Protective Effect of Asacol in Combination with Pantoprazole in Ulcera | CEG – Dove Medical Press

Homayoon Bashiri,1,2 Arezoo Bozorgomid1

1Infectious Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Department of Internal Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

Correspondence: Arezoo Bozorgomid Infectious Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran Tel +989188728269 Email Arezoobozorgomid@yahoo.com

Purpose: Mesalazine formulations are the drug of choice in the treatment of ulcerative colitis (UC). They are released at alkaline pH in order to deliver 5-aminosalicylic acid to the colon. The colonic pH is significantly lower in UC patients than in normal patients. This study was conducted for the first time to evaluate the clinical efficacy of co-administration of pantoprazole and Asacol in the treatment of ulcerative colitis patients who excrete intact Asacol tablets in the feces. Patients and Methods: Thirty patients with mild-to-moderate active ulcerative colitis who reported passing intact Asacol tablets in stools received oral Asacol plus pantoprazole for 2 weeks. The demographic characteristics of the patients and the body mass index were collected through interviews. For each patient, the stool frequency, visible blood, and presence of intact Asacol tablets in the stool were compared before and pantoprazole treatment. Results: There was a significant difference in the stool frequency (number of daily stools) before and after pantoprazole treatment (mean sd, 6.06 1.04 vs 1.5 0.5; P< 0.001). In addition, pantoprazole administration statistically reduced visible blood in the stool (100%; P< 0.001). Co-administration of pantoprazole and Asacol was effective in all age groups and both sexes. None of the patients reported the presence of intact Asacol tablets in their stools. Conclusions: Co-administration of pantoprazole and Asacol would be useful for symptom management UC patients that excrete intact Asacol tablets in their feces through increasing the gastric pH and releasing the maximum concentration of the drug in the proximal gastrointestinal tract.

Keywords: Asacol, pantoprazole, treatment, ulcerative colitis, pH

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Go here to see the original:
Protective Effect of Asacol in Combination with Pantoprazole in Ulcera | CEG - Dove Medical Press