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Category Archives: Myocardial Infarction

Development and Validation of a Risk Assessment Model for Venous Thromboembolism in Patients With Invasive Mechanical Ventilation – Cureus

Posted: Published on July 24th, 2022

Background Patients with invasive mechanical ventilation may be at high risk of acquiring venous thromboembolism (VTE). Continue reading

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Comparisons of invasive versus conservative management in chronic kidney disease in the ISCHEMIA-CKD trials – 2 Minute Medicine

Posted: Published on July 8th, 2022

1. Following invasive or conservative management of chronic coronary disease, patients with chronic kidney disease (CKD) stage 5 were found to have a significantly higher 3-year cumulative incidence of death and nonfatal myocardial infarction than patients with CKD stage 1. 2. Continue reading

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Elevated Residual Cholesterol Changes the Risk of Ischemic Heart Disease and Myocardial Infarction – Physician’s Weekly

Posted: Published on July 8th, 2022

For a study, researchers came up with the idea that reclassifying people who subsequently suffer from myocardial infarction and ischemic heart disease would be reasonable, given the inclusion of high residual cholesterol. They monitored 41,928 white Danish people from the Copenhagen General Population Study for more than ten years who had no prior history of ischemic cardiovascular disease, diabetes, or statin usage. Continue reading

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Time to Lay the ‘Widow-Maker’ to Rest – Medscape

Posted: Published on July 8th, 2022

In 1980, while studying coronary anatomy in medical school, I learned that a heart attack involving the left anterior descending artery was nicknamed the "widow-maker." I thought this was a clever term because it emphasized the importance of this artery, the occlusion of which carries a high risk for death. Continue reading

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Hospitalization Outcomes Related to Acute Kidney Injury in Inpatients With Acute Myocardial Infarction: A Cross-Sectional Nationwide Study – Cureus

Posted: Published on July 8th, 2022

Objective To delineate the differences in demographic characteristics and hospitalization outcomes in patients with acute myocardial infarction by comorbid acute kidney injury (AKI) and to explore the risk factors for in-hospital mortality due to AKI in acute myocardial infarction (AMI) inpatients. Continue reading

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The NLRP3 Inflammasome as a Novel Therapeutic Target for Cardiac Fibro | JIR – Dove Medical Press

Posted: Published on July 8th, 2022

Introduction Cardiac fibrosis is a common pathological feature of several cardiovascular diseases, leading to increased stiffness of the ventricular wall and impaired cardiac function.13 Inflammation is a crucial factor in cardiac fibrosis.4 Ischemia, hypoxia, and metabolic changes resulting from multiple causes lead to the infiltration of inflammatory cells and elevated levels of pro-inflammatory cytokines and chemokines.4,5 Interactions with damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns(PAMPs) can lead to activation and oligomerization of NLRP3 followed by recruitment of the apoptotic speck protein containing a caspase recruitment domain (ASC) and pro-caspase-1.6,7 The activated caspase-1 subsequently cleaves pro-IL-1 and pro-IL-18 to yield mature IL-1 and IL-18. In addition, caspase-1 triggers pyroptosis by cleaving Gasdermin D (GSDMD), resulting in the binding of the GSDMD N-terminal domain to phospholipids in the cell membrane, forming a GSDMD pore.8,9 NLRP3 is an important mediator of both autoimmunity and myocardial fibrosis.1012 Therefore, elucidating the mechanism by which the NLRP3 inflammasome influences cardiac fibrosis and summarizing potential treatments for targeting the inflammasome may suggest promising therapeutic strategies for the prevention and treatment of cardiac fibrosis. The inflammatory response is a normal physiological activity of the body in response to the invasion of external pathogenic microorganisms.13 The inflammasome plays a key r role in the inflammatory response.14,15 Five primary inflammasomes are currently known; these include the NLRP1, NLRP3, NLRC4, IPAF, and AIM2 inflammasomes Continue reading

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Cardiovascular Outcomes Following Noncardiac Surgery and Preoperative Atrial Fibrillation – Physician’s Weekly

Posted: Published on July 8th, 2022

In a nationwide cohort, researchers wanted to see how AF affected the risk of adverse outcomes after noncardiac surgery. From 2015 to 2019, they identified Medicare members hospitalized for noncardiac surgery and separated the study cohort into two groups: those with and without AF. Noncardiac surgery was divided into the following categories: vascular, thoracic, general, genitourinary, gynecological, orthopedics and neurosurgery, breast, head and neck, and transplant Continue reading

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Side Effects of "Way Too High Cholesterol" Eat This Not That – Eat This, Not That

Posted: Published on July 8th, 2022

We need cholesterol for our overall health, but too much is a bad thing. High cholesterol can cause major health problems and is called a silent killer because there's often no warning signs. While high cholesterol can be inherited, lifestyle choices like poor diet, lack of exercise and smoking can increase the risk. Continue reading

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Serious adverse event rates and reoperation after arthroscopic shoulder surgery: population based cohort study – The BMJ

Posted: Published on July 8th, 2022

Objective To provide clinicians and patients with accurate risk estimates of serious adverse events after common elective shoulder arthroscopic procedures, including reoperation within one year. Design Population based cohort study. Setting Hospital Episode Statistics for NHS England, including civil registration mortality data from the Office for National Statistics. Continue reading

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Study Draws Attention to Poor Levels of Cardiometabolic Health in US Adults – Endocrinology Network

Posted: Published on July 8th, 2022

New research from an analysis of trends in the cardiovascular health of US adults from 1999-2018 is drawing attention to concerning trends related to cardiometabolic health across the nation. Continue reading

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