Abstract Background: The frequency of cardiac rhythm abnormalities and their risk factors in community-dwelling adults are not well characterized. Methods: We determined the frequency of rhythm abnormalities in the UK Biobank, a national prospective cohort. We tested associations between risk factors and incident rhythm abnormalities using multivariable proportional hazards regression. Results: Of 502 627 adults (median age, 58 years [interquartile range, 13]; 54.4% women), 2.35% had a baseline rhythm abnormality. The prevalence increased with age with 4.84% of individuals aged 65 to 73 years affected. During 3 368 332 person-years of follow-up, 15 906 new rhythm abnormalities were detected (4.72 per 1000 person-years; 95% confidence interval [CI]: 4.654.80). Atrial fibrillation (3.11 per 1000 person-years; 95% CI: 3.053.17), bradyarrhythmias (0.89 per 1000 person-years; 95% CI: 0.860.92), and conduction system diseases (1.06 per 1000 person-years; 95% CI: 1.021.09) were more common than supraventricular (0.51 per 1000 person-years; 95% CI: 0.480.53) and ventricular arrhythmias (0.57 per 1000 person-years; 95% CI: 0.550.60). Older age (hazard ratio [HR]: 2.35 per 10-year increase; 95% CI: 2.292.41; P … Continue reading
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