’ll ever have has been called into question by past research, which found egg-producing stem cells in adult mice. In this latest study, Harvard researchers, in collaboration with Japanese scientists, used donated frozen ovaries from 20 year olds and ‘fished out’ the purported stem cells.   The researchers inserted a gene into the stem cells, which caused them to glow green.  If the cells produced eggs, those would glow green, too. The researchers first watched through a microscope as new eggs grew … Continue reading

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New Stem Cell Research Could End the Hard Stop of Female Fertility

Posted: Published on February 28th, 2012

A long-held belief about women and fertility is that each woman has a set amount of eggs in her lifetime and that when those eggs are depleted at menopause, so are her chances at having a biological child. However, research out of Massachusetts General Hospital questioning that view. Using stem cells taken from human ovaries, scientists have produced early-stage eggs, which brings up all sorts of questions about possible new methods for treating infertility. Nicholas Wade, writing in the New York Times, adds, "The ability to isolate stem cells from which eggs could be cultivated would help not only with fertility but also with biologists’ understanding of how drugs and nutrition affect the egg cells." RELATED: Gecko Foot Glue; When Alcohol Is a Health Food Jonathan Tilly, the director of Mass General's Vincent Center for Reproductive Biology and leader of the new research, had reported in 2004 that ovarian stem cells in mice could create new eggs "similar to how stem cells in male testes produce sperm throughout a man’s life." His new study attempted to prove this with humans. Researchers took healthy ovaries from patients having sex reassignment surgery, and injected stem cells from the ovaries into human ovarian tissue grafted … Continue reading

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Bad breath being used in Stem Cell research

Posted: Published on February 28th, 2012

SALT LAKE CITY — Researchers may have found a use for the chemical that causes the stench in bad breath, stink bombs, and flatulence. This smelly substance known as Hydrogen Sulphide has been used in helping to convert stem cells from human teeth into liver cells. The scientists conducting the investigation and research in the Journal of Breath Research claim that the gas increased the purity of the stem cells. The goal is that the liver cells produced from the stem cells could be used for repair if the organ was damaged. Hydrogen Sulphide is produced by bacteria, and is toxic in large amounts. A group in China has reportedly tested the gas on rats to enhance the survival of mesenchymal stem cells taken from the bone marrow. Researchers from the Nippon Dental University were investigating stem cells from dental pulp — the material in the middle of the tooth. The dental pulp was taken from patients undergoing a routine tooth extraction. Dr. Ken Yaegaki, the lead author of the study, told the BBC why the dental pulp was so effective. "High purity means there are less 'wrong cells' that are being differentiated to other tissues, or remaining as stem … Continue reading

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