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Stem cells a fix for 'broken hearts'?

Posted: Published on February 15th, 2012

When a piece of muscle in a person’s heart dies from lack of blood flow, it scars over and is lost.  But a team of researchers from the Cedars-Sinai Heart Institute in Los Angeles has proven that those muscles may not necessarily be gone forever. In a ground-breaking study that may change how heart attacks are treated, Dr. Eduardo Marban and his team used stem cells to re-grow damaged heart muscle.  In the 17 patients who received the therapy, Marban measured an average 50 percent reduction in the size of the scar tissue “One of the holy grails in medicine has been the use of medicine to achieve regeneration,” Marban said.  “Patients that were treated not only experienced shrinkage of their scars, but also new growth of their heart muscle, which is very exciting.” The stem cells were not derived from embryos, but instead were developed from the patients’ own hearts.  Marban’s team inserted a catheter into the diseased hearts and took a small biopsy of muscle.  In the laboratory, the tissue was manipulated into producing stem cells.  After a few weeks of marinating in culture, researchers had enough stem cells to re-inject them into the patients’ hearts.  Over the … Continue reading →

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Stem Cells Regrow Healthy Heart Muscle In Heart Attack Patients

Posted: Published on February 15th, 2012

Stem cells are proving themselves beneficial once again after scientists used the controversial building blocks to resurrect dead, scarred heart muscle damaged by recent heart attack. Results from a Cedars-Sinai Heart Institute clinical trial show that treating heart attack patients with an infusion of their own heart-derived cells helps damaged hearts re-grow healthy heart muscle. Reporting in The Lancet medical journal, the researchers said this is the clearest evidence yet that broken hearts can heal. All that is needed is a little help from one’s own heart stem cells. “We have been trying as doctors for centuries to find a treatment that actually reverses heart injury,” Eduardo Marban, MD, PhD, and lead author of the study, told WebMD. “That is what we seem to have been able to achieve in this small number of patients. If so, this could change the nature of medicine. We could go to the root of disease and cure it instead of just work around it.” Marban invented the “cardiosphere” culture technique used to create the stem cells and founded the company developing the treatment. “These findings suggest that this therapeutic approach is feasible and has the potential to provide a treatment strategy for cardiac … Continue reading →

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Scarred Hearts Can Be Mended With Stem Cell Therapy

Posted: Published on February 15th, 2012

February 15, 2012, 12:06 AM EST By Ryan Flinn (Adds comment from researcher in 13th paragraph.) Feb. 14 (Bloomberg) -- Stem cells grown from patients’ own cardiac tissue can heal damage once thought to be permanent after a heart attack, according to a study that suggests the experimental approach may one day help stave off heart failure. In a trial of 25 heart-attack patients, 17 who got the stem cell treatment showed a 50 percent reduction in cardiac scar tissue compared with no improvement for the eight who received standard care. The results, from the first of three sets of clinical trials generally needed for regulatory approval, were published today in the medical journal Lancet. “The findings in this paper are encouraging,” Deepak Srivastava, director of the San Francisco-based Gladstone Institute of Cardiovascular Disease, said in an interview. “There’s a dire need for new therapies for people with heart failure, it’s still the No. 1 cause of death in men and women.” The study, by researchers from Cedars-Sinai Heart Institute in Los Angeles and Johns Hopkins University in Baltimore, tested the approach in patients who recently suffered a heart attack, with the goal that repairing the damage might help stave … Continue reading →

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Stem cell treatments improve heart function after heart attack

Posted: Published on February 15th, 2012

Public release date: 14-Feb-2012 [ | E-mail | Share ] Contact: Jennifer Beal healthnews@wiley.com 44-124-377-0633 Wiley-Blackwell Stem cell therapy moderately improves heart function after a heart attack, according to a systematic review published in The Cochrane Library. But the researchers behind the review say larger clinical trials are needed to establish whether this benefit translates to a longer life. In a heart attack, the blood supply to parts of the heart is cut off by a blocked artery, causing damage to the heart tissue. The cells in the affected area start to die. This is called necrosis and in the days and weeks that follow, the necrotic area may grow, eventually leaving a large part of the heart unable to contract and increasing the risk of further heart problems. Stem cell therapy uses cells from the patient's own bone marrow to try to repair and reduce this damage. Currently, the treatment is only available in facilities with links to scientific research. The authors of the review drew together all the available evidence to ask whether adult bone marrow stem cells can effectively prevent and repair the damage caused by a heart attack. In 2008, a Cochrane review of 13 stem … Continue reading →

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Bone gives ‘some’ heart healing

Posted: Published on February 15th, 2012

14 February 2012 Last updated at 19:10 ET By James Gallagher Health and science reporter, BBC News Bone marrow stem cell therapy offers "moderate improvement" to heart attack patients, according to a large UK review of clinical trials. The analysis by the Cochrane Collaboration looked at 33 trials involving more than 1,700 patients. It said longer-term studies were needed to see if the experimental therapy affected life expectancy. The review comes a day after doctors reported the first case of using heart cells to heal heart attack damage. If a patient survives a heart attack, dead heart muscle is replaced with scar tissue - leaving the patient weaker and possibly on a lifetime of medicine. Researchers are beginning to show that taking cells from a heart, growing millions of new heart cells in the laboratory and pumping those back into the heart may reduce scar tissue and lead to new heart muscle. Continue reading the main story “Start Quote Stem cell therapy may also reduce the number of patients who later die or suffer from heart failure, but currently there is a lack of statistically significant evidence based on the small number of patients treated so far” End Quote Dr … Continue reading →

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Bone gives 'some' heart healing

Posted: Published on February 15th, 2012

14 February 2012 Last updated at 19:10 ET By James Gallagher Health and science reporter, BBC News Bone marrow stem cell therapy offers "moderate improvement" to heart attack patients, according to a large UK review of clinical trials. The analysis by the Cochrane Collaboration looked at 33 trials involving more than 1,700 patients. It said longer-term studies were needed to see if the experimental therapy affected life expectancy. The review comes a day after doctors reported the first case of using heart cells to heal heart attack damage. If a patient survives a heart attack, dead heart muscle is replaced with scar tissue - leaving the patient weaker and possibly on a lifetime of medicine. Researchers are beginning to show that taking cells from a heart, growing millions of new heart cells in the laboratory and pumping those back into the heart may reduce scar tissue and lead to new heart muscle. Continue reading the main story “Start Quote Stem cell therapy may also reduce the number of patients who later die or suffer from heart failure, but currently there is a lack of statistically significant evidence based on the small number of patients treated so far” End Quote Dr … Continue reading →

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Stem cell treatments improve heart function after heart attack

Posted: Published on February 15th, 2012

Public release date: 14-Feb-2012 [ | E-mail | Share ] Contact: Jennifer Beal healthnews@wiley.com 44-124-377-0633 Wiley-Blackwell Stem cell therapy moderately improves heart function after a heart attack, according to a systematic review published in The Cochrane Library. But the researchers behind the review say larger clinical trials are needed to establish whether this benefit translates to a longer life. In a heart attack, the blood supply to parts of the heart is cut off by a blocked artery, causing damage to the heart tissue. The cells in the affected area start to die. This is called necrosis and in the days and weeks that follow, the necrotic area may grow, eventually leaving a large part of the heart unable to contract and increasing the risk of further heart problems. Stem cell therapy uses cells from the patient's own bone marrow to try to repair and reduce this damage. Currently, the treatment is only available in facilities with links to scientific research. The authors of the review drew together all the available evidence to ask whether adult bone marrow stem cells can effectively prevent and repair the damage caused by a heart attack. In 2008, a Cochrane review of 13 stem … Continue reading →

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IMF prescriptions not relevant now? | Business Recorder

Posted: Published on February 15th, 2012

February 09, 2012 BR RESEARCH Wake up! Two words that sum up the Article IV review for Pakistan by the IMF. Just before repayment starts, the fund in an unprecedented tone has told the countrys economic managers to take pervasive actions, before it is too late. The point is simple; monetary and fiscal policies are not in sync with economic realities and in election year, the reality can get harsher, very quickly. The pointy references allude to the extent of pressure that the Fund may exercise on the countrys economic policies, should the depleting levels of foreign reserves take Pakistan back to the lenders window. The Funds tone betrays urgency. Over the past four months, not only has the central bank slashed the discount rate by 150 basis points, despite slippage in foreign reserves and structural imbalances, but also it has been active in the foreign exchange market shouldering the local currency against depreciation. SBPs consistent facilitation of the banking sector to continue lending to the government has also caught the attention of the IMF. Still there are many who plausibly contend that the prescription of the Fund should be set aside in favour of lower interest rates to boost … Continue reading →

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Kate's first solo visit

Posted: Published on February 15th, 2012

Rangers' administration Rangers Football Club has appointed an administrator after a court petition was lodged by HM Revenue and Customs (HMRC) to… Spiralling car insurance Action will be taken to reduce the £2 billion-a-year cost of insurance claims for whiplash to help deal with the UK's "compe… UK in Jordan over Qatada The Home Office minister James Brokenshire is in Jordan discussing the potential deportation of the radical cleric Abu… Syria's Zabadani battle Middle East Correspondent John Ray has just returned from Syria where he found rebels trapped under an assault from governme… Tevez returns The Manchester City striker Carlos Tevez flew back from his three months unauthorised leave with his family in Argentina.Fro… Bombings alarm Israel A bungled bombing in the Thai capital Bangkok that maimed the terrorist but killed no one has nevertheless alarmed Israel.It… Religion "marginalised"? In amongst the domes and spires of the Vatican, a British government minister has warned of the dangers of religion being… Lawrence witness review ITV News has learnt that the police are considering launching an investigation into alleged perjury by witnesses during the… Chainsaw attacker jailed CCTV footage has been released that shows the moment a man entered a Hull pub … Continue reading →

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The New War Against Synthetic Drugs

Posted: Published on February 15th, 2012

by Scott Arnold NASHVILLE, Tenn.- State lawmakers have called synthetic drugs a deadly epidemic. There's now a number of new pushes at the Capitol to get the dangerous drugs off the streets. While the drugs sold in convenience stores as potpourri, herbal incense, or bath salts sound harmless, many Tennesseeans have died using these products "There have been instances in which these synthetic drugs have triggered severe mental reactions which have resulted in hospitalization," said Nashville State Representative Mike Stewart State lawmakers have been getting an earful about the issue. A 7th grade class recently told State Rep Tony Shipley they even knew kids who had used Synthetic Drugs. "Then I asked them, I said how many of you all had taken some, no hands went up, but half of the heads went down, body language said that 50% of our 7th graders are messing with something that can kill them," Shipley told us. In response lawmakers have filed a number of bills designed to stop these drugs from being sold. Representative Shipley's bill makes it a felony to sell synthetic drugs. Representative Stewart's legislation would allow you to sue the store owner. There are other measures that would suspend … Continue reading →

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