UCLA scientists report the first evidence that a gene outside the brain controls the ability to rebound from sleep deprivation a surprising discovery that could eventually lead to greatly improved treatments for insomnia and other sleep disorders that do not involve getting a drug into the brain.
The scientists report that increasing the level of Bmal1 a critical master gene that regulates sleep patterns in skeletal muscle makes mice resistant to sleep deprivation.
When we first saw the importance of the muscle, we were surprised, said senior author Ketema Paul, UCLA associate professor of integrative biology and physiology. At first we didnt believe it, so we repeated the experiment several times. We finally realized this is not a mistake; this is real.
The research,published in the journal eLife, is the first evidence that a biological clock in the muscle can communicate with the brain, and is potentially good news for people who lose sleep because of factors including a crying newborn or a job that does not allow for normal sleep cycles, such as active military service.
Chronic sleep deprivation increases the risk for heart disease, stroke, diabetes, infectious diseases and other illnesses, said Paul, a neurobiologist and member of UCLAs Brain Research Institute. Having a resistance to sleep loss may reduce the risk of getting these diseases, Paul said, and his team reports evidence that increased Bmal1 in the skeletal muscle may provide this resistance.
Turning Bmal1 off throughout the brain and body in mice, using a molecular genetic technique, impaired their ability to rebound from sleep deprivation, the researchers report. Restoring the gene in the skeletal muscle enabled the mice to rebound from the sleep deficit, while restoring the gene in the brain, surprisingly, did not. Increasing the level of this gene in skeletal muscle also made mice less sleepy after longer periods of sleep deprivation. The researchers increased the level by genetically inserting extra copiesof the gene into the genome of the mice.
We show that not only is Bmal1 responsible for the ability to recover from sleep loss, but also that Bmal1 expression in the skeletal muscle is responsible for that process, Paul said. When we increased Bmal1 in the skeletal muscle, the mice were able to tolerate more sleep loss. That suggests the skeletal muscle is directly communicating with the brain.
In one part of the study, the researchers kept mice awake for almost 24 consecutive hours. The researchers measured the brain activity of the mice with an electroencephalogram and found that the brain activity revealed the mice with the additional Bmal1 in skeletal muscle about six times the normal amount were much less sleepy than the mice without additional Bmal1. The mice with increased Bmal1 slept substantially less than the other mice during the 24 hours following the sleep deprivation.
The researchers removed Bmal1 in the skeletal muscle by molecularly excising the gene from the mouse genome, and they found that the removal impaired the mices ability to recover from sleep loss; these mice were sleepier.
The researchers, who worked for more than three years on this series of studies, did not see any negative consequences of increasing Bmal1 in the muscle.
Why are sleep researchers just now discovering the importance of Bmal1 in the skeletal muscle, a gene that is also in humans?
I think one of the reasons weve missed this is because we spent so much time looking in the brain, Paul said.
Bmal1 is a master gene that turns other genes on and off, he said. Perhaps in the future, Paul said, scientists will produce a pill that increases the level of Bmal1 in the muscle, or even better, increases the level of the specific gene that is communicating with the brains master circadian clock. We have a few candidates that were studying, he said.
In future research, Paul wants to learn how the skeletal muscle communicates with the brain, and hopes to identify which gene downstream Bmal1 is affecting.
Co-authors are J. Christopher Ehlen, associate professor at Morehouse School of Medicine in Atlanta; Allison Brager, a scientific officer at Walter Reed Army Institute of Research who conducted the research as a postdoctoral scholar at Morehouse School of Medicine; Julie Baggs, a former research assistant at Morehouse School; Lennisha Pinckney, a former research technician at Morehouse; Cloe Gray, a postdoctoral scholar at Morehouse; Jason DeBruyne, an assistant professor at Morehouse; Karyn Esser, a professor of physiology and functional genomics at the University of Florida, Gainesville; and Joseph Takahashi, chairman of neuroscience at University of Texas Southwestern Medical Center and a Howard Hughes Medical Institute investigator. Paul led the research when he was on the neurobiology faculty at Morehouse School of Medicine.
Pauls research is funded by the National Institutes of Healths National Institute of Neurological Disorders and Stroke; and National Heart, Lung and Blood Institute (grantsR01 NS078410, U54 NS060659, P50 HL117929 and U54 NS083932).
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