A better understanding of the cause of autism may come from an unlikely source,eurological studies of the fruit fly. Neuroscientists working in the biology department at the University of Nevada, Reno have identified a new genetic mechanism they believe is responsible for disruption of the brain pathways connecting the left and right hemispheres of the brain; which has separately been linked to autism. This is an exciting find, Thomas Kidd, associate professor in the University's biology department, said. In the one striking mutant, called commissureless or comm, there are almost no connections between the two sides of the fruit flys nervous system. The fruit fly nervous system research was conducted in Kidds lab over several years. Fruit flies have brains and nerve cords that form using molecules surprisingly similar to those in human brains and spinal cords. The study, published in the scientific journal PLOS Genetics, shows that the human gene, called PRRG4, functions the same way as the fruit fly Comm at the molecular level, regulating which signals neurons can respond to in their environment. The Comm gene was thought to be unique to insects but our work shows that it is not, Elizabeth Justice, lead author of the … Continue reading
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