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A breakthrough in understanding the biology and treatment of ovarian cancer

Posted: Published on February 22nd, 2012

Public release date: 21-Feb-2012 [ | E-mail | Share ] Contact: Dr. Ian Zagon isz1@psu.edu Society for Experimental Biology and Medicine Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered that the presence and integrity of the opioid growth factor receptor (OGFr), which mediates the inhibitory action of opioid growth factor (OGF) on cell proliferation, is a key to understanding the progression and treatment of human ovarian cancer. Transplantation of human ovarian cancer cells that were molecularly engineered to have a reduced expression of OGFr, into immunocompromised mice resulted in ovarian tumors that grew rapidly. This discovery, reported in the February 2012 issue of Experimental Biology and Medicine, provides fresh new insights into the pathogenesis and therapy of a lethal cancer that is the fifth leading cause of cancer-related mortality among women in the USA, and has a death rate that is unchanged for over 75 years. The OGF (also-termed [Met5]-enkephalin)-OGFr axis plays a fundamental role in cancer, development, and cellular renewal by regulating cell proliferation. An important question addressed in this study relates to the requirement of this peptide-receptor system for the progression of carcinogenesis. Human ovarian cancer cell lines that were genetically modified to … Continue reading

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Letters to the Editor Feb. 18, 2012

Posted: Published on February 22nd, 2012

Widely prescribed drug for dogs has potentially lethal side-effect We all know that the big drug companies are not always truly honest with us regarding the potential side effects of their medications, and this is true for medications for dogs also. There is one drug for arthritis in dogs, Rimadyl, that is being widely prescribed in Crescent City. But what you are not being told is that one potential side-effect could be the death of your dog. I’ve done a lot of research on this drug and I will not give it to my dog. I’d like to offer for all who might be interested some links that are providing information about the risks of using Rimadyl. There are  thepetguardian.com/html/kpho_phoenix_-_dog_drug_may_be.html  and srdogs.com/ Pages/rimadylfr.html (this site also included a link on the side panel that shares the stories of some horrible deaths of dogs that may have resulted from Rimadyl. Very difficult to read for any dog lover.) Another is pets.groups.yahoo.com/group/ doghealth2/ (a yahoo group of over 1,400 dog lovers.) If you’d like more information, please feel free to e-mail me at This e-mail address is being protected from spam bots, you need JavaScript enabled to view it Leah L. Ward … Continue reading

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Drugs hope for memory improvement

Posted: Published on February 22nd, 2012

Drugs that improve connections between nerve cells in the brain may be able to improve people's memory and help understand disorders such as Alzheimer's disease, scientists have revealed. A new study, published in the journal PLoS Biology, found that when a protein used to strengthen synapses in the brain was given to rats, it improved their ability to learn and retain information. The study, led by doctors Jose A Esteban, Shira Knafo and Cesar Venero, is the result of collaboration between researchers at The Centro de Biologia Molecular Severo Ochoa at the Universidad Nacional de Educacion a Distancia (UNED) in Spain; the Brain Mind Institute at the Ecole polytechnique federale de Lausanne (EPFL) in Switzerland; and the Department of Neuroscience and Pharmacology at the Faculty of Health Sciences in Denmark. They looked at the connections, or synapses, which control cognitive function, and the way they change in strength and properties - known as synaptic plasticity. Alterations in synaptic plasticity, suggested to be the cellular basis for learning and memory, are thought to be responsible for multiple cognitive deficits such as autism and Alzheimer's disease. The new study looked at how synaptic plasticity can be manipulated to improve cognitive performance. Scientists … Continue reading

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FDA Slows Shortages of Two Cancer Drugs

Posted: Published on February 22nd, 2012

The Food and Drug Administration, along with private manufacturers, announced efforts on Tuesday that they say will stave off shortages for two cancer drugs. The FDA sped up approval of a new formulation of methotrexate, a drug used to treat children’s cancer, made by  APP Pharmaceutical. It said another company that makes the drug, Hospira, had pushed out extra doses to address the ongoing shortage. The FDA also said it would temporarily allow imports of an Indian-made drug called Lipodox, which is not yet approved in the United States but can be used as a substitute to cover shortages of the cancer drug Doxil. “Temporary importation of unapproved foreign drugs is considered in rare cases when there is a shortage of an approved drug that is critical to patients and the shortage cannot be resolved in a timely fashion with FDA-approved drugs,” the FDA said in a statement. “We must aggressively address the often life-threatening challenge of drug shortages,” FDA Commissioner Margaret Hamburg said at a news conference. “The FDA has been actively and aggressively working with industry … to ensure treatment and therapies get into the hand of those who need them, when they need them.” In an unusually coordinated … Continue reading

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FDA adds 2 makers of cancer drugs

Posted: Published on February 22nd, 2012

TRENTON, N.J. -- Federal regulators have approved new suppliers for two crucial cancer drugs, easing critical shortages that had been ratcheting up fears that patients, particularly children with leukemia, would miss lifesaving treatments. But there are currently 283 separate prescription drugs in short supply or unavailable nationwide, and regulators and manufacturers say shortages are a long-term problem that will continue to give patients and doctors nightmares. On Tuesday, the Food and Drug Administration said it will temporarily allow importation of a replacement drug for Doxil, a drug for recurrent ovarian or bone marrow cancer. The Johnson & Johnson drug hasn't been available for new patients for months because J&J's contract manufacturer had to shut down production over serious quality lapses. The FDA also has approved a new supplier for a preservative-free version of methotrexate, a crucial drug for children with a type of leukemia called ALL, for lymphomas and for the bone cancer osteosarcoma. The version with preservatives, the one that's been scarce, can be toxic or cause paralysis in children and other patients getting the drug either by injections into spinal cord fluid or at very high doses. The FDA also has approved the release of a batch manufactured … Continue reading

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The Philippine Society Of Hospital Pharmacists' 50th Anniversary And Annual Convention At The Historic Landmark Manila …

Posted: Published on February 22nd, 2012

MANILA, Philippines - Hospital pharmacy forms an integral part of patient health care. Over the years, the profession has endeavored to maintain and improve the medication management and pharmaceutical care of patients at the highest standards in a hospital setting. From just compounding and dispensing of medications, hospital pharmacists have evolved into be patient-focused professionals collaborating with doctors, nurses, and other allied health workers. They are now providing medication counseling, ensuring medication safety, promoting appropriate use of medications, monitoring adverse drug reactions, and reconciling patient medication orders and history. These new roles pose a challenge to the pharmacists of today who need continuous learning, training and education, and networking. The Philippine Society of Hospital Pharmacists (PSHP) is a nationwide organization of hospital pharmacists with the mission to promote safe and effective use of medication by enhancing the competence of its members and by collaborating with other healthcare professionals and allied organizations to improve the health and wellbeing of patients. In the last 50 years, the PSHP has been involved in supporting and providing the needs of hospital pharmacists through training and education, outreach programs, and giving scholarship grants. The PSHP developed a comprehensive Clinical Pharmacy Training Program in cooperation with … Continue reading

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Footsteps fail to keep pace with Pharmacy

Posted: Published on February 22nd, 2012

EAST Griffith Pharmacy has stormed through to the Griffith women’s division one touch football final, after a clinical display against Footsteps Podiatry on Monday night. Try as they might, Footsteps were unable to penetrate Pharmacy’s defence which repelled many attacking waves as they went about setting up an unassailable lead. With a storm before the start of play, the handling by both sides was above what could be expected with Madeline Lyons looking dangerous with ball in hand early for Pharmacy. Lyons was the first to put her side on the board when she made the most of a gap close to the ruck, to scoot away from the incoming defence. Turnovers in both team’s half began to creep into the game, but Pharmacy made the most of its attacking opportunities, doubling its lead. The lead crept out to three when Eliza Baddock sold a good dummy-pass before finding Sarah Mannell for the touchdown, with the girls in pink taking the three-try lead into the break. Footsteps needed to be the first to score after the resumption if they were to have a chance of climbing back into the game, but it was the front-runners that extended the lead as … Continue reading

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CVS Pharmacy: prescription for contaminated site

Posted: Published on February 22nd, 2012

Read more: Local, Economy, Business, Community, Environment, New CVS Pharmacy on the Corner of Front Street and Division in Traverse City, CVS Pharmacy, Front Street and Division Street, Traverse City Commissioners, Traverse City Commission, Jim Carruthers Traverse City Commission, CVS Zoning Change Approved TRAVERSE CITY -- Plans for a new CVS Pharmacy on the corner of Front Street and Division in Traverse City were given the go ahead Tuesday night by City Commissioners. Commissioners voted to change the area from a C-2 zone to a C-3, making the area a Community Center District, which allows the pharmacy to include a drive-thru window, driveway, and parking lot. The site has been vacant for nearly 20 years and is considered one of the most contaminated areas in Traverse City. Commissioners hope this new development will provide the clean-up, that is long overdue. Traverse City Commissioner Jim Carruthers says,"it's an ugly spot.. it looks bad. This is kind of the gateway to our town, this is one of the larger traffic corridors of the city. There's been a concerned with how it looks, so a tax capture will help kick-in some clean up dollars, environmental clean up dollars, that could be considered a positive." Commissioners say … Continue reading

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Sebastopol council rejects CVS Pharmacy design

Posted: Published on February 22nd, 2012

Published: Tuesday, February 21, 2012 at 3:00 a.m. Last Modified: Tuesday, February 21, 2012 at 10:57 p.m. The Sebastopol City Council reaffirmed its denial of the proposed CVS Pharmacy project Tuesday night, finding the project was out of sync with the city’s Main Street character. The council adopted a series of suggestions for design changes, should the developer decide to continue with the project. It recommended a litany of changes, including solar, larger windows and less parking. In a 3-2 vote, the council upheld the Design Review Board ruling against the design by the developer, Armstrong Development of Sacramento, which could send the project back to the drawing board. “I hope you take this back to the Design Review,” said Councilwoman Kathleen Shaffer. “I think you will be treated fairly and some resolution can be reached.” Shaffer, a supporter of the CVS project, and Councilman Patrick Slayter were the two votes on Armstrong’s behalf. Mayor Guy Wilson, Vice Mayor Mike Kyes and Councilwoman Sarah Gurney voted to uphold the Design Review Board. Bill McDermott, vice president for Armstrong, said he will take the council’s action and suggestions back to CVS before a decision is made whether to continue with the … Continue reading

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Adult Stem Cell Treatments for COPD – Real patient results, USA Stem Cells – Marian H. Testimonial – Video

Posted: Published on February 21st, 2012

20-12-2011 08:50 If you would like more information please call us Toll Free at 877-578-7908. Or visit our website at http://www.usastemcells.com Or click here to have a Free Phone Constultation with Dr. Matthew Burks usastemcells.com Real patient testimonials for USA Stem Cells. Adult stem cell therapy for COPD, Emphysema, and Pulmonary fibrosis. Continued here: Adult Stem Cell Treatments for COPD - Real patient results, USA Stem Cells - Marian H. Testimonial - Video … Continue reading

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