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While there's no cure, new drugs have made the feared disease recede

Posted: Published on February 25th, 2012

Zach Nielson at age 11 couldn't quite put his finger on the two words his doctors were avoiding using around him. But his mother certainly could. Deb Nielson knew people in wheelchairs, knew what it meant that Zach was waking up numb, knew how scary it was when he staggered stiffly down the hallway like a young drunk. But just over two years later, a new generation of powerful drugs has drained the power of the words "multiple sclerosis" for Zach and thousands of patients like him. The drugs have erased symptoms and reversed nerve scarring in the largest subgroup of MS sufferers, transforming for the first time victims' experience with the disease. Far from a life sentenced to relentless disability, Zach Nielson is among a growing group who feel as if their MS never happened. "When they first told me, I was worried it would get worse and worse, and I wouldn't be able to have my dream job," said Zach, who just turned 14. "Now I know I can be a pilot." The new class of drugs "gave me my active son back," Deb Nielson said. "I'm convinced of that now." Eight hundred MS patients are on Zach's … Continue reading

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CVS/pharmacy looking at entering central Iowa market

Posted: Published on February 25th, 2012

CVS/pharmacy, one of the largest retail pharmacy chains in the nation, has made a move to enter the central Iowa market. The company received a site plan approval this week from the city of Ankeny for a store at 104 E. First St. Mike DeAngelis, a spokesman for CVS/pharmacy, said the company is in the early planning stages for the store. Construction is planned to  begin in the second half of 2012, with an opening in 2013. Other sites may be on the company’s radar. “We are interested in expanding in the Des Moines market but we have no additional locations to announce at this time,” DeAngelis said. CVS/pharmacy has retail stores in Cedar Rapids, Iowa City, Davenport, Waterloo and Council Bluffs. It has more than 7,000 pharmacies nationwide. Walgreens also has more than 7,000 drugstores nationwide, including about 70 stores in Iowa. The CVS/pharmacy retail stores are part of the Rhode Island-based CVS Caremark Corp., which includes mail order, retail and specialty pharmacies; retail clinics; and is a provider of Medicare Part D Prescription Drug Plans. Its retail pharmacies also sell beauty, health and personal care brands, including the proprietary brands Cristophe, Essence of Beauty, Nuprin, Playskool and Skin … Continue reading

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The Rare Clinical Diseases Research Network

Posted: Published on February 25th, 2012

According to the Rare Clinical Diseases Research Network (RDCRN) website, the purpose of the RDCRN is to increase collaboration between the research and treatment efforts of the scientists and clinicians working with many different types of rare disease. The RDCRN receives funding from the National Institutes of Health (NIH) and Office for Rare Diseases Research in the U.S.A. The RDCRN also works to improve the availability of information and treatment to patients. By registering with the RDCRN contact registry, individuals will receive disease-specific information via email regarding open recruitment for clinical research, new clinical research sites, and activities related to raising awareness of specific neuromuscular diseases and advocacy efforts. The website also contains information regarding each of the included diseases. The RCDRN originally included five research consortia. In 2009, the Network received funding to expand the network to include an additional 14 consortia covering 95 rare diseases. To be considered a ?rare disease? by the RCDRN, the disease must affect less than 200,000 individuals in the U.S.A. A number of the neuromuscular diseases meet criteria for inclusion as a rare disease and are represented by the RCDRN. These include the mitochondrial diseases, inherited neuropathies including Charcot Marie Tooth disease, episodic … Continue reading

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Pembroke's Christine McSherry is an 'Inspirational Woman'

Posted: Published on February 25th, 2012

On the Tuesday before Christmas, Jarrett “Jett” McSherry, 16, traded a few friendly barbs with his older sister, played Modern Warfare 3 on his Xbox, and watched some of his favorite shows on Comedy Central. Christine McSherry of Pembroke, Jett’s mother, is determined to make sure her son can enjoy these lighthearted moments for years to come. Christine and her husband, Stephen, started the Jett Foundation in 2001 after Jett was diagnosed with Duchenne muscular dystrophy (DMD), a common and lethal genetic disorder. DMD, for which there is no known cure, progressively destroys a person’s muscle tissue. It affects one in every 3,500 males. Most children with the disease are confined to a wheelchair by age 12 and don’t live past their late teens. Christine has her own page in the new book “Boston, Inspirational Women,” which highlights some of the Bay State’s most recognizable and influential women. McSherry sees this as another networking tool to raise the Jett Foundation’s profile. “This is a vehicle to save my son’s life, so I’m pulling out all the stops,” said McSherry, who has helped raise more than $2 million to fund DMD research and increase awareness of the disease. The foundation helped … Continue reading

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Autism Is Jim Calhoun's Biggest Opponent

Posted: Published on February 25th, 2012

Jim Calhoun, like many coaches, is superstitious. He might have a lucky tie or piece of jewelry he must wear to end a losing streak, or keep a winning streak going. But one item that remains in good times and bad is the blue puzzle piece he wears on the lapel of his suit jacket. The symbol for Autism Speaks, like the cause itself, remains close to his heart at all times. "He has never taken it off," Jeff Calhoun said. "I can't tell you how many people who have mentioned it to me — parents, families touched by autism, who tell me how much it means to them. He is very passionate about it. Just by lending his name and reaching out to people, he has done more than we could ever ask." Said Amy Calhoun: "When I see that blue pin on his lapel, it sometimes brings tears to my eyes. He is taking this on for Reese." The cause is a personal one for the Calhoun family. Jeff and Amy's daughter, Reese, now 8, was diagnosed at 2, and her grandfather's involvement with the advocacy group Autism Speaks is very deep. But because he is scheduled to … Continue reading

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Training parents is good medicine for children with autism behavior problems

Posted: Published on February 25th, 2012

Public release date: 24-Feb-2012 [ | E-mail | Share ] Contact: Karen N. Peart karen.peart@yale.edu 203-432-1326 Yale University Children with autism spectrum disorders who also have serious behavioral problems responded better to medication combined with training for their parents than to treatment with medication alone, Yale researchers and their colleagues report in the February issue of Journal of the American Academy of Child & Adolescent Psychiatry. "Serious behavioral problems interfere with everyday living for children and their families," said senior author on the study Lawrence Scahill, professor at Yale University School of Nursing and the Child Study Center. "Decreasing these serious behavioral problems results in children who are more able to manage everyday living." Scahill and his team completed a federally funded multi-site trial on 124 children ages 4 to 13 with autism spectrum disorders at three U.S. sites including Yale, Ohio State University, and Indiana University. In addition to autism spectrum disorders, children in the study had serious behavioral problems, including multiple and prolonged tantrums, aggression, and/or self-injurious behavior on a daily basis. The children in the study were randomly assigned to medication alone for six months or medication plus a structured training program for their parents for six … Continue reading

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Meds for Autism Not Well Understood: Study

Posted: Published on February 25th, 2012

THURSDAY, Feb. 23 (HealthDay News) -- Children with autism may benefit from medications to treat children with attention-deficit hyperactivity disorder (ADHD) and other related disorders, but clearer guidelines are needed, a new study shows. Researchers analyzed data from more than 1,000 U.S. teens enrolled in special education programs, to assess the use of psychiatric medications in those with autism, ADHD and both conditions. Patients with both autism and ADHD had the highest rates of medicine use (about 58 percent), followed by those with ADHD only (around 49 percent) and those with autism only (about 34 percent), according to study author Paul Shattuck, an assistant professor at Washington University in St. Louis, and colleagues. Black teenagers with autism only or with autism and ADHD were less likely to receive medications than whites. "Observations from the present study reinforce the complexity of pharmacologic treatment of challenging behavior in kids with [autism spectrum disorders] and ADHD," Shattuck said in a university news release. "There needs to be a clearer guide for treating kids with both an [autism spectrum disorder] and ADHD." He noted that drug treatment for autism reflects a trial-and-error approach based on associated symptoms, and there is a poor understanding of … Continue reading

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4 things to know about stroke

Posted: Published on February 25th, 2012

1. Don’t wait. Holland Hospital Dr. Sandip Kothari said the biggest problem with stroke is getting people to the hospital right away. “As soon as they notice some of the symptoms, they need to go to the emergency room. Don’t sleep on it, don’t call your third cousin who is a nurse,” he said. When it comes to chest pain and heart attacks, Kothari said people are trained to go right to the emergency room, so the American Heart Association piggy-backed off that same sense of urgency by referring to strokes as brain attacks. Liz Dirkse, a West Olive resident, suffered a stroke last March. She said she found herself flapping her arms to get her husband’s attention and alert him that something was wrong because she couldn’t speak. “Everything was right on the tip of my tongue, but my brain couldn’t tell my mouth what to do. It seemed that my brain had lost the connection to the rest of my body.” 2. Know the symptoms. Before her stroke, Dirkse knew symptoms varied from patient to patient, and her sudden inability to talk and walk tipped her off to what was happening. Kothari said the major symptoms to be … Continue reading

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Professor links body chemical to spinal cord injuries

Posted: Published on February 25th, 2012

Purdue researchers have discovered that a certain chemical in the body is the reason behind the worst parts of spinal cord injuries. Riyi Shi, professor of neuroscience and biomedical engineering, said spinal cord injuries of all kinds are made worse after the initial injury by a compound in the body. “The physical injury happens instantaneously, “ said Shi. “Secondary injury is mostly chemical based.” The compound that does all this damage has been dubbed “acrolein,” according to Shi. “We found out in most spinal cord injuries, this compound increases the injury by five or six times,” he said. Shi explained that acrolein increases the production of free radicals. A free radical is an atom that first loses an electron. The atom then tries to acquire another electron, stealing one from another atom. The atom that has an electron stolen also becomes a free radical. If this cycle goes unchecked, it can cause severe tissue damage as many atoms and molecules are destabilized and destroyed. “People first tried to treat spinal cord injury through removing free radicals,” Shi said, “but the acrolein just makes more of them.” Shi explained the reason for the body’s production of acrolein is unknown. “All we … Continue reading

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FDA Advisory Panel Recommends Approval of Chelsea's NORTHER(TM) (droxidopa) for the Treatment of Symptomatic …

Posted: Published on February 25th, 2012

CHARLOTTE, N.C., Feb. 23, 2012 (GLOBE NEWSWIRE) -- Chelsea Therapeutics International, Ltd. (Nasdaq:CHTP - News) today announced that the Food and Drug Administration's (FDA) Cardiovascular and Renal Drugs Advisory Committee (CRDAC) voted 7-4 with 1 abstention and 1 non-vote to recommend approval of NORTHERA(TM) (droxidopa) for the treatment of symptomatic neurogenic orthostatic hypotension (also known as Neurogenic OH or NOH) in patients with primary autonomic failure (Parkinson's disease, multiple system atrophy and pure autonomic failure), dopamine beta hydroxylase deficiency and non-diabetic autonomic neuropathy. "Chelsea is committed to improving the lives of patients with Neurogenic OH," commented Dr. Simon Pedder, president and CEO of Chelsea Therapeutics. "We believe our clinical data demonstrates the significant symptomatic benefit of Northera treatment across a broad range of Neurogenic OH symptoms. Since no other treatment has been proven to alleviate the symptoms of neurogenic OH or improve patients' ability to carry out activities of daily living, we continue to believe Northera could fill this unmet need for patients with Parkinson's disease, MSA, PAF and other neurologic diseases. We are pleased by today's panel vote and we look forward to continuing to work with the FDA in advance of the March 28, 2012 PDUFA action date." … Continue reading

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