The effect of oral hormone therapy on the metabolome of postmenopausal women is profound. Different hormone therapy regimens result in discordant metabolomic effects that impact the risk for coronary heart disease, reports a study led by Raji Balasubramanian, associate professor in the School of Public Health and Health Sciences, University of Massachusetts, Amherst.
The study, based on the assessment of 481 metabolites in 934 women who participated in the Womens Health Initiative hormone therapy (WHI-HT) trials, is reported in the article Metabolomic Effects of Hormone Therapy and Associations with Coronary Heart Disease among Postmenopausal Women, published in the journal Circulation: Genomic and Precision Medicine.
Raji Balasubramanian, Sc.D., Associate Professor, Department of Biostatistics and Epidemiology, UMass-Amherst. [Raji Balasubramanian]Balasubramanians investigations build on earlier WHI-HT studies that report a 29% increase in the risk of coronary heart disease upon combined oral treatment with conjugated equine estrogens and medroxyprogesterone acetate (CEE+MPA) but not upon treatment with CEE alone.
To explain this difference in outcomes of the WHI-HT regimens, Balasubramanian and colleagues asked whether hormone therapy alters small-molecule metabolites. The answer is a resounding yes, says Balasubramanian.
In addition to coronary heart disease, the CEE+MPA regimen also increased risk of invasive breast cancer, stroke, pulmonary embolism, dementia, gallbladder disease, and urinary incontinence, while it reduced hip fractures, colorectal cancer, and diabetes. Earlier studies on the trial also show an association of CEE alone with a higher risk of stroke, and a lower risk of hip fracture
Our focus was on cardiovascular disease and understanding at a molecular level why these two hormone therapy regimens had disparate effects in regard to cardiovascular disease, Balasubramanian says.
The study reports metabolite changes assessed using liquid chromatography mass spectrometry in 431 women on a combined regimen (CEE+MPA) and 503 women on CEE alone, with both randomized groups including 50% placebo treatments. These metabolite profiling studies are carried out at the beginning and end of the year-long trial.
62% metabolites were significantly changed upon treatment with CEE alone, and 52% with CEE+MPA. The findings reveal profound changes in the metabolome, spanning a wide range of classes including lipids, amino acids and other small molecule metabolites, Balasubramanian says.
While the types, degrees and directions of change were analogous for most metabolites investigated in the two hormone therapy regimens, 22 metabolites showed discordant effects. Of these, 12 metabolites were associated with increased risk for coronary heart disease in an independent WHI-HT study on 944 participants and a metabolomics dataset nested within the Prevencin con Dieta Mediterrnea (PREDIMED) trial. The 12 metabolites included seven triacylglycerols,and the amino acid lysine.
In the CEE regimen, the direction of the changes in all 12 metabolites provided protection against coronary heart disease. The amino acid lysine was significantly altered by both hormone therapies, but in opposite directions. CEE alone increased lysine levels, providing a protective effect, whereas CEE+MPA decreased lysine levels, increasing the risk for coronary heart disease. In the CEE+MPA regimen, 11 metabolites were unchanged.
We believe that these disparate metabolomic effects between estrogen alone and estrogen in combination with medroxyprogesterone acetate may partially explain the differences in coronary heart disease risks observed in the original Womens Health Initiative Hormone Therapy trials, explains Balasubramanian.
Kathryn M. Rexrode, MD, MPH, Chief, Division of Womens Health, Department of Medicine, Associate Professor of Medicine, Harvard Medical School [Kathryn M. Rexrode]The study sets the stage for identifying other hormone therapy-related metabolomic changes in women of a broader age range and investigations into associations with other diseases, such as breast cancer.
Given the large changes in the metabolome with hormone therapy, we would like to see how these changes correlate with the impact of hormone therapy on a wide range of health outcomes. In addition, we hope to examine the impact of different hormone therapy formulations, such as transdermal estrogens, and different formulations of progestins. By better understanding the impact of hormone therapy on the metabolome we may advance understanding of hormones and health, says Kathryn M. Rexrode, MD, MPH, Chief, Division of Womens Health, Harvard Medical School, and senior author on the study.
Were excited to contribute to advancing research in womens health, Balasubramanian says.
- Home Remedies For Coronary Heart Disease - May 16th, 2018 [May 16th, 2018]
- Heart Disease in Women | National Heart, Lung, and Blood ... - October 17th, 2018 [October 17th, 2018]
- Home Remedies For Coronary Heart Disease | Speedy Remedies - December 26th, 2018 [December 26th, 2018]
- Coronary Heart Disease: Symptoms + Natural Remedies - Dr. Axe - December 26th, 2018 [December 26th, 2018]
- Coronary artery disease - Wikipedia - December 26th, 2018 [December 26th, 2018]
- Journal of Coronary Heart Diseases- Open Access Journals - February 20th, 2019 [February 20th, 2019]
- Heart Conferences | Heart Congress 2019 | Heart Failure ... - April 8th, 2019 [April 8th, 2019]
- Cardiac MRI Testing Market to Develop Rapidly by 2018 2026 - The Market Plan - September 24th, 2019 [September 24th, 2019]
- The Global C Reactive Protein Test Market To Progress At Cagr Between 2017 2025 - Zebvo - September 24th, 2019 [September 24th, 2019]
- Ventricular Assist Devices Market Progresses for Huge Profits During 2016 2024 - NewsVarsity - September 24th, 2019 [September 24th, 2019]
- Can you still be healthy if you're overweight? - Health24 - September 24th, 2019 [September 24th, 2019]
- Cardiogenic Shock Market Detailed Study Analysis with Forecast by 2025 - Analytics News - September 24th, 2019 [September 24th, 2019]
- Fractional Flow Reserve Market Projections Analysis 2019-2027 - Rapid News Network - September 24th, 2019 [September 24th, 2019]
- Self-expandable Stents Market : Advancements and Efficient Clinical Outcomes would Drive the Industry Growth with Top Key Player's Analysis -... - September 24th, 2019 [September 24th, 2019]
- Chronic Heart Failure Market: Study Provides In-depth Analysis of Chronic Heart Failure Market along with the Current Trends and Future Estimations... - September 24th, 2019 [September 24th, 2019]
- Nuclear Cardiology Market to Surge at a Robust Pace in Terms of Revenue Over 2015 2021 - Analytics News - September 24th, 2019 [September 24th, 2019]
- Global Cardiovascular Drugs Market Industry Analysis and Forecast (2018-2026) - NewsStoner - September 24th, 2019 [September 24th, 2019]
- Bare-metal Stents Market : Segmentation and Company Analysis to 2027 - Market Forecast - September 24th, 2019 [September 24th, 2019]
- Insomnia is Linked to Increased Risk for Heart Disease - Live Trading News - September 24th, 2019 [September 24th, 2019]
- Five Concrete Medical Reasons Why You Should Embrace Yoga - VIVA GLAM MAGAZINE - vivaglammagazine.com - September 24th, 2019 [September 24th, 2019]
- Carotid Stenting Systems Market Poised to Garner Maximum Revenues During 2018 to 2028 - SocioHerald - September 24th, 2019 [September 24th, 2019]
- Carotid Stents Market : Segmentation, Industry Trends and Development to 2026 - NewsStoner - September 24th, 2019 [September 24th, 2019]
- New report shares details about the Carotid Stents Market - Commerce Gazette - September 24th, 2019 [September 24th, 2019]
- Drug-Eluting Balloons Market to Garner Brimming Revenues by 2015 2021 - Analytics News - September 24th, 2019 [September 24th, 2019]
- Is Diet Soda Actually Killing You, Though? - Self - September 24th, 2019 [September 24th, 2019]
- Anti-angina Drugs Market to Witness Growth Acceleration During 2018 2026 - Wolf Mirror - September 24th, 2019 [September 24th, 2019]
- Anti Angina Drugs Market Sentiment Indicators Evaluation by 2018 2026 - Lake Shore Gazette - September 24th, 2019 [September 24th, 2019]
- Coronary Atherectomy Devices Market : Opportunities and Forecast Assessment, 2019-2027 - RedfoxInfo - September 24th, 2019 [September 24th, 2019]
- Combined Angiography Market to Witness Comprehensive Growth by 2016 2024 - NewsVarsity - September 24th, 2019 [September 24th, 2019]
- Seven home remedies to stop hiccups - Daily Sabah - September 24th, 2019 [September 24th, 2019]
- Resverlogix To Release Phase 3 Clinical Trial Data On A First-In-Class BET Bromodomain Inhibitor - Seeking Alpha - September 24th, 2019 [September 24th, 2019]
- Women with high blood pressure in pregnancy at increased risk of developing cardiovascular disorders - Independent.ie - September 24th, 2019 [September 24th, 2019]
- AI is Better at Foretelling Risk of Heart Attack - Healthcare Tech Outlook - September 24th, 2019 [September 24th, 2019]
- High blood pressure in pregnancy increases risk of future heart disease study - The Irish Times - September 24th, 2019 [September 24th, 2019]
- 30 Years of Research Shows Sauna Bathing is Game-Changer for Longevity and Heart Disease - Good News Network - September 24th, 2019 [September 24th, 2019]
- Coronary Artery Imaging Market Set to Witness an Uptick during 2017 2025 - Space Market Research - September 29th, 2019 [September 29th, 2019]
- Interventional Cardiology Devices Market Gain Impetus due to the Growing Demand over 2025 - Space Market Research - September 29th, 2019 [September 29th, 2019]
- High Pesticide Exposure Associated With Increased CAD and Stroke Risk - MedicalResearch.com - September 29th, 2019 [September 29th, 2019]
- The longevity files: A strong grip? Push-ups? Here's what actually can help you live to a ripe old age. - Bowling Green Daily News - September 29th, 2019 [September 29th, 2019]
- Heres what actually can help you live to a ripe old age - Pratt Tribune - September 29th, 2019 [September 29th, 2019]
- Pakistan at high risk of coronary heart diseases - The Nation - September 29th, 2019 [September 29th, 2019]
- Heart attack linked to air pollution - The Hindu - September 29th, 2019 [September 29th, 2019]
- The Weighty Cost of Diabetes - American Council on Science and Health - October 9th, 2019 [October 9th, 2019]
- Push-ups? Here's what can really help you live to a ripe old age - The Australian Financial Review - October 9th, 2019 [October 9th, 2019]
- Red meat study caused a stir here's what wasn't discussed - The Conversation UK - October 9th, 2019 [October 9th, 2019]
- I market, by application, is dominated by the cardiology segment, due to the vast population using various CVD drugs. This segment is projected to... - October 9th, 2019 [October 9th, 2019]
- At the heart of health!- The importance of a healthy heart for a healthy life - OyeYeah News - October 14th, 2019 [October 14th, 2019]
- Interventional Cardiology Devices Market Size 2019 Industry Analysis by Types, Applications, Key Players, and leading Countries Forecast to 2024 -... - October 14th, 2019 [October 14th, 2019]
- Angioplasty Balloons Market: Increasing Prevalence of Coronary Artery Disease to Drive the Market - Online News Guru - October 14th, 2019 [October 14th, 2019]
- Valvular Heart Disease Treatment Market: Information, Figures and Analytical Insights, 2019 2027 - Online News Guru - October 14th, 2019 [October 14th, 2019]
- More About The Dangers And Diseases Of Vaping - Star2.com - October 14th, 2019 [October 14th, 2019]
- Heart attack: The sign in your mouth that could increase your risk - Express - October 14th, 2019 [October 14th, 2019]
- Global Fractional Flow Reserve Market Industry Analysis and Forecast (2018-2026) - Markets Gazette - October 16th, 2019 [October 16th, 2019]
- Biologic Therapeutics Market Segmentation Detailed Study with Forecast to 2025 - Online News Guru - October 16th, 2019 [October 16th, 2019]
- Interventional Cardiology Devices Market Global industry analysis and forecast (2018-2026) - Markets Gazette - October 16th, 2019 [October 16th, 2019]
- Peanut Butter: Benefits and facts about the tasty food item - Republic World - Republic World - October 16th, 2019 [October 16th, 2019]
- Cardiopulmonary Resuscitation Market Global Industry Analysis and Forecast (2018-2026) - Science Examiner - October 16th, 2019 [October 16th, 2019]
- Fewer deaths in winter 2018-19 - Scottish Government News - October 16th, 2019 [October 16th, 2019]
- How to live longer: These three drinks may extend your lifespan - Express - October 16th, 2019 [October 16th, 2019]
- The Europe mobile cardiac telemetry systems market is expected to reach US$ 477,845.5 Mn in 2027 from US$ 167,462.4 Mn in 2018 - Yahoo Finance - October 16th, 2019 [October 16th, 2019]
- You Docs: Getting to the meat of the matter on the matter of meat - Roanoke Times - October 16th, 2019 [October 16th, 2019]
- Tips to manage heart diseases: Heres what you should know - The Indian Express - October 16th, 2019 [October 16th, 2019]
- Do You Think Heart Attacks Only Strike The Old? - Star2.com - October 16th, 2019 [October 16th, 2019]
- Diagnostic Radiopharmaceuticals & Contrast Media Market 2019 | Remarkable Growth Factors with Industry Size & Share, New Innovations of... - October 28th, 2019 [October 28th, 2019]
- Interventional Cardiology Devices Market Report Extensive Analysis 2019 | Specified by Production, Technology, Competition, and Revenue Forecast till... - October 28th, 2019 [October 28th, 2019]
- Shaq Promotes Heart Health at Spirit of the Heart Gala - Lasentinel - October 28th, 2019 [October 28th, 2019]
- Obesity Exacerbates Many Causes of Death, But Risks are Different for Men and Women - University Herald - October 28th, 2019 [October 28th, 2019]
- Sales Revenue of MR Conditional Pacemaker Devices Market to Soar in the Near Future Owing to Growing Consumer Adoption - Lake Shore Gazette - October 29th, 2019 [October 29th, 2019]
- World Stroke Day 2019: Stroke risk may be higher in youth owing to sedentary lifestyle - The Indian Express - October 29th, 2019 [October 29th, 2019]
- Women and men at risk of different obesity-related conditions - Medical News Today - October 29th, 2019 [October 29th, 2019]
- University Hospitals Designs the Cardiovascular Center of the Future | - Diagnostic and Interventional Cardiology - October 29th, 2019 [October 29th, 2019]
- Technological Innovations to Boost the Interventional Cardiology Devices Market - Press Release - Digital Journal - November 16th, 2019 [November 16th, 2019]
- On World Diabetes Day, here are a few tips to maintain a healthy heart - Mid-day - November 16th, 2019 [November 16th, 2019]
- Start the path to a healthier lifestyle by participating in Great American Smoke Out challenge - KRQE News 13 - November 16th, 2019 [November 16th, 2019]
- Multi-Center Clinical Study Demonstrates HeartTrends Improves Early Detection for Heart Disease in Healthy Individuals Cardiology2.0 - Cardiology2.0 - November 16th, 2019 [November 16th, 2019]
- Health benefits of tobacco cessation - SCNow - November 16th, 2019 [November 16th, 2019]
- Caladrius Biosciences Reports Positive Results for CLBS16 from the ESCaPE-CMD Trial at American Heart Association Scientific Sessions 2019 -... - November 16th, 2019 [November 16th, 2019]
- Subgroup Analysis of TWILIGHT Trial Patients With Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS) Who Underwent PCI Showed BRILINTA Monotherapy... - November 19th, 2019 [November 19th, 2019]
- Bengaluru-origin cardiologist performs path-breaking heart surgery in US - The New Indian Express - November 19th, 2019 [November 19th, 2019]
- Structural Heart Devices Market Understanding the Key Product Segments and their Future - Guru Online News - November 19th, 2019 [November 19th, 2019]